{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:46:21Z","timestamp":1785757581236,"version":"3.56.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2023TZXD080"],"award-info":[{"award-number":["2023TZXD080"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2025QC274"],"award-info":[{"award-number":["ZR2025QC274"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tstp20221138"],"award-info":[{"award-number":["tstp20221138"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tsqnz20231230"],"award-info":[{"award-number":["tsqnz20231230"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jep.2026.121845","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:12:03Z","timestamp":1778692323000},"page":"121845","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A neutral polysaccharide from the pulp of Trichosanthes kirilowii Maxim mitigates constipation through microbiota-dependent activation of brain-gut axis"],"prefix":"10.1016","volume":"368","author":[{"given":"Tao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.121845_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.123059","article-title":"The structural discrepancy between the ability of fructan and arabinogalactan to cure acute pharyngitis in Hosta plantaginea (Lam.) aschers flowers","volume":"350","author":"Bai","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.121845_bib2","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.ijbiomac.2022.11.243","article-title":"Soluble dietary fiber and cellulose from Saccharina japonica by-product ameliorate Loperamide-induced constipation via modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota","volume":"226","author":"Cao","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.121845_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2024.115141","article-title":"Ameliorative effects of Trichosanthes kirilowii Maxim. seed oil on hyperlipidemia rats associated with the regulation of gut microbiology and metabolomics","volume":"197","author":"Chen","year":"2024","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jep.2026.121845_bib4","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1039\/D0RA07135H","article-title":"Conjugate between hydrolyzed collagen from defatted seabass skin and epigallocatechin gallate (EGCG): characteristics, antioxidant activity and in vitro cellular bioactivity","volume":"11","author":"Chotphruethipong","year":"2021","journal-title":"RSC Adv."},{"key":"10.1016\/j.jep.2026.121845_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101350","article-title":"Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior","volume":"54","author":"Cook","year":"2021","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.jep.2026.121845_bib6","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota-gut-brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.jep.2026.121845_bib7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.54457\/DR.202502002","article-title":"Correlation between serum total bile acids and QTc interval prolongation in non-ST elevation myocardial infarction patients","volume":"5","author":"Fu","year":"2025","journal-title":"Dis. Res."},{"key":"10.1016\/j.jep.2026.121845_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156977","article-title":"Study on the effects of the atractylodes macrocephala koidz-raphanus sativus l herb pair in alleviating senile constipation via the gut microbiota-SCFAs-5-HT axis","volume":"145","author":"Gao","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121845_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.124597","article-title":"The change in structure and improvement of anti-aging effects of polysaccharides in Polygonati Rhizoma after the traditional \u201cNine Steaming-Nine Sun-Drying\u201d","volume":"373","author":"Guan","year":"2026","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.121845_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.117714","article-title":"Can diets alleviate constipation and promote bowel movement? Exploring the underlying mechanisms of effects","volume":"222","author":"Gui","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jep.2026.121845_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157417","article-title":"Xiaoer Qixing Cha alleviates functional constipation via regulating gut microbiota and short-chain fatty acids in mice","volume":"148","author":"He","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121845_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.142391","article-title":"Polysaccharide extracted from peony seed meal preventive effect of on loperamide-induced constipation in rats","volume":"308","author":"He","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"19","key":"10.1016\/j.jep.2026.121845_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.70140","article-title":"Bottom-up design of prebiotics and probiotics: an intestinal microbiota-centered approach to chronic and functional constipation management","volume":"69","author":"He","year":"2025","journal-title":"Mol. Nutr. Food Res."},{"issue":"13","key":"10.1016\/j.jep.2026.121845_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202413197","article-title":"Advances in fecal microbiota transplantation for gut dysbiosis-related diseases","volume":"12","author":"Hou","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jep.2026.121845_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.140493","article-title":"A novel polysaccharide from blueberry leaves: extraction, structural characterization, hypolipidemic and hypoglycaemic potentials","volume":"460","author":"Hu","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2026.121845_bib16","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1016\/j.ijbiomac.2020.08.072","article-title":"Microwave-assisted extraction, characterization and immunomodulatory activity on RAW264.7 cells of polysaccharides from Trichosanthes kirilowii Maxim seeds","volume":"164","author":"Hu","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.121845_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.129527","article-title":"Structure characterization of polysaccharides from Cistanche deserticola and their neuroprotective effects against oxidative stress in slow transit constipation mice","volume":"260","author":"Jiang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.jep.2026.121845_bib18","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2473522","article-title":"Interbacterial warfare in the human gut: insights from Bacteroidales' perspective","volume":"17","author":"Jiang","year":"2025","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jep.2026.121845_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1672600","article-title":"Polysaccharide from Trichosanthes kirilowii Maxim ameliorates diphenoxylate-induced functional constipation in mice","volume":"16","author":"Jiang","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2026.121845_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107487","article-title":"Structural characterization of polysaccharide from the peel of Trichosanthes kirilowii Maxim and its anti-hyperlipidemia activity by regulating gut microbiota and inhibiting cholesterol absorption","volume":"149","author":"Jing","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jep.2026.121845_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2025.112599","article-title":"From gut to brain: the roles of intestinal microbiota, immune system, and hormones in intestinal physiology and gut-brain-axis","volume":"607","author":"Khan","year":"2025","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jep.2026.121845_bib22","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1111\/apt.17852","article-title":"Functional constipation: pathophysiology, evaluation, and management","volume":"60","author":"Kilgore","year":"2024","journal-title":"Aliment. Pharm. Ther."},{"key":"10.1016\/j.jep.2026.121845_bib23","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.chom.2022.09.001","article-title":"Enteric VIP-producing neurons maintain gut microbiota homeostasis through regulating epithelium fucosylation","volume":"30","author":"Lei","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jep.2026.121845_bib24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jare.2023.04.014","article-title":"Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis","volume":"52","author":"Li","year":"2023","journal-title":"J. Adv. Res."},{"issue":"5","key":"10.1016\/j.jep.2026.121845_bib25","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.3168\/jds.2020-19449","article-title":"Synbiotic yogurt containing konjac mannan oligosaccharides and Bifidobacterium animalis ssp. lactis BB12 alleviates constipation in mice by modulating the stem cell factor (SCF)\/c-Kit pathway and gut microbiota","volume":"104","author":"Li","year":"2021","journal-title":"J. Dairy Sci."},{"issue":"3","key":"10.1016\/j.jep.2026.121845_bib26","doi-asserted-by":"crossref","DOI":"10.26599\/FSHW.2024.9250059","article-title":"Exploring the material basis and mechanism of Moringa oleifera in alleviating slow transit constipation based on network pharmacology and animal models","volume":"14","author":"Li","year":"2025","journal-title":"Food Sci. Hum. Wellness"},{"key":"10.1016\/j.jep.2026.121845_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.117874","article-title":"Extraction, characterization of aloe polysaccharides and the in-depth analysis of its prebiotic effects on mice gut microbiota","volume":"261","author":"Liu","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.121845_bib28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41522-025-00772-0","article-title":"Parabacteroides as a promising target for disease intervention: current stage and pending issues","volume":"11","author":"Liu","year":"2025","journal-title":"NPJ Biofilms Microbi."},{"issue":"5","key":"10.1016\/j.jep.2026.121845_bib29","article-title":"TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy","volume":"12","author":"Luo","year":"2024","journal-title":"Genes Dis."},{"key":"10.1016\/j.jep.2026.121845_bib30","article-title":"Exploring the links between pro-inflammatory diets, gut dysbiosis, serotonin, and their implications for psychiatric and neurodegenerative disorders","volume":"8","author":"Maia","year":"2024","journal-title":"Brain Behav. Immun. Integr"},{"key":"10.1016\/j.jep.2026.121845_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.139760","article-title":"Structural characterization of an apple polysaccharide and its anti-inflammatory effect through suppressing TLR4\/NF-\u03baB signaling","volume":"296","author":"Ma","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.jep.2026.121845_bib32","article-title":"Efficacy of a postbiotic and its components in promoting colonic transit and alleviating chronic constipation in humans and mice","volume":"6","author":"Ma","year":"2025","journal-title":"Cell Rep. Med."},{"issue":"10","key":"10.1016\/j.jep.2026.121845_bib33","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41579-025-01183-w","article-title":"Gut microbiota-derived short-chain fatty acids and their role in human health and disease","volume":"23","author":"Mukhopadhya","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.jep.2026.121845_bib34","article-title":"Artemisia argyi polysaccharide alleviates intestinal inflammation and intestinal flora dysbiosis in lipopolysaccharide-treated mice","volume":"1","author":"Ning","year":"2024","journal-title":"Food Med. Homol."},{"key":"10.1016\/j.jep.2026.121845_bib35","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/s41467-025-55845-7","article-title":"Selective utilization of medicinal polysaccharides by human gut Bacteroides and Parabacteroides species","volume":"16","author":"Qu","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jep.2026.121845_bib36","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12876-023-03104-8","article-title":"Comparative profiles of lubiprostone, linaclotide, and elobixibat for chronic constipation: a systematic literature review with meta-analysis and number needed to treat\/harm","volume":"24","author":"Rao","year":"2024","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.jep.2026.121845_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.116840","article-title":"2\u2019-Fucosyllactose synbiotics with Bifidobacterium bifidum to improve intestinal transcriptional function and gut microbiota in constipated mice","volume":"217","author":"Shan","year":"2025","journal-title":"Food Res. Int."},{"issue":"1","key":"10.1016\/j.jep.2026.121845_bib38","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1039\/D3FO03259K","article-title":"Ligilactobacillus acidipiscis YJ5 modulates the gut microbiota and produces beneficial metabolites to relieve constipation by enhancing the mucosal barrier","volume":"15","author":"Shen","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2026.121845_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.crfs.2025.100977","article-title":"Trichosanthes kirilowii Maxim. polysaccharide attenuates diabetes through the synergistic impact of lipid metabolism and modulating gut microbiota","volume":"10","author":"Song","year":"2025","journal-title":"Curr. Res. Food Sci."},{"issue":"11","key":"10.1016\/j.jep.2026.121845_bib40","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.3390\/biom13111586","article-title":"The oxidative stress and nervous distress connection in gastrointestinal disorders","volume":"13","author":"Stavely","year":"2023","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.jep.2026.121845_bib41","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-immunol-101921-042929","article-title":"Neuroimmune interactions in the intestine","volume":"42","author":"Wallrapp","year":"2024","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jep.2026.121845_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.149010","article-title":"Ganoderma lucidum dietary fiber and lactobacillus fermentum CECT5716 alleviate constipation via regulation of gut barrier and microbiota","volume":"333","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.121845_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.124495","article-title":"Structural characterisation of Cistanche tubulosa polysaccharides and their effects against non-alcoholic steatohepatitis via gut microbiota regulation","volume":"371","author":"Wang","year":"2026","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.121845_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130007","article-title":"Raspberry polysaccharides attenuate hepatic inflammation and oxidative stress in diet-induced obese mice by enhancing butyrate-mediated intestinal barrier function","volume":"262","author":"Wu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.jep.2026.121845_bib45","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jfutfo.2024.09.006","article-title":"Tryptophan metabolism and the gut-brain axis: focus on specific gut microbial genera","volume":"6","author":"Xia","year":"2026","journal-title":"J. Future Foods"},{"key":"10.1016\/j.jep.2026.121845_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2023.117874","article-title":"Extraction and structural profiling of polysaccharides from Rehmannia glutinosa and anti-inflammatory action via the NF-\u03baB\/I\u03baB\u03b1 pathway","volume":"208","author":"Xie","year":"2024","journal-title":"Ind. Crop. Prod."},{"issue":"9","key":"10.1016\/j.jep.2026.121845_bib47","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1016\/j.cell.2025.02.031","article-title":"Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force","volume":"188","author":"Xie","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.jep.2026.121845_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodcont.2022.109201","article-title":"Influence of different extraction methods on the chemical composition, antioxidant activity, and overall quality attributes of oils from Trichosanthes kirilowii Maxim seed","volume":"142","author":"Xu","year":"2022","journal-title":"Food Control"},{"issue":"22","key":"10.1016\/j.jep.2026.121845_bib49","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.1080\/10408398.2022.2025535","article-title":"Current advances in the anti-inflammatory effects and mechanisms of natural polysaccharides","volume":"63","author":"Yuan","year":"2023","journal-title":"Crit. Rev. Food Sci."},{"issue":"4","key":"10.1016\/j.jep.2026.121845_bib50","article-title":"Overview of research on the application of medicine food homologous bioactive ingredients to functional constipation","volume":"2","author":"Yu","year":"2025","journal-title":"Food Med. Homol."},{"key":"10.1016\/j.jep.2026.121845_bib51","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.chom.2023.10.011","article-title":"A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation","volume":"31","author":"Zhang","year":"2023","journal-title":"Cell Host Microbe"},{"issue":"3","key":"10.1016\/j.jep.2026.121845_bib52","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.26599\/FSHW.2022.9250119","article-title":"Preventive effect of kiwi berry (Actinidia arguta) on loperamide-induced constipation","volume":"13","author":"Zhang","year":"2024","journal-title":"Food Sci. Hum. Wellness"},{"key":"10.1016\/j.jep.2026.121845_bib53","article-title":"Kiwi berry (Actinidia arguta) polysaccharides alleviate constipation: defecation characteristics, gut microbiota and metabolites analysis","author":"Zhang","year":"2026","journal-title":"J. Future Foods"},{"key":"10.1016\/j.jep.2026.121845_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122905","article-title":"Polysaccharides from Lycium barbarum, yam, and sunflower ameliorate colitis in a structure and intrinsic flora-dependent manner","volume":"349","author":"Zhang","year":"2025","journal-title":"Carbohydr. Polym."},{"issue":"8","key":"10.1016\/j.jep.2026.121845_bib55","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.4014\/jmb.2002.02044","article-title":"Fecal microbiota transplantation (FMT) alleviates experimental colitis in mice by gut microbiota regulation","volume":"30","author":"Zhang","year":"2020","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.jep.2026.121845_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156970","article-title":"Mulberry leaf improves type 2 diabetes in mice via gut microbiota-SCFAs-GPRs axis and AMPK signaling pathway","volume":"145","author":"Zhang","year":"2025","journal-title":"Phytomedicine"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126006975?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126006975?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:03:21Z","timestamp":1785755001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126006975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":56,"alternative-id":["S0378874126006975"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121845","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A neutral polysaccharide from the pulp of Trichosanthes kirilowii Maxim mitigates constipation through microbiota-dependent activation of brain-gut axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121845","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121845"}}