{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:36:17Z","timestamp":1791822977944,"version":"4.3.4"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jep.2026.121443","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T20:02:32Z","timestamp":1772308952000},"page":"121443","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Integrated pathological assessment and multi-omics analysis of the effects of Pinellia ternata aqueous extract on lung and spleen dysfunction in a rat model of phlegm-dampness obstruction"],"prefix":"10.1016","volume":"363","author":[{"given":"Lili","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heling","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jep.2026.121443_bib1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2026.121443_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109415","article-title":"Supplementation with EPA and DHA omega-3 fatty acids improves peripheral immune cell mitochondrial dysfunction and inflammation in subjects with obesity","volume":"120","author":"Borja-Magno","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.jep.2026.121443_bib3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.med.58.071905.105316","article-title":"Airway surface dehydration in cystic fibrosis: pathogenesis and therapy","volume":"58","author":"Boucher","year":"2007","journal-title":"Annu. Rev. Med."},{"issue":"5","key":"10.1016\/j.jep.2026.121443_bib4","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.immuni.2023.04.004","article-title":"The spleen in local and systemic regulation of immunity","volume":"56","author":"Bronte","year":"2023","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.jep.2026.121443_bib5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jinf.2022.06.024","article-title":"Negative predictive value of procalcitonin to rule out bacterial respiratory co-infection in critical covid-19 patients","volume":"85","author":"Carbonell","year":"2022","journal-title":"J. Infect."},{"key":"10.1016\/j.jep.2026.121443_bib6","series-title":"Theoretical and Experimental Studies on the Injury of the Lung Caused by External Cold","author":"Chen","year":"2012"},{"key":"10.1016\/j.jep.2026.121443_bib7","first-page":"54","article-title":"Experimental Study on the Preliminary Pharmacodynamic Evaluation of Pinellia ternata (Banxia) from Different Geographical Origins","volume":"2","author":"Chen","year":"2008","journal-title":"J. Chengdu Univ. Tradit. Chin. Med."},{"issue":"8","key":"10.1016\/j.jep.2026.121443_bib8","doi-asserted-by":"crossref","first-page":"L797","DOI":"10.1152\/ajplung.00347.2013","article-title":"IL-1\u03b2 induction of MUC5AC gene expression is mediated by CREB and NF-\u03baB and repressed by dexamethasone","volume":"306","author":"Chen","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"9","key":"10.1016\/j.jep.2026.121443_bib9","first-page":"3337","article-title":"Research on the treatment of allergic rhinitis of lung qi deficiency type by the method of replenishing qi and consolidating the exterior","volume":"30","author":"Chen","year":"2015","journal-title":"China J. Traditional Chin. Med. Pharm."},{"issue":"3","key":"10.1016\/j.jep.2026.121443_bib10","first-page":"4011","article-title":"Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells","volume":"17","author":"Chen","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"17","key":"10.1016\/j.jep.2026.121443_bib11","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"Fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.jep.2026.121443_bib12","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/alr.22685","article-title":"Pepsin exposure in a non-acidic environment upregulates mucin 5AC (MUC5AC) expression via matrix metalloproteinase 9 (MMP9)\/nuclear factor \u03baB (NF-\u03baB) in human airway epithelial cells","volume":"11","author":"Choi","year":"2021","journal-title":"Int. Forum Allergy Rhinol."},{"issue":"9","key":"10.1016\/j.jep.2026.121443_bib13","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1358\/mf.1999.21.9.795606","article-title":"Proliferation of spleen cells in culture stimulated by 7-thia-8-oxoguanosine: evidence that both B- and T-cells are the targets of its action","volume":"21","author":"Colic","year":"1999","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2026.121443_bib14","series-title":"Pharmacopoeia of the People's Republic of China","author":"Commission","year":"2022"},{"issue":"7","key":"10.1016\/j.jep.2026.121443_bib15","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3109\/01902148.2014.920438","article-title":"Regulation of silicosis formation by lysophosphatidic acid and its receptors","volume":"40","author":"Cong","year":"2014","journal-title":"Exp. Lung Res."},{"issue":"5","key":"10.1016\/j.jep.2026.121443_bib16","first-page":"477","article-title":"Effect of Pinellia ternata (Banxia) extract on airway mucus hypersecretion","volume":"8","author":"Deng","year":"2009","journal-title":"Chin. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jep.2026.121443_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113638","article-title":"Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism","volume":"155","author":"Deng","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.121443_bib18","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.clnesp.2022.09.100","article-title":"Sex related differences in amino acid metabolism in chronic obstructive pulmonary disease","volume":"54","author":"Engelen","year":"2023","journal-title":"Clin. Nutrit. ESPEN"},{"issue":"6","key":"10.1016\/j.jep.2026.121443_bib19","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1093\/jn\/136.6.1558","article-title":"Specific amino acids increase mucin synthesis and microbiota in dextran sulfate sodium-treated rats","volume":"136","author":"Faure","year":"2006","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.jep.2026.121443_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1074-7613(00)80094-1","article-title":"Modulation of B lymphocyte antigen receptor signal transduction by a CD19\/CD22 regulatory loop","volume":"11","author":"Fujimoto","year":"1999","journal-title":"Immunity"},{"issue":"11","key":"10.1016\/j.jep.2026.121443_bib22","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1113\/EP087221","article-title":"TLR7 agonist attenuates acetylcholine-induced, Ca(2+) -dependent ionic currents in swine tracheal submucosal gland cells","volume":"103","author":"Gamo","year":"2018","journal-title":"Exp. Physiol."},{"issue":"11","key":"10.1016\/j.jep.2026.121443_bib23","first-page":"1206","article-title":"Comparison of the effects of establishing mouse models of acute lung injury by airway instillation and intraperitoneal injection of lipopolysaccharide","volume":"51","author":"Gu","year":"2020","journal-title":"J. Shanxi Med. Univ."},{"issue":"18","key":"10.1016\/j.jep.2026.121443_bib24","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of Coronavirus Disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.jep.2026.121443_bib25","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1111\/j.1471-4159.2012.07660.x","article-title":"Saturated long-chain fatty acids activate inflammatory signaling in astrocytes","volume":"120","author":"Gupta","year":"2012","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.jep.2026.121443_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133426","article-title":"Hyperphosphatemia is an independent risk factor for mortality in critically ill patients: results from a cross-sectional study","volume":"10","author":"Haider","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jep.2026.121443_bib27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tem.2021.03.002","article-title":"Role of medium-chain fatty acids in healthy metabolism: a clinical perspective","volume":"32","author":"Huang","year":"2021","journal-title":"Trends Endocrinol. Metabol."},{"issue":"4","key":"10.1016\/j.jep.2026.121443_bib28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4049\/immunohorizons.2100023","article-title":"ATP release drives inflammation with Lysophosphatidylcholine","volume":"5","author":"Ismaeel","year":"2021","journal-title":"Immunohorizons"},{"key":"10.1016\/j.jep.2026.121443_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.628302","article-title":"Sepsis-Pathophysiology and therapeutic concepts","volume":"8","author":"Jarczak","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.jep.2026.121443_bib30","author":"Jing"},{"issue":"10","key":"10.1016\/j.jep.2026.121443_bib31","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMoa1701632","article-title":"Airway mucin concentration as a marker of chronic bronchitis","volume":"377","author":"Kesimer","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.jep.2026.121443_bib32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"issue":"9","key":"10.1016\/j.jep.2026.121443_bib33","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nrd4099","article-title":"Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond","volume":"12","author":"Kunkel","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.jep.2026.121443_bib34","first-page":"548","article-title":"Measurement and significance of non-invasive pulmonary function in mice","volume":"26","author":"Li","year":"2018","journal-title":"Chin. J. Lab. Animal Sci."},{"issue":"1","key":"10.1016\/j.jep.2026.121443_bib35","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00697-19","article-title":"Toll-like receptor 2 (TLR2) and TLR4 mediate the IgA immune response induced by Mycoplasma hyopneumoniae","volume":"88","author":"Li","year":"2019","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.jep.2026.121443_bib36","first-page":"122","article-title":"Analysis of the evolution and reasons of the clinical dosage of Pinellia ternata in successive dynasties","volume":"25","author":"Li","year":"2023","journal-title":"J. Liaoning Univ. Traditional Chin. Med."},{"issue":"5","key":"10.1016\/j.jep.2026.121443_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.371","article-title":"The unique interplay of mitochondrial oxidative phosphorylation (OXPHOS) and immunity and its potential implication for the sex- and age-related morbidity of severe COVID-19 patients","volume":"4","author":"Li","year":"2023","journal-title":"MedComm"},{"key":"10.1016\/j.jep.2026.121443_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118599","article-title":"Shenling Baizhu decoction treats ulcerative colitis of spleen-deficiency and dampness obstruction types by targeting 'gut microbiota and galactose metabolism-bone marrow' axis","volume":"335","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2026.121443_bib39","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1164\/rccm.202201-0064ED","article-title":"The Mucin gene MUC5B is required for normal lung function","volume":"205","author":"Liegeois","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"12","key":"10.1016\/j.jep.2026.121443_bib40","first-page":"49","article-title":"Establishment of non-invasive pulmonary function parameters in rats","volume":"38","author":"Liu","year":"2017","journal-title":"Progr. Veterinary Med."},{"issue":"3","key":"10.1016\/j.jep.2026.121443_bib41","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1096\/fj.11-187351","article-title":"Autocrine abscisic acid plays a key role in quartz-induced macrophage activation","volume":"26","author":"Magnone","year":"2012","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.jep.2026.121443_bib42","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.kint.2019.12.014","article-title":"Spleen tyrosine kinase inhibition is an effective treatment for established vasculitis in a pre-clinical model","volume":"97","author":"McAdoo","year":"2020","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.jep.2026.121443_bib43","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s42003-021-02254-3","article-title":"Plasma methionine metabolic profile is associated with longevity in mammals","volume":"4","author":"Mota-Martorell","year":"2021","journal-title":"Commun. Biol."},{"issue":"2","key":"10.1016\/j.jep.2026.121443_bib44","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1053\/j.ajkd.2023.04.017","article-title":"Calcium and Phosphate disorders: core curriculum 2024","volume":"83","author":"Murray","year":"2024","journal-title":"Am. J. Kidney Dis."},{"issue":"2","key":"10.1016\/j.jep.2026.121443_bib45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ymgme.2009.01.015","article-title":"An overview of pulmonary surfactant in the neonate: genetics, metabolism, and the role of surfactant in health and disease","volume":"97","author":"Nkadi","year":"2009","journal-title":"Mol. Genet. Metabol."},{"issue":"1","key":"10.1016\/j.jep.2026.121443_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/md22010017","article-title":"The role of marine n-3 polyunsaturated fatty acids in inflammatory-based disease: the case of rheumatoid arthritis","volume":"22","author":"Parolini","year":"2023","journal-title":"Mar. Drugs"},{"issue":"17","key":"10.1016\/j.jep.2026.121443_bib47","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1200\/JCO.2013.53.1046","article-title":"Bruton's tyrosine kinase: from X-linked agammaglobulinemia toward targeted therapy for B-cell malignancies","volume":"32","author":"Ponader","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jep.2026.121443_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2021.126810","article-title":"Bacterial effectors mimicking ubiquitin-proteasome pathway tweak plant immunity","volume":"250","author":"Ramachandran","year":"2021","journal-title":"Microbiol. Res."},{"issue":"3","key":"10.1016\/j.jep.2026.121443_bib49","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/gb-2011-12-3-r22","article-title":"Improving RNA-Seq expression estimates by correcting for fragment bias","volume":"12","author":"Roberts","year":"2011","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.jep.2026.121443_bib50","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1165\/rcmb.2014-0343OC","article-title":"A pneumocyte-macrophage paracrine lipid axis drives the lung toward fibrosis","volume":"53","author":"Romero","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"3","key":"10.1016\/j.jep.2026.121443_bib51","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0002-9440(10)62051-2","article-title":"Synthesis of {alpha}(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin","volume":"167","author":"Satoh","year":"2005","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.jep.2026.121443_bib52","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1194\/jlr.R067629","article-title":"Short- and medium-chain fatty acids in energy metabolism: the cellular perspective","volume":"57","author":"Sch\u00f6nfeld","year":"2016","journal-title":"J. Lipid Res."},{"issue":"23","key":"10.1016\/j.jep.2026.121443_bib53","first-page":"332","article-title":"Effect of okara RNA and its enzymatic hydrolysates on immune function in mice","volume":"34","author":"Shao","year":"2013","journal-title":"Food Sci. Technol."},{"issue":"7","key":"10.1016\/j.jep.2026.121443_bib54","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.tips.2023.04.006","article-title":"Modulation of T cells by tryptophan metabolites in the kynurenine pathway","volume":"44","author":"Stone","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2026.121443_bib55","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/nutrit\/nuab027","article-title":"The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression","volume":"80","author":"Sutanto","year":"2022","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.jep.2026.121443_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115449","article-title":"Processed product (Pinelliae Rhizoma Praeparatum) of Pinellia ternata (Thunb.) Breit. Alleviates the allergic airway inflammation of cold phlegm via regulation of PKC\/EGFR\/MAPK\/PI3K-AKT signaling pathway","volume":"295","author":"Tao","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121443_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116720","article-title":"Pinellia ternata (Thunb.) Breit. attenuates the allergic airway inflammation of cold asthma via inhibiting the activation of TLR4-medicated NF-kB and NLRP3 signaling pathway","volume":"315","author":"Tao","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.jep.2026.121443_bib58","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1038\/ismej.2014.64","article-title":"Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism","volume":"8","author":"Tong","year":"2014","journal-title":"ISME J."},{"issue":"6","key":"10.1016\/j.jep.2026.121443_bib59","first-page":"489","article-title":"Evaluation of the property and flavor pharmacology of the chemically separated fractions of ephedra: an experimental study on the \"Xinwen\" (Pungent-Warm) diaphoretic and diuretic effects of the chemically separated fractions of ephedra","volume":"18","author":"Wang","year":"2011","journal-title":"Chin. J. Traditional Med. Sci.Technol."},{"key":"10.1016\/j.jep.2026.121443_bib60","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3389\/fbioe.2019.00351","article-title":"Metabolic engineering of Escherichia coli for the production of hyaluronic acid from glucose and galactose","volume":"7","author":"Woo","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"3","key":"10.1016\/j.jep.2026.121443_bib61","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1172\/JCI0213870","article-title":"Effects of reduced mucus oxygen concentration in airway pseudomonas infections of cystic fibrosis patients","volume":"109","author":"Worlitzsch","year":"2002","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jep.2026.121443_bib62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bbi.2022.04.016","article-title":"Lipopolysaccharide-induced inflammation increases nitric oxide production in taste buds","volume":"103","author":"Wu","year":"2022","journal-title":"Brain Behav. Immun."},{"issue":"17","key":"10.1016\/j.jep.2026.121443_bib63","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202500885R","article-title":"Red blood cell-mediated enhancement of hematopoietic stem cell functions via a Hes1-Dependent pathway","volume":"39","author":"Yamashita","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.jep.2026.121443_bib64","author":"Yang"},{"key":"10.1016\/j.jep.2026.121443_bib65","series-title":"Study on the Action Mechanism of Lung Yang in a Rat Model of Asthma with the Syndrome of Cold Fluid Retention in the Lung [Master","author":"Yu","year":"2004"},{"issue":"1","key":"10.1016\/j.jep.2026.121443_bib66","first-page":"1","article-title":"Pinelliae Rhizoma: a systematic review on botany, ethnopharmacology, phytochemistry, preclinical and clinical evidence","volume":"23","author":"Z","year":"2025","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2026.121443_bib67","series-title":"Study on Notch Pathway and Lymphocyte Development","author":"Zhang","year":"2007"},{"issue":"6","key":"10.1016\/j.jep.2026.121443_bib68","first-page":"128","article-title":"Research progress on chemical constituents and pharmacological effects of Chuanxiong (Ligusticum chuanxiong)","volume":"37","author":"Zhang","year":"2020","journal-title":"Inform. Traditional Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121443_bib69","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1180","article-title":"Lysophosphatidylcholine inhibits lung cancer cell proliferation by regulating fatty acid metabolism enzyme long-chain acyl-coenzyme A synthase 5","volume":"13","author":"Zhang","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"11","key":"10.1016\/j.jep.2026.121443_bib70","doi-asserted-by":"crossref","first-page":"6840","DOI":"10.1007\/s12010-023-04385-1","article-title":"Anti-Liver Fibrosis role of miRNA-96-5p via targeting FN1 and inhibiting ECM-receptor interaction pathway","volume":"195","author":"Zhang","year":"2023","journal-title":"Appl. Biochem. Biotechnol."},{"issue":"5","key":"10.1016\/j.jep.2026.121443_bib71","article-title":"Arachidonic acid metabolism in health and disease","volume":"4","author":"Zhang","year":"2023","journal-title":"MedComm (2020)"},{"key":"10.1016\/j.jep.2026.121443_bib72","series-title":"Effects of the Compatibility of Pinelliae Rhizoma Praeparatum (Fabanxia) and Ophiopogonis Radix (Maidong) on Rats with Phlegm-Dampness Obstructing the Lung Syndrome Model [Master","author":"Zhong","year":"2021"},{"key":"10.1016\/j.jep.2026.121443_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161581","article-title":"The IL17 signaling pathway: a potential signaling pathway mediating gill hyperplasia and inflammation under ammonia nitrogen stress was identified by multi-omics analysis","volume":"867","author":"Zhong","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.jep.2026.121443_bib74","first-page":"80","article-title":"Establishment of animal model for Phlegm-dampness obstructing the lung syndrome","volume":"39","author":"Zhong","year":"2023","journal-title":"J. Pharmacol. Clin. Appl. Chin. Materia Medica"},{"key":"10.1016\/j.jep.2026.121443_bib75","author":"Zhou"},{"key":"10.1016\/j.jep.2026.121443_bib76","author":"Zhou"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126002941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126002941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T02:36:43Z","timestamp":1775097403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126002941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":75,"alternative-id":["S0378874126002941"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121443","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated pathological assessment and multi-omics analysis of the effects of Pinellia ternata aqueous extract on lung and spleen dysfunction in a rat model of phlegm-dampness obstruction","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121443","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121443"}}