{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T04:02:05Z","timestamp":1776830525304,"version":"3.51.2"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jep.2026.121405","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T07:46:59Z","timestamp":1771573619000},"page":"121405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Ethnopharmacological evidence for the wound-healing activity of Vanillosmopsis erythropappa Schultz-bip leaf extract ointments"],"prefix":"10.1016","volume":"363","author":[{"given":"Du\u00edlio Teixeira Soares","family":"J\u00fanior","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Andrade","family":"Ven\u00e2ncio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro Jos\u00e9","family":"Gusm\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virg\u00ednia Ramos","family":"Pizziolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaspar","family":"Diaz-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3370-4149","authenticated-orcid":false,"given":"Marisa Alves Nogueira","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.121405_bib1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3390\/life13020317","article-title":"The therapeutic wound healing bioactivities of various medicinal plants","volume":"23","author":"Albahri","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.jep.2026.121405_bib2","series-title":"Planaltina","first-page":"464","article-title":"Cerrado: esp\u00e9cies vegetais \u00fateis","author":"Almeida","year":"1998"},{"key":"10.1016\/j.jep.2026.121405_bib3","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.3389\/fpls.2018.01340","article-title":"Identification of the bisabolol synthase in the endangered candeia tree (Eremanthus erythropappus (dc) mcleisch)","volume":"9","author":"Alves Gomes Albertti","year":"2018","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.jep.2026.121405_bib4","series-title":"Guia Para a Condu\u00e7\u00e3o De Estudos N\u00e3o Cl\u00ednicos De Toxicologia E Seguran\u00e7a Farmacol\u00f3gica Necess\u00e1rios Ao Desenvolvimento De Medicamentos, Anvisa. Bras\u00edlia","year":"2013"},{"key":"10.1016\/j.jep.2026.121405_bib5","doi-asserted-by":"crossref","DOI":"10.1590\/2179-8087.051616","article-title":"Sustainable management of Eremanthus erythropappus in Minas Gerais, Brazil-A review","volume":"25","author":"Ara\u00fajo","year":"2018","journal-title":"Floresta e Ambiente"},{"key":"10.1016\/j.jep.2026.121405_bib6","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.3390\/molecules23112819","article-title":"Lupeol, a pentacyclic triterpene, promotes migration, wound closure, andcontractile effect in vitro: possible involvement of PI3K\/Akt and p38\/ERK\/MAPK pathways","volume":"23","author":"Beserra","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121405_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3182627","article-title":"Lupeol, a dietary triterpene, enhances wound healing in streptozotocininduced hyperglycemic rats with modulatory effects on inflammation, oxidative stress, and angiogenesis","author":"Beserra","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2026.121405_bib8","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.3390\/ijms21144952","article-title":"From inflammation to skin repair: topical application of lupeol improves wound healing in rat skin by modulating cytokine levels, NF-\u03baB, Ki-67, growth factor expression, and collagen fiber distribution","volume":"21","author":"Beserra","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.121405_bib9","series-title":"Feridas: Como Tratar","author":"Borges","year":"2007"},{"key":"10.1016\/j.jep.2026.121405_bib10","first-page":"17","article-title":"Avalia\u00e7\u00e3o macrosc\u00f3pica de feridas cut\u00e2neas abertas, em ratos, tratadas com \u00f3leo de andiroba","volume":"15","author":"Brito","year":"2001","journal-title":"Rev. Para. Med."},{"key":"10.1016\/j.jep.2026.121405_bib11","first-page":"17","article-title":"Understanding chronic wound healing","volume":"34","author":"Broderick","year":"2009","journal-title":"Nurse Pract. Am. J. Prim Health Care"},{"key":"10.1016\/j.jep.2026.121405_bib12","series-title":"Tratamento T\u00f3pico Com Friedelina Acelera a Cicatriza\u00e7\u00e3o De Feridas Cut\u00e2neas em Camundongos Diab\u00e9ticos E Induz a Ativa\u00e7\u00e3o De Fibroblastos","author":"Carmo","year":"2019"},{"issue":"2","key":"10.1016\/j.jep.2026.121405_bib13","first-page":"165","article-title":"Valores de refer\u00eancia de alguns par\u00e2metros fisiol\u00f3gicos de ratos do biot\u00e9rio central da Universidade Estadual de Maring\u00e1, Estado do Paran\u00e1","volume":"28","author":"Dantas","year":"2006","journal-title":"Acta Sci. Health Sci."},{"key":"10.1016\/j.jep.2026.121405_bib14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cpm.2014.09.010","article-title":"Growth factors in wound healing: the present and the future?","volume":"32","author":"Dinh","year":"2015","journal-title":"Clin. Podiatr. Med. Surg."},{"key":"10.1016\/j.jep.2026.121405_bib15","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1073\/pnas.0803601105","article-title":"Beta-caryophyllene is a dietary cannabinoid","volume":"105","author":"Gertsch","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jep.2026.121405_bib16","first-page":"67","article-title":"Tratamento de ferida: revis\u00e3o da literatura","volume":"6","author":"Gomes","year":"2002","journal-title":"Rev. Min. Enferm."},{"key":"10.1016\/j.jep.2026.121405_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11746-009-1483-3","article-title":"A review of the application and pharmacological properties of \u03b1-Bisabolol and \u03b1-Bisabolol-Rich oils","volume":"87","author":"Kamatou","year":"2010","journal-title":"J. Am. Oil Chem."},{"key":"10.1016\/j.jep.2026.121405_bib18","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1590\/1983-084X\/09_189","article-title":"Avalia\u00e7\u00e3o das atividades cicatrizantes, anti-inflamat\u00f3ria t\u00f3pica e antioxidante do extrato etan\u00f3lico da Sideroxylon obtusifolium (quixabeira)","volume":"17","author":"Leite","year":"2015","journal-title":"Rev. Bras. Plantas Med."},{"key":"10.1016\/j.jep.2026.121405_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1995-7645(13)60053-X","article-title":"Wound healing effect of flavonoid rich fraction and luteolin isolated from Martynia annua Linn. on streptozotocin induced diabetic rats","volume":"6","author":"Lodhi","year":"2013","journal-title":"Asian Pac. J. Tropical Med."},{"key":"10.1016\/j.jep.2026.121405_bib20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.20398\/jscr.v7i2.11438","article-title":"Cicatriza\u00e7\u00e3o das feridas cir\u00fargicas","volume":"7","author":"Medeiros","year":"2016","journal-title":"J. Surg. Clin. Res."},{"key":"10.1016\/j.jep.2026.121405_bib21","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jss.2018.08.009","article-title":"Wound healing effect of kaempferol in diabetic and nondiabetic rats","volume":"233","author":"\u00d6zay","year":"2019","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.jep.2026.121405_bib23","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jep.2015.03.062","article-title":"Polyphenols rich fraction of Dicranopteris linearis promotes fibroblast cell migration and proliferation in vitro","volume":"168","author":"Ponnusamy","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121405_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/919342","article-title":"Ointment of Brassica oleracea var. capitata matures the extracellular matrix in skin wounds of Wistar rats","volume":"2015","author":"Sarandy","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2026.121405_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115464","article-title":"Hydroalcoholic extract of Remijia ferruginea accelerates the closure of skin wounds by modulating tissue morphology and antioxidant profile: an in vitro and in vivo study","volume":"296","author":"Sarandy","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121405_bib26","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.ijbiomac.2016.06.075","article-title":"Fabrication of Apigenin loaded gellan gum\u2013chitosan hydrogels (GGCH-HGs) for effective diabetic wound healing","volume":"91","author":"Shukla","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.121405_bib27","series-title":"Estudo Qu\u00edmico E Farmacol\u00f3gico De Vanillosmopsis Erythropappa Schultz Bip. (Asteraceae)","first-page":"94","author":"Silv\u00e9rio","year":"2004"},{"key":"10.1016\/j.jep.2026.121405_bib28","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1590\/S0102-695X2008000300017","article-title":"Pharmacological properties of the ethanol extract from Eremanthus erythropappus (DC.) McLeisch (Asteraceae)","volume":"18","author":"Silv\u00e9rio","year":"2008","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.jep.2026.121405_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-70010-8","article-title":"In vitro and in vivo evaluation of the diabetic wound healing properties of Saffron (Crocus Sativus L.) petals","volume":"14","author":"Soheilifar","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2026.121405_bib30","first-page":"1","article-title":"Importance of ethnopharmacological studies in drug discovery: role of medicinal plants","author":"S\u00fcntar","year":"2019","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.jep.2026.121405_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091355","article-title":"Low-intensity vibration improves angiogenesis and wound healing in diabetic mice","volume":"9","author":"Weinheimer-Haus","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2026.121405_bib32","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.4081\/ejh.2015.2467","article-title":"Apigenin induces dermal collagen synthesis via smad2\/3 signaling pathway","volume":"59","author":"Zhang","year":"2015","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.jep.2026.121405_bib33","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1002\/ptr.7090","article-title":"Apigenin enhances the viability of random skin flaps by activating autophagy","volume":"35","author":"Zhu","year":"2021","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2026.121405_bib34","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.3390\/ijms24054607","article-title":"Flavonoids as potential wound-healing molecules: emphasis on pathways perspective","volume":"24","author":"Zulkefli","year":"2023","journal-title":"Int. J. Mol. Sci."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126002564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126002564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:30:04Z","timestamp":1776184204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126002564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":33,"alternative-id":["S0378874126002564"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121405","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ethnopharmacological evidence for the wound-healing activity of Vanillosmopsis erythropappa Schultz-bip leaf extract ointments","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121405"}}