{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T17:16:28Z","timestamp":1794071788748,"version":"4.8.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007946","name":"Inner Mongolia Minzu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jep.2026.121363","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:18:55Z","timestamp":1771028335000},"page":"121363","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A multi-omics approach to decipher the protective mechanism of Myristica fragrans against acute lung injury"],"prefix":"10.1016","volume":"362","author":[{"given":"Qin-Qin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3804-6007","authenticated-orcid":false,"given":"Shilin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.121363_bib1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/978-1-0716-0822-7_10","article-title":"Construction of protein expression network","volume":"2189","author":"Afiqah-Aleng","year":"2021","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.jep.2026.121363_bib2","article-title":"The gene ontology knowledgebase in 2023","volume":"224","author":"Aleksander","year":"2023","journal-title":"Genetics"},{"issue":"7","key":"10.1016\/j.jep.2026.121363_bib3","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1002\/ptr.7491","article-title":"Nutmeg (Myristica fragrans houtt.) essential oil: a review on its composition, biological, and pharmacological activities","volume":"36","author":"Ashokkumar","year":"2022","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2026.121363_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115661","article-title":"Shufeng jiedu capsule inhibits inflammation and apoptosis by activating A2AAR and inhibiting NF-\u03baB to alleviate LPS-Induced ALI","volume":"298","author":"Cai","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121363_bib5","article-title":"Macrophage pyroptosis and its crucial role in ALI\/ARDS","volume":"16","author":"Cai","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2026.121363_bib6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.drudis.2021.09.007","article-title":"Machine-learning methods for ligand-protein molecular docking","volume":"27","author":"Crampon","year":"2022","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jep.2026.121363_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104759","article-title":"Systems pharmacology reveals the mechanism of activity of Ge-Gen-Qin-Lian decoction against LPS-Induced acute lung injury: a novel strategy for exploring active components and effective mechanism of TCM formulae","volume":"156","author":"Ding","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2026.121363_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ymeth.2024.10.009","article-title":"Imaging flow cytometry reveals LPS-Induced changes to intracellular intensity and distribution of \u03b1-synuclein in a TLR4-dependent manner in STC-1 cells","volume":"234","author":"Gorecki","year":"2025","journal-title":"Methods"},{"issue":"9","key":"10.1016\/j.jep.2026.121363_bib9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.53388\/TMR20250717002","article-title":"Dual-action therapeutics of ganoderma spores: integrating bioactivity and delivery for acute lung injury treatment","volume":"11","author":"Guo","year":"2026","journal-title":"Tradit Med Res"},{"issue":"11","key":"10.1016\/j.jep.2026.121363_bib10","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s12272-020-01285-4","article-title":"Phytochemical and pharmacological properties of Myristica fragrans houtt.: an updated review","volume":"43","author":"Ha","year":"2020","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"32","key":"10.1016\/j.jep.2026.121363_bib11","doi-asserted-by":"crossref","first-page":"35170","DOI":"10.1021\/acsomega.4c05649","article-title":"Neolignans and diarylnonanoid derivatives with anti-inflammatory activity from Myristica fragrans houtt. Seeds","volume":"9","author":"Le","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.jep.2026.121363_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2022.100158","article-title":"Multicomponent self-assembly based on bioactive molecules of traditional Chinese medicine (TCM)","volume":"4","author":"Li","year":"2022","journal-title":"Pharmacological Res. Modern Chin Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121363_bib13","article-title":"Classic signaling pathways in alveolar injury and repair involved in sepsis\u2010induced ALI\/ARDS: new research progress and prospect","volume":"2022","author":"Li","year":"2022","journal-title":"Dis. Markers."},{"issue":"6","key":"10.1016\/j.jep.2026.121363_bib14","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1021\/acs.jnatprod.4c00215","article-title":"UPLC-Q-TOF-MS\/MS-Based targeted discovery of chetomin analogues from Chaetomium cochliodes","volume":"87","author":"Liu","year":"2024","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2026.121363_bib15","article-title":"Three differential expression analysis methods for RNA sequencing: limma, EdgeR, DESeq2","volume":"175","author":"Liu","year":"2021","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jep.2026.121363_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114847","article-title":"Systematic exploration of the potential material basis and molecular mechanism of the Mongolian medicine Nutmeg-5 in improving cardiac remodeling after myocardial infarction","volume":"285","author":"Liu","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.jep.2026.121363_bib17","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1042\/CS20210879","article-title":"Pathogenesis of pneumonia and acute lung injury","volume":"136","author":"Long","year":"2022","journal-title":"Clin. Sci."},{"issue":"1","key":"10.1016\/j.jep.2026.121363_bib18","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12964-025-02149-4","article-title":"An examination of the LPS-TLR4 immune response through the analysis of molecular structures and protein\u2013protein interactions","volume":"23","author":"Luo","year":"2025","journal-title":"Cell Commun. Signal."},{"issue":"20","key":"10.1016\/j.jep.2026.121363_bib19","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.3390\/cells11203317","article-title":"Therapeutic targeting of NF-\u03baB in acute lung injury: a double-edged sword","volume":"11","author":"Millar","year":"2022","journal-title":"Cells."},{"issue":"2","key":"10.1016\/j.jep.2026.121363_bib20","first-page":"27","article-title":"Myristica fragrans: a comprehensive review","volume":"8","author":"Nagja","year":"2016","journal-title":"Int. J. Pharm. Pharmaceut. Sci."},{"issue":"1","key":"10.1016\/j.jep.2026.121363_bib21","article-title":"Green extraction of nutmeg (Myristica fragrans) phytochemicals: prospective strategies and roadblocks","volume":"9","author":"Putra","year":"2024","journal-title":"Open Agric."},{"key":"10.1016\/j.jep.2026.121363_bib22","article-title":"Nutmeg: a review on basic source, traditional use, chemical components, pharmacological activities, mechanism, and quality control","author":"Qi","year":"2025","journal-title":"Planta Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121363_bib23","first-page":"82","article-title":"Li Dongyuan's research on the use of spleen drugs","volume":"5","author":"Qinghua","year":"2024","journal-title":"Academic J. Medicine. Health Sci."},{"key":"10.1016\/j.jep.2026.121363_bib24","series-title":"Medicinal Spice and Condiment Crops","first-page":"325","article-title":"Nutmeg seeds (Myristica fragrans)","author":"Shah","year":"2024"},{"issue":"1","key":"10.1016\/j.jep.2026.121363_bib25","article-title":"Natural preservation of duck breast meat using nutmeg (Myristica fragrans) nanoemulsion: a green biotechnological approach","volume":"12","author":"Supamri","year":"2026","journal-title":"Cogent Food Agric."},{"issue":"12","key":"10.1016\/j.jep.2026.121363_bib26","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.3390\/antiox11122338","article-title":"Comprehensive characterization of chemical composition and antioxidant activity of lignan-rich coniferous knotwood extractives","volume":"11","author":"Ul\u2019yanovskii","year":"2022","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.jep.2026.121363_bib27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s12033-024-01055-3","article-title":"Lipopolysaccharide-educated cancer-associated fibroblasts facilitate malignant progression of ovarian cancer cells via the NF-kB\/IL-6\/JAK2 signal transduction","volume":"67","author":"Wang","year":"2025","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.jep.2026.121363_bib28","article-title":"Integrative analysis identifies oxidative stress biomarkers in non-alcoholic fatty liver disease via machine learning and weighted gene co-expression network analysis","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2026.121363_bib29","article-title":"The role of macrophages polarization in sepsis-induced acute lung injury","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2026.121363_bib30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3748\/wjg.v4.i1.2","article-title":"Current concept of spleen-stomach theory and spleen deficiency syndrome in TCM","volume":"4","author":"Wu","year":"1998","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jep.2026.121363_bib31","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0254-6272(13)60115-6","article-title":"Understanding association of spleen system with earth on traditional Chinese medicine theory","volume":"33","author":"Yang","year":"2013","journal-title":"J. Tradit. Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2026.121363_bib32","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3390\/biom15020192","article-title":"Natural compounds regulate macrophage polarization and alleviate inflammation against ALI\/ARDS","volume":"15","author":"Yin","year":"2025","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.jep.2026.121363_bib33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.15212\/AMM-2022-0049","article-title":"Multi-component Chinese medicine formulas for drug discovery: state of the art and future perspectives","volume":"2","author":"Zhang","year":"2023","journal-title":"Acta Materia Medica"},{"key":"10.1016\/j.jep.2026.121363_bib34","article-title":"Integrative network-based analysis on multiple Gene expression omnibus datasets identifies novel immune molecular markers implicated in non-alcoholic steatohepatitis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2026.121363_bib35","article-title":"Traditional Tibetan medicine to fight against COVID-19: basic theory and therapeutic drugs","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2026.121363_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116773","article-title":"Exploring immune-related pathogenesis in lung injury: providing new insights into ALI\/ARDS","volume":"175","author":"Zheng","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.121363_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114777","article-title":"Physalin B ameliorates inflammatory responses in lipopolysaccharide-induced acute lung injury mice by inhibiting NF-\u03baB and NLRP3 via the activation of the PI3K\/Akt pathway","volume":"284","author":"Zhong","year":"2022","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412600214X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412600214X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:47:30Z","timestamp":1777571250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412600214X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":37,"alternative-id":["S037887412600214X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121363","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A multi-omics approach to decipher the protective mechanism of Myristica fragrans against acute lung injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121363","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121363"}}