{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:14:13Z","timestamp":1792149253668,"version":"4.4.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012438","name":"Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jep.2026.121416","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T16:13:03Z","timestamp":1771690383000},"page":"121416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Corylin promotes longevity in Caenorhabditis elegans through DAF-16 and SKN-1 coordinated activation of autophagy-mitochondrial homeostasis axis"],"prefix":"10.1016","volume":"363","author":[{"given":"Fu-Yi","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Lan","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Sheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8912-6694","authenticated-orcid":false,"given":"Huai-Rong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jep.2026.121416_bib1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrd4023","article-title":"Pharmacological approaches to restore mitochondrial function","volume":"12","author":"Andreux","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"issue":"Pt B","key":"10.1016\/j.jep.2026.121416_bib2","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.freeradbiomed.2015.06.008","article-title":"SKN-1\/Nrf, stress responses, and aging in Caenorhabditis elegans","volume":"88","author":"Blackwell","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.jep.2026.121416_bib3","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0891-5849(02)00959-0","article-title":"Lipofuscin: mechanisms of age-related accumulation and influence on cell function","volume":"33","author":"Brunk","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2026.121416_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118142","article-title":"Psoralea corylifolia L. and its active component isobavachalcone demonstrate antibacterial activity against Mycobacterium abscessus","volume":"329","author":"Cao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121416_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105291","article-title":"Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and \u03b23-AR activation","volume":"164","author":"Chen","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.jep.2026.121416_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9040275","article-title":"Corylin inhibits vascular cell inflammation, proliferation and migration and reduces atherosclerosis in ApoE-Deficient mice","volume":"9","author":"Chen","year":"2020","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.jep.2026.121416_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19020380","article-title":"Corylin suppresses hepatocellular carcinoma progression via the inhibition of epithelial-mesenchymal transition, mediated by long noncoding RNA GAS5","volume":"19","author":"Chen","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2026.121416_bib8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13020-022-00704-6","article-title":"Psoralea corylifolia L.: a comprehensive review of its botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics","volume":"18","author":"Chen","year":"2023","journal-title":"Chin. Med."},{"issue":"28","key":"10.1016\/j.jep.2026.121416_bib9","doi-asserted-by":"crossref","first-page":"10281","DOI":"10.1080\/10408398.2023.2222404","article-title":"Targeting gut-brain axis by dietary flavonoids ameliorate aging-related cognition decline: evidences and mechanisms","volume":"64","author":"Chu","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"1","key":"10.1016\/j.jep.2026.121416_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1748-1716.2007.01780.x","article-title":"FOXO transcription factors in ageing and cancer","volume":"192","author":"Greer","year":"2008","journal-title":"Acta Physiol."},{"issue":"8","key":"10.1016\/j.jep.2026.121416_bib11","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.cell.2025.03.011","article-title":"From geroscience to precision geromedicine: understanding and managing aging","volume":"188","author":"Guido Kroemer","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.jep.2026.121416_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117136","article-title":"Bisphenol S decreased lifespan and healthspan via insulin\/IGF-1-like signaling-against mitochondrial stress in Caenorhabditis elegans","volume":"285","author":"He","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.jep.2026.121416_bib13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00281-022-00944-6","article-title":"The aging immune system in Alzheimer's and Parkinson's diseases","volume":"44","author":"Heavener","year":"2022","journal-title":"Semin. Immunopathol."},{"issue":"24","key":"10.1016\/j.jep.2026.121416_bib14","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0960-9822(01)00594-2","article-title":"daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans","volume":"11","author":"Henderson","year":"2001","journal-title":"Curr. Biol. : CB"},{"issue":"6909","key":"10.1016\/j.jep.2026.121416_bib15","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nature01135","article-title":"Stochastic and genetic factors influence tissue specific decline in ageing C. elegans","volume":"419","author":"Herndon","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jep.2026.121416_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/srep46299","article-title":"Corylin protects LPS-induced sepsis and attenuates LPS-induced inflammatory response","volume":"7","author":"Hung","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.jep.2026.121416_bib17","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1172\/JCI120842","article-title":"The role of mitochondria in aging","volume":"128","author":"Jang","year":"2018","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.jep.2026.121416_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.cstres.2025.100115","article-title":"Autophagy in proteostasis and aging in Caenorhabditis elegans","volume":"30","author":"Lange","year":"2025","journal-title":"Cell Stress Chaperones"},{"issue":"12","key":"10.1016\/j.jep.2026.121416_bib19","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.tem.2012.07.007","article-title":"Lessons from C. elegans: signaling pathways for longevity","volume":"23","author":"Lapierre","year":"2012","journal-title":"Trends Endocrinol. Metabol."},{"issue":"9","key":"10.1016\/j.jep.2026.121416_bib20","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1055\/s-0031-1298482","article-title":"Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation","volume":"78","author":"Lee","year":"2012","journal-title":"Planta Med."},{"issue":"7113","key":"10.1016\/j.jep.2026.121416_bib21","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jep.2026.121416_bib22","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1038\/ncomms3192","article-title":"Metformin improves healthspan and lifespan in mice","volume":"4","author":"Martin-Montalvo","year":"2013","journal-title":"Nat. Commun."},{"issue":"5638","key":"10.1016\/j.jep.2026.121416_bib23","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1126\/science.1087782","article-title":"Autophagy genes are essential for dauer development and life-span extension in C. elegans","volume":"301","author":"Mel\u00e9ndez","year":"2003","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.jep.2026.121416_bib24","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1124\/pr.55.4.1","article-title":"RNA interference in biology and medicine","volume":"55","author":"Milhavet","year":"2003","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.jep.2026.121416_bib25","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.cell.2013.06.016","article-title":"The NAD(+)\/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling","volume":"154","author":"Mouchiroud","year":"2013","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.jep.2026.121416_bib26","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.cmet.2012.09.007","article-title":"Mitochondrial SKN-1\/Nrf mediates a conserved starvation response","volume":"16","author":"Paek","year":"2012","journal-title":"Cell Metab."},{"issue":"20","key":"10.1016\/j.jep.2026.121416_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25204649","article-title":"Mechanisms of aging and the preventive effects of resveratrol on age-related diseases","volume":"25","author":"Pyo","year":"2020","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.jep.2026.121416_bib28","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nm.4132","article-title":"Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents","volume":"22","author":"Ryu","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.jep.2026.121416_bib29","series-title":"Maintenance of C. elegans","first-page":"1","author":"Stiernagle","year":"2006"},{"issue":"5","key":"10.1016\/j.jep.2026.121416_bib30","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/acel.12627","article-title":"The SKN-1\/Nrf2 transcription factor can protect against oxidative stress and increase lifespan in C. elegans by distinct mechanisms","volume":"16","author":"Tullet","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.jep.2026.121416_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2024.1369740","article-title":"Disrupting the SKN-1 homeostat: mechanistic insights and phenotypic outcomes","volume":"5","author":"Turner","year":"2024","journal-title":"Front. Aging"},{"issue":"8","key":"10.1016\/j.jep.2026.121416_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001048","article-title":"RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition","volume":"6","author":"Wang","year":"2010","journal-title":"PLoS Genet."},{"issue":"1","key":"10.1016\/j.jep.2026.121416_bib33","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/s41467-022-28908-2","article-title":"The flavonoid corylin exhibits lifespan extension properties in mouse","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"issue":"45","key":"10.1016\/j.jep.2026.121416_bib34","doi-asserted-by":"crossref","first-page":"24908","DOI":"10.1021\/acs.jafc.4c07756","article-title":"Unveiling the longevity potential of natural phytochemicals: a comprehensive review of active ingredients in dietary plants and herbs","volume":"72","author":"Wang","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.jep.2026.121416_bib35","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1096\/fj.201902319RRR","article-title":"Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt\/\u03b2-catenin signaling pathways","volume":"34","author":"Yu","year":"2020","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.jep.2026.121416_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14482","article-title":"Longevity humans have youthful erythrocyte function and metabolic signatures","volume":"24","author":"Yu","year":"2025","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.jep.2026.121416_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/cells9010109","article-title":"DAF-16\/FoxO in Caenorhabditis elegans and its role in metabolic remodeling","volume":"9","author":"Ze\u010di\u0107","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jep.2026.121416_bib38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1142\/S0192415X16500038","article-title":"The chemical constituents and bioactivities of Psoralea corylifolia Linn.: a review","volume":"44","author":"Zhang","year":"2016","journal-title":"Am. J. Chin. Med."},{"issue":"3","key":"10.1016\/j.jep.2026.121416_bib39","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126002679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126002679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:53:10Z","timestamp":1777571590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126002679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":39,"alternative-id":["S0378874126002679"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121416","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Corylin promotes longevity in Caenorhabditis elegans through DAF-16 and SKN-1 coordinated activation of autophagy-mitochondrial homeostasis axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121416","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121416"}}