{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:08:21Z","timestamp":1778548101746,"version":"3.51.4"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AT013164-01"],"award-info":[{"award-number":["R21 AT013164-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005924","name":"International Association for the Study of Pain","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","award":["3.4-8151"],"award-info":[{"award-number":["3.4-8151"]}],"id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","award":["19061"],"award-info":[{"award-number":["19061"]}],"id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jep.2026.121635","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T16:23:34Z","timestamp":1775579014000},"page":"121635","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Modulation of TNF-\u03b1, IL-1\u03b2 and myeloperoxidase contributes to the anti-inflammatory and analgesic effects of Paullinia pinnata Linn (Sapindaceae) extracts in complete Freund's adjuvant-induced mono-arthritis in rats"],"prefix":"10.1016","volume":"366","author":[{"given":"Pius Pum","family":"Tseuguem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Fofie","family":"Kuete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar Mofidi","family":"Tabatabaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anny","family":"Treat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedict James","family":"Kolber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin Joseph","family":"Tidgewell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5006-6927","authenticated-orcid":false,"given":"T\u00e9lesphore Beno\u00eet","family":"Nguelefack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2026.121635_bib1","first-page":"81","article-title":"Acute and sub-acute toxicity studies of the methanol extract of the leaves of Paullinia pinnata (Linn.) in Wistar albino mice and rats","volume":"42","author":"Adeyemo-Salami","year":"2013","journal-title":"Afr. J. Med. Med. Sci."},{"key":"10.1016\/j.jep.2026.121635_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116961","article-title":"Pharmacological insight of rutin as a potential candidate against peptic ulcer","volume":"177","author":"Akash","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"16","key":"10.1016\/j.jep.2026.121635_bib3","first-page":"4214","article-title":"Exploring the analgesic potential of isorhamnetin: insights from formalin-induced pain and diabetic neuropathy models","volume":"28","author":"Alqudah","year":"2024","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2026.121635_bib4","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s12264-017-0139-9","article-title":"Investigation of pain mechanisms by calcium imaging approaches","volume":"34","author":"Anderson","year":"2018","journal-title":"Neurosci. Bull."},{"issue":"3","key":"10.1016\/j.jep.2026.121635_bib5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.5606\/ArchRheumatol.2015.4567","article-title":"Evaluation of the prevalence of rheumatoid factor in five regions of Cameroon","volume":"30","author":"Atabonkeng","year":"2015","journal-title":"Archive Rheumatology"},{"key":"10.1016\/j.jep.2026.121635_bib6","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1093\/rheumatology\/kew325","article-title":"Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation","volume":"55","author":"Cavalli","year":"2017","journal-title":"Rheumatology"},{"key":"10.1016\/j.jep.2026.121635_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1744806917748051","article-title":"A simple and fast method to image calcium activity of neurons from intact dorsal root ganglia using fluorescent chemical Ca2+ indicators","volume":"13","author":"Chen","year":"2017","journal-title":"Mol. Pain"},{"issue":"1","key":"10.1016\/j.jep.2026.121635_bib8","doi-asserted-by":"crossref","DOI":"10.1136\/bmjmed-2021-000108","article-title":"Chronic pain and infection: mechanisms, causes, conditions, treatments, and controversies","volume":"1","author":"Cohen","year":"2022","journal-title":"BMJ Med"},{"key":"10.1016\/j.jep.2026.121635_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1678-9199-20-19","article-title":"Septic arthritis: immunopathogenesis, experimental models and therapy","volume":"20","author":"Colavite","year":"2014","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"issue":"1","key":"10.1016\/j.jep.2026.121635_bib10","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1080\/21691401.2019.1649269","article-title":"Evaluation of antiarthritic activity of nimbolide against Freund's adjuvant induced arthritis in rats","volume":"47","author":"Cui","year":"2019","journal-title":"Artif. Cell Nanomed. Biotechnol."},{"key":"10.1016\/j.jep.2026.121635_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2019.106659","article-title":"Generation of a robust model for inducing autoimmune arthritis in Sprague Dawley rats","volume":"102","author":"De","year":"2020","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"6","key":"10.1016\/j.jep.2026.121635_bib12","first-page":"589","article-title":"Septic arthritis: diagnosis and treatment","volume":"104","author":"Earwood","year":"2021","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.jep.2026.121635_bib13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.phrs.2016.01.027","article-title":"Neutrophils and arthritis: role in disease and pharmacological perspectives","volume":"112","author":"Fattori","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.jep.2026.121635_bib14","article-title":"Profiling human iPSC-derived sensory neurons for analgesic drug screening using a multi-electrode array","volume":"5","author":"Fofie","year":"2025","journal-title":"Cell Rep. Methods"},{"key":"10.1016\/j.jep.2026.121635_bib15","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s10787-025-01671-8","article-title":"Rutin: a pain-relieving flavonoid","volume":"33","author":"Forouzanfar","year":"2025","journal-title":"Inflammopharmacology"},{"issue":"3","key":"10.1016\/j.jep.2026.121635_bib16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jbspin.2018.07.004","article-title":"Methotrexate mechanism in treatment of rheumatoid arthritis","volume":"86","author":"Friedman","year":"2019","journal-title":"Jt. Bone Spine"},{"key":"10.1016\/j.jep.2026.121635_bib17","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00232-013-9561-8","article-title":"Serum myeloperoxidase activity, total antioxidant capacity and nitric oxide levels in patients with chronic otitis media","volume":"246","author":"Garca","year":"2013","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.jep.2026.121635_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110766","article-title":"Impact of dual neutralization of TNF-\u03b1 and IL-1\u03b2 along with Gentamicin treatment on the functions of blood and splenic neutrophils and its role on improvement of S. aureus induced septic arthritis","volume":"123","author":"Ghosh","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2026.121635_bib19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jpsychires.2014.04.002","article-title":"Behavioral phenotyping of Nestin-Cre mice: implications for genetic mouse models of psychiatric disorders","volume":"55","author":"Giusti","year":"2014","journal-title":"J. Psychiatr. Res."},{"issue":"110301","key":"10.1016\/j.jep.2026.121635_bib20","article-title":"Isorhamnetin: a review of pharmacological effects","volume":"128","author":"Gong","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.jep.2026.121635_bib21","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1097\/j.pain.0000000000000151","article-title":"Differential contributions of A- and C-nociceptors to primary and secondary inflammatory hypersensitivity in the rat","volume":"156","author":"Hsieh","year":"2015","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.jep.2026.121635_bib22","first-page":"351","article-title":"Evaluation of analgesic and antiinflammatory activities and phytochemical screening of the leaves extract of Paullinia pinnata (sapindaceae)","volume":"3","author":"Ior","year":"2011","journal-title":"J. Chem. Pharmaceut. Res."},{"issue":"1","key":"10.1016\/j.jep.2026.121635_bib23","doi-asserted-by":"crossref","DOI":"10.1186\/2045-9912-2-27","article-title":"Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study","volume":"2","author":"Ishibashi","year":"2012","journal-title":"Med. Gas Res."},{"key":"10.1016\/j.jep.2026.121635_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynpai.2024.100151","article-title":"A review of dorsal root ganglia and primary sensory neuron plasticity mediating inflammatory and chronic neuropathic pain","volume":"15","author":"Jang","year":"2024","journal-title":"Neurobiology of Pain"},{"issue":"7","key":"10.1016\/j.jep.2026.121635_bib25","article-title":"Pathophysiology and evolving treatment options of septic arthritis: a narrative review","volume":"16","author":"Kaye","year":"2024","journal-title":"Cureus"},{"issue":"10","key":"10.1016\/j.jep.2026.121635_bib26","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1523\/JNEUROSCI.17-10-03525.1997","article-title":"The role of calcium in the desensitization of Capsaicin responses in Rat Dorsal root ganglion neurons","volume":"17","author":"Koplas","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jep.2026.121635_bib27","first-page":"12","article-title":"Anti-Inflammatory and antiarthritic activity of anthraquinone derivatives in rodents,\u02ee","author":"Kshirsagar","year":"2014","journal-title":"Int. J. Inflamm."},{"key":"10.1016\/j.jep.2026.121635_bib28","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/art.43042","article-title":"Neutrophil activation markers and rheumatoid arthritis treatment response to the JAK1\/2 inhibitor baricitinib","volume":"77","author":"Kuley","year":"2025","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.jep.2026.121635_bib29","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1186\/s12906-016-1470-9","article-title":"Melastoma malabathricum Linn attenuates complete freund's adjuvant-induced chronic inflammation in Wistar rats via inflammation response","volume":"16","author":"Kumar","year":"2016","journal-title":"BMC Compl. Alternative Med."},{"issue":"2022","key":"10.1016\/j.jep.2026.121635_bib30","article-title":"When differential descending control of speed matters: descending modulation of A- versus C-Fiber evoked spinal nociception","volume":"3","author":"Lumb","year":"2022","journal-title":"Frontiers in Pain Research"},{"issue":"5","key":"10.1016\/j.jep.2026.121635_bib31","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.neuron.2015.02.022","article-title":"Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance","volume":"85","author":"Madisen","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.jep.2026.121635_bib32","article-title":"Therapeutic effects of the superoxide dismutase mimetic compound MnII Me2DO2A on experimental articular pain in rats","volume":"2013","author":"Mannelli","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2026.121635_bib33","article-title":"Aqueous and ethanol extracts of Acacia sieberiana (Fabaceae) stem bark reverse the pain\u2013depression dyad in mice through modulation of catecholamines, proinflammatory cytokines, and oxidative stress","volume":"2025","author":"Mbankou","year":"2025","journal-title":"Adv. Pharmacol. Pharm. Sci."},{"key":"10.1016\/j.jep.2026.121635_bib34","series-title":"The Essence of Analgesia and Analgesics","first-page":"17","article-title":"Primary and secondary hyperalgesia","author":"McClain","year":"2010"},{"key":"10.1016\/j.jep.2026.121635_bib35","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s11916-012-0300-0","article-title":"Neurophysiology of arthritis pain","volume":"16","author":"McDougall","year":"2012","journal-title":"Curr. Pain Headache Rep."},{"issue":"3","key":"10.1016\/j.jep.2026.121635_bib36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/ar571","article-title":"HLA-B27: natural function and pathogenic role in spondyloarthritis","volume":"4","author":"McMichael","year":"2002","journal-title":"Arthritis Res."},{"key":"10.1016\/j.jep.2026.121635_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106163","article-title":"Rutin ameliorates inflammation and improves metabolic function: a comprehensive analysis of scientific literature","volume":"178","author":"Muvhulawa","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.jep.2026.121635_bib38","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ejpain.2009.05.009","article-title":"Persistent deep mechanical hyperalgesia induced by repeated cold stress in rats","volume":"14","author":"Nasu","year":"2010","journal-title":"Eur. J. Pain"},{"issue":"14","key":"10.1016\/j.jep.2026.121635_bib39","doi-asserted-by":"crossref","first-page":"7903","DOI":"10.3390\/ijms25147903","article-title":"TRPA1, TRPV1, and caffeine: pain and analgesia","volume":"25","author":"Puthumana","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.jep.2026.121635_bib40","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/nm.2234","article-title":"Interactions between the immune and nervous systems in pain","volume":"16","author":"Ren","year":"2010","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.jep.2026.121635_bib41","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/ar.24506","article-title":"Isorhamnetin attenuates TNF-\u03b1-induced inflammation, proliferation, and migration in human bronchial epithelial cells via MAPK and NF-\u03baB pathways","volume":"304","author":"Ren","year":"2021","journal-title":"Anat. Rec."},{"issue":"8","key":"10.1016\/j.jep.2026.121635_bib42","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1097\/j.pain.0000000000002860","article-title":"Emergence of nociceptive functionality and opioid signaling in human induced pluripotent stem cell-derived sensory neurons","volume":"164","author":"R\u00f6derer","year":"2023","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.jep.2026.121635_bib43","first-page":"203","article-title":"Septic Arthritis of native joints","volume":"31","author":"Ross","year":"2017","journal-title":"Infect. Dis. Clin."},{"issue":"1","key":"10.1016\/j.jep.2026.121635_bib44","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3897\/folmed.65.e72448","article-title":"Rheumatoid Arthritis and proinflammatory cytokine IL-17","volume":"65","author":"Selimov","year":"2023","journal-title":"Folia Med."},{"issue":"6","key":"10.1016\/j.jep.2026.121635_bib45","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.berh.2006.08.001","article-title":"Infection and musculoskeletal conditions: infectious arthritis","volume":"20","author":"Tarkowski","year":"2006","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"issue":"5","key":"10.1016\/j.jep.2026.121635_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70339","article-title":"Screening of candidate analgesics using a patient-derived human iPSC model of nociception identifies putative compounds for therapeutic treatment","volume":"15","author":"Thornton","year":"2025","journal-title":"Clin. Transl. Med."},{"issue":"3","key":"10.1016\/j.jep.2026.121635_bib47","first-page":"168","article-title":"Understanding the mechanisms of action of methotrexate","volume":"65","author":"Tian","year":"2007","journal-title":"Bulletin of the New York University Hospital for Joint Diseases"},{"issue":"1","key":"10.1016\/j.jep.2026.121635_bib48","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/12703","article-title":"Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety","volume":"23","author":"Tronche","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jep.2026.121635_bib49","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jep.2019.02.048","article-title":"Aqueous and methanol extracts of Paullinia pinnata L. (Sapindaceae) improve inflammation, pain and histological features in CFA-induced monoarthritis: evidence from in vivo and in vitro studies","volume":"236","author":"Tseuguem","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2026.121635_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/5946291","article-title":"Aqueous and methanol extracts of Paullinia pinnata (Sapindaceae) improve monosodium urate-induced gouty arthritis in Rat: analgesic, Anti-Inflammatory, and antioxidant effects","volume":"2019","author":"Tseuguem","year":"2019","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"4","key":"10.1016\/j.jep.2026.121635_bib51","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/ar1762","article-title":"Aetiology and pathogenesis of reactive arthritis: role of non-antigen-presenting effects of HLA-B27","volume":"7","author":"V\u00e4h\u00e4miko","year":"2005","journal-title":"Arthritis Res. Ther."},{"issue":"22","key":"10.1016\/j.jep.2026.121635_bib52","doi-asserted-by":"crossref","first-page":"6767","DOI":"10.1113\/JP272599","article-title":"Secondary hyperalgesia is mediated by heat-insensitive A-fibre nociceptors","volume":"594","author":"Van den","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.jep.2026.121635_bib53","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.neulet.2003.12.002","article-title":"To the descending pain-control system in rats, inflammation-induced primary and secondary hyperalgesia are two different things","volume":"361","author":"Vanegas","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jep.2026.121635_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202249962","article-title":"Advances in experimental models of rheumatoid arthritis","volume":"53","author":"Wang","year":"2023","journal-title":"Eur. J. Immunol."},{"issue":"7","key":"10.1016\/j.jep.2026.121635_bib55","first-page":"455","article-title":"Rheumatoid Arthritis: common questions about diagnosis and management","volume":"97","author":"Wasserman","year":"2018","journal-title":"Am. Fam. Physician"},{"issue":"20","key":"10.1016\/j.jep.2026.121635_bib56","doi-asserted-by":"crossref","first-page":"23780","DOI":"10.18632\/aging.203649","article-title":"Matairesinol exerts anti-inflammatory and antioxidant effects in sepsis-mediated brain injury by repressing the MAPK and NF-\u03baB pathways through up-regulating AMPK","volume":"13","author":"Wu","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"7","key":"10.1016\/j.jep.2026.121635_bib57","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/BRS.0000000000002364","article-title":"Adiponectin downregulates TNF-\u03b1 expression in degenerated intervertebral discs","volume":"43","author":"Yuan","year":"2018","journal-title":"Spine"},{"issue":"23","key":"10.1016\/j.jep.2026.121635_bib58","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.12659\/MSM.903357","article-title":"Protective effect of pinitol against inflammatory mediators of rheumatoid arthritis via inhibition of protein tyrosine phosphatase non-receptor type 22 (PTPN22)","volume":"20","author":"Zheng","year":"2017","journal-title":"Med. Sci. Monit."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126004861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126004861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:12:55Z","timestamp":1778544775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126004861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":58,"alternative-id":["S0378874126004861"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121635","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of TNF-\u03b1, IL-1\u03b2 and myeloperoxidase contributes to the anti-inflammatory and analgesic effects of Paullinia pinnata Linn (Sapindaceae) extracts in complete Freund's adjuvant-induced mono-arthritis in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121635","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121635"}}