{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:48:35Z","timestamp":1785905315057,"version":"3.56.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010871","name":"Recruitment Program of Global Experts","doi-asserted-by":"publisher","award":["YNWR-CYJS-2019-011"],"award-info":[{"award-number":["YNWR-CYJS-2019-011"]}],"id":[{"id":"10.13039\/501100010871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011238","name":"State Key Laboratory of Phytochemistry and Plant Resources in West China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011238","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1802287"],"award-info":[{"award-number":["U1802287"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011190","name":"Kunming Institute of Botany, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011198","name":"State Key Laboratory of Drug Research, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jep.2026.121983","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T18:46:34Z","timestamp":1781462794000},"page":"121983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Anti-metastatic effect of Paris polyphylla var. yunnanensis and Paris fargesii in esophageal cancer preclinical models"],"prefix":"10.1016","volume":"370","author":[{"given":"Jing","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Gar-Lee","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Ling","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Shan","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Bik-San Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jep.2026.121983_bib1","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1016\/S0031-9422(00)80653-6","article-title":"Carbon-13 NMR spectroscopy of steroidal sapogenins and steroidal saponins","volume":"24","author":"Agrawal","year":"1985","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2026.121983_bib2","doi-asserted-by":"crossref","DOI":"10.1177\/15330338211033077","article-title":"EMT participates in the regulation of exosomes secretion and function in esophageal cancer cells","volume":"20","author":"Chen","year":"2021","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.jep.2026.121983_bib4","first-page":"91","article-title":"Studies on the saponin components of plants in Yunnan: steroid glycosides of Paris polyphylla var. yunnanensis","volume":"5","author":"Chen","year":"1983","journal-title":"Acta Bot. Yunnanica"},{"issue":"15","key":"10.1016\/j.jep.2026.121983_bib5","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1021\/jo00276a033","article-title":"Diosgenin-bearing, molluscicidal saponins from Allium vineale: an NMR approach for the structural assignment of oligosaccharide units","volume":"54","author":"Chen","year":"1989","journal-title":"J. Org. Chem."},{"issue":"1","key":"10.1016\/j.jep.2026.121983_bib3","first-page":"111","article-title":"Studies on the saponin components of plants in Yunnan X. Two new steroidal saponins of Paris axialis H Li","volume":"6","author":"Chen","year":"1984","journal-title":"Acta Bot. Yunnanica"},{"issue":"2","key":"10.1016\/j.jep.2026.121983_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.canlet.2004.06.042","article-title":"Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells","volume":"217","author":"Cheung","year":"2005","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jep.2026.121983_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.113068","article-title":"Structures\/cytotoxicity\/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A","volume":"210","author":"Dai","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"9","key":"10.1016\/j.jep.2026.121983_bib8","doi-asserted-by":"crossref","first-page":"14535","DOI":"10.1002\/jcp.28160","article-title":"The basics of epithelial\u2013mesenchymal transition (EMT): a study from a structure, dynamics, and functional perspective","volume":"234","author":"Das","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"9","key":"10.1016\/j.jep.2026.121983_bib9","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/ncb434","article-title":"Differentiation plasticity regulated by TGF-beta family proteins in development and disease","volume":"9","author":"Derynck","year":"2007","journal-title":"Nat. Cell Biol."},{"issue":"7","key":"10.1016\/j.jep.2026.121983_bib10","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3390\/molecules21070965","article-title":"Targeting epithelial\u2013mesenchymal transition (EMT) to overcome drug resistance in cancer","volume":"21","author":"Du","year":"2016","journal-title":"Molecules"},{"issue":"23","key":"10.1016\/j.jep.2026.121983_bib11","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1056\/NEJMra035010","article-title":"Esophageal cancer","volume":"349","author":"Enzinger","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2026.121983_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117272","article-title":"Comparative metabolome profiling of Paris polyphylla var. yunnanensis cultivars and Paris luquanensis and their biological activity in zebrafish model","volume":"319","author":"Gao","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.jep.2026.121983_bib13","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1093\/annonc\/mds069","article-title":"Trends in cancer mortality in China: an update","volume":"23","author":"Guo","year":"2012","journal-title":"Ann. Oncol."},{"issue":"24","key":"10.1016\/j.jep.2026.121983_bib14","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.7314\/APJCP.2014.15.24.10911","article-title":"Steroidal saponins from Paris polyphylla suppress adhesion, migration and invasion of human lung cancer A549 cells via down-regulating MMP-2 and MMP-9","volume":"15","author":"He","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.jep.2026.121983_bib15","series-title":"Investigation on Resources of Rare and Endangered Medicinal Plants in China","first-page":"157","author":"Huang","year":"2012"},{"key":"10.1016\/j.jep.2026.121983_bib16","series-title":"A Monograph of Paris (Melanthiaceae), Morphology, Biology, Systematics and Taxonomy","first-page":"1","author":"Ji","year":"2021"},{"issue":"6","key":"10.1016\/j.jep.2026.121983_bib17","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.jep.2026.121983_bib18","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial\u2013mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.jep.2026.121983_bib19","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.4161\/cbt.4.11.2136","article-title":"Effects of polyphyllin D, a steroidal saponin in Paris Polyphylla, in growth inhibition of human breast cancer cells and in xenograft","volume":"4","author":"Lee","year":"2005","journal-title":"Cancer Biol. Ther."},{"issue":"10","key":"10.1016\/j.jep.2026.121983_bib20","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1002\/ijc.23113","article-title":"Transforming growth factor-\u03b2 signaling in cancer invasion and metastasis","volume":"121","author":"Leivonen","year":"2007","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.jep.2026.121983_bib21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.7314\/APJCP.2012.13.1.205","article-title":"Paris polyphylla Smith extract induces apoptosis and activates cancer suppressor gene connexin26 expression","volume":"13","author":"Li","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"1","key":"10.1016\/j.jep.2026.121983_bib22","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/s41598-017-00934-x","article-title":"The adjuvant value of Andrographis paniculata in metastatic esophageal cancer treatment \u2013 from preclinical perspectives","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jep.2026.121983_bib23","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/s41598-017-00934-x","article-title":"The adjuvant value of Andrographis paniculata in metastatic esophageal cancer treatment\u2013from preclinical perspectives","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.jep.2026.121983_bib24","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jep.2014.04.049","article-title":"Paris saponin VII from trillium tschonoskii reverses multidrug resistance of adriamycin-resistant MCF-7\/ADR cells via P-glycoprotein inhibition and apoptosis augmentation","volume":"154","author":"Li","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.jep.2026.121983_bib25","doi-asserted-by":"crossref","first-page":"12916","DOI":"10.3390\/molecules181012916","article-title":"The anti-lung cancer activities of steroidal saponins of P. polyphylla Smith var. chinensis (Franch.) Hara through enhanced immunostimulation in experimental Lewis tumor-bearing C57BL\/6 mice and induction of apoptosis in the A549 cell line","volume":"18","author":"Li","year":"2013","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.jep.2026.121983_bib26","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/pca.2826","article-title":"Structural characterisation and discrimination of the aerial parts of Paris polyphylla var. yunnanensis and Paris polyphylla var. chinensis by UHPLC-QTOF-MS coupled with multivariate data analysis","volume":"30","author":"Liang","year":"2019","journal-title":"Phytochem. Anal."},{"issue":"1","key":"10.1016\/j.jep.2026.121983_bib27","first-page":"3","article-title":"Epidemiology of esophageal cancer in 2020 and projections to 2030 and 2040. Thorac","volume":"14","author":"Liu","year":"2023","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.jep.2026.121983_bib28","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jep.2013.06.033","article-title":"Correlation among cytotoxicity, hemolytic activity and the composition of steroidal saponins from Paris L","volume":"149","author":"Liu","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2026.121983_bib29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","article-title":"TGF-beta in cancer","volume":"134","author":"Massagu\u00e9","year":"2008","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jep.2026.121983_bib30","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1248\/cpb.30.712","article-title":"Steroid saponins from Paris polyphylla Sm.-supplement","volume":"30","author":"Miyamura","year":"1982","journal-title":"Chem. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.jep.2026.121983_bib31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1021\/jf00026a025","article-title":"Isolation and structure elucidation of dichotomin, a furostanol saponin implicated in hepatogenous photosensitization of sheep grazing Panicum dichotomiflorum","volume":"41","author":"Munday","year":"1993","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.jep.2026.121983_bib32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1517\/13543780903382609","article-title":"Targeting the transforming growth factor-beta signaling pathway in human cancer","volume":"19","author":"Nagaraj","year":"2010","journal-title":"Expert Opin. Invest. Drugs"},{"issue":"1","key":"10.1016\/j.jep.2026.121983_bib33","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1248\/cpb.37.116","article-title":"Studies on the constituents of Heloniopsis orientalis (Thunb.) C. Tanaka","volume":"37","author":"Nakano","year":"1989","journal-title":"Chem. Pharm. Bull."},{"issue":"6","key":"10.1016\/j.jep.2026.121983_bib34","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/jgh.13289","article-title":"Trends in esophageal cancer survival in United States adults from 1973 to 2009: a SEER database analysis","volume":"31","author":"Njei","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.jep.2026.121983_bib35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cell.2008.01.046","article-title":"TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4","volume":"133","author":"Padua","year":"2008","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.jep.2026.121983_bib36","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1093\/carcin\/bgm136","article-title":"Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency","volume":"28","author":"Pandey","year":"2007","journal-title":"Carcinogenesis"},{"issue":"7","key":"10.1016\/j.jep.2026.121983_bib37","first-page":"2603","article-title":"SMAD4 mediates mesenchymal\u2013epithelial reversion in SW480 colon carcinoma cells","volume":"30","author":"Pohl","year":"2010","journal-title":"Anticancer Res."},{"key":"10.1016\/j.jep.2026.121983_bib38","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jep.2018.05.028","article-title":"Seeing the light: shifting from wild rhizomes to extraction of active ingredients from above-ground parts of Paris polyphylla var. yunnanensis","volume":"224","author":"Qin","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121983_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103788","article-title":"Polyphyllosides A\u2013F, six new spirostanol saponins from the stems and leaves of Paris polyphylla var. chinensis","volume":"99","author":"Qin","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.jep.2026.121983_bib40","first-page":"27","article-title":"Medicinal properties of Paris polyphylla Smith: a review","volume":"6","author":"Shah","year":"2012","journal-title":"J. Herb. Med. Toxicol."},{"key":"10.1016\/j.jep.2026.121983_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155461","article-title":"Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelial\u2013mesenchymal transition","volume":"127","author":"Shi","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2026.121983_bib42","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1038\/s41598-025-86244-z","article-title":"Global, regional, and national burden of esophageal cancer using the 2019 global burden of disease study","volume":"15","author":"Sun","year":"2025","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jep.2026.121983_bib43","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1248\/cpb1953.4.104","article-title":"Saponins of Japnaese Dioscoreaceae. VI. The structure of Gracillin.(1)","volume":"4","author":"Tsukamoto","year":"1956","journal-title":"Pharm. Bull."},{"issue":"5","key":"10.1016\/j.jep.2026.121983_bib44","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1442-2050.2006.00602.x","article-title":"Obesity and lifestyle risk factors for gastroesophageal reflux disease, Barrett esophagus and esophageal adenocarcinoma","volume":"19","author":"Veugelers","year":"2006","journal-title":"Dis. Esophagus"},{"key":"10.1016\/j.jep.2026.121983_bib45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jep.2018.02.022","article-title":"Substituting one Paris for another? In vitro cytotoxic and in vivo antitumor activities of Paris forrestii, a substitute of Paris polyphylla var. yunnanensis","volume":"218","author":"Wang","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.121983_bib46","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.phytol.2015.02.011","article-title":"Steroidal saponins with cytotoxic activity from the rhizomes of Paris polyphylla var. yunnanensis","volume":"12","author":"Wen","year":"2015","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.jep.2026.121983_bib47","article-title":"Surgery combined with radiotherapy improved survival in metastatic esophageal cancer in a surveillance epidemiology and end results population-based Study","volume":"6","author":"Wu","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.jep.2026.121983_bib48","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1158\/1535-7163.MCT-08-0939","article-title":"The antitumoral effect of Paris Saponin I associated with the induction of apoptosis through the mitochondrial pathway","volume":"8","author":"Xiao","year":"2009","journal-title":"Mol. Cancer Ther."},{"issue":"7","key":"10.1016\/j.jep.2026.121983_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131560","article-title":"Rhizoma Paridis saponins suppresses Tumor growth in a rat model of N-Nitrosomethylbenzylamine-Induced esophageal cancer by inhibiting Cyclooxygenases-2 pathway","volume":"10","author":"Yan","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jep.2026.121983_bib50","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1142\/S0192415X17500343","article-title":"Paris polyphylla suppresses proliferation and vasculogenic mimicry of human osteosarcoma cells and inhibits Tumor growth in vivo","volume":"45","author":"Yao","year":"2017","journal-title":"Am. J. Chin. Med."},{"issue":"40","key":"10.1016\/j.jep.2026.121983_bib51","doi-asserted-by":"crossref","first-page":"19136","DOI":"10.1039\/D2NJ03666E","article-title":"Steroidal saponins with cytotoxic activity from the stems and leaves of Paris fargesii","volume":"46","author":"Yu","year":"2022","journal-title":"New J. Chem."},{"issue":"9","key":"10.1016\/j.jep.2026.121983_bib52","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1089\/jmf.2013.2957","article-title":"Polyphyllin D induces apoptosis in U87 human glioma cells through the c-Jun NH2-Terminal kinase pathway","volume":"17","author":"Yu","year":"2014","journal-title":"J. Med. Food"},{"issue":"12","key":"10.1016\/j.jep.2026.121983_bib53","first-page":"3570","article-title":"Andrographis paniculata elicits anti-invasion activities by suppressing TM4SF3 gene expression and by anoikis-sensitization in esophageal cancer cells","volume":"5","author":"Yue","year":"2015","journal-title":"Am. J. Cancer Res."},{"issue":"3","key":"10.1016\/j.jep.2026.121983_bib54","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000447209","article-title":"Anti-Cancer effects of Paris Polyphylla ethanol extract by inducing cancer cell apoptosis and cycle arrest in prostate cancer cells","volume":"11","author":"Zhang","year":"2018","journal-title":"Curr. Urol."},{"key":"10.1016\/j.jep.2026.121983_bib55","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.12659\/MSM.895084","article-title":"Rhizoma Paridis saponins induces cell cycle arrest and apoptosis in non-small cell lung carcinoma A549 cells","volume":"21","author":"Zhang","year":"2015","journal-title":"Med. Sci. Monit."},{"issue":"6","key":"10.1016\/j.jep.2026.121983_bib56","article-title":"Chemical constituents from rhizome of Paris fargesii franch","volume":"23","author":"Zhao","year":"2011","journal-title":"Nat. Prod. R&D"},{"issue":"1","key":"10.1016\/j.jep.2026.121983_bib57","first-page":"63","article-title":"Polyphyllin \u2165 Induces Apopiosis ofaEsophageal Cencer CellscThrougc Actitating JaK Pathway and pegulates Aerobic Glycalysis Tgrough Inhitition oi ERK\/c-Myc Pathway","volume":"29","author":"Zhong","year":"2020","journal-title":"China Cancer"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126008378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126008378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:16:49Z","timestamp":1785903409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126008378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":57,"alternative-id":["S0378874126008378"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.121983","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-metastatic effect of Paris polyphylla var. yunnanensis and Paris fargesii in esophageal cancer preclinical models","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.121983","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"121983"}}