{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T14:17:13Z","timestamp":1783174633019,"version":"3.54.6"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2023-KH139287"],"award-info":[{"award-number":["RS-2023-KH139287"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jep.2026.121961","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:27:37Z","timestamp":1780417657000},"page":"121961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Traditional herbal medicine Hyangsapyeongwi-san inhibits alcohol-induced gastric injury in mice by regulating NLRP3 inflammasome signaling"],"prefix":"10.1016","volume":"369","author":[{"given":"Eugene","family":"Huh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Gyoung","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hye","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingoo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungmin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minsik","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suji","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Hoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyangsook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Pyo","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8189-4066","authenticated-orcid":false,"given":"Myung Sook","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.121961_bib1","series-title":"Gastritis","author":"Azer","year":"2025"},{"issue":"2","key":"10.1016\/j.jep.2026.121961_bib2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2026.121961_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.879021","article-title":"The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases","volume":"14","author":"Blevins","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"4","key":"10.1016\/j.jep.2026.121961_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2165\/00003495-198224040-00002","article-title":"Ranitidine: a review of its pharmacology and therapeutic use in peptic ulcer disease and other allied diseases","volume":"24","author":"Brogden","year":"1982","journal-title":"Drugs"},{"issue":"9","key":"10.1016\/j.jep.2026.121961_bib5","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1080\/14656566.2024.2373348","article-title":"Perspectives on the current pharmacological strategies for chronic and atrophic gastritis: can more be done?","volume":"25","author":"Dilaghi","year":"2024","journal-title":"Expert Opin. Pharmacother."},{"issue":"1","key":"10.1016\/j.jep.2026.121961_bib6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12964-024-02017-7","article-title":"Helicobacter pylori infection promotes M1 macrophage polarization and gastric inflammation by activation of NLRP3 inflammasome via TNF\/TNFR1 axis","volume":"23","author":"Fei","year":"2025","journal-title":"Cell Commun. Signal."},{"issue":"12","key":"10.1016\/j.jep.2026.121961_bib7","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"3","key":"10.1016\/j.jep.2026.121961_bib8","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/jgh.15257","article-title":"Role of nucleotide binding oligomerization domain-like receptor protein 3 inflammasome in stress-induced gastric injury","volume":"36","author":"Higashimori","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2026.121961_bib9","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.redox.2017.04.020","article-title":"Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome","volume":"12","author":"Hoyt","year":"2017","journal-title":"Redox Biol."},{"issue":"13","key":"10.1016\/j.jep.2026.121961_bib10","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2023.38.e115","article-title":"Clinical Practice Guideline for Gastritis in Korea","volume":"38","author":"Kang","year":"2023","journal-title":"J. Kor. Med. Sci."},{"issue":"1","key":"10.1016\/j.jep.2026.121961_bib11","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jep.2013.11.027","article-title":"Chemical composition, cytotoxicity and in vitro antitrypanosomal and antiplasmodial activity of the essential oils of four Cymbopogon species from Benin","volume":"151","author":"Kpoviessi","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2026.121961_bib12","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1002\/ptr.2840","article-title":"Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease","volume":"23","author":"Lee","year":"2009","journal-title":"Phytother Res."},{"issue":"2","key":"10.1016\/j.jep.2026.121961_bib13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/00952990.2023.2297349","article-title":"Ethanol causes non-communicable disease through activation of NLRP3 inflammasome: a review on mechanism of action and potential interventions","volume":"50","author":"Liu","year":"2024","journal-title":"Am. J. Drug Alcohol Abuse"},{"issue":"1","key":"10.1016\/j.jep.2026.121961_bib14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-024-01958-2","article-title":"Pyroptosis in health and disease: mechanisms, regulation and clinical perspective","volume":"9","author":"Liu","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jep.2026.121961_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.978190","article-title":"NLRP3 inflammasome in digestive diseases: from mechanism to therapy","volume":"13","author":"Qiang","year":"2022","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.jep.2026.121961_bib16","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1345\/aph.10122","article-title":"Ping wei san, a Chinese medicine for gastrointestinal disorders","volume":"35","author":"Riedlinger","year":"2001","journal-title":"Ann. Pharmacother."},{"issue":"4","key":"10.1016\/j.jep.2026.121961_bib17","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1053\/j.gastro.2021.06.078","article-title":"AGA clinical practice update on the diagnosis and management of atrophic gastritis: expert review","volume":"161","author":"Shah","year":"2021","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jep.2026.121961_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13020-021-00565-5","article-title":"Qingwei San treats oral ulcer subjected to stomach heat syndrome in db\/db mice by targeting TLR4\/MyD88\/NF-kappaB pathway","volume":"17","author":"Shi","year":"2022","journal-title":"Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2026.121961_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0304-3835(03)00002-8","article-title":"Blocking of NF-kappaB activation enhances the tumor necrosis factor alpha-induced apoptosis of a human gastric cancer cell line","volume":"193","author":"Ueda","year":"2003","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.jep.2026.121961_bib20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12906-020-02906-7","article-title":"Poncirin attenuates CCL4-induced liver injury through inhibition of oxidative stress and inflammatory cytokines in mice","volume":"20","author":"Ullah","year":"2020","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.jep.2026.121961_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107210","article-title":"Poncirin ameliorates oxygen glucose deprivation\/reperfusion injury in cortical neurons via inhibiting NOX4-mediated NLRP3 inflammasome activation","volume":"102","author":"Wang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2026.121961_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1074606","article-title":"NLRP3 inflammasome-induced pyroptosis in digestive system tumors","volume":"14","author":"Wen","year":"2023","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.jep.2026.121961_bib23","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/jaoacint\/qsad024","article-title":"Comprehensive characterization and identification of chemical constituents of Xiangsha pingwei pills by UPLC-Q-TOF-MS","volume":"106","author":"Xiong","year":"2023","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.jep.2026.121961_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172672","article-title":"Simvastatin induces differentiation in rabbit articular chondrocytes via Wnt\/beta-catenin pathway","volume":"863","author":"Yu","year":"2019","journal-title":"Eur. J. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126008159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126008159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:29:29Z","timestamp":1783171769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126008159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":24,"alternative-id":["S0378874126008159"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121961","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Traditional herbal medicine Hyangsapyeongwi-san inhibits alcohol-induced gastric injury in mice by regulating NLRP3 inflammasome signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121961","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121961"}}