{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:30:59Z","timestamp":1790875859943,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515110851"],"award-info":[{"award-number":["2022A1515110851"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZZYSM202211002"],"award-info":[{"award-number":["SZZYSM202211002"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017622","name":"Shenzhen Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305105"],"award-info":[{"award-number":["82305105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jep.2026.121373","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:41:56Z","timestamp":1770914516000},"page":"121373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Gynostemma pentaphyllum polysaccharides alleviate ulcerative colitis in mice via the Nrf2\/ROS\/NLRP3 axis and modulation of the gut microbiota"],"prefix":"10.1016","volume":"363","author":[{"given":"Min","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qincheng","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YunHai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoju","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7376-0690","authenticated-orcid":false,"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.121373_bib48","doi-asserted-by":"crossref","first-page":"113020","DOI":"10.1016\/j.intimp.2024.113020","article-title":"Carthamin yellow alleviates dextran sodium sulfate-induced ulcerative colitis by repairing the intestinal barrier and activating the nrf2\/GPX4 axis","volume":"141","author":"Bian","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2026.121373_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102603","article-title":"Personalized redox medicine in inflammatory bowel diseases: an emerging role for HIF-1\u03b1 and NRF2 as therapeutic targets","volume":"60","author":"Bourgonje","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2026.121373_bib13","doi-asserted-by":"crossref","first-page":"696148","DOI":"10.3389\/fimmu.2021.696148","article-title":"Synergistic protective effect of konjac mannan oligosaccharides and bacillus subtilis on intestinal epithelial barrier dysfunction in caco-2 cell model and mice model of lipopolysaccharide stimulation","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2026.121373_bib4","article-title":"\u03b2-1,3\/1,6-Glucans and immunity: state of the art and future directions","volume":"65","author":"De Marco Castro","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jep.2026.121373_bib5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.carbpol.2016.09.073","article-title":"The polysaccharide and low molecular weight components of opuntia ficus indica cladodes: structure and skin repairing properties","volume":"157","author":"Di Lorenzo","year":"2017","journal-title":"Carbohydr. Polym."},{"issue":"Pt 3","key":"10.1016\/j.jep.2026.121373_bib26","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.foodres.2016.11.016","article-title":"Polysaccharides from macroalgae: recent advances, innovative technologies and challenges in extraction and purification","volume":"99","author":"Garcia-Vaquero","year":"2017","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jep.2026.121373_bib7","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.chom.2024.07.028","article-title":"Engineered probiotic ameliorates ulcerative colitis by restoring gut microbiota and redox homeostasis","volume":"32","author":"Guo","year":"2024","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jep.2026.121373_bib8","article-title":"The function of natural polysaccharides in the treatment of ulcerative colitis","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2026.121373_bib9","doi-asserted-by":"crossref","first-page":"112001","DOI":"10.1016\/j.fct.2021.112001","article-title":"The possible mechanism of the protective effect of a sulfated polysaccharide from gracilaria lemaneiformis against colitis induced by dextran sulfate sodium in mice","volume":"149","author":"Han","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2026.121373_bib10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3390\/antiox12020236","article-title":"The regulatory effect of phytochemicals on chronic diseases by targeting Nrf2-ARE signaling pathway","volume":"12","author":"He","year":"2023","journal-title":"Antioxidants"},{"issue":"8067","key":"10.1016\/j.jep.2026.121373_bib14","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41586-025-08940-0","article-title":"Global evolution of inflammatory bowel disease across epidemiologic stages","volume":"642","author":"Hracs","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jep.2026.121373_bib12","doi-asserted-by":"crossref","first-page":"113394","DOI":"10.1016\/j.jep.2020.113394","article-title":"Qingchang huashi formula attenuates DSS-induced colitis in mice by restoring gut microbiota-metabolism homeostasis and goblet cell function","volume":"266","author":"Hu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121373_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.144964","article-title":"Phytochemistry, bioactivities and application of Gynostemma pentaphyllum polysaccharide: a review","volume":"322","author":"Hu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"12","key":"10.1016\/j.jep.2026.121373_bib36","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201981","article-title":"Decoction of heat-clearing, detoxifying and blood stasis removing relieves acute soft tissue injury via modulating MiR-26b-5p\/COX2 axis to inhibit inflammation","volume":"40","author":"Jiang","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jep.2026.121373_bib15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0140-6736(17)31263-1","article-title":"Towards therapeutic choices in ulcerative colitis","volume":"390","author":"Laharie","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2026.121373_bib16","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2026.121373_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124164","article-title":"Comparison of physicochemical characteristics, antioxidant and immunomodulatory activities of polysaccharides from wine grapes","volume":"239","author":"Leng","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.121373_bib57","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.phrs.2016.02.010","article-title":"Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in c57BL\/6 mice by suppressing th17 responses","volume":"110","author":"Li","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2026.121373_bib18","article-title":"Effect of polysaccharide extracted from Gynostemma Pentaphyllum on the body weight and Gut Microbiota of mice","volume":"9","author":"Li","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jep.2026.121373_bib19","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.foodchem.2018.10.138","article-title":"Simultaneous decoloration and purification of crude oligosaccharides from pumpkin (Cucurbita moschata Duch) by macroporous adsorbent resin","volume":"277","author":"Liang","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2026.121373_bib21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jpha.2023.07.009","article-title":"Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy","volume":"14","author":"Linghu","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jep.2026.121373_bib22","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3390\/molecules24081554","article-title":"Extraction, purification, structural characteristics, biological activities and pharmacological applications of acemannan, a polysaccharide from aloe vera: a review","volume":"24","author":"Liu","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121373_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijbiomac.2014.05.014","article-title":"Anticancer and immunoregulatory activity of Gynostemma pentaphyllum polysaccharides in H22 tumor-bearing mice","volume":"69","author":"Liu","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.121373_bib24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1089\/ars.2015.6615","article-title":"Nuclear factor E2-Related Factor-2 negatively regulates NLRP3 inflammasome activity by inhibiting reactive oxygen species-induced NLRP3 priming","volume":"26","author":"Liu","year":"2017","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jep.2026.121373_bib54","first-page":"155979","article-title":"Exploring the mechanisms of huangqin qingfei decoction on acute lung injury by LC-MS combined network pharmacology analysis","volume":"134","author":"Liu","year":"2024","journal-title":"Phytomed. Int. J. Phytotherap. Phytopharmacol."},{"key":"10.1016\/j.jep.2026.121373_bib25","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1016\/j.apsb.2021.03.011","article-title":"Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation","volume":"11","author":"Lv","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jep.2026.121373_bib27","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jep.2026.121373_bib28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12876-021-01693-w","article-title":"Gut microbiota composition and functional prediction in diarrhea-predominant irritable bowel syndrome","volume":"21","author":"Mei","year":"2021","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.jep.2026.121373_bib29","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3390\/antiox13080985","article-title":"Gut Microbiota dysbiosis, oxidative stress, inflammation, and epigenetic alterations in metabolic diseases","volume":"13","author":"Mostafavi Abdolmaleky","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2026.121373_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1390351","article-title":"The emerging role of oxidative stress in inflammatory bowel disease","volume":"15","author":"Muro","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2026.121373_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117189","article-title":"Polysaccharides from natural resources exhibit great potential in the treatment of ulcerative colitis: a review","volume":"254","author":"Niu","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.121373_bib32","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.tcb.2020.08.004","article-title":"Tight junction structure and function revisited","volume":"30","author":"Otani","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jep.2026.121373_bib33","doi-asserted-by":"crossref","first-page":"123635","DOI":"10.1016\/j.carbpol.2025.123635","article-title":"Hempseed cell wall polysaccharides are dominated by linear xylans and cellulose: comprehensive structural profiling of ten cultivars of industrial hemp, cannabis sativa l","volume":"361","author":"Pandeya","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.121373_bib34","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.carbpol.2015.10.053","article-title":"Structural characterization and antioxidant activity in vitro of polysaccharides from angelica and astragalus","volume":"137","author":"Pu","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.121373_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111490","article-title":"Hepatoprotection of pine nut polysaccharide via NRF2\/ARE\/MKP1\/JNK signaling pathways against carbon tetrachloride-induced liver injury in mice","volume":"142","author":"Qu","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2026.121373_bib37","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1111\/j.1572-0241.1998.00607.x","article-title":"Correlation between endoscopic severity and the clinical activity index in ulcerative colitis","volume":"93","author":"Seo","year":"1998","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jep.2026.121373_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154667","article-title":"Astragalus polysaccharide ameliorates vascular endothelial dysfunction by stimulating macrophage M2 polarization via potentiating Nrf2\/HO-1 signaling pathway","volume":"112","author":"Sha","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121373_bib39","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3390\/molecules21081085","article-title":"Immunomodulatory and antioxidant effects of polysaccharides from Gynostemma pentaphyllum makino in immunosuppressed mice","volume":"21","author":"Shang","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121373_bib40","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.3390\/ijms26062503","article-title":"Gut microbiota serves as a crucial independent biomarker in inflammatory bowel disease (IBD)","volume":"26","author":"Sharma","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.121373_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012477","article-title":"Microbe-derived antioxidants reduce lipopolysaccharide-induced inflammatory responses by activating the Nrf2 pathway to inhibit the ROS\/NLRP3\/IL-1\u03b2 signaling pathway","volume":"23","author":"Shen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.121373_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.123387","article-title":"Polygonatum cyrtonema hua polysaccharide alleviates ulcerative colitis via gut microbiota-independent modulation of inflammatory immune response","volume":"356","author":"Shi","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.121373_bib43","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2276814","article-title":"Modulating the gut microbiota is involved in the effect of low-molecular-weight glycyrrhiza polysaccharide on immune function","volume":"15","author":"Song","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jep.2026.121373_bib44","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.3390\/molecules26206249","article-title":"Progress in the medicinal value, bioactive compounds, and pharmacological activities of Gynostemma pentaphyllum","volume":"26","author":"Su","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121373_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.715506","article-title":"Metabolic influences of gut microbiota dysbiosis on inflammatory bowel disease","volume":"12","author":"Sultan","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jep.2026.121373_bib46","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1039\/C8FO01946K","article-title":"The impacts of natural polysaccharides on intestinal microbiota and immune responses - a review","volume":"10","author":"Tang","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2026.121373_bib47","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4535194","article-title":"Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies","volume":"2017","author":"Tian","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2026.121373_bib1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.carbpol.2019.02.006","article-title":"Structural characterization, physicochemical properties and \u03b1-glucosidase inhibitory activity of polysaccharide from the fruits of wax apple","volume":"211","author":"Wang","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.121373_bib49","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10719-020-09949-5","article-title":"Effects of extraction methods on antioxidant and immunomodulatory activities of polysaccharides from superfine powder Gynostemma pentaphyllum makino","volume":"37","author":"Wang","year":"2020","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.jep.2026.121373_bib55","doi-asserted-by":"crossref","first-page":"116538","DOI":"10.1016\/j.jep.2023.116538","article-title":"Modified gegen qinlian decoction ameliorated ulcerative colitis by attenuating inflammation and oxidative stress and enhancing intestinal barrier function in vivo and in vitro","volume":"313","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121373_bib50","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.tips.2024.08.003","article-title":"Ulcerative colitis: clinical biomarkers, therapeutic targets, and emerging treatments","volume":"45","author":"Wangchuk","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jep.2026.121373_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103746","article-title":"Anemoside B4 alleviates ulcerative colitis by attenuating intestinal oxidative stress and NLRP3 inflammasome via activating aryl hydrocarbon receptor through remodeling the gut microbiome and metabolites","volume":"85","author":"Wu","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2026.121373_bib53","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ijbiomac.2019.09.115","article-title":"Structural characterization, antioxidant and antimicrobial activity of water-soluble polysaccharides from bamboo (Phyllostachys pubescens mazel) leaves","volume":"142","author":"Xiao","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.121373_bib56","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1476-4598-13-48","article-title":"Chemoprevention of dietary digitoflavone on colitis-associated colon tumorigenesis through inducing Nrf2 signaling pathway and inhibition of inflammation","volume":"13","author":"Yang","year":"2014","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jep.2026.121373_bib58","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6635460","article-title":"The Keap1-Nrf2 System: a mediator between oxidative stress and aging","volume":"2021","author":"Yu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2026.121373_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.885039","article-title":"Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2\/NLRP3 pathway","volume":"13","author":"Yue","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2026.121373_bib6","doi-asserted-by":"crossref","first-page":"116551","DOI":"10.1016\/j.carbpol.2020.116551","article-title":"Structural characterization of polysaccharides with potential antioxidant and immunomodulatory activities from chinese water chestnut peels","volume":"246","author":"Zeng","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.121373_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117559","article-title":"Fractionation, chemical characterization and immunostimulatory activity of \u03b2-glucan and galactoglucan from Russula vinosa Lindblad","volume":"256","author":"Zhang","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.jep.2026.121373_bib64","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13020-022-00591-x","article-title":"Chinese herbal medicines in the treatment of ulcerative colitis: a review","volume":"17","author":"Zhang","year":"2022","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2026.121373_bib60","article-title":"Curcumin alleviates DSS-induced anxiety-like behaviors via the microbial-brain-gut axis","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2026.121373_bib62","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ijbiomac.2018.11.020","article-title":"Water-soluble yeast \u03b2-glucan fractions with different molecular weights: extraction and separation by acidolysis assisted-size exclusion chromatography and their association with proliferative activity","volume":"123","author":"Zheng","year":"2019","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126002242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126002242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:54:49Z","timestamp":1777571689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126002242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":60,"alternative-id":["S0378874126002242"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121373","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gynostemma pentaphyllum polysaccharides alleviate ulcerative colitis in mice via the Nrf2\/ROS\/NLRP3 axis and modulation of the gut microbiota","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121373","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121373"}}