{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T14:15:44Z","timestamp":1783174544632,"version":"3.54.6"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7232093"],"award-info":[{"award-number":["7232093"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007301","name":"Kunming University of Science and Technology","doi-asserted-by":"publisher","award":["KUST-PE2022006Y"],"award-info":[{"award-number":["KUST-PE2022006Y"]}],"id":[{"id":"10.13039\/501100007301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470436"],"award-info":[{"award-number":["82470436"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170280"],"award-info":[{"award-number":["82170280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jep.2026.121964","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:49:48Z","timestamp":1780415388000},"page":"121964","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Extract of Agathis dammara and its active monomer araucarone attenuate metabolic dysfunction-associated steatotic liver disease by targeting carboxylesterase 2"],"prefix":"10.1016","volume":"370","author":[{"given":"Ankang","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhewei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zejiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingkun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0627-9968","authenticated-orcid":false,"given":"Rong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jep.2026.121964_bib1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s13679-024-00582-z","article-title":"Resmetirom and metabolic dysfunction-associated steatohepatitis: perspectives on multidisciplinary management from global healthcare professionals","volume":"13","author":"Au","year":"2024","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.jep.2026.121964_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115742","article-title":"Discovery of novel carboxylesterase 2 inhibitors for the treatment of delayed diarrhea and ulcerative colitis","volume":"215","author":"Cao","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"12","key":"10.1016\/j.jep.2026.121964_bib3","article-title":"Lipid metabolism in MASLD and MASH: from mechanism to the clinic","volume":"6","author":"Carli","year":"2024","journal-title":"JHEP Rep."},{"key":"10.1016\/j.jep.2026.121964_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101725","article-title":"Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism","volume":"72","author":"Chalhoub","year":"2023","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.jep.2026.121964_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2021.100075","article-title":"Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease","volume":"62","author":"Chalhoub","year":"2021","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.jep.2026.121964_bib6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.7570\/jomes23052","article-title":"Metabolic dysfunction-associated steatotic liver disease (MASLD): a state-of-the-art review","volume":"32","author":"Chan","year":"2023","journal-title":"J. Obes. Metab. Syndr."},{"key":"10.1016\/j.jep.2026.121964_bib7","first-page":"90","article-title":"Damar minyak of agathis","author":"Di","year":"2013","journal-title":"Furniture Inter. Des"},{"issue":"5","key":"10.1016\/j.jep.2026.121964_bib8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3390\/genes12050645","article-title":"The role of lipid sensing nuclear receptors (PPARs and LXR) and metabolic lipases in obesity, diabetes and NAFLD","volume":"12","author":"Dixon","year":"2021","journal-title":"Genes"},{"issue":"2","key":"10.1016\/j.jep.2026.121964_bib9","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.apsb.2021.09.019","article-title":"Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma","volume":"12","author":"Du","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"24","key":"10.1016\/j.jep.2026.121964_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232415489","article-title":"Non-alcoholic fatty liver disease (NAFLD) pathogenesis and natural products for prevention and treatment","volume":"23","author":"Guo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jep.2026.121964_bib11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2309000","article-title":"A phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis","volume":"390","author":"Harrison","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2026.121964_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155937","article-title":"Obesity and MASLD: is weight loss the (only) key to treat metabolic liver disease?","volume":"157","author":"Huttasch","year":"2024","journal-title":"Metabolism"},{"issue":"5","key":"10.1016\/j.jep.2026.121964_bib13","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s10620-015-3977-1","article-title":"Animal models of nonalcoholic steatohepatitis: eat, delete, and inflame","volume":"61","author":"Ibrahim","year":"2016","journal-title":"Dig. Dis. Sci."},{"issue":"3","key":"10.1016\/j.jep.2026.121964_bib14","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.apsb.2022.01.009","article-title":"Optical substrates for drug-metabolizing enzymes: recent advances and future perspectives","volume":"12","author":"Jin","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"6","key":"10.1016\/j.jep.2026.121964_bib15","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s40265-024-02045-0","article-title":"Resmetirom: first approval","volume":"84","author":"Keam","year":"2024","journal-title":"Drugs"},{"issue":"8","key":"10.1016\/j.jep.2026.121964_bib16","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/apt.13981","article-title":"Randomised clinical trial: the efficacy and safety of oltipraz, a liver X receptor alpha-inhibitory dithiolethione in patients with non-alcoholic fatty liver disease","volume":"45","author":"Kim","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"7","key":"10.1016\/j.jep.2026.121964_bib17","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/0031-9422(90)83045-3","article-title":"Chemistry of Fijian plants. 6. Ent-pimarane and ent-abietane diterpenes from Euphorbia-Fidjiana","volume":"29","author":"Lal","year":"1990","journal-title":"Phytochemistry"},{"issue":"6","key":"10.1016\/j.jep.2026.121964_bib18","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1002\/hep.28472","article-title":"Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice","volume":"63","author":"Li","year":"2016","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jep.2026.121964_bib19","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s13238-017-0437-z","article-title":"Carboxylesterases in lipid metabolism: from mouse to human","volume":"9","author":"Lian","year":"2018","journal-title":"Protein Cell"},{"issue":"44","key":"10.1016\/j.jep.2026.121964_bib20","doi-asserted-by":"crossref","first-page":"11647","DOI":"10.1021\/acs.jafc.8b04116","article-title":"Ursolic acid, a novel liver X receptor \u03b1 (LXR\u03b1) antagonist inhibiting ligand-induced nonalcoholic fatty liver and drug-induced lipogenesis","volume":"66","author":"Lin","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"24","key":"10.1016\/j.jep.2026.121964_bib21","article-title":"Natural small molecule hinokitone mitigates NASH fibrosis by targeting regulation of FXR-mediated hepatocyte apoptosis","volume":"S2090\u20131232","author":"Ma","year":"2024","journal-title":"J. Adv. Res."},{"issue":"8","key":"10.1016\/j.jep.2026.121964_bib22","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/j.drudis.2022.05.007","article-title":"Impact of fenofibrate on NAFLD\/NASH: a genetic perspective","volume":"27","author":"Mahmoudi","year":"2022","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jep.2026.121964_bib23","article-title":"Application of Agathis dammara extract in the preparation of products against non-alcoholic fatty liver disease","volume":"7","author":"Qi","year":"2021","journal-title":"China Patent CN201911255818"},{"issue":"3","key":"10.1016\/j.jep.2026.121964_bib24","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.celrep.2016.12.070","article-title":"Human carboxylesterase 2 reverses obesity-induced diacylglycerol accumulation and glucose intolerance","volume":"18","author":"Ruby","year":"2017","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.jep.2026.121964_bib25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.5694\/mja2.50142","article-title":"An updated review of lipid-modifying therapy","volume":"211","author":"Simons","year":"2019","journal-title":"Med. J. Aust."},{"issue":"6","key":"10.1016\/j.jep.2026.121964_bib26","doi-asserted-by":"crossref","first-page":"670","DOI":"10.2174\/1389557520666201117110834","article-title":"A review of research progress on Agathis dammara and its application prospects for cardiovascular diseases and fatty liver disease","volume":"21","author":"Wang","year":"2021","journal-title":"Mini Rev. Med. Chem."},{"issue":"5","key":"10.1016\/j.jep.2026.121964_bib27","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.apsb.2018.05.005","article-title":"Human carboxylesterases: a comprehensive review","volume":"8","author":"Wang","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"issue":"4","key":"10.1016\/j.jep.2026.121964_bib28","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s11418-024-01816-z","article-title":"Hinokione: an abietene diterpene with pancreatic \u03b2 cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara","volume":"78","author":"Wang","year":"2024","journal-title":"J. Nat. Med."},{"issue":"3","key":"10.1016\/j.jep.2026.121964_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2024.103910","article-title":"NAFLD and NASH: etiology, targets and emerging therapies","volume":"29","author":"Wei","year":"2024","journal-title":"Drug Discov. Today"},{"issue":"2","key":"10.1016\/j.jep.2026.121964_bib30","doi-asserted-by":"crossref","first-page":"G166","DOI":"10.1152\/ajpgi.00315.2020","article-title":"Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice","volume":"320","author":"Xu","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"11","key":"10.1016\/j.jep.2026.121964_bib31","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1007\/s00216-020-02494-y","article-title":"Construction and application of a high-content analysis for identifying human carboxylesterase 2 inhibitors in living cell system","volume":"412","author":"Xue","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"issue":"4","key":"10.1016\/j.jep.2026.121964_bib32","first-page":"492","article-title":"Novel araucarene diterpenes from Agathis dammara exert hypoglycemic activity by promoting pancreatic \u03b2 cell regeneration and glucose uptake","volume":"23","author":"Yu","year":"2025","journal-title":"Chin. J. Nat. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.121964_bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s13659-024-00440-4","article-title":"Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others","volume":"14","author":"Yu","year":"2024","journal-title":"Nat. Prod. Bioprospect."},{"issue":"2","key":"10.1016\/j.jep.2026.121964_bib34","first-page":"239","article-title":"Agathis dammara extract and its monomer araucarone attenuate abdominal aortic aneurysm in mice","volume":"39","author":"Zhang","year":"2025","journal-title":"Cardiovasc. Drugs Ther."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126008184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126008184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:19:20Z","timestamp":1783171160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126008184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":34,"alternative-id":["S0378874126008184"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121964","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extract of Agathis dammara and its active monomer araucarone attenuate metabolic dysfunction-associated steatotic liver disease by targeting carboxylesterase 2","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121964","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121964"}}