{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:15:25Z","timestamp":1791573325495,"version":"4.3.4"},"reference-count":120,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004846","name":"Beijing University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007946","name":"Inner Mongolia Minzu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jep.2026.121402","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T20:02:35Z","timestamp":1771358555000},"page":"121402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Zha-Chong Shi-San-Wei Pill inhibits ferroptosis in cerebral ischemia via bioinformatics and experimental confirmation methods"],"prefix":"10.1016","volume":"363","author":[{"given":"Jinfeng","family":"Shang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jep.2026.121402_bib1","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/s10753-015-0133-1","article-title":"The neuroprotective effect of glycyrrhizic acid on an experimental model of focal cerebral ischemia in rats","volume":"38","author":"Akman","year":"2015","journal-title":"Inflammation"},{"issue":"9","key":"10.1016\/j.jep.2026.121402_bib2","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1007\/s12035-024-03964-5","article-title":"HIF-1\u03b1 induced by hypoxia promotes peripheral nerve injury recovery through regulating ferroptosis in DRG neuron","volume":"61","author":"An","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.jep.2026.121402_bib3","first-page":"62","article-title":"Progress in the research on pharmacodynamics of Mongolian medicine Zhachong Shisanwei Pills","volume":"26","author":"Bai","year":"2020","journal-title":"JMPCM"},{"issue":"14","key":"10.1016\/j.jep.2026.121402_bib4","first-page":"2177","article-title":"Review of pharmacological mechanism, clinical application, prescription source and clinical application of the classic Mongolian medicinal prescription Zhachong-13 flavor pills","volume":"16","author":"Bao","year":"2021","journal-title":"WJTCM"},{"issue":"3","key":"10.1016\/j.jep.2026.121402_bib5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/s41593-025-01872-y","article-title":"Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke","volume":"28","author":"Bernier","year":"2025","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jep.2026.121402_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2000.tb05594.x","article-title":"Programmed cell death (PCD). Apoptosis, autophagic PCD, or others","volume":"926","author":"Bursch","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"2021","key":"10.1016\/j.jep.2026.121402_bib7","article-title":"Antibodies targeting the transferrin receptor 1 (TfR1) as direct anti-cancer agents","volume":"12","author":"Candelaria","year":"2021","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.jep.2026.121402_bib8","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s12975-019-00772-1","article-title":"Glycyrrhizin prevents hemorrhagic transformation and improves neurological outcome in ischemic stroke with delayed thrombolysis through targeting peroxynitrite-mediated HMGB1 signaling","volume":"11","author":"Chen","year":"2020","journal-title":"Transl Stroke Res"},{"issue":"1","key":"10.1016\/j.jep.2026.121402_bib9","article-title":"2-Methoxyestradiol attenuates lung injury induced by chronic intermittent hypoxia via inhibiting the HIF1-\u03b1\/SLC7A11 pathway","volume":"15","author":"Chen","year":"2025","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.jep.2026.121402_bib11","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s12031-019-01474-x","article-title":"Dynamic alterations of brain injury, functional recovery, and metabolites profile after cerebral Ischemia\/reperfusion in rats contributes to potential biomarkers","volume":"70","author":"Cheng","year":"2020","journal-title":"J. Mol. Neurosci."},{"issue":"2023","key":"10.1016\/j.jep.2026.121402_bib12","article-title":"Molecular mechanisms of ferroptosis and their involvement in brain diseases","volume":"244","author":"Costa","year":"2023","journal-title":"Pharmacol. Ther."},{"issue":"39","key":"10.1016\/j.jep.2026.121402_bib13","doi-asserted-by":"crossref","first-page":"E1352","DOI":"10.1503\/cmaj.221415","article-title":"A practical approach to the acute management of patients with likely cerebral ischemia","volume":"194","author":"Coutts","year":"2022","journal-title":"CMAJ (Can. Med. Assoc. J.)"},{"issue":"34","key":"10.1016\/j.jep.2026.121402_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202310227","article-title":"Protosappanin A protects DOX-induced myocardial injury and cardiac dysfunction by targeting ACSL4\/FTH1 axis-dependent ferroptosis","volume":"11","author":"Cui","year":"2024","journal-title":"Adv. Sci."},{"issue":"10","key":"10.1016\/j.jep.2026.121402_bib15","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1038\/s12276-024-01314-y","article-title":"Hepatocyte activation and liver injury following cerebral ischemia promote HMGB1-mediated hepcidin upregulation in hepatocytes and regulation of systemic iron levels","volume":"56","author":"Davaanyam","year":"2024","journal-title":"Exp. Mol. Med."},{"issue":"5","key":"10.1016\/j.jep.2026.121402_bib16","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3390\/antiox11050861","article-title":"Crosstalk between Heme Oxygenase-1 and iron metabolism in macrophages: implications for the modulation of inflammation and immunity","volume":"11","author":"de Oliveira","year":"2022","journal-title":"Antioxidants"},{"issue":"5","key":"10.1016\/j.jep.2026.121402_bib17","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jep.2026.121402_bib18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3892\/mmr.2021.12557","article-title":"HIF 1\u03b1 in cerebral ischemia","volume":"25","author":"Dong","year":"2022","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.jep.2026.121402_bib19","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1007\/s12035-022-03197-4","article-title":"Therapeutic potentials of MicroRNA-126 in cerebral ischemia","volume":"60","author":"Ebrahimi","year":"2023","journal-title":"Mol. Neurobiol."},{"issue":"2019","key":"10.1016\/j.jep.2026.121402_bib20","article-title":"Icariin modulates carrageenan-induced acute inflammation through HO-1\/Nrf2 and NF-kB signaling pathways","volume":"120","author":"El-Shitany","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jep.2026.121402_bib22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s43556-023-00142-2","article-title":"The mechanism of ferroptosis and its related diseases","volume":"4","author":"Feng","year":"2023","journal-title":"Mol. Biomed."},{"issue":"12","key":"10.1016\/j.jep.2026.121402_bib23","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.amjmed.2021.07.027","article-title":"Ischemic stroke","volume":"134","author":"Feske","year":"2021","journal-title":"Am. J. Med."},{"issue":"2","key":"10.1016\/j.jep.2026.121402_bib24","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1001\/jamaneurol.2015.3886","article-title":"Time to reperfusion and treatment effect for acute ischemic stroke: a randomized clinical trial","volume":"73","author":"Fransen","year":"2016","journal-title":"JAMA Neurol."},{"issue":"2022","key":"10.1016\/j.jep.2026.121402_bib25","article-title":"Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K\/AKT\/Nrf2 and SLC7A11\/GPX4 signaling pathway after ischemia","volume":"289","author":"Fu","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2026.121402_bib26","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1007\/s10528-024-10936-w","article-title":"Glycyrrhizic acid inhibits Hippocampal Neuron apoptosis by activating the PI3K\/AKT signaling pathway","volume":"63","author":"Fu","year":"2025","journal-title":"Biochem. Genet."},{"issue":"5","key":"10.1016\/j.jep.2026.121402_bib27","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1021\/acschemneuro.7b00435","article-title":"Activation of Nrf2 and hypoxic adaptive response contribute to neuroprotection elicited by phenylhydroxamic acid selective HDAC6 inhibitors","volume":"9","author":"Gaisina","year":"2018","journal-title":"ACS Chem. Neurosci."},{"issue":"11","key":"10.1016\/j.jep.2026.121402_bib28","first-page":"1411","article-title":"Brain ischemia\/reperfusion injury and mitochondrial complex I damage","volume":"84","author":"Galkin","year":"2019","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.jep.2026.121402_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089450","article-title":"Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on focal cerebral ischemia\/reperfusion-induced inflammation, oxidative stress, and apoptosis in rats","volume":"9","author":"Gong","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.jep.2026.121402_bib30","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1080\/14728222.2024.2446319","article-title":"An update on the role of ferroptosis in ischemic stroke: from molecular pathways to neuroprotection","volume":"28","author":"Gowtham","year":"2024","journal-title":"Expert Opin. Ther. Targets"},{"issue":"7","key":"10.1016\/j.jep.2026.121402_bib31","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209845","article-title":"Duration of benefit and risk of dual antiplatelet therapy up to 72 hours after mild ischemic stroke and transient ischemic attack","volume":"103","author":"Guan","year":"2024","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.jep.2026.121402_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202507384","article-title":"Iron overload mediates the differential cell fate of astrocytes from neurons and its regulatory mechanisms in ischemic stroke","volume":"13","author":"Guo","year":"2026","journal-title":"Adv. Sci."},{"issue":"2022","key":"10.1016\/j.jep.2026.121402_bib34","article-title":"Cell membrane-coated biomimetic magnetic nanoparticles for the bio-specific extraction of components from Gualou Guizhi decoction exhibiting activities against oxygen-glucose deprivation\/reperfusion injury","volume":"209","author":"He","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"2021","key":"10.1016\/j.jep.2026.121402_bib35","article-title":"Biological functions and regulatory mechanisms of hypoxia-inducible Factor-1\u03b1 in ischemic stroke","volume":"12","author":"He","year":"2021","journal-title":"Front. Immunol."},{"issue":"2020","key":"10.1016\/j.jep.2026.121402_bib36","article-title":"Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator","volume":"241","author":"He","year":"2020","journal-title":"Biomaterials"},{"issue":"2024","key":"10.1016\/j.jep.2026.121402_bib37","article-title":"The interplay between ferroptosis and inflammation: therapeutic implications for cerebral ischemia-reperfusion","volume":"15","author":"He","year":"2024","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.jep.2026.121402_bib39","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1158\/2159-8290.CD-19-1500","article-title":"The lipogenic regulator SREBP2 induces transferrin in circulating melanoma cells and suppresses ferroptosis","volume":"11","author":"Hong","year":"2021","journal-title":"Cancer Discov."},{"issue":"2024","key":"10.1016\/j.jep.2026.121402_bib40","article-title":"Zhachong Shisanwei pill drug-containing serum protects H2O2-Induced PC12 cells injury by suppressing apoptosis, oxidative stress via regulating the MAPK signaling pathway","volume":"15","author":"Hu","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"2024","key":"10.1016\/j.jep.2026.121402_bib41","article-title":"The role of ferroptosis and its mechanism in ischemic stroke","volume":"372","author":"Hu","year":"2024","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.jep.2026.121402_bib42","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13020-025-01163-5","article-title":"Buyang Huanwu Decoction improves energy metabolism disorders after cerebral ischemia-reperfusion by regulating the SIRT1\/AMPK signaling pathway to promote glycolysis and the tricarboxylic acid cycle","volume":"20","author":"Hu","year":"2025","journal-title":"Chin. Med."},{"issue":"13-15","key":"10.1016\/j.jep.2026.121402_bib43","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1089\/ars.2023.0492","article-title":"Preconditioning exercise inhibits neuron ferroptosis and ameliorates brain ischemia damage by skeletal muscle-derived exosomes via regulating miR-484\/ACSL4 axis","volume":"41","author":"Huang","year":"2024","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jep.2026.121402_bib44","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.freeradbiomed.2022.02.004","article-title":"Oxidative stress and regeneration","volume":"181","author":"Jaganjac","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"21","key":"10.1016\/j.jep.2026.121402_bib45","first-page":"100","article-title":"Clinical study on zhachong shisanwei pills combined with warming-wax therapy for cerebral infarction in convalescent stage","volume":"53","author":"Jia","year":"2021","journal-title":"JNCM"},{"issue":"6","key":"10.1016\/j.jep.2026.121402_bib46","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3390\/cells13060512","article-title":"Hypoxic conditions modulate chondrogenesis through the circadian clock: the role of hypoxia-inducible Factor-1\u03b1","volume":"13","author":"Juh\u00e1sz","year":"2024","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.jep.2026.121402_bib47","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0891-5849(02)01006-7","article-title":"The labile iron pool: characterization, measurement, and participation in cellular processes","volume":"33","author":"Kakhlon","year":"2002","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121402_bib48","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.nbd.2011.12.056","article-title":"Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion","volume":"46","author":"Kim","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.jep.2026.121402_bib49","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/bjp.2008.79","article-title":"Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-kappaB-dependent iNOS and proinflammatory cytokines production","volume":"154","author":"Kim","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"2021","key":"10.1016\/j.jep.2026.121402_bib50","article-title":"Inhibition of hypoxia inducible factor 1 by YC-1 attenuates tissue plasminogen activator induced hemorrhagic transformation by suppressing HMGB1\/TLR4\/NF-\u03baB mediated neutrophil infiltration in thromboembolic stroke rats","volume":"94","author":"Kong","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2026.121402_bib52","first-page":"2043","article-title":"YC 1 reduces inflammatory responses by inhibiting nuclear factor \u03baB translocation in mice subjected to transient focal cerebral ischemia","volume":"18","author":"Lee","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.jep.2026.121402_bib53","first-page":"869","article-title":"Mechanistic insights of neuronal death and neuroprotective therapeutic approaches in stroke","volume":"21","author":"Li","year":"2026","journal-title":"Neural Regen. Res."},{"issue":"4","key":"10.1016\/j.jep.2026.121402_bib54","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1007\/s11064-023-04095-4","article-title":"SIRT5 regulates ferroptosis through the Nrf2\/HO-1 signaling axis to participate in ischemia-reperfusion injury in ischemic stroke","volume":"49","author":"Li","year":"2024","journal-title":"Neurochem. Res."},{"issue":"6","key":"10.1016\/j.jep.2026.121402_bib55","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3390\/antiox14060665","article-title":"Multi-omics and experimental validation identify GPX7 and glutathione-associated oxidative stress as potential biomarkers in ischemic stroke","volume":"14","author":"Li","year":"2025","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.jep.2026.121402_bib56","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/s41401-023-01177-5","article-title":"Caffeic acid alleviates cerebral ischemic injury in rats by resisting ferroptosis via Nrf2 signaling pathway","volume":"45","author":"Li","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.jep.2026.121402_bib57","doi-asserted-by":"crossref","first-page":"611","DOI":"10.4103\/1673-5374.380870","article-title":"Ferroptosis and endoplasmic reticulum stress in ischemic stroke","volume":"19","author":"Li","year":"2024","journal-title":"Neural Regen. Res."},{"issue":"2024","key":"10.1016\/j.jep.2026.121402_bib58","article-title":"Catalpol alleviates hypoxia ischemia-induced brain damage by inhibiting ferroptosis through the PI3K\/NRF2\/system Xc-\/GPX4 axis in neonatal rats","volume":"968","author":"Lin","year":"2024","journal-title":"Eur. J. Pharmacol."},{"issue":"2022","key":"10.1016\/j.jep.2026.121402_bib59","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neuroscience.2022.02.013","article-title":"Ferroptosis is involved in hypoxic-ischemic brain damage in neonatal rats","volume":"487","author":"Lin","year":"2022","journal-title":"Neuroscience"},{"issue":"2020","key":"10.1016\/j.jep.2026.121402_bib60","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.3389\/fphar.2020.01220","article-title":"A potent antioxidant endogenous neurohormone melatonin, rescued MCAO by attenuating oxidative stress-associated neuroinflammation","volume":"11","author":"Ling","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"11","key":"10.1016\/j.jep.2026.121402_bib61","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3390\/antiox13111329","article-title":"Interactions between ferroptosis and oxidative stress in ischemic stroke","volume":"13","author":"Liu","year":"2024","journal-title":"Antioxidants"},{"issue":"5","key":"10.1016\/j.jep.2026.121402_bib62","first-page":"10","article-title":"Analysis of the therapeutic effect of Mongolian medicine Zhachong Shisanwei Pils combined with cerebral protein hydrolysate injection in the treatment of stroke","volume":"28","author":"Liu","year":"2022","journal-title":"JMPCM"},{"issue":"2020","key":"10.1016\/j.jep.2026.121402_bib63","article-title":"Crosstalk between autophagy and ferroptosis and its putative role in ischemic stroke","volume":"14","author":"Liu","year":"2020","journal-title":"Front. Cell. Neurosci."},{"issue":"3","key":"10.1016\/j.jep.2026.121402_bib64","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neulet.2010.06.065","article-title":"Promotion of rat brain-derived progenitor cell neurogenesis by liquiritigenin treatment: underlying mechanisms","volume":"481","author":"Liu","year":"2010","journal-title":"Neurosci. Lett."},{"issue":"8","key":"10.1016\/j.jep.2026.121402_bib65","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/s11064-024-04161-5","article-title":"Ferritinophagy and ferroptosis in cerebral ischemia reperfusion injury","volume":"49","author":"Liu","year":"2024","journal-title":"Neurochem. Res."},{"issue":"7","key":"10.1016\/j.jep.2026.121402_bib66","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.1007\/s12035-025-04815-7","article-title":"Exploring the nexus: how ferroptosis, microglia, and neuroinflammation converge in ischemic stroke pathogenesis","volume":"62","author":"Liu","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.jep.2026.121402_bib67","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.298","article-title":"Iron homeostasis imbalance and ferroptosis in brain diseases","volume":"4","author":"Long","year":"2023","journal-title":"MedComm"},{"issue":"29","key":"10.1016\/j.jep.2026.121402_bib68","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202401462","article-title":"Phosphorus dendrimers Co-deliver fibronectin and edaravone for combined ischemic stroke treatment via cooperative modulation of microglia\/neurons and vascular regeneration","volume":"13","author":"Ma","year":"2024","journal-title":"Adv. Healthcare Mater."},{"issue":"11","key":"10.1016\/j.jep.2026.121402_bib69","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/s41419-023-06290-1","article-title":"Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis","volume":"14","author":"Marmolejo-Garza","year":"2023","journal-title":"Cell Death Dis."},{"issue":"2023","key":"10.1016\/j.jep.2026.121402_bib70","article-title":"Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6\/p-Nrf2\/GPX4 and SIRT6\/NCOA4\/FTH1 pathways","volume":"157","author":"Mi","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.jep.2026.121402_bib71","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/STROKEAHA.122.038466","article-title":"Clinically ineffective reperfusion after endovascular therapy in acute ischemic stroke","volume":"54","author":"Nie","year":"2023","journal-title":"Stroke"},{"issue":"2024","key":"10.1016\/j.jep.2026.121402_bib72","article-title":"Tongqiao Huoxue Decoction inhibits ferroptosis by facilitating ACSL4 ubiquitination degradation for neuroprotection against cerebral ischemia-reperfusion injury","volume":"130","author":"Ou","year":"2024","journal-title":"Phytomedicine"},{"issue":"2023","key":"10.1016\/j.jep.2026.121402_bib73","article-title":"Advances in antitumor research of HIF-1\u03b1 inhibitor YC-1 and its derivatives","volume":"133","author":"Ouyang","year":"2023","journal-title":"Bioorg. Chem."},{"issue":"2025","key":"10.1016\/j.jep.2026.121402_bib74","article-title":"Mangiferin mitigates neurological deficits and ferroptosis via NRF2\/ARE pathway activation in cerebral ischemia-reperfusion rats","volume":"16","author":"Peng","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"2021","key":"10.1016\/j.jep.2026.121402_bib75","article-title":"Crosstalk between oxidative stress and ferroptosis\/oxytosis in ischemic stroke: possible targets and molecular mechanisms","volume":"2021","author":"Ren","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.jep.2026.121402_bib76","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12964-020-00575-0","article-title":"CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis","volume":"18","author":"Sabbir","year":"2020","journal-title":"Cell Commun. Signal."},{"issue":"9","key":"10.1016\/j.jep.2026.121402_bib77","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.7150\/ijbs.80735","article-title":"Stroke by inducing HDAC9-dependent deacetylation of HIF-1 and Sp1, promotes TfR1 transcription and GPX4 reduction, thus determining ferroptotic neuronal death","volume":"19","author":"Sanguigno","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2026.121402_bib78","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainresbull.2019.01.005","article-title":"Functional and pharmacological analysis of agmatine administration in different cerebral ischemia animal models","volume":"146","author":"Selakovic","year":"2019","journal-title":"Brain Res. Bull."},{"issue":"2","key":"10.1016\/j.jep.2026.121402_bib79","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0955-0674(00)00194-0","article-title":"HIF-1 and mechanisms of hypoxia sensing","volume":"13","author":"Semenza","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"issue":"11","key":"10.1016\/j.jep.2026.121402_bib80","first-page":"96","article-title":"Effects of zhachong shisanwei pills on rats with cerebral ischemia by regulating hippo signaling pathway","volume":"31","author":"Shabuerjiang","year":"2024","journal-title":"CJITCM"},{"issue":"2024","key":"10.1016\/j.jep.2026.121402_bib81","article-title":"Chrysin inhibits ferroptosis of cerebral ischemia\/reperfusion injury via regulating HIF-1\u03b1\/CP loop","volume":"174","author":"Shang","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.jep.2026.121402_bib82","first-page":"760","article-title":"Clinical study of Zhachong Shisanwei Pills combined with butylphthalide in treatment of acute cerebral infarction","volume":"37","author":"Shen","year":"2022","journal-title":"Drug Clinic"},{"issue":"7","key":"10.1016\/j.jep.2026.121402_bib83","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/15459683221085287","article-title":"The TWIST tool predicts when patients will recover independent walking after stroke: an observational study","volume":"36","author":"Smith","year":"2022","journal-title":"Neurorehabilitation Neural Repair"},{"issue":"2023","key":"10.1016\/j.jep.2026.121402_bib84","article-title":"Zhachong Shisanwei Pill resists ischemic stroke by lysosome pathway based on proteomics and bioinformatics","volume":"301","author":"Song","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.121402_bib85","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s10565-024-09844-x","article-title":"METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke","volume":"40","author":"Su","year":"2024","journal-title":"Cell Biol. Toxicol."},{"issue":"5","key":"10.1016\/j.jep.2026.121402_bib86","first-page":"6490","article-title":"Therapeutic window for YC 1 following glutamate induced neuronal damage and transient focal cerebral ischemia","volume":"17","author":"Tai","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"2025","key":"10.1016\/j.jep.2026.121402_bib87","article-title":"Guilu Erxian glue mitigates spermatogenesis dysfunction through HIF-1\u03b1\/SLC7A11-mediated ferroptosis inhibition: an integrated metabolomics and network pharmacology study","volume":"148","author":"Tang","year":"2025","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.jep.2026.121402_bib88","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3390\/cells14060423","article-title":"Stabilization of transcription factor, HIF-1\u03b1 by prolylhydroxylase 1 knockout reduces cardiac injury after myocardial infarction in mice","volume":"14","author":"Thirunavukkarasu","year":"2025","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.jep.2026.121402_bib89","first-page":"488","article-title":"Effect of Mongolian medicine Zhachong Shisan Pill on neurobehavioral function of rats with cerebral ischemia","volume":"45","author":"Tian","year":"2022","journal-title":"Drug Eval Res."},{"issue":"1","key":"10.1016\/j.jep.2026.121402_bib90","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/10286020.2024.2379981","article-title":"Online identification of chemical constituents in Mongolian medicine Zhachong-13 pills by UHPLC-Q-exactive Orbitrap MS","volume":"27","author":"Tian","year":"2025","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"10","key":"10.1016\/j.jep.2026.121402_bib91","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.3390\/brainsci13101367","article-title":"The interplay between mitochondrial dysfunction and ferroptosis during ischemia-associated central nervous system diseases","volume":"13","author":"Tian","year":"2023","journal-title":"Brain Sci."},{"key":"10.1016\/j.jep.2026.121402_bib92","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.freeradbiomed.2021.04.030","article-title":"Iron-binding cellular profile of transferrin using label-free Raman hyperspectral imaging and singular value decomposition (SVD)","volume":"169","author":"Tubbesing","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.jep.2026.121402_bib93","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.24272\/j.issn.2095-8137.2024.239","article-title":"Ferroptosis in ischemic stroke: animal models and mechanisms","volume":"45","author":"Tuo","year":"2024","journal-title":"Zool. Res."},{"issue":"1","key":"10.1016\/j.jep.2026.121402_bib94","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41392-022-00917-z","article-title":"Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia\/reperfusion","volume":"7","author":"Tuo","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"2023","key":"10.1016\/j.jep.2026.121402_bib95","article-title":"HIF-1, an important regulator in potential new therapeutic approaches to ischemic stroke","volume":"170","author":"Vatte","year":"2023","journal-title":"Neurochem. Int."},{"issue":"9","key":"10.1016\/j.jep.2026.121402_bib96","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.3390\/antiox10091384","article-title":"The alterations in mitochondrial dynamics following cerebral Ischemia\/Reperfusion Injury","volume":"10","author":"Vongsfak","year":"2021","journal-title":"Antioxidants"},{"issue":"2025","key":"10.1016\/j.jep.2026.121402_bib97","article-title":"Astragali radix - curcumae rhizoma herb pair suppresses hepatocellular carcinoma through EGFR\/AKT\/mTOR pathway and induces lipid peroxidation-related ferroptosis via HIF-1\u03b1\/HO-1\/GPX4 axis","volume":"348","author":"Wang","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"Pt A","key":"10.1016\/j.jep.2026.121402_bib98","article-title":"Exploring the neuroprotective mechanism of the Mongolian medicine ZSP against acute ischemic stroke from TRPV1\/NMDAR-mediated excitotoxicity","volume":"355","author":"Wang","year":"2026","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2026.121402_bib99","first-page":"248","article-title":"Zhachong shisanwei pills combined with vinpocetine in treatment of sequela of stroke","volume":"38","author":"Wang","year":"2020","journal-title":"CATCM"},{"key":"10.1016\/j.jep.2026.121402_bib100","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5147069","article-title":"Sesamin protects against and ameliorates rat intestinal Ischemia\/reperfusion injury with involvement of activating Nrf2\/HO-1\/NQO1 signaling pathway","author":"Wang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"12","key":"10.1016\/j.jep.2026.121402_bib101","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.2174\/0929867325666181001104550","article-title":"A review: the anti-inflammatory, anticancer and antibacterial properties of four kinds of Licorice flavonoids isolated from Licorice","volume":"27","author":"Wang","year":"2020","journal-title":"Curr. Med. Chem."},{"issue":"2022","key":"10.1016\/j.jep.2026.121402_bib102","article-title":"New insights in ferroptosis: potential therapeutic targets for the treatment of ischemic stroke","volume":"13","author":"Wei","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"2023","key":"10.1016\/j.jep.2026.121402_bib103","article-title":"15, 16-Dihydrotanshinone I protects against ischemic stroke by inhibiting ferroptosis via the activation of nuclear factor erythroid 2-related factor 2","volume":"114","author":"Wu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121402_bib104","doi-asserted-by":"crossref","unstructured":"Xu, J., Wang, A., Meng, X., Yalkun, G., Xu, A., Gao, Z., Chen, H., Ji, Y., Xu, J., Geng, D., Zhu, R., Liu, B., Dong, A., Mu, H., Lu, Z., Li, S., Zheng, H., Chen, X., Wang, Y., Zhao, X., et al., 2021 TASTE trial investigators\u2020, 2021. Edaravone dexborneol versus edaravone alone for the treatment of acute ischemic stroke: a phase III, randomized, double-blind, comparative trial. Stroke. 52(3), 772\u2013780. https:\/\/doi.org\/10.1161\/STROKEAHA.120.031197.","DOI":"10.1161\/STROKEAHA.120.031197"},{"issue":"3","key":"10.1016\/j.jep.2026.121402_bib105","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3892\/etm.2023.11812","article-title":"Regulation of the p53-mediated ferroptosis signaling pathway in cerebral ischemia stroke","volume":"25","author":"Xu","year":"2023","journal-title":"Exp. Ther. Med."},{"issue":"3","key":"10.1016\/j.jep.2026.121402_bib106","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s12035-021-02706-1","article-title":"COX-2\/PGE2 pathway inhibits the ferroptosis induced by cerebral ischemia reperfusion","volume":"59","author":"Xu","year":"2022","journal-title":"Mol. Neurobiol."},{"issue":"2025","key":"10.1016\/j.jep.2026.121402_bib107","article-title":"Effect of liquiritin on the expression of BDNF, Bax, and Bcl-2 in the hippocampus of post-stroke depression rats","volume":"9","author":"Yan","year":"2025","journal-title":"Cereb Circ Cogn Behav."},{"issue":"6","key":"10.1016\/j.jep.2026.121402_bib108","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/bab.1825","article-title":"Protective effect of glycyrrhizic acid on cerebral ischemia\/reperfusion injury via inhibiting HMGB1-mediated TLR4\/NF-\u03baB pathway","volume":"66","author":"Yan","year":"2019","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.jep.2026.121402_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154382","article-title":"The application of proteomics and metabolomics to reveal the molecular mechanism of Nutmeg-5 in ameliorating cardiac fibrosis following myocardial infarction","volume":"105","author":"Yan","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121402_bib110","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neuro.2013.08.012","article-title":"Neuroprotective effects of liquiritigenin isolated from licorice roots on glutamate-induced apoptosis in hippocampal neuronal cells","volume":"39","author":"Yang","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jep.2026.121402_bib111","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuroscience.2024.08.025","article-title":"The mechanism of hypoxia-inducible factor-1\u03b1 enhancing the transcriptional activity of transferrin ferroportin 1 and regulating the Nrf2\/HO-1 pathway in ferroptosis after cerebral ischemic injury","volume":"559","author":"Yao","year":"2024","journal-title":"Neuroscience"},{"issue":"9","key":"10.1016\/j.jep.2026.121402_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e30418","article-title":"Electroacupuncture pretreatment alleviates rats cerebral ischemia-reperfusion injury by inhibiting ferroptosis","volume":"10","author":"Ye","year":"2024","journal-title":"Heliyon"},{"issue":"2","key":"10.1016\/j.jep.2026.121402_bib113","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1124\/mol.107.036418","article-title":"Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1alpha accumulation and VEGF expression","volume":"72","author":"Yeh","year":"2007","journal-title":"Mol. Pharmacol."},{"issue":"8","key":"10.1016\/j.jep.2026.121402_bib114","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1007\/s12035-016-0111-0","article-title":"Nrf2-a promising therapeutic target for defensing against oxidative stress in stroke","volume":"54","author":"Zhang","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"2020","key":"10.1016\/j.jep.2026.121402_bib115","article-title":"The Nrf-2\/HO-1 signaling axis: a ray of hope in cardiovascular diseases","volume":"2020","author":"Zhang","year":"2020","journal-title":"Cardiol. Res. Pract."},{"issue":"3","key":"10.1016\/j.jep.2026.121402_bib116","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14456","article-title":"Neutral polysaccharide from Gastrodia elata alleviates cerebral ischemia-reperfusion injury by inhibiting ferroptosis-mediated neuroinflammation via the NRF2\/HO-1 signaling pathway","volume":"30","author":"Zhang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"2022","key":"10.1016\/j.jep.2026.121402_bib117","article-title":"Potential application of traditional Chinese medicine in cerebral ischemia-Focusing on ferroptosis","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.jep.2026.121402_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.168022","article-title":"Hepcidin\/HIF-1\u03b1 is involved in the endogenous recovery and ferroptosis after cerebral ischemia in mice","volume":"1871","author":"Zhao","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"4","key":"10.1016\/j.jep.2026.121402_bib119","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3892\/mmr.2021.12352","article-title":"Erastin induced ferroptosis causes physiological and pathological changes in healthy tissues of mice","volume":"24","author":"Zhao","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2026.121402_bib120","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.2147\/OTT.S254995","article-title":"The role of erastin in ferroptosis and its prospects in cancer therapy","volume":"13","author":"Zhao","year":"2020","journal-title":"OncoTargets Ther."},{"issue":"2023","key":"10.1016\/j.jep.2026.121402_bib121","article-title":"Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor","volume":"59","author":"Zhao","year":"2023","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.jep.2026.121402_bib122","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3892\/ijmm.2021.5070","article-title":"Neuronal injuries in cerebral infarction and ischemic stroke: from mechanisms to treatment","volume":"49","author":"Zhao","year":"2022","journal-title":"Int. J. Mol. Med."},{"issue":"2025","key":"10.1016\/j.jep.2026.121402_bib123","article-title":"Regression of oxidative stress by targeting Nrf2\/HO-1 signaling: the potential therapeutic drugs for cerebral ischemia-reperfusion injury","volume":"193","author":"Zhou","year":"2025","journal-title":"Biomed. Pharmacother."},{"issue":"2022","key":"10.1016\/j.jep.2026.121402_bib124","article-title":"Crosstalk between the oxidative stress and glia cells after stroke: from mechanism to therapies","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Immunol."},{"issue":"2022","key":"10.1016\/j.jep.2026.121402_bib125","article-title":"Glycyrrhizin attenuates hypoxic-ischemic brain damage by inhibiting ferroptosis and neuroinflammation in neonatal rats via the HMGB1\/GPX4 pathway","volume":"2022","author":"Zhu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126002539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126002539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T13:16:24Z","timestamp":1775308584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126002539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":120,"alternative-id":["S0378874126002539"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121402","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zha-Chong Shi-San-Wei Pill inhibits ferroptosis in cerebral ischemia via bioinformatics and experimental confirmation methods","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121402","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121402"}}