{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:34:35Z","timestamp":1791038075507,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1707410"],"award-info":[{"award-number":["2018YFC1707410"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jep.2026.121618","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:26:29Z","timestamp":1774970789000},"page":"121618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Identification of potential biomarkers for Polygonum multiflorum\u2013induced liver injury in a clinical cohort: integrating machine learning of metabolomics with transcriptomic profiling"],"prefix":"10.1016","volume":"366","author":[{"given":"Chao","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoren","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erjun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jep.2026.121618_bib1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jhep.2019.01.026","article-title":"Autophagy in liver diseases: time for translation","volume":"70","author":"Allaire","year":"2019","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.jep.2026.121618_bib2","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbae399","article-title":"Unveiling hidden connections in omics data via pyPARAGON: an integrative hybrid approach for disease network construction","volume":"25","author":"Arici","year":"2024","journal-title":"Briefings Bioinf."},{"issue":"4","key":"10.1016\/j.jep.2026.121618_bib3","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1590\/s0004-2803.202204000-84","article-title":"Liver injury induced by herbal and dietary supplements: a pooled analysis of case reports","volume":"59","author":"Assis","year":"2022","journal-title":"Arq. Gastroenterol."},{"issue":"20","key":"10.1016\/j.jep.2026.121618_bib4","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.12998\/wjcc.v9.i20.5490","article-title":"Herb-induced liver injury: systematic review and meta-analysis","volume":"9","author":"Ballotin","year":"2021","journal-title":"World J. Clin. Cases"},{"issue":"47","key":"10.1016\/j.jep.2026.121618_bib5","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.A109.046102","article-title":"RAB39a binds caspase-1 and is required for caspase-1-dependent interleukin-1\u03b2 secretion","volume":"291","author":"Becker","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.jep.2026.121618_bib6","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1124\/dmd.121.000732","article-title":"Novel clinical biomarkers for drug-induced liver injury","volume":"50","author":"Chen","year":"2022","journal-title":"Drug Metab. Dispos."},{"issue":"7","key":"10.1016\/j.jep.2026.121618_bib7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/00004836-200608000-00014","article-title":"Acute hepatitis due to shen-min: a herbal product derived from Polygonum multiflorum","volume":"40","author":"C\u00e1rdenas","year":"2006","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.jep.2026.121618_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1432049","article-title":"Gut microbiota causally affects drug-induced liver injury via plasma metabolites: a Mendelian randomization study","volume":"15","author":"Fu","year":"2024","journal-title":"Front. Microbiol."},{"issue":"15","key":"10.1016\/j.jep.2026.121618_bib10","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.2169\/internalmedicine.49.3509","article-title":"Toxic hepatitis induced by show-wu-pian, a Chinese herbal preparation","volume":"49","author":"Furukawa","year":"2010","journal-title":"Intern. Med."},{"issue":"7","key":"10.1016\/j.jep.2026.121618_bib11","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.3390\/ijms20071688","article-title":"Rab39a and Rab39b display different intracellular distribution and function in sphingolipids and phospholipids transport","volume":"20","author":"Gambarte Tudela","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.jep.2026.121618_bib12","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.1002\/ptr.70067","article-title":"Zingibroside R1 isolated from Achyranthes bidentata blume ameliorates LPS\/D-GalN-Induced liver injury by regulating succinic acid metabolism via the Gut Microbiota","volume":"39","author":"Guo","year":"2025","journal-title":"Phytother Res."},{"issue":"2","key":"10.1016\/j.jep.2026.121618_bib13","first-page":"369","article-title":"Therapeutic intervention of Opuntia Ficus Indica (L.) fruit and seed powder against CCl4-induced acute liver injury in wistar rats","volume":"44","author":"Hafeez","year":"2024","journal-title":"Pak. Vet. J."},{"issue":"3","key":"10.1016\/j.jep.2026.121618_bib14","first-page":"931","article-title":"Efficacy of resatorvid and AlphaLipoic acid in ameliorating gentamicin-induced liver injury: insights from rat model study","volume":"44","author":"Hatipoglu","year":"2024","journal-title":"Pak. Vet. J."},{"key":"10.1016\/j.jep.2026.121618_bib15","article-title":"Graveoline attenuates D-GalN\/LPS-induced acute liver injury via inhibition of JAK1\/STAT3 signaling pathway","volume":"177","author":"He","year":"2024","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"issue":"1","key":"10.1016\/j.jep.2026.121618_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e23659","article-title":"A novel sphingolipid metabolism-related long noncoding RNA signature predicts the prognosis, immune landscape and therapeutic response in pancreatic adenocarcinoma","volume":"10","author":"He","year":"2024","journal-title":"Heliyon"},{"issue":"3","key":"10.1016\/j.jep.2026.121618_bib17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3390\/livers4030027","article-title":"Targeting autophagy for acetaminophen-induced liver injury: an update","volume":"4","author":"Hinz","year":"2024","journal-title":"Livers"},{"key":"10.1016\/j.jep.2026.121618_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116217","article-title":"Potential biomarkers screening of Polygonum multiflorum radix-induced liver injury based on metabonomics analysis of clinical samples","volume":"308","author":"Hu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121618_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113845","article-title":"Exploration of components and mechanisms of Polygoni Multiflori Radix-induced hepatotoxicity using siRNA -mediated CYP3A4 or UGT1A1 knockdown liver cells","volume":"270","author":"Hu","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.121618_bib20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12906-024-04463-9","article-title":"Study on the differential hepatotoxicity of raw polygonum multiflorum and polygonum multiflorum praeparata and its mechanism","volume":"24","author":"Huang","year":"2024","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.jep.2026.121618_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2020.592434","article-title":"Metabolomics profiling and diagnosis biomarkers searching for drug-induced liver injury implicated to Polygonum multiflorum: a cross-sectional cohort Study","volume":"7","author":"Huang","year":"2020","journal-title":"Front. Med."},{"issue":"8","key":"10.1016\/j.jep.2026.121618_bib22","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/15563650.2023.2259089","article-title":"Novel biomarkers for drug-induced liver injury","volume":"61","author":"Humphries","year":"2023","journal-title":"Clin. Toxicol."},{"issue":"11","key":"10.1016\/j.jep.2026.121618_bib23","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.stem.2024.09.014","article-title":"Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis","volume":"31","author":"Ionescu","year":"2024","journal-title":"Cell Stem Cell"},{"issue":"4","key":"10.1016\/j.jep.2026.121618_bib24","doi-asserted-by":"crossref","first-page":"493","DOI":"10.5009\/gnl.2011.5.4.493","article-title":"Drug-Induced liver injury: twenty five cases of acute hepatitis following ingestion of Polygonum multiflorum thunb","volume":"5","author":"Jung","year":"2011","journal-title":"Gut Liver"},{"key":"10.1016\/j.jep.2026.121618_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.878817","article-title":"Hepatotoxicity of the major anthraquinones derived from polygoni multiflori radix based on bile acid homeostasis","volume":"13","author":"Kang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2026.121618_bib26","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.chom.2022.05.002","article-title":"Host hepatic metabolism is modulated by gut microbiota-derived sphingolipids","volume":"30","author":"Le","year":"2022","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.jep.2026.121618_bib27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3350\/cmh.2024.0716","article-title":"Unveiling the distinctive gut microbiota and metabolites in liver cirrhosis and its complications: novel diagnostic biomarkers: editorial on \"Gut microbiome and metabolome signatures in liver cirrhosis-related complications\"","volume":"31","author":"Lee","year":"2025","journal-title":"Clin. Mol. Hepatol."},{"issue":"1","key":"10.1016\/j.jep.2026.121618_bib28","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/hep.30660","article-title":"HLA-B\u221735:01 allele is a potential biomarker for predicting Polygonum multiflorum-Induced liver injury in humans","volume":"70","author":"Li","year":"2019","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jep.2026.121618_bib29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s11684-007-0012-8","article-title":"Clinical analysis of 275 cases of acute drug-induced liver disease","volume":"1","author":"Li","year":"2007","journal-title":"Front. Med. China"},{"issue":"1","key":"10.1016\/j.jep.2026.121618_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41421-025-00789-x","article-title":"A decrease in Flavonifractor plautii and its product, phytosphingosine, predisposes individuals with phlegm-dampness constitution to metabolic disorders","volume":"11","author":"Li","year":"2025","journal-title":"Cell Discov."},{"issue":"2","key":"10.1016\/j.jep.2026.121618_bib31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.pbb.2005.09.004","article-title":"Neuroprotective effects of Polygonum multiflorum on nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice","volume":"82","author":"Li","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jep.2026.121618_bib32","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jep.2014.11.009","article-title":"Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: a review","volume":"159","author":"Lin","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121618_bib33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jep.2014.12.045","article-title":"Hepatotoxic assessment of Polygoni Multiflori Radix extract and toxicokinetic study of stilbene glucoside and anthraquinones in rats","volume":"162","author":"Ma","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"7503","key":"10.1016\/j.jep.2026.121618_bib34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature13475","article-title":"Sphingolipid metabolites in inflammatory disease","volume":"510","author":"Maceyka","year":"2014","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jep.2026.121618_bib35","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/cei\/uxae032","article-title":"Dysregulated lipid metabolism networks modulate T-cell function in people with relapsing-remitting multiple sclerosis","volume":"217","author":"Martin-Gutierrez","year":"2024","journal-title":"Clin. Exp. Immunol."},{"issue":"7","key":"10.1016\/j.jep.2026.121618_bib36","doi-asserted-by":"crossref","first-page":"W30","DOI":"10.7326\/0003-4819-140-7-200404060-00042-w3","article-title":"New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from Polygonum multiflorum","volume":"140","author":"Mazzanti","year":"2004","journal-title":"Ann. Intern. Med."},{"issue":"10","key":"10.1016\/j.jep.2026.121618_bib37","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/aps.2017.32","article-title":"Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-\u03b3","volume":"38","author":"Meng","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.jep.2026.121618_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-023-04707-1","article-title":"Emerging role of lipophagy in liver disorders","volume":"479","author":"Nazeer","year":"2024","journal-title":"Mol. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.jep.2026.121618_bib40","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1046\/j.1440-1746.2001.02309.x","article-title":"Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum","volume":"16","author":"Park","year":"2001","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.jep.2026.121618_bib41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41401-020-0360-3","article-title":"The hepatotoxicity of Polygonum multiflorum: the emerging role of the immune-mediated liver injury","volume":"42","author":"Rao","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.jep.2026.121618_bib42","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/clpt.2012.108","article-title":"Alanine aminotransferase: a clinical and regulatory tool for detecting liver injury-past, present, and future","volume":"92","author":"Senior","year":"2012","journal-title":"Clin. Pharmacol. Ther."},{"issue":"8","key":"10.1016\/j.jep.2026.121618_bib43","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1053\/j.gastro.2019.02.002","article-title":"Incidence and etiology of drug-induced liver injury in mainland China","volume":"156","author":"Shen","year":"2019","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.jep.2026.121618_bib44","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1080\/15548627.2019.1596499","article-title":"Reduced autophagy efficiency induces innate immune activation leading to neurodegeneration","volume":"15","author":"Shukla","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2026.121618_bib45","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3389\/fphar.2019.00335","article-title":"Susceptibility-Related factor and biomarkers of dietary supplement Polygonum multiflorum-Induced liver injury in rats","volume":"10","author":"Tu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2026.121618_bib46","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2147\/JIR.S299892","article-title":"Susceptibility-Related cytokine Panel for prediction of Polygonum multiflorum-Induced hepatotoxicity in humans","volume":"14","author":"Tu","year":"2021","journal-title":"J. Inflamm. Res."},{"issue":"12","key":"10.1016\/j.jep.2026.121618_bib47","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1080\/15548627.2024.2384348","article-title":"Preserving mitochondrial homeostasis protects against drug-induced liver injury via inducing OPTN (Optineurin)-dependent Mitophagy","volume":"20","author":"Wang","year":"2024","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.jep.2026.121618_bib48","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jep.2011.11.022","article-title":"Lipid regulation effects of Polygoni Multiflori Radix, its processed products and its major substances on steatosis human liver cell line L02","volume":"139","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2026.121618_bib49","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.4254\/wjh.v13.i9.1019","article-title":"Herbal and dietary supplement induced liver injury: highlights from the recent literature","volume":"13","author":"Woo","year":"2021","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.jep.2026.121618_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.569144","article-title":"Lipidomics analysis indicates disturbed hepatocellular lipid metabolism in Reynoutria multiflora-Induced idiosyncratic liver injury","volume":"11","author":"Wu","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2026.121618_bib51","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/03602532.2024.2405163","article-title":"Drug metabolism and transport mediated the hepatotoxicity of Pleuropterus multiflorus root: a review","volume":"56","author":"Wu","year":"2024","journal-title":"Drug Metab. Rev."},{"issue":"7","key":"10.1016\/j.jep.2026.121618_bib52","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.2174\/1386207326666230823093958","article-title":"Elucidating the mechanism of buyanghuanwu decoction acting on pulmonary fibrosis based on network pharmacology and animal studies","volume":"27","author":"Xing","year":"2024","journal-title":"Comb. Chem. High Throughput Screen."},{"issue":"14","key":"10.1016\/j.jep.2026.121618_bib53","article-title":"Disturbing Cholesterol\/Sphingolipid metabolism by squalene Epoxidase arises crizotinib hepatotoxicity","volume":"12","author":"Yan","year":"2025","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"issue":"3","key":"10.1016\/j.jep.2026.121618_bib54","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1254\/jphs.FP0050333","article-title":"Reduction of atherosclerosis in cholesterol-fed rabbits and decrease of expressions of intracellular adhesion molecule-1 and vascular endothelial growth factor in foam cells by a water-soluble fraction of Polygonum multiflorum","volume":"99","author":"Yang","year":"2005","journal-title":"J. Pharmacol. Sci."},{"issue":"12","key":"10.1016\/j.jep.2026.121618_bib55","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3748\/wjg.v26.i12.1329","article-title":"Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population","volume":"26","author":"Yang","year":"2020","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jep.2026.121618_bib56","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00204-019-02595-3","article-title":"Risk profiling using metabolomic characteristics for susceptible individuals of drug-induced liver injury caused by Polygonum multiflorum","volume":"94","author":"Zhang","year":"2020","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.jep.2026.121618_bib57","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/10543400903572753","article-title":"Weighted gene coexpression network analysis: state of the art","volume":"20","author":"Zhao","year":"2010","journal-title":"J. Biopharm. Stat."},{"issue":"5","key":"10.1016\/j.jep.2026.121618_bib58","doi-asserted-by":"crossref","DOI":"10.1093\/hr\/uhad047","article-title":"The first chromosome-level Fallopia multiflora genome assembly provides insights into stilbene biosynthesis","volume":"10","author":"Zhao","year":"2023","journal-title":"Hortic. Res."},{"issue":"12","key":"10.1016\/j.jep.2026.121618_bib59","first-page":"1442","article-title":"[Clinical Analysis of Drug-induced Liver Injury Caused by Polygonum multiflorum and its Preparations]","volume":"35","author":"Zhu","year":"2015","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.jep.2026.121618_bib60","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1360\/N972018-00995","article-title":"Metabolomic study on the susceptible factors of idiosyncratic traditional Chinese Medicine-induced liver injury: exemplification of a Polygonum multiflorum preparation","volume":"64","author":"Zhou","year":"2019","journal-title":"Chin. Sci. Bull."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126004691?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126004691?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T14:34:24Z","timestamp":1777300464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126004691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":58,"alternative-id":["S0378874126004691"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121618","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of potential biomarkers for Polygonum multiflorum\u2013induced liver injury in a clinical cohort: integrating machine learning of metabolomics with transcriptomic profiling","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121618","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121618"}}