{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:11:27Z","timestamp":1780395087535,"version":"3.54.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["ZG2024001\\u201303"],"award-info":[{"award-number":["ZG2024001\\u201303"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2021A04801"],"award-info":[{"award-number":["CI2021A04801"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2021B016"],"award-info":[{"award-number":["CI2021B016"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023C006YG"],"award-info":[{"award-number":["CI2023C006YG"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005045","name":"Ministry of Finance of the People's Republic of China","doi-asserted-by":"publisher","award":["ZXKT25036"],"award-info":[{"award-number":["ZXKT25036"]}],"id":[{"id":"10.13039\/501100005045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jep.2026.121455","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:08:14Z","timestamp":1772899694000},"page":"121455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Study on chronic toxicity, metabolic profiles and potential mechanisms of Aristolochiae Fructus in rats"],"prefix":"10.1016","volume":"364","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5552-2920","authenticated-orcid":false,"given":"Haisheng","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhuo","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rushuang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5798-4405","authenticated-orcid":false,"given":"Aihua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"26","key":"10.1016\/j.jep.2026.121455_bib1","doi-asserted-by":"crossref","first-page":"16293","DOI":"10.1021\/acs.jafc.5c06473","article-title":"Analysis of honey and environmental samples from BEN endemic villages in Serbia: identification of a novel human exposure pathway for aristolochic acids and aristolactams","volume":"73","author":"Au","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.jep.2026.121455_bib2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1021\/acs.chemrestox.4c00045","article-title":"Effects of heavy metal Co-Exposure on the formation of DNA adducts from aristolochic acid I: implications for balkan endemic nephropathy development","volume":"37","author":"Au","year":"2024","journal-title":"J. Chem. Res. Toxicol."},{"issue":"2","key":"10.1016\/j.jep.2026.121455_bib3","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1021\/acs.chemrestox.2c00415","article-title":"Bioaccumulation and DNA adduct formation of aristolactam I: unmasking a toxicological mechanism in the pathophysiology of aristolochic acid nephropathy","volume":"36","author":"Au","year":"2023","journal-title":"J. Chem. Res. Toxicol."},{"issue":"5","key":"10.1016\/j.jep.2026.121455_bib4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/15376516.2025.2457340","article-title":"Clinical and safety outcomes associated with aristolochic acid exposure: a systematic review and meta-analysis","volume":"35","author":"Cui","year":"2025","journal-title":"J. Toxicol. Mech. Methods"},{"issue":"4","key":"10.1016\/j.jep.2026.121455_bib5","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/ame2.12041","article-title":"Reference values for selected hematological, biochemical and physiological parameters of Sprague-Dawley rats at the animal house, faculty of medicine, University of Colombo, Sri Lanka. J","volume":"1","author":"Delwatta","year":"2018","journal-title":"Animal Model. Exp. Med."},{"issue":"43","key":"10.1016\/j.jep.2026.121455_bib6","doi-asserted-by":"crossref","first-page":"8733","DOI":"10.1039\/D5AY01417D","article-title":"UPLC-MS\/MS analysis of aristolochic acid I and aristolactam I in multiple matrices for exposure assessment","volume":"17","author":"Ding","year":"2025","journal-title":"J. Anal. Methods"},{"issue":"Pt 2","key":"10.1016\/j.jep.2026.121455_bib7","article-title":"Fasudil targets the RhoA\/ROCK-NLRP3 axis to attenuate aristolochic acid-induced renal pyroptosis: translational validation by in vivo molecular imaging","volume":"168","author":"Gao","year":"2026","journal-title":"Int. Immunopharmacol. J."},{"issue":"11","key":"10.1016\/j.jep.2026.121455_bib8","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3390\/toxics13110919","article-title":"Enterohepatic recirculation-mediated reabsorption of aristolochic acid I: revealed by toxicokinetics and metabolite identification in rats","volume":"13","author":"Huang","year":"2025","journal-title":"Toxics J."},{"issue":"2","key":"10.1016\/j.jep.2026.121455_bib9","first-page":"162","article-title":"Research of Chinese medicines containing aristolochic acid on its nephrotoxicity from clinical manifestations and pathogenic mechanisms","volume":"35","author":"Hou","year":"2019","journal-title":"J. Pharmacol. Clin. Chinese Materia Medica."},{"issue":"4","key":"10.1016\/j.jep.2026.121455_bib10","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/mutage\/geaf012","article-title":"Genotoxic effects of aristolochic acid I on functional human-induced hepatocyte-like cells","volume":"40","author":"Hu","year":"2025","journal-title":"J. Mutagenesis"},{"issue":"7","key":"10.1016\/j.jep.2026.121455_bib11","first-page":"403","article-title":"Effect of aristolochic acid I on liver metabolic enzymes of mice","volume":"17","author":"Ji","year":"2020","journal-title":"J. Chinese J. Pharmacovigilance"},{"issue":"5","key":"10.1016\/j.jep.2026.121455_bib12","first-page":"405","article-title":"The review and analysis of aristolochic acid side-effects","volume":"38","author":"Jiang","year":"2021","journal-title":"J. Chinese J. Drug Evaluat."},{"issue":"4","key":"10.1016\/j.jep.2026.121455_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S2225-4110(16)30111-0","article-title":"Chemical Constituents and Pharmacology of the Aristolochia (m\u0103d\u014du ling) species","volume":"2","author":"Kuo","year":"2012","journal-title":"J. Tradit. Complement. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121455_bib14","first-page":"75","article-title":"A study of human serum preparation methods for metabolomic analysis based on liquid chromatography-mass spectrometry","volume":"13","author":"Li","year":"2021","journal-title":"j. chinese journal of oncology prevention and treatment"},{"issue":"1","key":"10.1016\/j.jep.2026.121455_bib15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12967-023-04815-y","article-title":"Transcriptomic insights into UTUC: role of inflammatory fibrosis and potential for personalized treatment","volume":"22","author":"Li","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jep.2026.121455_bib16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.toxlet.2020.08.014","article-title":"Aristolochic acid I promotes the invasion and migration of hepatocellular carcinoma cells by activating the C3a\/C3aR complement system","volume":"378","author":"Li","year":"2023","journal-title":"J. Toxicol. Lett."},{"issue":"10","key":"10.1016\/j.jep.2026.121455_bib17","first-page":"1394","article-title":"Analysis of chemical constituent of Black Ginseng Rhizome in serum, urine and feces of rats by UPLC-Q-TOF-MS","volume":"33","author":"Lin","year":"2022","journal-title":"J. Tradit. Chinese Drug Res. Clin. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2026.121455_bib18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/path.6349","article-title":"Aristolochic acid-related renal cell carcinoma exhibits a distinct tumor-immune microenvironment favoring response to immune checkpoint blockade","volume":"264","author":"Lin","year":"2024","journal-title":"J. Pathol."},{"key":"10.1016\/j.jep.2026.121455_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116202","article-title":"Long-term oral administration of Asarum heterotropoides f. mandshuricum (Maxim.) Kitag. decoction and its aristolochic acid analogs do not cause renal toxicity in mice","volume":"307","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121455_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.761593","article-title":"Quantitative determination and toxicity evaluation of aristolochic acid analogues in Asarum heterotropoides F. Schmidt (xixin) and traditional Chinese patent medicines","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2026.121455_bib21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1293\/tox.2025-0014","article-title":"Protective effects of roselle (Hibiscus sabdariffa) aqueous extract against aristolochic acid-induced developmental nephrotoxicity in zebrafish","volume":"38","author":"Lu","year":"2025","journal-title":"J. Toxicol. Pathol."},{"issue":"9","key":"10.1016\/j.jep.2026.121455_bib22","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1007\/s00204-025-04087-z","article-title":"Whether aristolochic acid directly drives hepatocarcinogenesis: comprehensive investigations from mutational signatures to animal models","volume":"99","author":"Lu","year":"2025","journal-title":"J. Arch Toxicol."},{"issue":"1","key":"10.1016\/j.jep.2026.121455_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s40264-014-0244-x","article-title":"Aristolochic acid nephropathy: epidemiology, clinical presentation and treatment","volume":"38","author":"Luciano","year":"2015","journal-title":"J. Drug Saf."},{"key":"10.1016\/j.jep.2026.121455_bib24","series-title":"Chinese Pharmacopoeia [2015 Edition] (Volume I)","first-page":"51","year":"2015"},{"key":"10.1016\/j.jep.2026.121455_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2022.463417","article-title":"Ultra-performance chromatography-electrospray tandemmass spectrometry analysis of bile acid profiles in the enterohepatic circulation following geniposide and acetaminophen-induced liver injury","volume":"1680","author":"Qin","year":"2022","journal-title":"J. Chromatogr. A"},{"issue":"18","key":"10.1016\/j.jep.2026.121455_bib38","doi-asserted-by":"crossref","first-page":"9421","DOI":"10.1021\/acs.analchem.5b02287","article-title":"PredRet: prediction of retention time by direct mapping between multiple chromatographic systems","volume":"87","author":"Stanstrup","year":"2015","journal-title":"Anal Chem"},{"issue":"1","key":"10.1016\/j.jep.2026.121455_bib26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4062\/biomolther.2022.054","article-title":"Melatonin Attenuates mitochondrial damage in aristolochic acid-induced acute kidney injury","volume":"31","author":"Sun","year":"2023","journal-title":"J. Biomol. Ther. (Seoul)."},{"key":"10.1016\/j.jep.2026.121455_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116568","article-title":"Study on the difference and correlation between the contents and toxicity of aristolochic acid analogues in Aristolochia plants","volume":"315","author":"Tian","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121455_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2025.115708","article-title":"Aristolochic acid I promotes renal tubulointerstitial fibrosis by activating the mannan-binding lectin serine protease 1-complement system","volume":"205","author":"Wang","year":"2025","journal-title":"J. Food Chem. Toxicol."},{"issue":"13","key":"10.1016\/j.jep.2026.121455_bib29","first-page":"112","article-title":"Qualitative analysis of metabolites of aristolochiae fructus aqueous extract in rats","volume":"29","author":"Wang","year":"2023","journal-title":"J. Chinese J. Experiment. Trad. Med. Formulae"},{"key":"10.1016\/j.jep.2026.121455_bib30","article-title":"Hepatorenal Toxicity induced by water extract of Aristolochiae fructus in rats and qualitative analysis of Aristolochic acid metabolites","author":"Wang","year":"2023","journal-title":"D. China Academy of Chinese Medical Sciences (CACMS)"},{"key":"10.1016\/j.jep.2026.121455_bib31","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.3389\/fimmu.2019.02277","article-title":"Interleukin-22 attenuated renal tubular injury in aristolochic acid nephropathy via suppressing activation of NLR P3 inflammasome","volume":"10","author":"Wang","year":"2019","journal-title":"J. Front. Immunol."},{"key":"10.1016\/j.jep.2026.121455_bib32","article-title":"IGFBP-5\/TGF-\u03b21-mediated crosstalk between endothelial and tubular epithelial cells promotes interstitial fibrosis","author":"Wang","year":"2025","journal-title":"J. Nephrol. Dial Transplant."},{"key":"10.1016\/j.jep.2026.121455_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2025.115592","article-title":"Mechanisms of aristolochic acid I hepatotoxicity: central role of PDK4-Induced mitochondrial dysfunction and hepatic inflammation","volume":"203","author":"Wang","year":"2025","journal-title":"J. Food Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.jep.2026.121455_bib34","doi-asserted-by":"crossref","first-page":"579","DOI":"10.23876\/j.krcp.22.211","article-title":"Overview of aristolochic acid nephropathy: an update","volume":"42","author":"Zhou","year":"2023","journal-title":"J. Kidney Res. Clin. Pract."},{"issue":"4","key":"10.1016\/j.jep.2026.121455_bib36","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/st9.0000000000000083","article-title":"Toxicological evaluation of aristolochic acid II following single and repeated oral administration over a 24-week period","volume":"3","author":"Yi","year":"2025","journal-title":"Science of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2026.121455_bib35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.toxlet.2024.02.013","article-title":"Mitochondrial uptake of aristolactam I plays a critical role in its toxicity","volume":"394","author":"Zhou","year":"2024","journal-title":"J. Toxicol. Lett."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126003065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126003065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T14:45:30Z","timestamp":1776177930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126003065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":37,"alternative-id":["S0378874126003065"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121455","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study on chronic toxicity, metabolic profiles and potential mechanisms of Aristolochiae Fructus in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121455","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121455"}}