{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:15:26Z","timestamp":1783138526995,"version":"3.54.6"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8257151611"],"award-info":[{"award-number":["8257151611"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110172"],"award-info":[{"award-number":["2023A1515110172"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jep.2026.121917","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T15:04:08Z","timestamp":1779807848000},"page":"121917","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Jiawei Sini San ameliorates cognitive deficits in CUMS depression rats by reshaping dendritic spines through regulating TRPC6-activated ROCK2-Cofilin signaling pathway"],"prefix":"10.1016","volume":"369","author":[{"given":"Tiange","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyinghua","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.121917_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neubiorev.2018.12.002","article-title":"Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability","volume":"99","author":"Antoniuk","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"8","key":"10.1016\/j.jep.2026.121917_bib2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/ncb1150","article-title":"Rapid vesicular translocation and insertion of TRP channels","volume":"6","author":"Bezzerides","year":"2004","journal-title":"Nat. Cell Biol."},{"issue":"8","key":"10.1016\/j.jep.2026.121917_bib3","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1111\/febs.16065","article-title":"Long-term plasticity in the hippocampus: maintaining within and 'tagging' between synapses","volume":"289","author":"Bin Ibrahim","year":"2022","journal-title":"FEBS J."},{"issue":"3","key":"10.1016\/j.jep.2026.121917_bib4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.conb.2007.04.009","article-title":"Do thin spines learn to be mushroom spines that remember?","volume":"17","author":"Bourne","year":"2007","journal-title":"Curr. Opin. Neurobiol."},{"issue":"2","key":"10.1016\/j.jep.2026.121917_bib5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biopsych.2021.05.008","article-title":"Brain-derived neurotrophic factor signaling in depression and antidepressant action","volume":"90","author":"Castr\u00e9n","year":"2021","journal-title":"Biol. Psychiatry"},{"issue":"11","key":"10.1016\/j.jep.2026.121917_bib6","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.tins.2023.08.001","article-title":"Synapse organizers as molecular codes for synaptic plasticity","volume":"46","author":"Connor","year":"2023","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jep.2026.121917_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-psych-122216-011613","article-title":"Cryan JF. Depression's unholy trinity: dysregulated stress, immunity, and the microbiome","volume":"71","author":"Cruz-Pereira","year":"2020","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.jep.2026.121917_bib8","series-title":"Clinical Study on the Treatment of Comorbid Depression with Migraine in Liver Depression and Qi Stagnation Type with Jia Wei Si Ni San. D","author":"Cui","year":"2024"},{"issue":"3","key":"10.1016\/j.jep.2026.121917_bib9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.12740\/PP\/OnlineFirst\/105415","article-title":"Cognitive dysfunctions in depression-significance, description and treatment prospects","volume":"54","author":"Czerwi\u0144ska","year":"2020","journal-title":"Psychiatr. Pol."},{"issue":"3","key":"10.1016\/j.jep.2026.121917_bib10","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nm.4050","article-title":"Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants","volume":"22","author":"Duman","year":"2016","journal-title":"Nat Med"},{"issue":"12","key":"10.1016\/j.jep.2026.121917_bib11","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1038\/s41380-022-01804-3","article-title":"Analysis of hyperforin action at TRPC6 channel leads to the development of a new class of antidepressant drugs","volume":"27","author":"El","year":"2022","journal-title":"Mol. Psychiatr."},{"issue":"3","key":"10.1016\/j.jep.2026.121917_bib12","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0306-4522(00)00146-9","article-title":"The multifarious hippocampal mossy fiber pathway: a review","volume":"98","author":"Henze","year":"2000","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.jep.2026.121917_bib13","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/s41467-019-09562-7","article-title":"Esterlis I. Lower synaptic density is associated with depression severity and network alterations","volume":"10","author":"Holmes","year":"2019","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.jep.2026.121917_bib14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/02699930903407948","article-title":"Emotion regulation in depression: relation to cognitive inhibition","volume":"24","author":"Joormann","year":"2010","journal-title":"Cogn. Emot."},{"issue":"12","key":"10.1016\/j.jep.2026.121917_bib15","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1016\/j.bbadis.2013.08.012","article-title":"Structural plasticity of dendritic spines: the underlying mechanisms and its dysregulation in brain disorders","volume":"1832","author":"Lai","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"7526","key":"10.1016\/j.jep.2026.121917_bib16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/515182a","article-title":"Medical research: if depression were cancer","volume":"515","author":"Ledford","year":"2014","journal-title":"Nature"},{"issue":"7735","key":"10.1016\/j.jep.2026.121917_bib17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41586-018-0740-8","article-title":"Thompson SM reward behaviour is regulated by the strength of hippocampus-nucleus accumbens synapses","volume":"564","author":"LeGates","year":"2018","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.jep.2026.121917_bib18","first-page":"2602","article-title":"Study on the mechanism of miR-124-hippocampal neurogenesis of Jiawei Sini San in enhancing stress resilience of CUMS rats","volume":"37","author":"Luo","year":"2021","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"issue":"11","key":"10.1016\/j.jep.2026.121917_bib19","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41583-023-00742-5","article-title":"Excitation-transcription coupling, neuronal gene expression and synaptic plasticity","volume":"24","author":"Ma","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jep.2026.121917_bib20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-neuro-090919-022842","article-title":"Synaptic plasticity forms and functions","volume":"43","author":"Magee","year":"2020","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.jep.2026.121917_bib21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jad.2022.10.035","article-title":"Psychotic depression and deaths due to suicide","volume":"321","author":"Palj\u00e4rvi","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.jep.2026.121917_bib22","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1146\/annurev-neuro-110920-040422","article-title":"Synaptic mechanisms regulating mood state transitions in depression","volume":"45","author":"Parekh","year":"2022","journal-title":"Annu. Rev. Neurosci."},{"issue":"24","key":"10.1016\/j.jep.2026.121917_bib23","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1101\/gad.174060.111","article-title":"A TRPC5-regulated calcium signaling pathway controls dendrite patterning in the mammalian brain","volume":"25","author":"Puram","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.jep.2026.121917_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119252","article-title":"Guilu Erxian Jiao remodels dendritic spine morphology through activation of the hippocampal TRPC6-CaMKIV-CREB signaling pathway and suppresses fear memory generalization in rats with post-traumatic stress disorder","volume":"340","author":"Qu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121917_bib25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smrv.2017.05.002","article-title":"The role of sleep in regulating structural plasticity and synaptic strength: implications for memory and cognitive function","volume":"39","author":"Raven","year":"2018","journal-title":"Sleep Med. Rev."},{"issue":"1","key":"10.1016\/j.jep.2026.121917_bib26","first-page":"88","article-title":"Effect of Jiawei Sini Decoction on HPA function of rats with restraint psychological stress","volume":"31","author":"Shi","year":"2008","journal-title":"Herbal medicine"},{"issue":"2","key":"10.1016\/j.jep.2026.121917_bib27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.biopsych.2020.12.006","article-title":"Neurobiology of the rapid-acting antidepressant effects of ketamine: impact and opportunities","volume":"90","author":"Shinohara","year":"2021","journal-title":"Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.jep.2026.121917_bib28","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1523\/JNEUROSCI.22-08-03251.2002","article-title":"Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression","volume":"22","author":"Shirayama","year":"2002","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.jep.2026.121917_bib29","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrn3085","article-title":"A pathophysiological framework of hippocampal dysfunction in ageing and disease","volume":"12","author":"Small","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"issue":"6","key":"10.1016\/j.jep.2026.121917_bib30","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1038\/s41380-022-01520-y","article-title":"Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications","volume":"27","author":"Tartt","year":"2022","journal-title":"Mol. Psychiatr."},{"issue":"2","key":"10.1016\/j.jep.2026.121917_bib31","doi-asserted-by":"crossref","first-page":"385","DOI":"10.31083\/j.jin.2020.02.1246","article-title":"Antidepressant pathways of the Chinese herb jiaweisinisan through genetic ontology analysis","volume":"19","author":"Wang","year":"2020","journal-title":"J. Integr. Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2026.121917_bib32","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1080\/13880209.2021.1954666","article-title":"Cerebrospinal fluid proteomics reveal potential protein targets of JiaWeiSiNiSan in preventing chronic psychological stress damage","volume":"59","author":"Wang","year":"2021","journal-title":"Pharm. Biol."},{"issue":"4","key":"10.1016\/j.jep.2026.121917_bib33","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0149-7634(05)80194-0","article-title":"Chronic mild stress-induced anhedonia: a realistic animal model of depression","volume":"16","author":"Willner","year":"1992","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1\u20132","key":"10.1016\/j.jep.2026.121917_bib34","article-title":"Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons","volume":"531","author":"Woolley","year":"1990","journal-title":"Brain Res."},{"issue":"12","key":"10.1016\/j.jep.2026.121917_bib35","article-title":"Jiaweisinisan facilitates neurogenesis in the hippocampus after stress damage","volume":"8","author":"Wu","year":"2013","journal-title":"Neural Regen. Res."},{"issue":"3","key":"10.1016\/j.jep.2026.121917_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14455","article-title":"Luteolin alleviates depression-like behavior by modulating glycerophospholipid metabolism in the hippocampus and prefrontal cortex of LOD rats","volume":"30","author":"Wu","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"4","key":"10.1016\/j.jep.2026.121917_bib37","first-page":"569","article-title":"Regulatory of Jiaweisinisan on expression of hippocampal BDNF, NR1and dental gyrus neurogenesis in rats with chronic stressed-depression","volume":"32","author":"Yan","year":"2016","journal-title":"Chin. Pharmacol. Bull."},{"key":"10.1016\/j.jep.2026.121917_bib38","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2147\/DDDT.S234262","article-title":"Tetrandrine suppresses transient receptor potential cation channel protein 6 Overexpression- induced podocyte damage via blockage of RhoA\/ROCK1 signaling","volume":"14","author":"Yu","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"issue":"47","key":"10.1016\/j.jep.2026.121917_bib39","doi-asserted-by":"crossref","first-page":"11837","DOI":"10.1523\/JNEUROSCI.1188-16.2016","article-title":"Store-operated calcium channel complex in postsynaptic spines: a new therapeutic target for Alzheimer's disease treatment","volume":"36","author":"Zhang","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jep.2026.121917_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177860","article-title":"Quercetin alleviates depression in CUMS rats via modulating immune plasticity in the choroid plexus to inhibit hippocampal microglial activation","volume":"1003","author":"Zhang","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2026.121917_bib41","first-page":"636","article-title":"Influences of modified sini decoction on hippocampal lesion of rats with chronic unpredictable mild psychological stress","volume":"29","author":"Zhang","year":"2012","journal-title":"J. Guangzhou Univ. Chin. Med."},{"key":"10.1016\/j.jep.2026.121917_bib42","first-page":"1817","article-title":"Clinical study on JWSNS in the treatment of post-stroke depression","volume":"8","author":"Zhong","year":"2008","journal-title":"J. Chinese Archives of Traditional Chinese Medicine"},{"issue":"7","key":"10.1016\/j.jep.2026.121917_bib43","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nn.2127","article-title":"Critical role of TRPC6 channels in the formation of excitatory synapses","volume":"11","author":"Zhou","year":"2008","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2026.121917_bib44","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuropharm.2008.07.031","article-title":"Critical role of rho-kinase ROCK2 in the regulation of spine and synaptic function","volume":"56","author":"Zhou","year":"2009","journal-title":"Neuropharmacology"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126007695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126007695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:16:50Z","timestamp":1783135010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126007695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":44,"alternative-id":["S0378874126007695"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121917","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Jiawei Sini San ameliorates cognitive deficits in CUMS depression rats by reshaping dendritic spines through regulating TRPC6-activated ROCK2-Cofilin signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121917","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121917"}}