{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:06:04Z","timestamp":1784707564602,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903812"],"award-info":[{"award-number":["81903812"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["QJRC2023017"],"award-info":[{"award-number":["QJRC2023017"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2026NSFSC0170"],"award-info":[{"award-number":["2026NSFSC0170"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2025ZNSFSC0599"],"award-info":[{"award-number":["2025ZNSFSC0599"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017949","name":"Health Commission of Shanxi Province","doi-asserted-by":"publisher","award":["2025ZYYD026"],"award-info":[{"award-number":["2025ZYYD026"]}],"id":[{"id":"10.13039\/100017949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jep.2026.121514","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:01:43Z","timestamp":1773334903000},"page":"121514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Sanhuang xiexin decoction ameliorates gastric ulcers by activating EGFR\/PI3K\/AKT pathway based on \u201cdrug-target-metabolite\u201d network"],"prefix":"10.1016","volume":"365","author":[{"given":"Xinyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixi","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10447","key":"10.1016\/j.jep.2026.121514_bib1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0140-6736(24)00155-7","article-title":"Peptic ulcer disease","volume":"404","author":"Almadi","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2026.121514_bib2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.semcancer.2019.07.009","article-title":"PI3K\/Akt\/mTOR inhibitors in cancer: at the bench and bedside","volume":"59","author":"Alzahrani","year":"2019","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.jep.2026.121514_bib3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jep.2016.10.049","article-title":"Gastroprotective activity of the rhizome ethanol extract of Zingiber simaoense Y. Y. Qian in rats","volume":"194","author":"Baiubon","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121514_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2023.115303","article-title":"A fast and accurate colorimetric assay for quantifying hippuric acid in human urine","volume":"680","author":"Bhattacharyya","year":"2023","journal-title":"Anal. Biochem."},{"issue":"6","key":"10.1016\/j.jep.2026.121514_bib5","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1158\/0008-5472.CAN-18-0668","article-title":"IDO1 and kynurenine pathway metabolites activate PI3K-Akt signaling in the neoplastic Colon epithelium to promote cancer cell proliferation and inhibit apoptosis","volume":"79","author":"Bishnupuri","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.jep.2026.121514_bib6","article-title":"Research status of Sanhuang Xiexin decoction and analyses of key technologies and core issues","author":"Chen","year":"2016","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"5","key":"10.1016\/j.jep.2026.121514_bib7","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/SGA.0000000000000478","article-title":"Peptic ulcer disease","volume":"42","author":"Dunlap","year":"2019","journal-title":"Gastroenterol. Nurs."},{"issue":"Pt B","key":"10.1016\/j.jep.2026.121514_bib8","article-title":"Vitro UPLC analysis and mass method identification, and in vivo or cellular immune anti-inflammatory function of Sanhuang Xiexin Decoction (SHXD)","volume":"318","author":"Gao","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.121514_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12943-023-01827-6","article-title":"PI3K\/AKT\/mTOR signaling transduction pathway and targeted therapies in cancer","volume":"22","author":"Glaviano","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jep.2026.121514_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117793","article-title":"Treatment of gastric ulcer, traditional Chinese medicine may be a better choice","volume":"324","author":"Gong","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2026.121514_bib11","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1111\/1750-3841.16214","article-title":"Protective effect of active components of Eucommia ulmoides leaves on gastric ulcers in rats: involvement of the PI3K\/Akt\/NF-\u03baB pathway","volume":"87","author":"Gong","year":"2022","journal-title":"J. Food Sci."},{"key":"10.1016\/j.jep.2026.121514_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117739","article-title":"Licorice flavonoid ameliorates ethanol-induced gastric ulcer in rats by suppressing apoptosis via PI3K\/AKT signaling pathway","volume":"325","author":"Guo","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121514_bib13","article-title":"Current advances in coptidis rhizoma for gastrointestinal and other cancers","volume":"12","author":"He","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2026.121514_bib14","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1172\/JCI69600","article-title":"Glutamine and cancer: cell biology, physiology, and clinical opportunities","volume":"123","author":"Hensley","year":"2013","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.jep.2026.121514_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/nu13062078","article-title":"Protective effects of small-molecule oligopeptides isolated from tilapia fish scale on ethanol-induced gastroduodenal injury in rats","volume":"13","author":"Hu","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2026.121514_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155963","article-title":"Dehydroevodiamine targeting IKK\u03b2 to alleviate acute gastric injury via inhibiting the p65\/NLRP3 axis","volume":"134","author":"Hu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121514_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1003627","article-title":"Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats","volume":"9","author":"Huang","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jep.2026.121514_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156887","article-title":"Daidzein alleviates ethanol-induced acute gastric injury in rats by targeting ESR1 and activating the PI3K\/AKT\/CREB signaling pathway","volume":"143","author":"Jiang","year":"2025","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2026.121514_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1053\/j.gastro.2008.05.030","article-title":"Gastric mucosal defense and cytoprotection: bench to bedside","volume":"135","author":"Laine","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2026.121514_bib20","article-title":"Assessment of the potential of Sarcandra glabra (thunb.) nakai. in treating ethanol-induced gastric ulcer in rats based on metabolomics and network analysis","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2026.121514_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115682","article-title":"Sanhuang xiexin decoction ameliorates secondary liver injury in DSS-induced colitis involve regulating inflammation and bile acid metabolism","volume":"299","author":"Li","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2026.121514_bib22","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3390\/molecules14030979","article-title":"Flavonoids with gastroprotective activity","volume":"14","author":"Mota","year":"2009","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.jep.2026.121514_bib23","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/s00535-016-1207-z","article-title":"Gastrointestinal mucosal barrier function and diseases","volume":"51","author":"Oshima","year":"2016","journal-title":"J. Gastroenterol."},{"issue":"12","key":"10.1016\/j.jep.2026.121514_bib24","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1007\/s11655-023-3555-x","article-title":"Sanhuang xiexin decoction ameliorates TNBC by modulating JAK2-STAT3 and lipid metabolism","volume":"30","author":"Qi","year":"2024","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2026.121514_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.autneu.2022.103041","article-title":"The multiple roles of dopamine receptor activation in the modulation of gastrointestinal motility and mucosal function","volume":"244","author":"Serio","year":"2023","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.jep.2026.121514_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119730","article-title":"Integrating metabolomics and network pharmacology to investigate Mu Jin powder prevents ethanol-induced gastric ulcer in rats","volume":"347","author":"Shi","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2026.121514_bib27","doi-asserted-by":"crossref","first-page":"6408","DOI":"10.1039\/D4FO01071J","article-title":"Gastroprotective effects of polysaccharides from purple sweet potato (Ipomoea batatas (L.) Lam) on an ethanol-induced gastric ulcer via regulating immunity and activating the PI3K\/Akt\/Rheb\/mTOR pathway","volume":"15","author":"Sun","year":"2024","journal-title":"Food Funct."},{"issue":"25","key":"10.1016\/j.jep.2026.121514_bib28","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/0024-3205(85)90112-2","article-title":"Effects of L-dopa and L-tyrosine on release of free and conjugated dopamine, homovanillic acid and dihydroxyphenylacetic acid from slices of rat striatum","volume":"37","author":"Tyce","year":"1985","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.jep.2026.121514_bib29","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1038\/s41598-018-22094-2","article-title":"Xiexin tang improves the symptom of type 2 diabetic rats by modulation of the gut microbiota","volume":"8","author":"Wei","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2026.121514_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117901","article-title":"The active components and potential mechanisms of Wuji Wan in the treatment of ethanol-induced gastric ulcer: an integrated metabolomics, network pharmacology and experimental validation","volume":"326","author":"Wu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121514_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115537","article-title":"Sanhuang Xiexin decoction ameliorates DSS-induced colitis in mice by regulating intestinal inflammation, intestinal barrier, and intestinal flora","volume":"297","author":"Wu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121514_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155791","article-title":"Cinnamaldehyde alleviates aspirin-induced gastric mucosal injury by regulating pi3k\/akt pathway-mediated apoptosis, autophagy and ferroptosis","volume":"132","author":"Yan","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121514_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.149879","article-title":"Hippuric acid alleviates dextran sulfate sodium-induced colitis via suppressing inflammatory activity and modulating gut microbiota","volume":"710","author":"Yang","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2026.121514_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124001","article-title":"Dendrobium huoshanense stem polysaccharide ameliorates alcohol-induced gastric ulcer in rats through Nrf2-mediated strengthening of gastric mucosal barrier","volume":"236","author":"Ye","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.121514_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155866","article-title":"Pretreatment with dan-shen-yin granules alleviates ethanol-induced gastric mucosal damage in rats by inhibiting oxidative stress and apoptosis via Akt\/Nrf2 signaling pathway","volume":"132","author":"Zhao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121514_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120218","article-title":"Improved efficacy of Panax notoginseng saponin loaded into BSP\/alginate microspheres for the treatment of alcoholic gastric ulcers","volume":"596","author":"Zhou","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jep.2026.121514_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1646905","article-title":"Applications of network pharmacology in traditional Chinese medicine research","volume":"2020","author":"Zhou","year":"2020","journal-title":"Evid. Based Complement. Alternat. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412600365X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412600365X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T10:40:33Z","timestamp":1776163233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412600365X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":37,"alternative-id":["S037887412600365X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121514","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sanhuang xiexin decoction ameliorates gastric ulcers by activating EGFR\/PI3K\/AKT pathway based on \u201cdrug-target-metabolite\u201d network","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121514","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121514"}}