{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T04:24:23Z","timestamp":1783225463696,"version":"3.54.6"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007956","name":"Nanjing University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jep.2026.121429","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:57:03Z","timestamp":1772643423000},"page":"121429","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Cimifugin relieves the relapse of allergic asthma via inhibiting ILC2 migration by targeting CCR9"],"prefix":"10.1016","volume":"363","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9886-8394","authenticated-orcid":false,"given":"Anqi","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7601-9152","authenticated-orcid":false,"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongwen","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyi","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifan","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jep.2026.121429_bib1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jaip.2019.11.008","article-title":"Allergic endotypes and phenotypes of asthma","volume":"8","author":"Akar-Ghibril","year":"2020","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.jep.2026.121429_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.918458","article-title":"Heterogeneity of ILC2s in the lungs","volume":"13","author":"Asaoka","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2026.121429_bib3","doi-asserted-by":"crossref","first-page":"7850","DOI":"10.1038\/s41467-024-52252-2","article-title":"TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma","volume":"15","author":"Bao","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2026.121429_bib4","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3389\/fphar.2019.01698","article-title":"A Chinese prescription yu-ping-feng-san administered in remission restores bronchial epithelial barrier to inhibit house dust mite-induced asthma recurrence","volume":"10","author":"Bao","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"11","key":"10.1016\/j.jep.2026.121429_bib5","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.trecan.2018.09.001","article-title":"The role of type 1 conventional dendritic cells in cancer immunity","volume":"4","author":"B\u00f6ttcher","year":"2018","journal-title":"Trends Cancer"},{"issue":"7","key":"10.1016\/j.jep.2026.121429_bib6","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1111\/all.13386","article-title":"Food allergen-sensitized CCR9(+) lymphocytes enhance airways allergic inflammation in mice","volume":"73","author":"Castan","year":"2018","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.jep.2026.121429_bib7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jaci.2020.05.042","article-title":"ILC2s: are they what we think they are?","volume":"146","author":"Cavagnero","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2026.121429_bib8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ctim.2016.10.010","article-title":"A randomized placebo-controlled trial of traditional Chinese medicine as an add-on therapy to oral montelukast in the treatment of mild persistent asthma in children","volume":"29","author":"Chan","year":"2016","journal-title":"Compl. Ther. Med."},{"issue":"6","key":"10.1016\/j.jep.2026.121429_bib9","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1164\/rccm.201612-2427OC","article-title":"Allergen-induced increases in Sputum levels of group 2 innate lymphoid cells in subjects with asthma","volume":"196","author":"Chen","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.jep.2026.121429_bib10","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.jmb.2008.02.015","article-title":"Alanine scanning mutagenesis of anti-TRAP (AT) reveals residues involved in binding to TRAP","volume":"377","author":"Chen","year":"2008","journal-title":"J. Mol. Biol."},{"issue":"11","key":"10.1016\/j.jep.2026.121429_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009034","article-title":"Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection","volume":"16","author":"Das Sarma","year":"2020","journal-title":"PLoS Pathog."},{"issue":"6","key":"10.1016\/j.jep.2026.121429_bib12","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00281-019-00770-3","article-title":"Resolution of allergic asthma","volume":"41","author":"Finotto","year":"2019","journal-title":"Semin. Immunopathol."},{"issue":"6","key":"10.1016\/j.jep.2026.121429_bib13","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.jaci.2016.09.028","article-title":"Individualized therapy for persistent asthma in young children","volume":"138","author":"Fitzpatrick","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2026.121429_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154657","article-title":"Cimifugin suppresses type 2 airway inflammation by binding to SPR and regulating its protein expression in a non-enzymatic manner","volume":"111","author":"Gu","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121429_bib15","doi-asserted-by":"crossref","first-page":"409","DOI":"10.12659\/MSM.912042","article-title":"Cimifugin inhibits inflammatory responses of RAW264.7 cells induced by lipopolysaccharide","volume":"25","author":"Han","year":"2019","journal-title":"Med. Sci. Monit."},{"issue":"3","key":"10.1016\/j.jep.2026.121429_bib16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000115891","article-title":"Human eosinophils show chemotaxis to lymphoid chemokines and exhibit antigen-presenting-cell-like properties upon stimulation with IFN-gamma, IL-3 and GM-CSF","volume":"146","author":"Jung","year":"2008","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"3","key":"10.1016\/j.jep.2026.121429_bib17","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000522342","article-title":"Potential for CCR9+ IL-17+ regulatory T cell as a predictor of early necrotizing enterocolitis","volume":"119","author":"Li","year":"2022","journal-title":"Neonatology"},{"issue":"6","key":"10.1016\/j.jep.2026.121429_bib18","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20200471","article-title":"Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and inflammation via NF-\u03baB\/MAPK pathway","volume":"40","author":"Liu","year":"2020","journal-title":"Biosci. Rep."},{"issue":"10","key":"10.1016\/j.jep.2026.121429_bib19","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41422-021-00529-2","article-title":"Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells","volume":"31","author":"Liu","year":"2021","journal-title":"Cell Res."},{"issue":"3","key":"10.1016\/j.jep.2026.121429_bib20","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0091-6749(03)01798-6","article-title":"Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge","volume":"112","author":"Liu","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2026.121429_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154783","article-title":"A systematic pharmacology-based in vivo study to reveal the effective mechanism of Yupingfeng in asthma treatment","volume":"114","author":"Liu","year":"2023","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2026.121429_bib22","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1186\/s12967-023-04665-8","article-title":"C-C chemokine receptor 5 is essential for conventional NK cell trafficking and liver injury in a murine hepatitis virus-induced fulminant hepatic failure model","volume":"21","author":"Liu","year":"2023","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121429_bib23","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1186\/s12906-017-1988-5","article-title":"Potential effectiveness of Chinese herbal medicine Yu ping feng san for adult allergic rhinitis: a systematic review and meta-analysis of randomized controlled trials","volume":"17","author":"Luo","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121429_bib24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.immuni.2016.06.017","article-title":"Allergen-experienced group 2 innate lymphoid cells acquire memory-like properties and enhance allergic lung inflammation","volume":"45","author":"Martinez-Gonzalez","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jep.2026.121429_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.671966","article-title":"The fate of activated group 2 innate lymphoid cells","volume":"12","author":"Math\u00e4","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2026.121429_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155272","article-title":"CX3CL1\/CX3CR1 interaction protects against lipotoxicity-induced nonalcoholic steatohepatitis by regulating macrophage migration and M1\/M2 status","volume":"136","author":"Ni","year":"2022","journal-title":"Metabolism"},{"issue":"9","key":"10.1016\/j.jep.2026.121429_bib27","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.4049\/jimmunol.165.9.5069","article-title":"The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system","volume":"165","author":"Papadakis","year":"2000","journal-title":"J. Immunol."},{"issue":"10122","key":"10.1016\/j.jep.2026.121429_bib28","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0140-6736(17)33311-1","article-title":"Asthma","volume":"391","author":"Papi","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2026.121429_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.536326","article-title":"The regulatory function of CCR9(+) dendritic cells in inflammation and autoimmunity","volume":"11","author":"Pathak","year":"2020","journal-title":"Front. Immunol."},{"issue":"10221","key":"10.1016\/j.jep.2026.121429_bib30","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0140-6736(19)33005-3","article-title":"Intersection of biology and therapeutics: type 2 targeted therapeutics for adult asthma","volume":"395","author":"Peters","year":"2020","journal-title":"Lancet"},{"issue":"18","key":"10.1016\/j.jep.2026.121429_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184331","article-title":"Molecular docking: shifting paradigms in drug discovery","volume":"20","author":"Pinzi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jep.2026.121429_bib32","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.jaci.2021.09.013","article-title":"Airway administration of OM-85, a bacterial lysate, blocks experimental asthma by targeting dendritic cells and the epithelium\/IL-33\/ILC2 axis","volume":"149","author":"Pivniouk","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2026.121429_bib33","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jaci.2015.05.037","article-title":"Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia","volume":"137","author":"Smith","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2026.121429_bib34","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41392-023-01344-4","article-title":"Pathogenesis of allergic diseases and implications for therapeutic interventions","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jep.2026.121429_bib35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.canlet.2019.10.032","article-title":"Blocking migration of regulatory T cells to leukemic hematopoietic microenvironment delays disease progression in mouse leukemia model","volume":"469","author":"Wang","year":"2020","journal-title":"Cancer Lett."},{"issue":"11","key":"10.1016\/j.jep.2026.121429_bib36","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1111\/jcmm.13204","article-title":"Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions","volume":"21","author":"Wang","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jep.2026.121429_bib37","article-title":"The roles of CCR9\/CCL25 in inflammation and inflammation-associated diseases","volume":"9","author":"Wu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"9","key":"10.1016\/j.jep.2026.121429_bib38","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1182\/blood.V98.9.2626","article-title":"Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gammadelta(+) gut intraepithelial lymphocytes","volume":"98","author":"Wurbel","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.jep.2026.121429_bib39","article-title":"Cimifugin ameliorates lipotoxicity-induced hepatocyte damage and steatosis through TLR4\/p38 MAPK- and SIRT1-Involved pathways","volume":"2022","author":"Yang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.jep.2026.121429_bib40","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1021\/acs.analchem.2c04643","article-title":"DNAzyme-Based microscale thermophoresis sensor","volume":"95","author":"Yu","year":"2023","journal-title":"Anal. Chem."},{"issue":"9","key":"10.1016\/j.jep.2026.121429_bib41","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1084\/jem.190.9.1241","article-title":"Human G protein-coupled receptor GPR-9-6\/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis","volume":"190","author":"Zabel","year":"1999","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.jep.2026.121429_bib42","doi-asserted-by":"crossref","first-page":"7239","DOI":"10.1021\/acsomega.3c09697","article-title":"Cimifugin relieves histamine-independent itch in atopic dermatitis via targeting the CQ receptor MrgprA3","volume":"9","author":"Zheng","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.jep.2026.121429_bib43","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.phymed.2018.09.190","article-title":"Yu-ping-feng-San ameliorates recurrent allergic inflammation of atopic dermatitis by repairing tight junction defects of the epithelial barrier","volume":"54","author":"Zheng","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121429_bib44","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev-pathmechdis-012419-032847","article-title":"DAMPs, PAMPs, and LAMPs in immunity and Sterile inflammation","volume":"15","author":"Zindel","year":"2020","journal-title":"Annu. Rev. Pathol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126002801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126002801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:55:33Z","timestamp":1777571733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126002801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":44,"alternative-id":["S0378874126002801"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121429","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cimifugin relieves the relapse of allergic asthma via inhibiting ILC2 migration by targeting CCR9","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121429","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121429"}}