{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:21:15Z","timestamp":1791649275463,"version":"4.3.4"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jep.2026.121544","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:06:39Z","timestamp":1773680799000},"page":"121544","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Efficacy of Rhizoma Drynariae (Drynaria roosii Nakaike) extracts in treating osteoporosis in rat models: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"364","author":[{"given":"Rui","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongping","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feilong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jep.2026.121544_bib1","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1007\/s00198-010-1379-y","article-title":"Early changes in biochemical markers of bone turnover and their relationship with bone mineral density changes after 24 months of treatment with teriparatide","volume":"22","author":"Blumsohn","year":"2011","journal-title":"Osteoporos. Int."},{"issue":"2","key":"10.1016\/j.jep.2026.121544_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","article-title":"Functions of RANKL\/RANK\/OPG in bone modeling and remodeling","volume":"473","author":"Boyce","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"issue":"7","key":"10.1016\/j.jep.2026.121544_bib3","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.4314\/tjpr.v15i7.13","article-title":"Protective effect of rhizoma drynariae extract on osteoporosis in ovariectomized rat model","volume":"15","author":"Cai","year":"2016","journal-title":"Trop. J. Pharmaceut. Res."},{"issue":"6","key":"10.1016\/j.jep.2026.121544_bib4","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s00198-022-06657-8","article-title":"Prevalence of osteoporosis and incidence of related fractures in developed economies in the Asia Pacific region: a systematic review","volume":"34","author":"Chandran","year":"2023","journal-title":"Osteoporos. Int."},{"issue":"10","key":"10.1016\/j.jep.2026.121544_bib5","first-page":"4","article-title":"Intervention effect of rhizoma drynariae total flavone on osteoporosis in ovariectomized rats","volume":"28","author":"Chen","year":"2021","journal-title":"China Modern Medicine"},{"issue":"12","key":"10.1016\/j.jep.2026.121544_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12122880","article-title":"Sclerostin and cardiovascular risk: evaluating the cardiovascular safety of romosozumab in osteoporosis treatment","volume":"12","author":"Chiu","year":"2024","journal-title":"Biomedicines"},{"issue":"10169","key":"10.1016\/j.jep.2026.121544_bib7","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","article-title":"Osteoporosis","volume":"393","author":"Compston","year":"2019","journal-title":"Lancet"},{"issue":"16","key":"10.1016\/j.jep.2026.121544_bib8","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1607948","article-title":"Romosozumab treatment in postmenopausal women with osteoporosis","volume":"375","author":"Cosman","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.jep.2026.121544_bib9","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1007\/s00198-014-2794-2","article-title":"Clinician's guide to prevention and treatment of osteoporosis","volume":"25","author":"Cosman","year":"2014","journal-title":"Osteoporos. Int."},{"issue":"8","key":"10.1016\/j.jep.2026.121544_bib10","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJMoa0809493","article-title":"Denosumab for prevention of fractures in postmenopausal women with osteoporosis","volume":"361","author":"Cummings","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2026.121544_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1361864","article-title":"Targeting bone homeostasis regulation: potential of traditional Chinese medicine flavonoids in the treatment of osteoporosis","volume":"15","author":"Du","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2026.121544_bib12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/jbmr\/zjaf003","article-title":"Bone turnover markers predict changes in bone mineral density in men treated with abaloparatide: results from the abaloparatide for the treatment of men with osteoporosis (ATOM) study","volume":"40","author":"Eastell","year":"2025","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.jep.2026.121544_bib13","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1210\/jc.2019-00221","article-title":"Pharmacological management of osteoporosis in postmenopausal women: an endocrine society\u2217 clinical practice guideline","volume":"104","author":"Eastell","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.jep.2026.121544_bib14","first-page":"6330","article-title":"Protective effects of naringin on glucocorticoid-induced osteoporosis through regulating the PI3K\/Akt\/mTOR signaling pathway","volume":"13","author":"Ge","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.jep.2026.121544_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE's risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"issue":"1","key":"10.1016\/j.jep.2026.121544_bib16","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1186\/s13018-021-02842-3","article-title":"Rhizoma drynariae total flavonoids combined with calcium carbonate ameliorates bone loss in experimentally induced osteoporosis in rats via the regulation of Wnt3a\/\u03b2-catenin pathway","volume":"16","author":"Hu","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"issue":"4","key":"10.1016\/j.jep.2026.121544_bib17","first-page":"116","article-title":"Comparison study on effects of rhizoma drynariae and estrogen on osteoporosis in ovariectomized rats","volume":"19","author":"Jia","year":"2006","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"key":"10.1016\/j.jep.2026.121544_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115181","article-title":"The mechanism of metformin combined with total flavonoids of rhizoma drynariae on ovariectomy-induced osteoporotic rats","volume":"165","author":"Jiang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.121544_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113379","article-title":"Effect of flavonoids from rhizoma drynariae on osteoporosis rats and osteocytes","volume":"153","author":"Jin","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jep.2026.121544_bib20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00198-018-4704-5","article-title":"European guidance for the diagnosis and management of osteoporosis in postmenopausal women","volume":"30","author":"Kanis","year":"2019","journal-title":"Osteoporos. Int."},{"issue":"5","key":"10.1016\/j.jep.2026.121544_bib21","first-page":"888","article-title":"Naringin inhibits iron deposition and cell apoptosis in bone tissue of osteoporotic rats","volume":"29","author":"Lan","year":"2025","journal-title":"Chinese J. Tissue Eng. Res."},{"issue":"3","key":"10.1016\/j.jep.2026.121544_bib22","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.bbrc.2014.08.117","article-title":"Naringin prevents ovariectomy-induced osteoporosis and promotes osteoclasts apoptosis through the mitochondria-mediated apoptosis pathway","volume":"452","author":"Li","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.jep.2026.121544_bib23","first-page":"5","article-title":"A study on effect of extract of rhizoma drynariae on serological indexes and curative effect in ovariectomy-induced osteoporotic rats","volume":"51","author":"Li","year":"2019","journal-title":"J. New Chinese. Med."},{"issue":"2","key":"10.1016\/j.jep.2026.121544_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0317832","article-title":"Integrated metagenomic and metabolomic analyses of the effects of total flavonoids of rhizoma drynariae on reducing ovariectomized-induced osteoporosis by regulating gut microbiota and related metabolites","volume":"20","author":"Li","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2026.121544_bib25","article-title":"Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages","volume":"13","author":"Li","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.jep.2026.121544_bib26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11914-025-00948-9","article-title":"Atypical femoral fractures induced by anti-resorptive medications","volume":"24","author":"Li","year":"2026","journal-title":"Curr. Osteoporos. Rep."},{"issue":"4","key":"10.1016\/j.jep.2026.121544_bib27","first-page":"9","article-title":"Treatment effect of drynaria total flavonoids on ovariectomized osteoporosis rats","volume":"19","author":"Li","year":"2011","journal-title":"Journal of Traditional Chinese Orthopedics and Traumatology of China"},{"key":"10.1016\/j.jep.2026.121544_bib28","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"Br. Med. J."},{"issue":"9","key":"10.1016\/j.jep.2026.121544_bib29","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1002\/ptr.7525","article-title":"Total flavonoids of rhizoma drynariae promote angiogenesis and osteogenesis in bone defects","volume":"36","author":"Lin","year":"2022","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2026.121544_bib30","article-title":"Extracts of drynariae rhizoma promote bone formation in OVX rats through modulating the gut microbiota","author":"Lin","year":"2024","journal-title":"Planta Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121544_bib31","first-page":"46","article-title":"Effect of assemble flavone of rhizome drynaria on experimental osteoporosis and microcirculation","volume":"12","author":"Liu","year":"2006","journal-title":"Chin. J. Osteoporos."},{"issue":"5","key":"10.1016\/j.jep.2026.121544_bib32","first-page":"411","article-title":"Effect of Drynaria fortunei J. SM on Cbfa1 mRNA expression in bone of ovariectomized rats","volume":"17","author":"Liu","year":"2011","journal-title":"Chin. J. Osteoporos."},{"issue":"15","key":"10.1016\/j.jep.2026.121544_bib33","first-page":"3688","article-title":"Total flavonoids of drynariae rhizoma attenuate age-related osteoporosis in rats via modulation of the PI3K\/AKT\/NF-\u03baB axis","volume":"45","author":"Liu","year":"2025","journal-title":"Chinese J. Gerontol."},{"issue":"8","key":"10.1016\/j.jep.2026.121544_bib34","first-page":"10","article-title":"Stimulation of Wnt\/\u03b2-catenin signaling pathway is involved in the effect of naringin on the prevention of disuse osteoporosis","volume":"36","author":"Lu","year":"2016","journal-title":"Chinese J. Orthopaedics."},{"issue":"S1","key":"10.1016\/j.jep.2026.121544_bib35","first-page":"31","article-title":"Bone histomorphometric study of rhizoma drynariae against osteoporosis in ovariectomized rats","volume":"19","author":"Ma","year":"1999","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"issue":"6","key":"10.1016\/j.jep.2026.121544_bib36","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3892\/etm.2021.10050","article-title":"Total flavonoids of rhizoma drynariae combined with calcium attenuate osteoporosis by reducing reactive oxygen species generation","volume":"21","author":"Mu","year":"2021","journal-title":"Exp. Ther. Med."},{"issue":"7","key":"10.1016\/j.jep.2026.121544_bib38","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nrendo.2015.71","article-title":"Short-term and long-term effects of osteoporosis therapies","volume":"11","author":"Reid","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"issue":"15","key":"10.1016\/j.jep.2026.121544_bib39","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1056\/NEJMoa1708322","article-title":"Romosozumab or alendronate for fracture prevention in women with osteoporosis","volume":"377","author":"Saag","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121544_bib40","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1186\/s13018-021-02772-0","article-title":"The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis","volume":"16","author":"Salari","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"issue":"3","key":"10.1016\/j.jep.2026.121544_bib41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1210\/endrev\/bnac031","article-title":"Bone turnover markers: basic biology to clinical applications","volume":"44","author":"Schini","year":"2023","journal-title":"Endocr. Rev."},{"issue":"3","key":"10.1016\/j.jep.2026.121544_bib42","first-page":"11","article-title":"Effect of drynaria flavonoids on the expression of pain mediators and osteoporotic pain in the osteoporosis model of ovariectomized rats","volume":"19","author":"Shang","year":"2017","journal-title":"journal of liaoning university of tcm"},{"issue":"7","key":"10.1016\/j.jep.2026.121544_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22071033","article-title":"Total flavonoids of drynariae rhizoma prevent bone loss induced by hindlimb unloading in rats","volume":"22","author":"Song","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121544_bib44","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bonr.2016.09.001","article-title":"Effects of total flavonoids from Drynariae rhizoma prevent bone loss in vivo and in vitro","volume":"5","author":"Song","year":"2016","journal-title":"BoneKEy Rep."},{"key":"10.1016\/j.jep.2026.121544_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2024.100544","article-title":"Gu Sui Bu (Drynaria fortunei J. Smith) prevents osteoporosis in ovariectomized rats by inhibiting pyroptosis through NLRP3\/GSDMD\/CASPASE-1","volume":"13","author":"Su","year":"2024","journal-title":"Pharmacological Research - Modern Chinese Medicine"},{"issue":"1","key":"10.1016\/j.jep.2026.121544_bib46","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s13018-025-05665-8","article-title":"Therapeutic potential of total flavonoids of rhizoma drynariae: inhibiting adipogenesis and promoting osteogenesis via MAPK\/HIF-1\u03b1 pathway in primary osteoporosis","volume":"20","author":"Su","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"issue":"15","key":"10.1016\/j.jep.2026.121544_bib47","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.2174\/0113862073261905231110061401","article-title":"Proteomic analysis based on TMT regarding the therapeutic action of rhizoma drynariae on rats in an osteoporosis model","volume":"27","author":"SuHui","year":"2024","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.jep.2026.121544_bib48","article-title":"Exploring the mechanism of total flavonoids of drynariae rhizoma to improve large bone defects by network pharmacology and experimental assessment","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2026.121544_bib49","article-title":"The effects of combined treatment with naringin and treadmill exercise on osteoporosis in ovariectomized rats","volume":"5","author":"Sun","year":"2015","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.jep.2026.121544_bib50","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1111\/jcmm.15072","article-title":"A polysaccharide from the dried rhizome of Drynaria fortunei (Kunze) J. Sm. prevents ovariectomized (OVX)-induced osteoporosis in rats","volume":"24","author":"Sun","year":"2019","journal-title":"J. Cell Mol. Med."},{"issue":"8","key":"10.1016\/j.jep.2026.121544_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26083650","article-title":"Mechanistic integration of network pharmacology and in vivo validation: TFRD combat osteoporosis via PI3K\/AKT pathway activation","volume":"26","author":"Tan","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"21","key":"10.1016\/j.jep.2026.121544_bib52","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1056\/NEJMcp2307353","article-title":"Postmenopausal osteoporosis","volume":"389","author":"Walker","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.jep.2026.121544_bib53","first-page":"1476","article-title":"Mechanism of Gusuibu (drynariae rhizoma) in preventing and treating postmenopausal osteoporosis based on network pharmacology combined with experimental verification","volume":"42","author":"Wang","year":"2022","journal-title":"Journal of Hunan University of Chinese Medicine"},{"issue":"1","key":"10.1016\/j.jep.2026.121544_bib54","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1080\/13880209.2022.2110267","article-title":"Effects of osthole on osteoporotic rats: a systematic review and meta-analysis","volume":"60","author":"Wu","year":"2022","journal-title":"Pharm. Biol."},{"issue":"4","key":"10.1016\/j.jep.2026.121544_bib55","first-page":"11","article-title":"Effect of drynaria fortunei total flavonoids on collagen typeIexpression in bone tissue and bone metabolism in the ovariectomized rats","volume":"26","author":"Wu","year":"2014","journal-title":"The Journal of Traditional Chinese Orthopedics and Traumatology"},{"issue":"6","key":"10.1016\/j.jep.2026.121544_bib56","article-title":"Study on the mechanism of preventing and treating postmenopausal osteoporosis by the combination of total flavonoids of Gusuibu(Rhizoma drynariae) and adipokines based on molecular docking and experimental verification","volume":"28","author":"Wu","year":"2022","journal-title":"Guidelines of Traditional Chinese Medicine"},{"issue":"1","key":"10.1016\/j.jep.2026.121544_bib57","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1038\/s41467-025-59719-w","article-title":"FABP4 inhibition suppresses bone resorption and protects against postmenopausal osteoporosis in ovariectomized mice","volume":"16","author":"Xie","year":"2025","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.jep.2026.121544_bib58","first-page":"59","article-title":"Effect of osteopractic total flavone on bone mineral density and bone histomorphometry in ovariectomized rats","volume":"29","author":"Xie","year":"2004","journal-title":"China J. Chin. Mater. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121544_bib59","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1080\/13880209.2024.2407531","article-title":"Osteoprotective effect of Achyranthes bidentata root extract on osteoporotic rats: a systematic review and meta-analysis","volume":"62","author":"Yang","year":"2024","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2026.121544_bib60","first-page":"89","article-title":"Ovariectomized rat model of osteoporosis: a practical guide","volume":"19","author":"Yousefzadeh","year":"2020","journal-title":"EXCLI J."},{"issue":"10","key":"10.1016\/j.jep.2026.121544_bib61","first-page":"1192","article-title":"Effect of drynaria total flavonoids on trabecular microstructure of alveolar bone in ovariectomized rats","volume":"49","author":"Zeng","year":"2018","journal-title":"Journal of Shanxi Medical University"},{"key":"10.1016\/j.jep.2026.121544_bib62","article-title":"Total flavonoids of drynariae rhizoma improve glucocorticoid-induced osteoporosis of rats: uhplc-ms-based qualitative analysis, network pharmacology strategy and pharmacodynamic validation","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.jep.2026.121544_bib63","first-page":"35","article-title":"Protective effects of Rhizoma drynariae on bone microarchitecture of ovariectomized rats","volume":"33","author":"Zhang","year":"2020","journal-title":"Shandong Sci."},{"key":"10.1016\/j.jep.2026.121544_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1234756","article-title":"Effects of resveratrol in an animal model of osteoporosis: a meta-analysis of preclinical evidence","volume":"10","author":"Zhao","year":"2023","journal-title":"Front. Nutr."},{"issue":"5","key":"10.1016\/j.jep.2026.121544_bib65","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.apsb.2024.02.005","article-title":"Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ER\u03b1 signaling","volume":"14","author":"Zhao","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"Pt 3","key":"10.1016\/j.jep.2026.121544_bib66","article-title":"Active components and mechanisms of total flavonoids from Rhizoma Drynariae in enhancing cranial bone regeneration: an investigation employing serum pharmacochemistry and network pharmacology approaches","volume":"319","author":"Zhao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121544_bib67","article-title":"Biological deciphering of the \"Kidney Governing Bones\" theory in traditional Chinese medicine","volume":"2022","author":"Zhu","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126003958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126003958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:29:05Z","timestamp":1776184145000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126003958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":66,"alternative-id":["S0378874126003958"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121544","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of Rhizoma Drynariae (Drynaria roosii Nakaike) extracts in treating osteoporosis in rat models: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121544","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"121544"}}