{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:20:49Z","timestamp":1783182049679,"version":"3.54.6"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014472","name":"Scientific Research Foundation of Hunan Provincial Education Department","doi-asserted-by":"publisher","award":["24A0555"],"award-info":[{"award-number":["24A0555"]}],"id":[{"id":"10.13039\/100014472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011324","name":"Qingdao University","doi-asserted-by":"publisher","award":["YLJT20242032"],"award-info":[{"award-number":["YLJT20242032"]}],"id":[{"id":"10.13039\/501100011324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011324","name":"Qingdao University","doi-asserted-by":"publisher","award":["YLJT20241003"],"award-info":[{"award-number":["YLJT20241003"]}],"id":[{"id":"10.13039\/501100011324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ70430"],"award-info":[{"award-number":["2025JJ70430"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jep.2026.121789","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:06:35Z","timestamp":1777539995000},"page":"121789","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Polygonatum sibiricum polysaccharide alleviates irritable bowel syndrome via multidimensional phenotypic improvement and sex-specific gut microbiota modulation in mice"],"prefix":"10.1016","volume":"367","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0213-0365","authenticated-orcid":false,"given":"Juzuo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaye","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demiao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2026.121789_bib1","doi-asserted-by":"crossref","first-page":"G338","DOI":"10.1152\/ajpgi.00116.2018","article-title":"Histamine-mediated potentiation of transient receptor potential (TRP) ankyrin 1 and TRP vanilloid 4 signaling in submucosal neurons in patients with irritable bowel syndrome","volume":"316","author":"Balemans","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"1","key":"10.1016\/j.jep.2026.121789_bib2","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2023-003836","article-title":"Frequency of irritable bowel syndrome in spondyloarthritis: a multicentric cross-sectional study and meta-analysis","volume":"10","author":"Bernard","year":"2024","journal-title":"RMD Open"},{"issue":"9","key":"10.1016\/j.jep.2026.121789_bib3","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1001\/jama.2020.22532","article-title":"Diagnosis and treatment of irritable bowel syndrome: a review","volume":"325","author":"Camilleri","year":"2021","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.jep.2026.121789_bib4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s11655-021-3521-4","article-title":"Treatment of irritable bowel syndrome by Chinese medicine: a review","volume":"29","author":"Chen","year":"2023","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2026.121789_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155565","article-title":"Exploring the anti-skin inflammation substances and mechanism of Paeonia lactiflora Pall. Flower via network pharmacology-HPLC integration","volume":"129","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.jep.2026.121789_bib6","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1001\/jama.2015.0954","article-title":"Irritable bowel syndrome: a clinical review","volume":"313","author":"Chey","year":"2015","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.jep.2026.121789_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23051170","article-title":"A review: the bioactivities and pharmacological applications of Polygonatum sibiricum polysaccharides","volume":"23","author":"Cui","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121789_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156370","article-title":"Anti-colorectal cancer actions of Glycyrrhiza uralensis Fisch. and its underlying mechanism via HPLC integration and network pharmacological approaches","volume":"138","author":"Duan","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121789_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2025.108094","article-title":"The sex related differences in health and disease: a systematic review of sex-specific gut microbiota and possible implications for microbial pathogenesis","volume":"209","author":"Ghaffar","year":"2025","journal-title":"Microb. Pathog."},{"issue":"7603","key":"10.1016\/j.jep.2026.121789_bib10","article-title":"Irritable bowel syndrome","volume":"533","author":"Grayson","year":"2016","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jep.2026.121789_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/nu12041037","article-title":"Mechanisms of action of prebiotics and their effects on gastro-intestinal disorders in adults","volume":"12","author":"Guarino","year":"2020","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.jep.2026.121789_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.217","article-title":"Majorbio Cloud 2024: update single-cell and multiomics workflows","volume":"3","author":"Han","year":"2024","journal-title":"iMeta"},{"issue":"26","key":"10.1016\/j.jep.2026.121789_bib13","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.3748\/wjg.v29.i26.4120","article-title":"Irritable bowel syndrome: epidemiology, overlap disorders, pathophysiology and treatment","volume":"29","author":"Huang","year":"2023","journal-title":"World J. Gastroenterol."},{"issue":"12","key":"10.1016\/j.jep.2026.121789_bib14","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1136\/gutjnl-2020-320919","article-title":"Microbiome alterations in IBS","volume":"69","author":"Jeffery","year":"2020","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.jep.2026.121789_bib15","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/jdi.14192","article-title":"Polygonatum sibiricum (Huang Jing) polysaccharide reduces diabetic cardiomyopathy through increasing cyclic guanosine monophosphate-protein kinase G signaling in diabetic mice","volume":"15","author":"Lei","year":"2024","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.jep.2026.121789_bib16","doi-asserted-by":"crossref","DOI":"10.2141\/jpsa.2025002","article-title":"Network pharmacology suggests mechanisms for therapeutic effects of Caulis Sinomenii on Avian gout","volume":"62","author":"Li","year":"2025","journal-title":"J. Poultry Sci."},{"key":"10.1016\/j.jep.2026.121789_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140343","article-title":"Polysaccharide from steamed Polygonatum sibiricum ameliorates ulcerative colitis by protecting the intestinal mucosal barrier and regulating gut microbiota","volume":"301","author":"Li","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.jep.2026.121789_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/molecules30051098","article-title":"Preparation, structure, function, and application of dietary polysaccharides from Polygonatum sibiricum in the food industry: a review","volume":"30","author":"Li","year":"2025","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121789_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1074671","article-title":"Advances in Polygonatum sibiricum polysaccharides: extraction, purification, structure, biosynthesis, and bioactivity","volume":"9","author":"Liu","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jep.2026.121789_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118024","article-title":"Research progress on medicinal components and pharmacological activities of polygonatum sibiricum","volume":"328","author":"Liu","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.121789_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13568-022-01376-z","article-title":"Polysaccharides from the leaves of Polygonatum sibiricum Red. regulate the gut microbiota and affect the production of short-chain fatty acids in mice","volume":"12","author":"Luo","year":"2022","journal-title":"AMB Express"},{"issue":"5","key":"10.1016\/j.jep.2026.121789_bib22","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2174\/1573412913666170330150807","article-title":"Compositional monosaccharide analysis of Morus nigra Linn by HPLC and HPCE quantitative determination and comparison of polysaccharide from Morus nigra Linn by HPCE and HPLC","volume":"13","author":"Ma","year":"2017","journal-title":"Curr. Pharmaceut. Anal."},{"key":"10.1016\/j.jep.2026.121789_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1421607","article-title":"Mechanisms of action and applications of Polygonatum sibiricum polysaccharide at the intestinal mucosa barrier: a review","volume":"15","author":"Ren","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.121789_bib24","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13293-023-00490-2","article-title":"Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases","volume":"14","author":"Santos-Marcos","year":"2023","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.jep.2026.121789_bib25","article-title":"Causal association of gastroesophageal reflux disease on irritable bowel syndrome: a two-sample Mendelian randomization study","volume":"15","author":"Wu","year":"2024","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.jep.2026.121789_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1142\/S0192415X15500019","article-title":"Traditional Chinese medicine formulas for irritable bowel syndrome: from ancient wisdoms to scientific understandings","volume":"43","author":"Xiao","year":"2015","journal-title":"Am. J. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121789_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.4673","article-title":"Assisted fermentation by a modified Bacillus subtilis strain producing protease improved the quality of sufu","volume":"13","author":"Xu","year":"2025","journal-title":"Food Sci. Nutr."},{"issue":"1","key":"10.1016\/j.jep.2026.121789_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2023.100731","article-title":"Trophoblast-specific knockdown of CSPG4 expression causes pregnancy complications with poor placentation in mice","volume":"23","author":"Xu","year":"2023","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.jep.2026.121789_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/1518080","article-title":"Total water-soluble flavonoids from Lithocarpus litseifolius (Hance) Chun (Sweet tea) improve glucose homeostasis through multitarget signalling in GDM mice","volume":"2024","author":"Xu","year":"2024","journal-title":"J. Diabetes Res."},{"issue":"4","key":"10.1016\/j.jep.2026.121789_bib30","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1002\/fsn3.3202","article-title":"Preparation of oral nanoparticles of Perillae Fructus oil and prevention application of cold stress in mice","volume":"11","author":"Xu","year":"2023","journal-title":"Food Sci. Nutr."},{"issue":"1","key":"10.1016\/j.jep.2026.121789_bib31","doi-asserted-by":"crossref","DOI":"10.1080\/09540105.2024.2358801","article-title":"Composition and toxicity of total water-soluble flavonoids from Lithocarpus litseifolius (Hance) Chun (sweet tea)","volume":"35","author":"Xu","year":"2024","journal-title":"Food Agric. Immunol."},{"key":"10.1016\/j.jep.2026.121789_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2025.466253","article-title":"A methylation-assisted gas chromatography-mass spectrometry strategy for comprehensive monosaccharide profiling in Polygonatum polysaccharides: overcoming limitations of conventional chromatographic techniques","volume":"1759","author":"Xu","year":"2025","journal-title":"J. Chromatogr., A"},{"key":"10.1016\/j.jep.2026.121789_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.134068","article-title":"Positive effects of steamed Polygonatum sibiricum polysaccharides including a glucofructan on fatty acids and intestinal microflora","volume":"402","author":"Xu","year":"2023","journal-title":"Food Chem."},{"issue":"4","key":"10.1016\/j.jep.2026.121789_bib34","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.62347\/CUXA2243","article-title":"Expression of transient receptor potential vanilloid type 1 (TRPV1) in colonic mucosa of patients with irritable bowel syndrome","volume":"17","author":"Zhang","year":"2025","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.jep.2026.121789_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118219","article-title":"Structures of fructan and galactan from Polygonatum cyrtonema and their utilization by probiotic bacteria","volume":"267","author":"Zhang","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.121789_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120219","article-title":"The protective effects and mechanisms of Polygonatum sibiricum polysaccharides in chronic stress-induced neural damage","volume":"352","author":"Zhang","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.121789_bib37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2174\/1871530321666210208221158","article-title":"Bioactive compounds of Polygonatum sibiricum - therapeutic effect and biological activity","volume":"22","author":"Zhao","year":"2022","journal-title":"Endocr., Metab. Immune Disord.: Drug Targets"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126006410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126006410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:01:15Z","timestamp":1783180875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126006410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":37,"alternative-id":["S0378874126006410"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121789","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polygonatum sibiricum polysaccharide alleviates irritable bowel syndrome via multidimensional phenotypic improvement and sex-specific gut microbiota modulation in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121789","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121789"}}