{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:26:04Z","timestamp":1791861964328,"version":"4.3.4"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jep.2026.121962","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:46:16Z","timestamp":1781048776000},"page":"121962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Neuroprotective effects of aqueous extract of Pterocarpus mildbraedii Harms. on some biochemical markers in Alzheimer's disease using an AlCl3-induced rat model: Integrated ADMET, network pharmacology, molecular docking, and in vivo experimental validation"],"prefix":"10.1016","volume":"370","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-4174","authenticated-orcid":false,"given":"Yolande Sandrine","family":"Mengue Ngadena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1718-7657","authenticated-orcid":false,"given":"Marie Blondelle","family":"Njoupoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0698-9473","authenticated-orcid":false,"given":"Franklin","family":"Zemo Gamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0233-5299","authenticated-orcid":false,"given":"Pascal Emmanuel","family":"Owona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9694-9779","authenticated-orcid":false,"given":"Ronald","family":"Bidingha A Goufani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paule Cynthia","family":"Bouguem Yandja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1649-846X","authenticated-orcid":false,"given":"Daniel","family":"Akingbolabo Ogunlakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2963-9994","authenticated-orcid":false,"given":"Danielle Claude","family":"Bilanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6092-3251","authenticated-orcid":false,"given":"Samir","family":"Chtita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5315-6285","authenticated-orcid":false,"given":"Paul D\u00e9sir\u00e9","family":"Dzeufiet Djomeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.121962_bib1","article-title":"Lessons from lonely flies: molecular and neuronal mechanisms underlying social isolation and locomotor deficits","volume":"156","author":"Agrawal","year":"2024","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.jep.2026.121962_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13195-024-01542-4","article-title":"Association of oxidative stress and inflammatory metabolites with Alzheimer's disease cerebrospinal fluid biomarkers in mild cognitive impairment","volume":"16","author":"Ahmad","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.jep.2026.121962_bib3","doi-asserted-by":"crossref","first-page":"72827","DOI":"10.1007\/s11356-022-20735-8","article-title":"Amelioration of aluminum-induced hepatic and nephrotoxicity by Premna odorata extract is mediated by lowering MMP9 and TGF-\u03b2 gene alterations in Wistar rat","volume":"29","author":"Ahmed","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.jep.2026.121962_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3390\/nutraceuticals4020015","article-title":"The effect of oral GABA on the nervous system: potential for therapeutic intervention","volume":"4","author":"Almutairi","year":"2024","journal-title":"Nutraceuticals"},{"key":"10.1016\/j.jep.2026.121962_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150218","article-title":"GABAergic implications in anxiety and related disorders","volume":"724","author":"Arora","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2026.121962_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.plaphy.2004.12.003","article-title":"Exposure to toxic concentrations of aluminum activates a MAPK-like protein in cell suspension cultures of Coffea arabica","volume":"43","author":"Arroyo-Serralta","year":"2005","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.jep.2026.121962_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/9780470110218.ch1","article-title":"Assay methods for cholinesterases","volume":"5","author":"Augustinsson","year":"1957","journal-title":"Methods Biochem. Anal."},{"key":"10.1016\/j.jep.2026.121962_bib8","series-title":"Natural Medicinal Plants","article-title":"Natural products altering GABAergic transmission","author":"Banerjee","year":"2021"},{"key":"10.1016\/j.jep.2026.121962_bib9","first-page":"1105","article-title":"Review on histological and functional effect of aluminium chloride on cerebral cortex of the brain","volume":"6","author":"Berihu","year":"2015","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"10.1016\/j.jep.2026.121962_bib10","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s10571-022-01271-y","article-title":"Impact of calcium influx on endoplasmic reticulum in excitotoxic neurons: role of chemical chaperone 4-PBA","volume":"43","author":"Bhardwaj","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.jep.2026.121962_bib11","first-page":"76","article-title":"The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease","volume":"14","author":"Budni","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jep.2026.121962_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117211","article-title":"Calcium dysregulation in Alzheimer's disease: unraveling the molecular nexus of neuronal dysfunction and therapeutic opportunities","volume":"242","author":"Chaudhary","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2026.121962_bib13","first-page":"28297","article-title":"Free radicals scavenging and antioxidant activities of ethanol leaf extract of Pterocarpus mildbraedii harms","volume":"13","author":"Chilaka","year":"2021","journal-title":"Int. J. Curr. Res."},{"key":"10.1016\/j.jep.2026.121962_bib14","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-023-00639-y","article-title":"Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases","volume":"18","author":"Chu","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.jep.2026.121962_bib15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3390\/nu17010078","article-title":"Mechanistic and therapeutic insights into flavonoid-based inhibition of acetylcholinesterase: implications for neurodegenerative diseases","volume":"17","author":"Cichon","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2026.121962_bib16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41386-021-01100-8","article-title":"Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine","volume":"47","author":"Cools","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jep.2026.121962_bib17","first-page":"1","article-title":"Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer's disease","author":"Dey","year":"2022","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.jep.2026.121962_bib18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulphydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jep.2026.121962_bib19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2026.121962_bib20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.9734\/ejmp\/2020\/v31i1030278","article-title":"Cardioprotective activities of Pterocarpus mildbraedii leaves on isoproterenol-induced myocardial infarction in rats","volume":"31","author":"Fajobi","year":"2020","journal-title":"Eur. J. Med. Plants"},{"key":"10.1016\/j.jep.2026.121962_bib21","first-page":"1047","article-title":"Neuroprotective effects of Nigella sativa oil on anxiety and locomotor activity in rodents subjected to oxidative stress","volume":"95","author":"Farhat","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.121962_bib22","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0736-0266(00)00049-8","article-title":"The effects of static and intermittent compression on nitric oxide production in articular cartilage explants","volume":"19","author":"Fermor","year":"2001","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.jep.2026.121962_bib23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.17816\/ACEN.2017.4.5","article-title":"Expression of MAPK and inflammasomes in cells of the brain in experimental Alzheimer's disease","volume":"11","author":"Gorina","year":"2017","journal-title":"Ann. Clin. Exp. Neurol."},{"issue":"3","key":"10.1016\/j.jep.2026.121962_bib24","doi-asserted-by":"crossref","DOI":"10.1177\/1559325818798282","article-title":"Nonmonotonic dose\u2013response curves occur in dose ranges that are relevant to regulatory decision-making","volume":"16","author":"Hill","year":"2018","journal-title":"Dose-Response"},{"key":"10.1016\/j.jep.2026.121962_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106720","article-title":"An MMP-9 exclusive neutralizing antibody attenuates blood-brain barrier breakdown in mice with stroke and reduces stroke patient-derived MMP-9 activity","volume":"190","author":"Ji","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.jep.2026.121962_bib26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2967\/jnmt.125.271777","article-title":"Brain primer, Part 1: the neuroanatomy and physiology behind memory and aging","volume":"54","author":"Johnson","year":"2026","journal-title":"J. Nucl. Med. Technol."},{"key":"10.1016\/j.jep.2026.121962_bib27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13064-026-00243-y","article-title":"Molecular mechanisms of aging in the pathogenesis of Alzheimer's disease","volume":"21","author":"Kakkar","year":"2026","journal-title":"Discov. Neurosci."},{"key":"10.1016\/j.jep.2026.121962_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102481","article-title":"Pathogenesis, diagnostics, and therapeutics for Alzheimer's disease: breaking the memory barrier","volume":"101","author":"Kamatham","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.jep.2026.121962_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/bn\/8815830","article-title":"Antiamnesic and neurotrophic effects of Parkia biglobosa (Jacq.) R. Br. (Fabaceae) aqueous extract on in vivo and in vitro models of excitotoxicity","volume":"2025","author":"Kandeda","year":"2025","journal-title":"Behav. Neurol."},{"key":"10.1016\/j.jep.2026.121962_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6610864","article-title":"Ziziphus jujuba (Rhamnaceae) alleviates working memory impairment and restores neurochemical alterations in the prefrontal cortex of D-galactose-treated rats","volume":"2021","author":"Kandeda","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2026.121962_bib31","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3390\/ijms21041505","article-title":"Lipids and Alzheimer's disease","volume":"21","author":"Kao","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.121962_bib32","doi-asserted-by":"crossref","first-page":"6976","DOI":"10.1021\/acsomega.3c08791","article-title":"Barbaloin's Chemical intervention in aluminum chloride induced cognitive deficits and changes in rats through modulation of oxidative stress, cytokines, and BDNF expression","volume":"9","author":"Kazmi","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.jep.2026.121962_bib33","article-title":"The neuroprotective effect of Xylopia parviflora against aluminum chloride-induced neurotoxicity in rats","volume":"8","author":"Kemadjou","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2026.121962_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2026.115814","article-title":"Aluminum chloride in Alzheimer's disease: a dual focus on molecular mechanisms and rat experimental models","volume":"403","author":"Khattab","year":"2026","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jep.2026.121962_bib35","article-title":"Neurotherapeutics across blood\u2013brain barrier: screening of BBB-permeable and CNS-active molecules for neurodegenerative disease","volume":"16","author":"Kumar","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2026.121962_bib36","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40035-024-00432-x","article-title":"Updates in Alzheimer's disease: from basic research to diagnosis and therapies","volume":"13","author":"Liu","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.jep.2026.121962_bib37","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer disease: an update on pathobiology and treatment strategies","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jep.2026.121962_bib38","first-page":"119","article-title":"The fluorometric measurement of glutamic decarboxylase activity in brain","volume":"232","author":"Lowe","year":"1958","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2026.121962_bib39","volume":"183","author":"Mengue","year":"2025","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2026.121962_bib40","doi-asserted-by":"crossref","first-page":"82","DOI":"10.9734\/ajrimps\/2023\/v12i3224","article-title":"Bridelia atroviridis (Phyllanthaceae) aqueous extract attenuates scopolamine-induced amnesia and depression in rat: role of cholinergic, monoaminergic, and antioxidant mechanisms","volume":"12","author":"Mengue","year":"2023","journal-title":"Asian J. Res. Med. Pharm. Sci."},{"key":"10.1016\/j.jep.2026.121962_bib41","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6038996","article-title":"Flavonoids as promising neuroprotectants and their therapeutic potential against Alzheimer's disease","author":"Minocha","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2026.121962_bib42","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2026.121962_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharma5010001","article-title":"Disparity of prescribed psychotropics in Alzheimer's disease with neuropsychiatric symptoms","volume":"5","author":"Nathaniel","year":"2025","journal-title":"Pharmacoepidemiology"},{"key":"10.1016\/j.jep.2026.121962_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2025.115794","article-title":"Total flavonoid content revised: an overview of past, present, and future determinations in phytochemical analysis","volume":"700","author":"Nicolescu","year":"2025","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2026.121962_bib45","doi-asserted-by":"crossref","first-page":"984","DOI":"10.3390\/ijms27020984","article-title":"Roles of MAPKs, including those activated by BDNF\/TrkB, and their contribution in neurodegenerative diseases","volume":"27","author":"Numakawa","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.121962_bib46","article-title":"Quercetin mitigates aluminium chloride-induced neurotoxicity by modulating oxidative stress, neuroinflammation, and neurotransmitter dysregulation in rats","author":"Onaolapo","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.jep.2026.121962_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e33843","volume":"10","author":"Owona","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2026.121962_bib48","article-title":"Exploring the effects of Pterocarpus soyauxii against menopause-related NAFLD based on network pharmacology, molecular docking, and experimental validation","volume":"22","author":"Owona","year":"2025","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jep.2026.121962_bib49","article-title":"Phytoestrogens 7-O-acetylformonetin and khrinone A from Pterocarpus soyauxii Taub. inhibit human papillomavirus replication: an integrative immunological, chemical, and computational approach to cervical cancer prevention","author":"Owona","year":"2025","journal-title":"Chin. J. Anal. Chem."},{"key":"10.1016\/j.jep.2026.121962_bib50","author":"Owona","year":"2025","journal-title":"J. Comput. Biophys. Chem."},{"key":"10.1016\/j.jep.2026.121962_bib51","article-title":"Anti-breast cancer effects of Pterocarpus soyauxii Taub aqueous extract and its compounds by integrating ADMET, network pharmacology, molecular docking, dynamic simulation, CLC-Pred and pdCSMCancer\/PPI approaches, and in vitro validation","volume":"353","author":"Owona","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121962_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2026.121563","article-title":"Huangqi Guizhi Wuwu decoction promotes neuroprotection and functional recovery after ischemic stroke via activation of the PI3K\/Akt\/mTOR signaling pathway and modulation of microglial polarization","volume":"365","author":"Pan","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121962_bib53","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.3390\/nu16244368","article-title":"Mechanisms and potential benefits of neuroprotective agents in neurological health","volume":"16","author":"Pekdemir","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2026.121962_bib54","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.3390\/ijms25115633","article-title":"Valosin-containing protein (VCP): a review of its diverse molecular functions and clinical phenotypes","volume":"25","author":"Pontifex","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.121962_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2015.00280","article-title":"A delicate balance: role of MMP-9 in brain development and pathophysiology of neurodevelopmental disorders","volume":"9","author":"Reinhard","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"6","key":"10.1016\/j.jep.2026.121962_bib56","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.3390\/molecules27061770","article-title":"Phenolics as GABAA receptor ligands: an updated review","volume":"27","author":"R\u00edos","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.121962_bib57","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/antiox9010061","article-title":"Polyphenols from food and natural products: neuroprotection and safety","volume":"9","author":"Silva","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2026.121962_bib58","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0003-2697(72)90132-7","article-title":"Colorimetric assay of catalase","volume":"47","author":"Sinha","year":"1972","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2026.121962_bib59","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.yebeh.2014.11.022","article-title":"Effects of a lyophilized aqueous extract of Feretia apodanthera Del (Rubiaceae) on pentylenetetrazole-induced kindling, oxidative stress and cognitive impairment in mice","volume":"43","author":"Taiwe","year":"2015","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.jep.2026.121962_bib60","first-page":"1","article-title":"Hepatoprotective properties of methanol leaf extract of Pterocarpus mildbraedii Harms on carbon tetrachloride- induced hepatotoxicity in albino rats (Rattus norvegicus)","volume":"28","author":"Thelma","year":"2019","journal-title":"Eur. J. Med. Plants"},{"key":"10.1016\/j.jep.2026.121962_bib61","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.3390\/ijms24087228","article-title":"Aluminium in the human brain: routes of penetration, toxicity, and resulting complications","volume":"24","author":"\u0141ukasz","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.121962_bib62","first-page":"89","article-title":"Nephroprotective effect of aqueous leaf extract of Pterocarpus mildbraedii on carbon tetrachloride-induced nephrotoxicity in male Wistar rats","volume":"50","author":"Urom","year":"2023","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.jep.2026.121962_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2025.115526","article-title":"The involvement of Na,K-ATPase enzyme in the development of Alzheimer's disease","volume":"396","author":"Vrbjar","year":"2026","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jep.2026.121962_bib64","doi-asserted-by":"crossref","first-page":"75","DOI":"10.18773\/austprescr.2024.021","article-title":"New and emerging drug therapies for Alzheimer disease","volume":"47","author":"Waite","year":"2024","journal-title":"Aust. Prescr."},{"key":"10.1016\/j.jep.2026.121962_bib65","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s11033-020-05361-2","article-title":"Biological barriers, and the influence of protein binding on the passage of drugs across them","volume":"47","author":"Wanat","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jep.2026.121962_bib66","series-title":"Global Dementia Observatory (GDO)","year":"2026"},{"key":"10.1016\/j.jep.2026.121962_bib67","first-page":"305","article-title":"The thiobarbituric acid reagent as a test for the oxidation of unsaturated fatty acids by various agents","volume":"24","author":"Wilbur","year":"1949","journal-title":"Arch. Biochem."},{"key":"10.1016\/j.jep.2026.121962_bib68","article-title":"Current understanding of the interactions between metal ions and apolipoprotein E in Alzheimer's disease","volume":"172","author":"Xu","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jep.2026.121962_bib69","article-title":"Application of cresyl violet staining in neurodegenerative disease models: standardized protocols for neuronal density assessment","volume":"402","author":"Yang","year":"2025","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jep.2026.121962_bib70","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1423-0127-19-51","article-title":"Aluminum overload increases oxidative stress in four functional brain areas of neonatal rats","volume":"19","author":"Yuan","year":"2012","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.jep.2026.121962_bib71","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1186\/s40001-025-02886-9","article-title":"Pathological mechanisms and treatment progression of Alzheimer's disease","volume":"30","author":"Zhang","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.jep.2026.121962_bib72","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1021\/acs.jafc.6b00331","article-title":"Polyphenol\u2013aluminum complex formation: implications for aluminum tolerance in plants","volume":"64","author":"Zhang","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2026.121962_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e40665","article-title":"GABA and its receptors' mechanisms in the treatment of insomnia","volume":"10","author":"Zhu","year":"2024","journal-title":"Heliyon"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126008160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126008160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:58:56Z","timestamp":1783036736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126008160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":73,"alternative-id":["S0378874126008160"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121962","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective effects of aqueous extract of Pterocarpus mildbraedii Harms. on some biochemical markers in Alzheimer's disease using an AlCl3-induced rat model: Integrated ADMET, network pharmacology, molecular docking, and in vivo experimental validation","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121962","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121962"}}