{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:22:17Z","timestamp":1783102937788,"version":"3.54.6"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["310177\/2022-7"],"award-info":[{"award-number":["310177\/2022-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["BFP-0417-2.10\/24"],"award-info":[{"award-number":["BFP-0417-2.10\/24"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jep.2026.121945","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T15:31:17Z","timestamp":1780155077000},"page":"121945","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Evaluation of the antiulcerogenic and antidiarrheal activities of essential oils from Croton jacobinensis Baill. (Euphorbiaceae) and its major compound \u03b1-pinene"],"prefix":"10.1016","volume":"369","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2081-8304","authenticated-orcid":false,"given":"Jos\u00e9 Jailson Lima","family":"Bezerra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcilene Souza","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suelen Cristina Louren\u00e7o","family":"de Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Victor","family":"de Oliveira Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falio C\u00e9sar Ribeiro","family":"de Oliveira Farias de Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivone Antonia","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Vanusa","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Tereza","family":"dos Santos Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Maria","family":"do Amaral Ferraz Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Fernando Morais","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.121945_bib1","doi-asserted-by":"crossref","first-page":"5921","DOI":"10.3390\/molecules29245921","article-title":"Larvicidal and oviposition activity of commercial essential oils of Abies sibirica Ledeb., Pogostemon cablin (Blanco) Benth., Juniperus communis L. and their combinations against Aedes aegypti","volume":"29","author":"Aguiar","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121945_bib2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/10412905.2019.1607785","article-title":"Chemical composition and antimicrobial activity of essential oils of a Croton tetradenius Baill","volume":"31","author":"Almeida-Pereira","year":"2019","journal-title":"germplasm. J. Essent. Oil Res."},{"key":"10.1016\/j.jep.2026.121945_bib3","series-title":"Hunter's Tropical Medicine and Emerging Infectious Diseases","first-page":"16","article-title":"Gastrointestinal diseases","author":"Ananthakrishnan","year":"2020"},{"key":"10.1016\/j.jep.2026.121945_bib4","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/ptr.1639","article-title":"Evaluation of some medicinal plant extracts for antidiarrhoeal activity","volume":"19","author":"Atta","year":"2005","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2026.121945_bib5","article-title":"Chemical composition, antibacterial activity, and antibiotic-potentiating effect mediated by the essential oil of the leaves of Croton urticifolius Lam. (Euphorbiaceae)","volume":"8","author":"Barbosa","year":"2025","journal-title":"Pharmacol. Res. Nat. Prod."},{"key":"10.1016\/j.jep.2026.121945_bib6","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.sajb.2024.10.020","article-title":"Anticancer potential of essential oils from Croton L. species (Euphorbiaceae): a comprehensive review of ethnomedicinal, pharmacological, phytochemical, and toxicological evidence","volume":"175","author":"Bezerra","year":"2024","journal-title":"South Afr. J. Bot."},{"key":"10.1016\/j.jep.2026.121945_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2026.121371","article-title":"Chemical composition and evaluation of the anti-candida activity of essential oils of Croton jacobinensis Baill. and its main compound \u03b1-pinene: in vitro and in vivo insights","volume":"362","author":"Bezerra","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121945_bib8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.sajb.2025.11.028","article-title":"Ethnomedicinal uses, antiparasitic potential, and chemical composition of essential oils from Croton species (Euphorbiaceae): a comprehensive review","volume":"188","author":"Bezerra","year":"2026","journal-title":"South Afr. J. Bot."},{"key":"10.1016\/j.jep.2026.121945_bib7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/compounds6010002","article-title":"A comprehensive review of the antiulcerogenic and antidiarrheal properties of Croton L. Species (Euphorbiaceae)","volume":"6","author":"Bezerra","year":"2026","journal-title":"Compounds"},{"key":"10.1016\/j.jep.2026.121945_bib10","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1007\/s10787-022-00989-x","article-title":"Gastrointestinal effects of Mentha aquatica L. essential oil","volume":"30","author":"Braga","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2026.121945_bib11","first-page":"352","article-title":"Esp\u00e9cies com potential medicinal ocorrentes em comunidades rurais de Caxing\u00f3, Piau\u00ed, Brasil","volume":"19","author":"Carvalho","year":"2017","journal-title":"Rev. Bras. Plantas Med."},{"key":"10.1016\/j.jep.2026.121945_bib12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.5897\/JMPR2015.6038","article-title":"Ethnobotanical and ethnoveterinary study of medicinal plants used in the municipality of Bom principio do Piaui, Piaui, Brazil","volume":"10","author":"Castro","year":"2016","journal-title":"J. Med. Plants Res."},{"key":"10.1016\/j.jep.2026.121945_bib13","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1472-8206.2011.01021.x","article-title":"Essential oil of Croton zehntneri and its major constituent anethole display gastroprotective effect by increasing the surface mucous layer","volume":"27","author":"Coelho\u2010de\u2010Souza","year":"2013","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2026.121945_bib14","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1007\/s11101-024-10031-3","article-title":"Exploring phytochemistry, antioxidant capacity, and biological potential of essential oils obtained from Euphorbiaceae species","volume":"24","author":"Costa","year":"2025","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.jep.2026.121945_bib15","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.3390\/antibiotics10111387","article-title":"Chemical profile of the volatile constituents and antimicrobial activity of the essential oils from Croton adipatus, Croton thurifer, and Croton collinus","volume":"10","author":"Cucho-Medrano","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.jep.2026.121945_bib16","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.3390\/molecules27092881","article-title":"Treatment of gastrointestinal disorders\u2014Plants and potential mechanisms of action of their constituents","volume":"27","author":"Czigle","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121945_bib17","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1186\/s12906-016-1357-9","article-title":"Evaluation of the anti-diarrheal activity of the leaf extract of Croton macrostachyus Hocsht. ex del. (Euphorbiaceae) in mice model","volume":"16","author":"Degu","year":"2016","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2026.121945_bib18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4103\/0975-1483.93578","article-title":"Investigation of the mechanisms underlying the gastroprotective effect of Cymbopogon citratus essential oil","volume":"4","author":"Fernandes","year":"2012","journal-title":"J. Young Pharm."},{"key":"10.1016\/j.jep.2026.121945_bib19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.7861\/clinmed.2020-0980","article-title":"Management of functional gastrointestinal disorders","volume":"21","author":"Fikree","year":"2021","journal-title":"Clin. Med."},{"key":"10.1016\/j.jep.2026.121945_bib20","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.3390\/antibiotics11121712","article-title":"Chemical composition and in vitro and in silico antileishmanial evaluation of the essential oil from Croton linearis Jacq","volume":"11","author":"Garc\u00eda-D\u00edaz","year":"2022","journal-title":"stems. Antibiotics."},{"key":"10.1016\/j.jep.2026.121945_bib21","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3390\/futurepharmacol4040045","article-title":"Antinociceptive potential of Croton Genus: a systematic review","volume":"4","author":"Guerrero-Solano","year":"2024","journal-title":"Fut. Pharmacol."},{"key":"10.1016\/j.jep.2026.121945_bib22","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/ptr.728","article-title":"Studies on the antidiarrhoeal effect of dragon's blood from Croton urucurana","volume":"15","author":"Gurgel","year":"2001","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2026.121945_bib23","first-page":"334","article-title":"Side effects of omeprazole: a system biology study","volume":"14","author":"Hamzeloo-Moghadam","year":"2021","journal-title":"Gastroenterol. Hepatol. Bed Bench."},{"key":"10.1016\/j.jep.2026.121945_bib26","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1078\/09447110260573155","article-title":"Effect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa","volume":"9","author":"Hiruma-Lima","year":"2002","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121945_bib24","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1211\/0022357991772349","article-title":"Effects of an essential oil from the bark of Croton cajucara Benth. on experimental gastric ulcer models in rats and mice","volume":"51","author":"Hiruma-Lima","year":"1999","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2026.121945_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0378-8741(99)00127-0","article-title":"Gastroprotective effect of essential oil from Croton cajucara Benth. (Euphorbiaceae)","volume":"69","author":"Hiruma-Lima","year":"2000","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121945_bib27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000504570","article-title":"Use of evidence-based herbal medicines for patients with functional gastrointestinal disorders: a conceptional framework for risk-benefit assessment and regulatory approaches","volume":"38","author":"Holtmann","year":"2020","journal-title":"Dig. Dis."},{"key":"10.1016\/j.jep.2026.121945_bib28","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.3390\/biomedicines11051420","article-title":"Gastrointestinal disease: new diagnostic and therapeutic approaches","volume":"11","author":"Jab\u0142o\u0144ska","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jep.2026.121945_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/B978-012263951-7\/50006-5","article-title":"Biology and diseases of mice","volume":"35\u2013120","author":"Jacoby","year":"2002","journal-title":"Lab. Anim. Med."},{"key":"10.1016\/j.jep.2026.121945_bib30","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4103\/0975-1483.51881","article-title":"Gastroprotective effect of medicinal plants from Chapada do Araripe, Brazil","volume":"1","author":"Leite","year":"2009","journal-title":"J. Young Pharm."},{"key":"10.1016\/j.jep.2026.121945_bib31","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1080\/13880209.2017.1355926","article-title":"Antimicrobial, modulatory and chemical analysis of the oil of Croton limae","volume":"55","author":"Leite","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2026.121945_bib32","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1080\/15287394.2022.2146618","article-title":"Identification of bioactive compounds and cytogenotoxicity of the essential oil from the leaves of Croton heliotropiifolius Kunth","volume":"85","author":"Lopes","year":"2022","journal-title":"J. Toxicol. Environ. Health, Part A"},{"key":"10.1016\/j.jep.2026.121945_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106146","article-title":"Emerging pharmacotherapy for inflammatory bowel diseases","volume":"178","author":"Luo","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2026.121945_bib34","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.3390\/molecules28052361","article-title":"Chemistry and bioactivity of Croton essential oils: literature survey and Croton hirtus from Vietnam","volume":"28","author":"Luu-Dam","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121945_bib35","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jep.2019.03.032","article-title":"Medicinal plants of the Caatinga, northeastern Brazil: ethnopharmacopeia (1980\u20131990) of the late professor Francisco Jos\u00e9 de Abreu Matos","volume":"237","author":"Magalh\u00e3es","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121945_bib36","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.micpath.2017.09.034","article-title":"Chemical composition and modulation of bacterial drug resistance of the essential oil from leaves of Croton grewioides","volume":"111","author":"Medeiros","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.jep.2026.121945_bib37","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0021-5198(19)52438-6","article-title":"Effect of polyamines on acidified ethanol-induced gastric lesions in rats","volume":"33","author":"Mizui","year":"1983","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.jep.2026.121945_bib38","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2987\/8756-971X(2006)22[161:LAOEOF]2.0.CO;2","article-title":"Larvicidal activity of essential oils from Brazilian Croton species against Aedes aegypti","volume":"22","author":"Morais","year":"2006","journal-title":"L. J. Am. Mosq. Control Assoc."},{"key":"10.1016\/j.jep.2026.121945_bib39","first-page":"2404","article-title":"Essential oils from Croton species: Chemical composition, in vitro and in silico antileishmanial evaluation, antioxidant and cytotoxicity activities","volume":"30","author":"Morais","year":"2019","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.jep.2026.121945_bib40","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0021-5198(19)39795-1","article-title":"Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine","volume":"57","author":"Morimoto","year":"1991","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.jep.2026.121945_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116908","article-title":"Essential oil from leaves of Croton blanchetianus Baill does not present acute oral toxicity, has antigenotoxic action and reduces neurogenic and inflammatory nociception in mice","volume":"318","author":"Nascimento","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121945_bib42","first-page":"893","article-title":"Acaricidal activity against Tetranychus urticae and essential oil composition of four Croton species from Caatinga biome in northeastern Brazil","volume":"6","author":"Neves","year":"2011","journal-title":"Nat. Prod. Commun."},{"issue":"10","key":"10.1016\/j.jep.2026.121945_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0333527","article-title":"Evaluation of the antidiarrheal activity of dichloromethane-methanol crude extract of the aerial parts of Croton kinondoensis (Euphorbiaceae) in mice","volume":"20","author":"Noor","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2026.121945_bib44","series-title":"OECD Guidelines for the Testing of Chemicals, Section 4","article-title":"Test No. 425: acute oral toxicity: up-and-down procedure","year":"2022"},{"key":"10.1016\/j.jep.2026.121945_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118206","article-title":"Cytotoxic, acute oral toxicity, genotoxic and mutagenic assessment of the essential oil from fresh leaves of Croton argyrophyllus (Kunth.)","volume":"330","author":"Oliveira","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121945_bib46","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.phymed.2018.02.004","article-title":"Anti-inflammatory and anti-edematogenic action of the Croton campestris A. St.-Hil (Euphorbiaceae) essential oil and the compound \u03b2-caryophyllene in in vivo models","volume":"41","author":"Oliveira-Tintino","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121945_bib47","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1079\/BJN20061827","article-title":"The gastroprotective effect of the essential oil of Croton cajucara is different in normal rats than in malnourished rats","volume":"96","author":"Paula","year":"2006","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.jep.2026.121945_bib48","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.phymed.2008.02.024","article-title":"The antiulcer effect of Croton cajucara Benth in normoproteic and malnourished rats","volume":"15","author":"Paula","year":"2008","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.121945_bib49","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1590\/2179-8087.024212","article-title":"Esp\u00e9cies da caatinga como alternativa para o desenvolvimento de novos fitof\u00e1rmacos","volume":"21","author":"Pereira J\u00fanior","year":"2014","journal-title":"Floresta Ambient"},{"key":"10.1016\/j.jep.2026.121945_bib50","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4103\/0973-1296.149725","article-title":"Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species","volume":"11","author":"Pinheiro","year":"2015","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.jep.2026.121945_bib51","first-page":"122","article-title":"Chemical Composition and larvicidal activity against Aedes aegypti of essential oils from Croton jacobinenesis Baill","volume":"15","author":"Pinto","year":"2016","journal-title":"Bol. Latinoam. Caribe Plantas Med. Aromat."},{"key":"10.1016\/j.jep.2026.121945_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.103085","article-title":"The role of alpha-pinene on the NLRP3-Caspase 1 pathway in the ulcerative colitis model in rats","volume":"97","author":"Rahimi","year":"2025","journal-title":"Tissue Cell"},{"key":"10.1016\/j.jep.2026.121945_bib52","doi-asserted-by":"crossref","first-page":"8615","DOI":"10.1007\/s11033-023-08765-y","article-title":"The effects of alpha-pinene on the Nrf2-HO1 signaling pathway in gastric damage in rats","volume":"50","author":"Rahimi","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jep.2026.121945_bib54","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1093\/ije\/dyac033","article-title":"The global burden of peptic ulcer disease in 204 countries and territories from 1990 to 2019: a systematic analysis for the Global burden of disease study 2019","volume":"51","author":"Ren","year":"2022","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.jep.2026.121945_bib55","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1089\/jmf.2010.0173","article-title":"Involvement of glutathione, sulfhydryl compounds, nitric oxide, vasoactive intestinal peptide, and heat-shock protein-70 in the gastroprotective mechanism of Croton cajucara Benth. (Euphorbiaceae) essential oil","volume":"14","author":"Rozza","year":"2011","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2026.121945_bib56","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1590\/S2175-78602012000100014","article-title":"An overview of recent taxonomic studies on Euphorbiaceae sl in Brazil","volume":"63","author":"Secco","year":"2012","journal-title":"Rodriguesia"},{"key":"10.1016\/j.jep.2026.121945_bib57","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4103\/0974-8490.181465","article-title":"Croton grewioides Baill. (Euphorbiaceae) shows antidiarrheal activity in mice","volume":"8","author":"Silva","year":"2016","journal-title":"Pharmacogn. Res."},{"key":"10.1016\/j.jep.2026.121945_bib58","doi-asserted-by":"crossref","DOI":"10.1590\/0103-8478cr20161054","article-title":"Chemical composition and yield of essential oil from three Croton species","volume":"47","author":"Souza","year":"2017","journal-title":"Ci\u00eancia Rural."},{"key":"10.1016\/j.jep.2026.121945_bib59","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/tax.603013","article-title":"A revised infrageneric classification and molecular phylogeny of New world Croton (Euphorbiaceae)","volume":"60","author":"van Ee","year":"2011","journal-title":"Taxon"},{"key":"10.1016\/j.jep.2026.121945_bib60","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1080\/14786419.2024.2331025","article-title":"Chemodiversity essential oil from three species of Croton (Euphorbiaceae) and assessment of antimicrobial potential","volume":"39","author":"Venancio","year":"2025","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2026.121945_bib61","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.biopha.2017.02.005","article-title":"Gastroprotective effect and mechanism of action of Croton rhamnifolioides essential oil in mice","volume":"89","author":"Vidal","year":"2017","journal-title":"Biomed. Pharmacother."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126007993?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126007993?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:58:43Z","timestamp":1783101523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126007993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":61,"alternative-id":["S0378874126007993"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121945","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the antiulcerogenic and antidiarrheal activities of essential oils from Croton jacobinensis Baill. (Euphorbiaceae) and its major compound \u03b1-pinene","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121945","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121945"}}