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Soc."},{"key":"10.1016\/j.jep.2026.121704_bib93","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jaci.2024.04.021","article-title":"The nasal basal cell population shifts toward a diseased phenotype with impaired barrier formation capacity in allergic rhinitis","volume":"154","author":"Ruysseveldt","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2026.121704_bib94","doi-asserted-by":"crossref","DOI":"10.1002\/clt2.12130","article-title":"Worldwide prevalence of rhinitis in adults: a review of definitions and temporal evolution","volume":"12","author":"Savour\u00e9","year":"2022","journal-title":"Clin. Transl. Allergy"},{"key":"10.1016\/j.jep.2026.121704_bib95","doi-asserted-by":"crossref","unstructured":"Shamji, M.H., Boyle, R.J., n.d. Exploring treatment adherence in allergic rhinitis, inflammasome mechanisms in asthma, and chronic cough: insights from recent studies. Clin. Exp. Allergy n\/a. https:\/\/doi.org\/10.1111\/cea.70023.","DOI":"10.1111\/cea.70023"},{"key":"10.1016\/j.jep.2026.121704_bib96","doi-asserted-by":"crossref","unstructured":"Shanaida, M., Oleshchuk, O., Shevchuk, O., Posokhova, K., Ivankiv, Y., Mocherniuk, K., Klantsa, M., Korda, M., n.d. Herbal medicines and drugs interactions: cytochrome P450 responsibility. Curr. Med. Chem. 33, 1\u201330. https:\/\/doi.org\/10.2174\/0109298673428595251209114801.","DOI":"10.2174\/0109298673428595251209114801"},{"key":"10.1016\/j.jep.2026.121704_bib97","doi-asserted-by":"crossref","DOI":"10.1111\/cea.70004","article-title":"Adherence to treatment in allergic rhinitis during the pollen season in Europe: a MASK-air study","author":"Sousa-Pinto","year":"2025","journal-title":"Clin. Exp. Allergy: J. Br. Soc. Allergy Clin. 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