{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:11:44Z","timestamp":1791227504362,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LY21H050005"],"award-info":[{"award-number":["LY21H050005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018553","name":"Science and Technology Plan Project of Wenzhou Municipality","doi-asserted-by":"publisher","award":["Y20220116"],"award-info":[{"award-number":["Y20220116"]}],"id":[{"id":"10.13039\/501100018553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jep.2026.121516","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:20:49Z","timestamp":1773127249000},"page":"121516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Nephropathy 1 Formula (N1F) mitigates cisplatin-induced acute kidney injury by inhibiting TAK1-dependent NF-\u03baB signaling"],"prefix":"10.1016","volume":"364","author":[{"given":"Xilong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangjing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dian","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinguo","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongheng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jep.2026.121516_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22738","article-title":"Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1\/FOXO-3, and NF- kB-p65 signaling pathways","volume":"35","author":"Ali","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"13","key":"10.1016\/j.jep.2026.121516_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23137241","article-title":"Can cisplatin therapy be improved? Pathways that can be targeted","volume":"23","author":"Ali","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2026.121516_bib3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/phar.2500","article-title":"Cisplatin-induced nephrotoxicity in an outpatient setting","volume":"41","author":"Burns","year":"2021","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jep.2026.121516_bib4","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.2147\/COPD.S476808","article-title":"Screening COPD-related biomarkers and traditional Chinese medicine prediction based on bioinformatics and machine learning","volume":"19","author":"Cao","year":"2024","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"10.1016\/j.jep.2026.121516_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114480","article-title":"Involvement of the inhibition of mitochondrial apoptotic, p53, NF-\u03baB pathways and the activation of Nrf2\/HO-1 pathway in the protective effects of curcumin against copper sulfate-induced nephrotoxicity in mice","volume":"249","author":"Dai","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jep.2026.121516_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2024.106939","article-title":"Advances in understanding cisplatin-induced toxicity: molecular mechanisms and protective strategies","volume":"203","author":"Elmorsy","year":"2024","journal-title":"Eur. J. Pharmaceut. Sci. : Off. J. European Federat. Pharm. Sci."},{"issue":"9","key":"10.1016\/j.jep.2026.121516_bib7","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.7150\/thno.81406","article-title":"The STAT1\/HMGB1\/NF-\u03baB pathway in chronic inflammation and kidney injury after cisplatin exposure","volume":"13","author":"Fu","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.jep.2026.121516_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118179","article-title":"Chinese herbal medicine for the treatment of diabetic nephropathy: from clinical evidence to potential mechanisms","volume":"330","author":"Gong","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121516_bib9","series-title":"Essentials of Chinese Materia Medica and Medical Formulas: New Century Traditional Chinese Medicine","author":"Gong","year":"2017"},{"key":"10.1016\/j.jep.2026.121516_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155757","article-title":"Baicalein alleviates cisplatin-induced acute kidney injury by inhibiting ALOX12-dependent ferroptosis","volume":"130","author":"Guo","year":"2024","journal-title":"Phytomedicine : Int. J. Phytoth. Phytopham."},{"issue":"5","key":"10.1016\/j.jep.2026.121516_bib11","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1053\/j.ackd.2021.08.001","article-title":"Conventional chemotherapy nephrotoxicity","volume":"28","author":"Gupta","year":"2021","journal-title":"Adv. Chron. Kidney Dis."},{"key":"10.1016\/j.jep.2026.121516_bib12","article-title":"Exploring the mechanism of curcumin in the treatment of colon cancer based on network pharmacology and molecular docking","volume":"14","author":"He","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2026.121516_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116168","article-title":"An herbal formulation \"Shenshuaifu Granule\" alleviates cisplatin-induced nephrotoxicity by suppressing inflammation and apoptosis through inhibition of the TLR4\/MyD88\/NF-\u03baB pathway","volume":"306","author":"Jin","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121516_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156752","article-title":"Curcumol ameliorates cisplatin-induced nephrotoxicity by targeting TAK1 and inhibiting MAPK and NF-\u03baB pathways","volume":"141","author":"Jin","year":"2025","journal-title":"Phytomedicine : Int. J. Phytoth. Phytopham."},{"key":"10.1016\/j.jep.2026.121516_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102382","article-title":"Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes","volume":"54","author":"Kim","year":"2022","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.jep.2026.121516_bib16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s10157-022-02292-z","article-title":"Neferine mitigates cisplatin-induced acute kidney injury in mice by regulating autophagy and apoptosis","volume":"27","author":"Li","year":"2023","journal-title":"Clin. Exp. Nephrol."},{"issue":"1","key":"10.1016\/j.jep.2026.121516_bib17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13321-022-00636-1","article-title":"Machine learning for identification of silylated derivatives from mass spectra","volume":"14","author":"Ljoncheva","year":"2022","journal-title":"J. Cheminf."},{"issue":"9","key":"10.1016\/j.jep.2026.121516_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12091728","article-title":"Redox regulation of Nrf2 in cisplatin-induced kidney injury","volume":"12","author":"Mapuskar","year":"2023","journal-title":"Antioxidants"},{"issue":"23","key":"10.1016\/j.jep.2026.121516_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27238367","article-title":"Natural products as anticancer agents: current status and future perspectives","volume":"27","author":"Naeem","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121516_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150873","article-title":"Hyaluronic acid-coated zein nanoparticle-mediated resveratrol therapy for the reduction of cisplatin-associated nephrotoxicity","volume":"736","author":"Ning","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.jep.2026.121516_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/10408347.2014.881250","article-title":"Surface plasmon resonance (SPR) biosensors in pharmaceutical analysis","volume":"45","author":"Olaru","year":"2015","journal-title":"Crit. Rev. Anal. Chem."},{"issue":"3","key":"10.1016\/j.jep.2026.121516_bib22","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1142\/S0192415X24500265","article-title":"Development and application of traditional Chinese medicine using AI machine learning and deep learning strategies","volume":"52","author":"Pan","year":"2024","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2026.121516_bib23","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.15889","article-title":"Neighborhood-based inference and restricted Boltzmann machine for small molecule-miRNA associations prediction","volume":"11","author":"Qu","year":"2023","journal-title":"PeerJ"},{"key":"10.1016\/j.jep.2026.121516_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1408474","article-title":"Traditional Chinese herbal medicine: harnessing dendritic cells for anti-tumor benefits","volume":"15","author":"Shen","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2026.121516_bib25","series-title":"Chinese Traditional Healing (3 Vols): the Berlin Collections of Manuscript Volumes from the 16th Through the Early 20th Century","author":"Unschuld","year":"2014"},{"issue":"37","key":"10.1016\/j.jep.2026.121516_bib26","doi-asserted-by":"crossref","first-page":"20496","DOI":"10.1021\/acs.jafc.4c05185","article-title":"Ocotillol-Type Pseudoginsenoside-F11 alleviates lipopolysaccharide-induced acute kidney injury through regulation of macrophage function by suppressing the NF-\u03baB\/NLRP3\/IL-1\u03b2 signaling pathway","volume":"72","author":"Wang","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"8","key":"10.1016\/j.jep.2026.121516_bib27","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1038\/s41401-021-00837-8","article-title":"Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-\u03baB p65 pathway","volume":"43","author":"Wen","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2026.121516_bib28","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.2147\/DDDT.S375281","article-title":"Integrated metabonomics and network pharmacology to reveal the action mechanism effect of shaoyao decoction on ulcerative colitis","volume":"16","author":"Wu","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"issue":"2","key":"10.1016\/j.jep.2026.121516_bib29","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2406395","article-title":"Reserpine alleviates cisplatin-induced acute kidney injury via anti-ferroptosis and cGAS\/STING pathway","volume":"46","author":"Xu","year":"2024","journal-title":"Ren. Fail."},{"key":"10.1016\/j.jep.2026.121516_bib37","doi-asserted-by":"crossref","first-page":"152339","DOI":"10.1016\/j.bbrc.2025.152339","article-title":"Mesenchymal stem cells-derived miR-143-3p attenuate acute kidney injury by suppressing TAK1-driven necroptosis","volume":"778","author":"Xu","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.jep.2026.121516_bib30","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2375033","article-title":"Screening of active components in Astragalus mongholicus Bunge and Panax notoginseng formula for anti-fibrosis in CKD: nobiletin inhibits Lgals1\/PI3K\/AKT signaling to improve renal fibrosis","volume":"46","author":"Yang","year":"2024","journal-title":"Ren. Fail."},{"issue":"13","key":"10.1016\/j.jep.2026.121516_bib31","article-title":"HUWE1-Mediated degradation of MUTYH facilitates DNA damage and mitochondrial dysfunction to promote acute kidney injury","volume":"12","author":"Yang","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"13","key":"10.1016\/j.jep.2026.121516_bib32","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.7150\/thno.84655","article-title":"TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy","volume":"13","author":"Yu","year":"2023","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.jep.2026.121516_bib33","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s12013-024-01244-6","article-title":"N1F(Improved-Nephropathy 1 formula) ameliorates renal interstitial fibrosis via inhibiting extracellular matrix deposition and regulating the FGF23\/P38MAPK\/Wnt pathway","volume":"82","author":"Yu","year":"2024","journal-title":"Cell Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.jep.2026.121516_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00268-9","article-title":"Screening and predicted value of potential biomarkers for breast cancer using bioinformatics analysis","volume":"11","author":"Zeng","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jep.2026.121516_bib35","doi-asserted-by":"crossref","first-page":"294","DOI":"10.7150\/ijbs.78097","article-title":"Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury","volume":"19","author":"Zhang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"15","key":"10.1016\/j.jep.2026.121516_bib36","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1111\/febs.15202","article-title":"USP15 potentiates NF-\u03baB activation by differentially stabilizing TAB2 and TAB3","volume":"287","author":"Zhou","year":"2020","journal-title":"FEBS J."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126003673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126003673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:29:23Z","timestamp":1776184163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126003673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":37,"alternative-id":["S0378874126003673"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121516","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nephropathy 1 Formula (N1F) mitigates cisplatin-induced acute kidney injury by inhibiting TAK1-dependent NF-\u03baB signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121516","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121516"}}