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Sci."},{"issue":"12","key":"10.1016\/j.jep.2026.121331_bib145","first-page":"808","article-title":"Evaluation of therapeutic potential of Dioscorea bulbifera tubers on learning and memory impairment in high fat diet (HFD) and ICV streptozotocin (STZ)-induced experimental dementia in mice","volume":"2","author":"Neha","year":"2013","journal-title":"Global. J. Res. Med. Plants & Indigen. 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Technol."},{"issue":"2","key":"10.1016\/j.jep.2026.121331_bib156","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.canlet.2009.11.018","article-title":"RNA polymerase\u2014An important molecular target of triptolide in cancer cells","volume":"292","author":"Pan","year":"2010","journal-title":"Cancer. 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J. Food Prop."},{"issue":"4","key":"10.1016\/j.jep.2026.121331_bib167","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.5530\/ijper.20250520","article-title":"Development and optimization of novel microwave-assisted extraction for rich-flavonoids and polyphenols from Dioscorea bulbifera leaves by response surface methodology","volume":"59","author":"Reddy","year":"2025","journal-title":"Ind. J. Pharm. Edu. Res."},{"issue":"2","key":"10.1016\/j.jep.2026.121331_bib168","first-page":"370","article-title":"The intake of yam (Dioscorea bulbifera Linn) attenuated the hyperglycemia and the bone fragility in female diabetic rats","volume":"29","author":"R\u00eago","year":"2014","journal-title":"Nutr. Hosp."},{"issue":"2","key":"10.1016\/j.jep.2026.121331_bib169","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/1750-3841.15002","article-title":"Carbohydrate and bioactive compounds composition of starchy tropical fruits and tubers, in relation to pre and postharvest conditions:a review","volume":"85","author":"Rinaldo","year":"2020","journal-title":"J. Food Sci."},{"key":"10.1016\/j.jep.2026.121331_bib170","doi-asserted-by":"crossref","DOI":"10.1088\/1755-1315\/810\/1\/012005","article-title":"Phytochemical and antioxidant analysis of fermented \u2018Dayak\u2019 wild yam (Dioscorea hispida dennst), purple yam (Dioscorea alata) and air potato (Dioscorea bulbifera L.) tuber flour","volume":"810","author":"Rudito","year":"2021","journal-title":"IOP Conf. Ser. Earth Environ. 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Eng."},{"key":"10.1016\/j.jep.2026.121331_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcab.2025.103672","article-title":"Influence of different drying techniques on physicochemical and techno-functional properties, gelatinization, pasting behaviors, and morphology of bitter yam (Dioscorea bulbifera L.)","volume":"68","author":"Sahoo","year":"2025","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"10.1016\/j.jep.2026.121331_bib174","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2025.100678","article-title":"Evaluation of the cardio-protective effect of saponin-rich fraction of Dioscorea bulbifera in mitigating doxorubicin-induced cardiotoxicity in rats: a microanatomical study","volume":"16","author":"Saka","year":"2025","journal-title":"Pharmacol. Res. - Mod. Chin. 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Sci."},{"issue":"6","key":"10.1016\/j.jep.2026.121331_bib177","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3390\/foods10061341","article-title":"Variation in the physical and functional properties of yam (Dioscorea spp.) flour produced by different processing techniques","volume":"10","author":"Setyawan","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.jep.2026.121331_bib178","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.133416","article-title":"Maillard reaction chemistry in formation of critical intermediates and flavour compounds and their antioxidant properties","volume":"393","author":"Shakoor","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2026.121331_bib179","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155623","article-title":"Detoxification and underlying mechanisms towards toxic alkaloids by Traditional Chinese medicine processing:a comprehensive review","volume":"129","author":"Shan","year":"2024","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jep.2026.121331_bib180","first-page":"B)619","article-title":"Synergistic efficacy of three plant extracts, Bergenia ciliata, Acorus calamus and Dioscorea bulbifera for antimicrobial activity","volume":"7","author":"Shankar","year":"2016","journal-title":"Int. J. Pharma Bio Sci."},{"key":"10.1016\/j.jep.2026.121331_bib181","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.ijbiomac.2017.04.085","article-title":"Purification, characterization and biological significance of mannose binding lectin from Dioscorea bulbifera bulbils","volume":"102","author":"Sharma","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.jep.2026.121331_bib182","first-page":"32","article-title":"Cytokines as potential biomarkers of liver toxicity induced by Dioscorea bulbifera L. Biosci","volume":"8","author":"Sheng","year":"2014","journal-title":"Trends"},{"key":"10.1016\/j.jep.2026.121331_bib183","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.taap.2018.12.012","article-title":"Dictamnine-induced hepatotoxicity in mice:the role of metabolic activation of furan","volume":"364","author":"Shi","year":"2019","journal-title":"Toxicol. Appl. 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Sci."},{"key":"10.1016\/j.jep.2026.121331_bib190","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.984858","article-title":"Detoxification technology and mechanism of processing with angelicae sinensis radix in reducing the hepatotoxicity induced by rhizoma dioscoreae Bulbiferae in vivo","volume":"13","author":"Song","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"Pt 3","key":"10.1016\/j.jep.2026.121331_bib191","article-title":"Investigation of the principle of concoction by using the processing excipient Glycyrrhiza uralensis Fisch. juice to reduce the main toxicity of Dioscorea bulbifera L. and enhance its main efficacy as expectorant and cough suppressant","volume":"319","author":"Song","year":"2024","journal-title":"J. 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Lett."},{"key":"10.1016\/j.jep.2026.121331_bib196","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154174","article-title":"Diosbulbin b:an important component responsible for hepatotoxicity and protein covalent binding induced by Dioscorea bulbifera L","volume":"102","author":"Tan","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121331_bib197","series-title":"Effects of Dioscoreae Bulbiferae Rhizoma Combined with Angelica sinensis on the Expression of grp78 and Bad Genes in Rat Liver","author":"Tang","year":"2012"},{"issue":"7","key":"10.1016\/j.jep.2026.121331_bib198","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1248\/cpb.c14-00057","article-title":"New norclerodane diterpenoids from the tubers of Dioscorea bulbifera","volume":"62","author":"Tang","year":"2014","journal-title":"Chem. Pharm. 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J."},{"key":"10.1016\/j.jep.2026.121331_bib203","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.biopha.2017.11.008","article-title":"Revalidation of the neuroprotective effects of a United States patented polyherbal formulation on scopolamine induced learning and memory impairment in rats","volume":"97","author":"Upadhyay","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"9","key":"10.1016\/j.jep.2026.121331_bib204","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1097\/00042737-200109000-00003","article-title":"Polyamine metabolism revisited","volume":"13","author":"Urdiales","year":"2001","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.jep.2026.121331_bib205","doi-asserted-by":"crossref","first-page":"e293","DOI":"10.1016\/S2352-3018(25)00011-6","article-title":"Prevention and control of HPV-related cancers in people living with HIV","volume":"12","author":"Uusk\u00fcla","year":"2025","journal-title":"Lancet. HIV."},{"key":"10.1016\/j.jep.2026.121331_bib206","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1039\/C0FO00048E","article-title":"Protective role of air potato (Dioscorea bulbifera) of yam family in myocardial ischemic reperfusion injury","volume":"1","author":"Vasanthi","year":"2010","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.jep.2026.121331_bib207","first-page":"1","article-title":"The influence of different processing methods on the anti-gastric cancer effect and hepatotoxicity of Dioscorea bulbifera L. J. Jining","volume":"45","author":"Wang","year":"2022","journal-title":"Med. 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Toxicol."},{"key":"10.1016\/j.jep.2026.121331_bib227","first-page":"240","article-title":"Glycyrrhiza, a commonly used medicinal herb:review of species classification, pharmacology, active ingredient biosynthesis, and synthetic biology","volume":"75","author":"Wu","year":"2024","journal-title":"J. Adv. Res."},{"issue":"10","key":"10.1016\/j.jep.2026.121331_bib228","first-page":"817","article-title":"Experimental study on enhancing the antitussive efficacy and reducing the toxicity of Dioscorea bulbifera L. by the processing technology","volume":"55","author":"Wu","year":"2020","journal-title":"Chin. Pharm J."},{"issue":"1","key":"10.1016\/j.jep.2026.121331_bib229","first-page":"57","article-title":"The crucial role of metabolic regulation in differential hepatotoxicity induced by furanoids in Dioscorea bulbifera","volume":"18","author":"Wu","year":"2020","journal-title":"Chin. J. Nat. 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Chem."},{"issue":"14","key":"10.1016\/j.jep.2026.121331_bib234","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e34591","article-title":"New compatible pair of TCM:Paeoniae Radix Alba effectively alleviate Psoraleae Fructus-induced liver injury by suppressing NLRP3 inflammasome activation","volume":"10","author":"Xu","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2026.121331_bib235","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115365","article-title":"Aqueous extract of Paeoniae Radix Alba (Paeonia lactiflora Pall.) ameliorates DSS-induced colitis in mice by tunning the intestinal physical barrier, immune responses, and microbiota","volume":"294","author":"Yan","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.121331_bib236","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23549","article-title":"Glycyrrhizin protects against diosbulbin B-induced hepatotoxicity by inhibiting the metabolic activation of diosbulbin B","volume":"38","author":"Yang","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"10","key":"10.1016\/j.jep.2026.121331_bib237","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1124\/dmd.114.058222","article-title":"Metabolism of diosbulbin B in vitro and in vivo in rats:formation of reactive metabolites and human enzymes involved","volume":"42","author":"Yang","year":"2014","journal-title":"Drug Metab. Dispos."},{"issue":"3","key":"10.1016\/j.jep.2026.121331_bib238","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jep.2013.08.010","article-title":"Gender-related pharmacokinetics and absolute bioavailability of diosbulbin B in rats determined by ultra-performance liquid chromatography-tandem mass spectrometry","volume":"149","author":"Yang","year":"2013","journal-title":"J. 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Chem."},{"key":"10.1016\/j.jep.2026.121331_bib245","doi-asserted-by":"crossref","first-page":"676","DOI":"10.3389\/fphar.2019.00676","article-title":"Diosbulbin B-induced mitochondria-dependent apoptosis in L-02 hepatocytes is regulated by reactive oxygen species-mediated autophagy","volume":"10","author":"Ye","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2026.121331_bib246","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1021\/tx5002145","article-title":"Identification of amino acid and glutathione N-conjugates of toosendanin:bioactivation of the furan ring mediated by CYP3A4","volume":"27","author":"Yu","year":"2014","journal-title":"Chem. Res. Toxicol."},{"issue":"1","key":"10.1016\/j.jep.2026.121331_bib248","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eng.2019.01.002","article-title":"The quest for the modernization and internationalization of Traditional Chinese medicine","volume":"5","author":"Zhang","year":"2019","journal-title":"Engineering"},{"issue":"8","key":"10.1016\/j.jep.2026.121331_bib249","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.3390\/molecules21081094","article-title":"Compositions, formation mechanism, and neuroprotective effect of compound precipitation from the traditional Chinese prescription huang-lian-jie-du-tang","volume":"21","author":"Zhang","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121331_bib250","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113964","article-title":"Traditional herbal medicine and nanomedicine:converging disciplines to improve therapeutic efficacy and human health","volume":"178","author":"Zhang","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jep.2026.121331_bib251","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2022.05.008","article-title":"Evidence for adduction of biologic amines with reactive metabolite of 8-epidiosbulbin E acetate in vitro and in vivo","volume":"365","author":"Zhang","year":"2022","journal-title":"Toxicol. Lett."},{"issue":"10","key":"10.1016\/j.jep.2026.121331_bib252","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1021\/acs.chemrestox.2c00130","article-title":"Asparagine and glutamine residues participate in protein covalent binding by epoxide metabolite of 8-epidiosbulbin E acetate in vitro and in vivo","volume":"35","author":"Zhang","year":"2022","journal-title":"Chem. Res. 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Pharmacol."},{"key":"10.1016\/j.jep.2026.121331_bib255","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118614","article-title":"8-epidiosbulbin E acetate triggers apoptosis via metabolic activation-mediated crosstalk between mitochondria and endoplasmic reticulum","volume":"302","author":"Zhang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jep.2026.121331_bib256","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1080\/01480545.2024.2440451","article-title":"Introduced paeoniflorin reduces the main toxicity induced by diosbulbin B, the major toxic compound of Dioscorea bulbifera L.:Involved inhibiting inflammation and ferroptosis","volume":"48","author":"Zhang","year":"2024","journal-title":"Drug Chem. 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