{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:46:59Z","timestamp":1785757619099,"version":"3.56.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY23H280007"],"award-info":[{"award-number":["LY23H280007"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jep.2026.121828","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:42:40Z","timestamp":1778244160000},"page":"121828","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["From grey relational-network pharmacology screening to mechanism elucidation: 4-methoxy-2- (3-methylethoxyethane) -phenylisobutyrate from Pimpinella diversifolia essential oil alleviates D-GalN\/LPS-induced ALI by targeting the GSK-3\u03b2\/NF-\u03baB axis"],"prefix":"10.1016","volume":"368","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7269-3071","authenticated-orcid":false,"given":"Ruonan","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runze","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoning","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunchun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.121828_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6276438","article-title":"Alleviation of drugs and chemicals toxicity: biomedical value of antioxidants","volume":"2018","author":"Abdel-Daim","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2026.121828_bib2","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.5650\/jos.ess20153","article-title":"Determination of bioactive lipid and antioxidant activity of onobrychis, Pimpinella, Trifolium, and Phleum spp. seed and oils","volume":"69","author":"Ahmed","year":"2020","journal-title":"J. Oleo Sci."},{"key":"10.1016\/j.jep.2026.121828_bib3","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3390\/biomedicines11041203","article-title":"Ameliorative effects of isoeugenol and eugenol against impaired nerve function and inflammatory and oxidative mediators in diabetic neuropathic rats","volume":"11","author":"Alharthy","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jep.2026.121828_bib4","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.3390\/antiox12091653","article-title":"Oxidative stress in liver pathophysiology and disease","volume":"12","author":"Allameh","year":"2023","journal-title":"Antioxidants-basel"},{"key":"10.1016\/j.jep.2026.121828_bib5","first-page":"37","article-title":"Pimpinella anisum L. fruit: chemical composition and effect on rat model of nonalcoholic fatty liver disease","volume":"22","author":"Asadollahpoor","year":"2017","journal-title":"Journal of Research in Medical Sciences the Official Journal of Isfahan University of Medical Sciences"},{"key":"10.1016\/j.jep.2026.121828_bib6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1080\/08923973.2023.2197141","article-title":"Anti-inflammatory activity of 2-methoxy-4-vinylphenol involves inhibition of lipopolysaccharide-induced inducible nitric oxidase synthase by heme oxygenase-1","volume":"45","author":"Asami","year":"2023","journal-title":"IMMUNOPHARM IMMUNOT"},{"key":"10.1016\/j.jep.2026.121828_bib7","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.2174\/1389200219666180723144850","article-title":"Essential oils: extraction techniques, pharmaceutical and therapeutic potential - a review","volume":"19","author":"Aziz","year":"2018","journal-title":"CURR DRUG METAB"},{"key":"10.1016\/j.jep.2026.121828_bib8","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.ajpath.2023.06.002","article-title":"Oxidative stress\u2013induced liver damage and remodeling of the liver vasculature","volume":"193","author":"Banerjee","year":"2023","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jep.2026.121828_bib9","first-page":"1","article-title":"Comparative assessment of phytochemical profiles and antioxidant properties of Tunisian and Egyptian anise (Pimpinella anisum L.) seeds","author":"Bettaieb Rebey","year":"2017","journal-title":"Plant Biosyst."},{"key":"10.1016\/j.jep.2026.121828_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.134482","article-title":"Theoretical studies, spectroscopic investigation, molecular docking, molecular dynamics and MMGBSA calculations with 2\u2010hydrazinoquinoline","volume":"1274","author":"Bhattacharya","year":"2023","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jep.2026.121828_bib11","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jhep.2013.03.033","article-title":"Decoding cell death signals in liver inflammation","volume":"59","author":"Brenner","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2026.121828_bib12","first-page":"3","article-title":"Between religion and science: some aspects: concerning illness and healing in antiquity","volume":"XXIV","author":"Bungau","year":"2015","journal-title":"Transylvanian"},{"key":"10.1016\/j.jep.2026.121828_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173458","article-title":"Polystyrene nanoplastics induce intestinal and hepatic inflammation through activation of NF-\u03baB\/NLRP3 pathways and related gut-liver axis in mice","volume":"935","author":"Chen","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jep.2026.121828_bib14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BFb0027661","article-title":"Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death","author":"Decker","year":"1974","journal-title":"Rev Physiol Bioch P"},{"key":"10.1016\/j.jep.2026.121828_bib15","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2026.121828_bib16","series-title":"Kupffer Cells in the Liver","first-page":"785","author":"Dixon","year":"2013"},{"key":"10.1016\/j.jep.2026.121828_bib17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00210-012-0820-5","article-title":"Inhibitory effect of anethole in nonimmune acute inflammation","volume":"386","author":"Domiciano","year":"2013","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jep.2026.121828_bib18","first-page":"62","article-title":"Pharmacognostic identification of the folk medicine pimpinella diversifolia","author":"Dong","year":"1991","journal-title":"J. Guiyang Coll. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2026.121828_bib19","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1002\/hep.30937","article-title":"Vitamin D receptor activation in liver macrophages ameliorates hepatic inflammation, steatosis, and insulin resistance in mice","volume":"71","author":"Dong","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2026.121828_bib20","first-page":"197","article-title":"Research on the medicinal effects of extracts from pimpinella diversifolia","volume":"16","author":"Dong","year":"2021","journal-title":"Chin. J. Prev. Med."},{"key":"10.1016\/j.jep.2026.121828_bib21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s12064-024-00419-2","article-title":"Application of network pharmacology in synergistic action of Chinese herbal compounds","volume":"143","author":"Duan","year":"2024","journal-title":"Theor. Biosci."},{"key":"10.1016\/j.jep.2026.121828_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/agriculture12020224","article-title":"Acaricidal and antioxidant activities of anise oil (Pimpinella anisum) and the oil's effect on protease and acetylcholinesterase in the two-spotted spider mite (Tetranychus urticae Koch)","volume":"12","author":"El-Sayed","year":"2022","journal-title":"Agriculture"},{"key":"10.1016\/j.jep.2026.121828_bib23","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.yexcr.2007.12.015","article-title":"Inhibition of GSK3 differentially modulates NF-\u03baB, CREB, AP-1 and \u03b2-catenin signaling in hepatocytes, but fails to promote TNF-\u03b1-induced apoptosis","volume":"314","author":"G\u00f6tschel","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jep.2026.121828_bib24","first-page":"2108","article-title":"First-Pass effect and its influence on drug bioavailability: a focus on therapeutics in Pakistan","volume":"4","author":"Hamza","year":"2026","journal-title":"Int. J. Pharmaceutical Sci."},{"key":"10.1016\/j.jep.2026.121828_bib25","first-page":"16","article-title":"Research method of spectrum-effect relationship and its application in traditional Chinese medicine research","volume":"49","author":"Han","year":"2021","journal-title":"Guangzhou Chem. Ind."},{"key":"10.1016\/j.jep.2026.121828_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2023.105017","article-title":"Protective effects of Pimpinella diversifolia DC. root essential oil against lipopolysaccharide\/D-galactosamine-induced acute liver injury in mice through inhibiting inflammation and reducing oxidative stress","volume":"16","author":"Hua","year":"2023","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.jep.2026.121828_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.indcrop.2018.01.076","article-title":"Aniseed (Pimpinella anisum L.) essential oil reduces pro-inflammatory cytokines and stimulates mucus secretion in primary airway bronchial and tracheal epithelial cell lines","volume":"114","author":"Iannarelli","year":"2018","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jep.2026.121828_bib28","doi-asserted-by":"crossref","DOI":"10.1080\/10717544.2023.2241661","article-title":"Oral delivery of nerolidol alleviates cyclophosphamide-induced renal inflammation, apoptosis, and fibrosis via modulation of NF-kappaB\/cleaved caspase-3\/TGF-beta signaling molecules","volume":"30","author":"Iqubal","year":"2023","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jep.2026.121828_bib29","first-page":"2655","article-title":"Spectrum-effect relationship of extracts from Bletilla striata on inflammatory factors inhibit activities","volume":"41","author":"Jiang","year":"2018","journal-title":"J. Chin. Med. Mater."},{"key":"10.1016\/j.jep.2026.121828_bib30","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.3390\/ijms20184422","article-title":"Coelonin, an anti-inflammation active component of Bletilla striata and its potential mechanism","volume":"20","author":"Jiang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.121828_bib31","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s11064-006-9128-5","article-title":"Glycogen Synthase Kinase-3 (GSK3): inflammation, diseases, and therapeutics","volume":"32","author":"Jope","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jep.2026.121828_bib32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10311-016-0572-4","article-title":"Essential oil components decrease pulmonary and hepatic cells inflammation induced by air pollution particulate matter","volume":"14","author":"Kfoury","year":"2016","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.jep.2026.121828_bib33","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/ajg.2017.98","article-title":"The natural history of severe acute liver injury","volume":"112","author":"Koch","year":"2017","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jep.2026.121828_bib34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2026.121828_bib35","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/biof.2058","article-title":"Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK\/AKT pathway","volume":"6","author":"Lei","year":"2024","journal-title":"Biofactors"},{"key":"10.1016\/j.jep.2026.121828_bib36","first-page":"62","article-title":"Establishment of the spectrum-effect relationship in traditional chinese medicine","volume":"21","author":"Li","year":"2002","journal-title":"Education Of Chinese Med"},{"key":"10.1016\/j.jep.2026.121828_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131285","article-title":"Molecular dynamics revealed the effect of epoxy group on triglyceride digestion","volume":"373","author":"Li","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2026.121828_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115765","article-title":"Spectrum-effect relationship analysis based on HPLC-FT-ICR-MS and multivariate statistical analysis to reveal the pharmacodynamic substances of ling-gui-zhu-gan decoction on Alzheimer's disease","volume":"237","author":"Li","year":"2024","journal-title":"J Pharmaceut Biomed"},{"key":"10.1016\/j.jep.2026.121828_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137394","article-title":"From non-affinity to high-affinity: rapid preparation of nanobodies utilizing high-precision alphafold and structural-interaction analysis for detection of enrofloxacin in marine fish","volume":"488","author":"Li","year":"2025","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jep.2026.121828_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116281","article-title":"Exploring active ingredients of anti-osteoarthritis in raw and wine-processed Dipsaci Radix based on spectrum-effect relationship combined with chemometrics","volume":"309","author":"Lv","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121828_bib41","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ni1221","article-title":"Toll-like receptor\u2013mediated cytokine production is differentially regulated by glycogen synthase kinase 3","volume":"6","author":"Martin","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jep.2026.121828_bib42","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/157340911795677602","article-title":"Molecular docking: a powerful approach for structure-based drug discovery","volume":"7","author":"Meng","year":"2011","journal-title":"CURR COMPUT-AID DRUG"},{"key":"10.1016\/j.jep.2026.121828_bib43","article-title":"Angelicin attenuates sepsis-associated acute liver injury via p38 MAPK inhibition and NF-\u03baB-mediated Nrf2\/Keap1 activation to suppress inflammation and oxidative stress","volume":"SIN","author":"Pan","year":"2025","journal-title":"ACTA BIOCH BIOPH"},{"key":"10.1016\/j.jep.2026.121828_bib44","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3390\/nu10070863","article-title":"Kahweol ameliorates the liver inflammation through the inhibition of NF-\u03baB and STAT3 activation in primary kupffer cells and primary hepatocytes","volume":"10","author":"Seo","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2026.121828_bib45","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70129","article-title":"AKR7A5 knockout promote acute liver injury by inducing inflammatory response, oxidative stress and apoptosis in mice","volume":"28","author":"Shi","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jep.2026.121828_bib46","first-page":"840","article-title":"Evaluation of analgesic and antiinflammatory activity of Pimpinella anisum fixed oil extract","volume":"83","author":"Ta","year":"2006","journal-title":"Indian Vet. J."},{"key":"10.1016\/j.jep.2026.121828_bib47","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/ptr.2154","article-title":"Effect of essential oils and isolated compounds from Pimpinella species on NF-kappaB: a target for antiinflammatory therapy","volume":"21","author":"Tabanca","year":"2007","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2026.121828_bib48","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.cgh.2023.04.005","article-title":"Liver transplantation 2023: status report, Current and future challenges","volume":"21","author":"Terrault","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2026.121828_bib49","doi-asserted-by":"crossref","first-page":"R1141","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jep.2026.121828_bib50","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.3390\/plants10112378","article-title":"Apiaceae essential oils: boosters of terbinafine activity against dermatophytes and potent anti-inflammatory effectors","volume":"10","author":"Trifan","year":"2021","journal-title":"Plants-Basel"},{"key":"10.1016\/j.jep.2026.121828_bib51","first-page":"75","article-title":"Experimental Study on the anti-inflammatory, hemostatic and coagulation effects of extracts from Pimpinella Diversifolia","volume":"38","author":"Wang","year":"2017","journal-title":"Yunnan Journal of Traditional Chinese Medicine and Materia Medica"},{"key":"10.1016\/j.jep.2026.121828_bib52","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/21691401.2025.2475088","article-title":"The integration of metabolites from Forsythia suspensa and gut microbiota ameliorates drug-induced liver injury: network pharmacology and molecular docking studies","volume":"53","author":"Wang","year":"2025","journal-title":"Artif. Cell Nanomed. Biotechnol."},{"key":"10.1016\/j.jep.2026.121828_bib53","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00011-014-0720-x","article-title":"Oxidative stress promotes d-GalN\/LPS-induced acute hepatotoxicity by increasing glycogen synthase kinase 3\u03b2 activity","volume":"63","author":"Wei","year":"2014","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jep.2026.121828_bib54","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41423-020-00558-8","article-title":"Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities","volume":"18","author":"Wen","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jep.2026.121828_bib55","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.3390\/molecules28041571","article-title":"Emerging biopharmaceuticals from Pimpinella Genus","volume":"28","author":"Wu","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121828_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116926","article-title":"Study on the substance basis of the efficacy of eucommiae cortex before and after salt processing for the treatment of kidney-yang deficiency syndrome based on the spectrum-effect relationship","volume":"318","author":"Wu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121828_bib57","article-title":"Study on the chemical components of essentiale oil from Zhejiang Pimpinella Diversifolia","volume":"21","author":"Xu","year":"2012","journal-title":"China Pharmaceuticals"},{"key":"10.1016\/j.jep.2026.121828_bib58","first-page":"27","article-title":"Effects of extracts from pimpinella diversifolia on blood glucose and related factors in type 2 diabetic mice","volume":"43","author":"Yang","year":"2022","journal-title":"Hubei Journal of Animal and Veterinary Sciences"},{"key":"10.1016\/j.jep.2026.121828_bib59","first-page":"E1375","article-title":"Overexpression of NF-\u03baB p65 in macrophages ameliorates atherosclerosis in apoE-knockout mice","volume":"305","author":"Ye","year":"2013","journal-title":"Am J Physiol-Endoc M"},{"key":"10.1016\/j.jep.2026.121828_bib60","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/mco2.104","article-title":"NF-\u03baB signaling in inflammation and cancer","volume":"2","author":"Zhang","year":"2021","journal-title":"MedComm"},{"key":"10.1016\/j.jep.2026.121828_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2022.102164","article-title":"Bioactive coumarin-derivative esculetin decreases hepatic stellate cell activation via induction of cellular senescence via the PI3K-Akt-GSK3\u03b2 pathway","volume":"50","author":"Zhang","year":"2022","journal-title":"Food Biosci."},{"key":"10.1016\/j.jep.2026.121828_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2025.106049","article-title":"Elucidation of the potential active ingredients and mechanism of Brassica rapa L. extract in alleviating ethanol-induced HepG2 cell injury based on network pharmacology","volume":"65","author":"Zhang","year":"2025","journal-title":"Food Biosci."},{"key":"10.1016\/j.jep.2026.121828_bib62","first-page":"8","article-title":"Antioxidant activity of total flavonoids from Pimpinella diversifolia DC","volume":"25","author":"Zhao","year":"2019","journal-title":"Tianjin Agricultural Sciences"},{"key":"10.1016\/j.jep.2026.121828_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116306","article-title":"Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula","volume":"309","author":"Zhao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121828_bib64","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.3390\/nu15204349","article-title":"Eriodictyol alleviated LPS\/D-GalN-Induced acute liver injury by inhibiting oxidative stress and cell apoptosis via PI3K\/AKT signaling pathway","volume":"15","author":"Zheng","year":"2023","journal-title":"Nutrients"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412600680X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412600680X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:06:44Z","timestamp":1785755204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412600680X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":65,"alternative-id":["S037887412600680X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121828","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From grey relational-network pharmacology screening to mechanism elucidation: 4-methoxy-2- (3-methylethoxyethane) -phenylisobutyrate from Pimpinella diversifolia essential oil alleviates D-GalN\/LPS-induced ALI by targeting the GSK-3\u03b2\/NF-\u03baB axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121828","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121828"}}