{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:13:54Z","timestamp":1787991234182,"version":"build-2784847793"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jep.2026.122063","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:34:48Z","timestamp":1781678088000},"page":"122063","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Cordyceps sinensis polysaccharide disrupts the macrophage pyroptosis-neutrophil extracellular traps axis to ameliorate acute lung injury"],"prefix":"10.1016","volume":"370","author":[{"given":"Jingwen","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shushu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangmei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-9308","authenticated-orcid":false,"given":"Yuchi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2026.122063_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctmp.2025.200200","article-title":"Prevention and control of acute respiratory viral infections in adult population: a systematic review and meta-analysis on ginseng-based clinical trials","volume":"6","author":"Adusei-Mensah","year":"2025","journal-title":"Clin. Tradit. Med. Pharmacol."},{"key":"10.1016\/j.jep.2026.122063_bib2","article-title":"Macrophage pyroptosis and its crucial role in ALI\/ARDS","volume":"16","author":"Cai","year":"2025","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.jep.2026.122063_bib3","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1039\/D2FO02555H","article-title":"Polysaccharides from natural Cordyceps sinensis attenuated dextran sodium sulfate-induced colitis in C57BL\/6J mice","volume":"14","author":"Chen","year":"2023","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.jep.2026.122063_bib4","doi-asserted-by":"crossref","DOI":"10.1186\/s11658-023-00462-9","article-title":"The NLRP3 inflammasome: contributions to inflammation-related diseases","volume":"28","author":"Chen","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"1","key":"10.1016\/j.jep.2026.122063_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s11658-023-00462-9","article-title":"The NLRP3 inflammasome: contributions to inflammation-related diseases","volume":"28","author":"Chen","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"2","key":"10.1016\/j.jep.2026.122063_bib6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1142\/S0192415X14500281","article-title":"Cordyceps sinensis prevents apoptosis in mouse liver with D-galactosamine\/lipopolysaccharide-induced fulminant hepatic failure","volume":"42","author":"Cheng","year":"2014","journal-title":"Am. J. Chin. Med."},{"issue":"Pt 4","key":"10.1016\/j.jep.2026.122063_bib7","article-title":"Ganoderma lucidum low molecular weight polysaccharide promotes the repair of spinal cord injury through anti-inflammatory and antioxidant","volume":"322","author":"Chong","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122063_bib8","article-title":"Cordyceps spp.: a review on its immune-stimulatory and other biological potentials","volume":"11","author":"Das","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2026.122063_bib9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/joim.13585","article-title":"The role of extracellular histones in COVID-19","volume":"293","author":"De Vries","year":"2023","journal-title":"J. Intern. Med."},{"issue":"8","key":"10.1016\/j.jep.2026.122063_bib10","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1039\/D3FO03770C","article-title":"Cordyceps sinensis accelerates stem cell recruitment to human skeletal muscle after exercise","volume":"15","author":"Dewi","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2026.122063_bib11","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.carbpol.2016.09.073","article-title":"The polysaccharide and low molecular weight components of Opuntia ficus indica cladodes: structure and skin repairing properties","volume":"157","author":"Di Lorenzo","year":"2017","journal-title":"Carbohydr. Polym."},{"issue":"29","key":"10.1016\/j.jep.2026.122063_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202501952","article-title":"Inhalability and bioactivity of spray-dried versus pressurized gas eXpanded liquid technology-processed yeast beta-glucan microparticles for anti-fibrotic therapies","volume":"14","author":"Dowdall","year":"2025","journal-title":"Adv. Healthcare Mater."},{"issue":"1","key":"10.1016\/j.jep.2026.122063_bib13","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41467-024-45210-5","article-title":"PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury","volume":"15","author":"Du","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2026.122063_bib14","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.ijbiomac.2018.04.004","article-title":"Protective properties of combined fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum on colon immune dysfunction","volume":"114","author":"Fan","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122063_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116621","article-title":"NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1\/HS and downstream pathways","volume":"175","author":"Fei","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.122063_bib16","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.carbpol.2015.05.079","article-title":"Structure-function relationships of immunostimulatory polysaccharides: a review","volume":"132","author":"Ferreira","year":"2015","journal-title":"Carbohydr. Polym."},{"issue":"Pt 1","key":"10.1016\/j.jep.2026.122063_bib17","article-title":"Tetrastigma hemsleyanum polysaccharide ameliorates cytokine storm syndrome via the IFN-\u03b3-JAK2\/STAT pathway","volume":"275","author":"Fu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.jep.2026.122063_bib18","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20190789","article-title":"Protective effect of Cordyceps sinensis extract on lipopolysaccharide-induced acute lung injury in mice","volume":"39","author":"Fu","year":"2019","journal-title":"Biosci. Rep."},{"issue":"1","key":"10.1016\/j.jep.2026.122063_bib19","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/s41467-026-68580-4","article-title":"Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer's disease retina","volume":"17","author":"Gaire","year":"2026","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.jep.2026.122063_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70430","article-title":"Cordycepin targets HRD1 to promote cancer cell PD-L1 ubiquitin-proteasome degradation and increase antitumor immunity","volume":"6","author":"Geng","year":"2025","journal-title":"MedComm"},{"issue":"Pt 1","key":"10.1016\/j.jep.2026.122063_bib21","article-title":"Elucidation of antioxidant activities of intracellular and extracellular polysaccharides from Cordyceps militaris in vitro and their protective effects on ulcerative colitis in vivo","volume":"267","author":"Guo","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"Pt 1","key":"10.1016\/j.jep.2026.122063_bib22","article-title":"Tetrastigma hemsleyanum Diels et Gilg polysaccharide mitigates macrophage pyroptosis and prevents acute lung injury by regulating NLRP3\/Caspase-1\/GSDMD signaling pathways","volume":"323","author":"Guo","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122063_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2025.10.075","article-title":"Alveolar macrophage-derived TGF-\u03b2 promotes acute lung injury recovery by regulating inflammatory monocyte-derived macrophages","author":"Hou","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jep.2026.122063_bib24","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.actbio.2024.03.031","article-title":"Immunometabolic reprogramming of macrophages with inhalable CRISPR\/Cas9 nanotherapeutics for acute lung injury intervention","volume":"181","author":"Huang","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jep.2026.122063_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112637","article-title":"Hydrolyzed low-molecular-weight polysaccharide from Enteromorpha prolifera exhibits high anti-inflammatory activity and promotes wound healing","volume":"133","author":"Jiang","year":"2022","journal-title":"Biomater. Adv."},{"issue":"Pt 2","key":"10.1016\/j.jep.2026.122063_bib26","article-title":"The effects of Cordyceps polysaccharides on ischemic brain injury in rats via intervening with IL-23\/IL-17 axis and the intestinal barrier","volume":"283","author":"Jiang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.jep.2026.122063_bib27","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cmi.2015.95","article-title":"Molecular mechanisms regulating NLRP3 inflammasome activation","volume":"13","author":"Jo","year":"2016","journal-title":"Cell. Mol. Immunol."},{"issue":"2","key":"10.1016\/j.jep.2026.122063_bib28","doi-asserted-by":"crossref","first-page":"733","DOI":"10.7150\/ijbs.87646","article-title":"Pyroptotic macrophage-derived microvesicles accelerate Formation of neutrophil extracellular traps via GSDMD-N-expressing mitochondrial transfer during sepsis","volume":"20","author":"Kuang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"Pt 1","key":"10.1016\/j.jep.2026.122063_bib29","article-title":"Low molecular weight polysaccharide of Tremella fuciformis exhibits stronger antioxidant and immunomodulatory activities than high molecular weight polysaccharide","volume":"281","author":"Lee","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122063_bib30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ijbiomac.2022.01.111","article-title":"In vivo pharmacokinetic study of a Cucurbita moschata polysaccharide after oral administration","volume":"203","author":"Li","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122063_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.900895","article-title":"The emerging role of neutrophil extracellular traps in fungal infection","volume":"12","author":"Liang","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jep.2026.122063_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2025.105037","article-title":"Advancements in novel polysaccharide analysis: emerging spectral technology approaches","volume":"162","author":"Lin","year":"2025","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.jep.2026.122063_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102960","article-title":"CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-\u03baB pathway","volume":"68","author":"Liu","year":"2023","journal-title":"Redox Biol."},{"issue":"Pt 1","key":"10.1016\/j.jep.2026.122063_bib34","article-title":"Potentilla anserina L. polysaccharide ameliorates LPS-induced acute lung injury and relevant intestinal mucosal barrier impairment","volume":"305","author":"Liu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"19","key":"10.1016\/j.jep.2026.122063_bib35","doi-asserted-by":"crossref","first-page":"6576","DOI":"10.3390\/molecules27196576","article-title":"Chinese cordyceps: bioactive components, antitumor effects and underlying Mechanism-A review","volume":"27","author":"Liu","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.122063_bib36","article-title":"Cordycepin attenuates NLRP3\/Caspase-1\/GSDMD-mediated LPS-induced macrophage pyroptosis","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.122063_bib37","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13020-024-00895-0","article-title":"Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway","volume":"19","author":"Lu","year":"2024","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2026.122063_bib38","article-title":"METTL3 promotes neutrophil extracellular trap formation via SYK\/ERK\/MEK signaling during acute lung injury","volume":"1423","author":"Luo","year":"2026","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jep.2026.122063_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.121064","article-title":"Compound yujie decoction ameliorates LPS-induced acute lung injury by suppressing NLRP3 inflammasome-mediated macrophage pyroptosis","volume":"359","author":"Ma","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122063_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119631","article-title":"Fermented Cordyceps Powder alleviates silica-induced inflammation and fibrosis by inhibiting M1 macrophage polarization via the HMGB1-TLR4-NF-\u03baB pathway","volume":"345","author":"Pu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122063_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116113","article-title":"Cordyceps sinensis polysaccharide inhibits colon cancer cells growth by inducing apoptosis and autophagy flux blockage via mTOR signaling","volume":"237","author":"Qi","year":"2020","journal-title":"Carbohydr. Polym."},{"issue":"8","key":"10.1016\/j.jep.2026.122063_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1744","article-title":"Cyclic-di-GMP induces inflammation and acute lung injury through direct binding to MD2","volume":"14","author":"Qian","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.jep.2026.122063_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1610266","article-title":"Regulation of neutrophil extracellular trap formation by c-di-GMP in Pseudomonas aeruginosa-induced pleural infection","volume":"16","author":"Qing","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2026.122063_bib44","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jare.2024.07.028","article-title":"Single-cell atlas of human gingiva unveils a NETs-related neutrophil subpopulation regulating periodontal immunity","volume":"72","author":"Qiu","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jep.2026.122063_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.953195","article-title":"The role of neutrophil extracellular traps in acute lung injury","volume":"13","author":"Scozzi","year":"2022","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.jep.2026.122063_bib46","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.7150\/ijbs.99456","article-title":"Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice","volume":"20","author":"Sha","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2026.122063_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108545","article-title":"NLRP3 and cancer: pathogenesis and therapeutic opportunities","volume":"251","author":"Tengesdal","year":"2023","journal-title":"Pharmacol. Ther."},{"issue":"10","key":"10.1016\/j.jep.2026.122063_bib48","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s11655-023-3593-4","article-title":"Protective mechanism of Cordyceps sinensis treatment on acute kidney injury-induced acute lung injury through AMPK\/mTOR signaling pathway","volume":"29","author":"Wang","year":"2023","journal-title":"Chin. J. Integr. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.122063_bib49","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13020-025-01069-2","article-title":"Hyssopus cuspidatus volatile oil: a potential treatment for steroid-resistant asthma via inhibition of neutrophil extracellular traps","volume":"20","author":"Wang","year":"2025","journal-title":"Chin. Med."},{"issue":"4","key":"10.1016\/j.jep.2026.122063_bib50","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3390\/biom14040416","article-title":"Composition and function of neutrophil extracellular traps","volume":"14","author":"Wang","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.jep.2026.122063_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106083","article-title":"Xuanfei Baidu decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1\/IL17A pathway","volume":"176","author":"Wang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2026.122063_bib52","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.carbpol.2015.02.012","article-title":"Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells","volume":"125","author":"Wang","year":"2015","journal-title":"Carbohydr. Polym."},{"issue":"Pt 2","key":"10.1016\/j.jep.2026.122063_bib53","article-title":"Effect of monosaccharide composition and proportion on the bioactivity of polysaccharides: a review","volume":"254","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"7","key":"10.1016\/j.jep.2026.122063_bib54","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1111\/febs.70346","article-title":"Pentraxin-related protein PTX3 alleviates blast-induced acute lung injury by promoting efferocytosis to eliminate ferroptotic alveolar epithelial cells in vitro","volume":"293","author":"Weng","year":"2025","journal-title":"FEBS J."},{"issue":"2","key":"10.1016\/j.jep.2026.122063_bib55","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cell.2024.11.018","article-title":"Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells","volume":"188","author":"Wright","year":"2025","journal-title":"Cell"},{"issue":"Pt 1","key":"10.1016\/j.jep.2026.122063_bib56","article-title":"Bletilla striata polysaccharides alleviate ARDS by inhibiting NETs-induced pyroptosis in pulmonary alveolar macrophage through the PAD4 pathway","volume":"305","author":"Wu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122063_bib57","doi-asserted-by":"crossref","DOI":"10.2147\/JIR.S582921","article-title":"Anti-Inflammatory mechanisms and translational relevance of Cordyceps sinensis and its bioactive constituents","volume":"19","author":"Xie","year":"2026","journal-title":"J. Inflamm. Res."},{"issue":"2","key":"10.1016\/j.jep.2026.122063_bib58","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.3390\/ijms24021423","article-title":"Poria cocos polysaccharide ameliorated antibiotic-associated diarrhea in mice via regulating the homeostasis of the gut microbiota and intestinal mucosal barrier","volume":"24","author":"Xu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.122063_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115054","article-title":"Melastoma dodecandrum polysaccharide alleviates allergic rhinitis in mice through modulating NLRP3 and IL-17 axis","volume":"161","author":"Xu","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2026.122063_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154531","article-title":"The effects of Ophiocordyceps sinensis combined with ACEI\/ARB on diabetic kidney disease: a systematic review and meta-analysis","volume":"108","author":"Yan","year":"2023","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jep.2026.122063_bib61","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3892\/ijmm.2013.1580","article-title":"The role of quantitative changes in the epxression of insulin receptor substrate-1 and nuclear ubiquitin in abnormal glycometabolism in the livers of KKay mice and the relative therapeutic mechanisms of astragalus polysaccharide","volume":"33","author":"Ye","year":"2014","journal-title":"Int. J. Mol. Med."},{"issue":"22","key":"10.1016\/j.jep.2026.122063_bib62","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.181686","article-title":"Loss of PADI2 and PADI4 ameliorates sepsis-induced acute lung injury by suppressing NLRP3+ macrophages","volume":"9","author":"Yu","year":"2024","journal-title":"JCI Insight"},{"issue":"Pt 6","key":"10.1016\/j.jep.2026.122063_bib63","article-title":"The polysaccharide from purple sweet potato (Ipomoea batatas (L.) Lam) alleviates lipopolysaccharide-induced acute lung injury in mice via the VIP\/cAMP\/PKA\/AQPs signaling pathway","volume":"282","author":"Yue","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"11\u201312","key":"10.1016\/j.jep.2026.122063_bib64","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1007\/s10495-025-02168-z","article-title":"Targeting PANoptosis: a promising therapeutic strategy for ALI\/ARDS","volume":"30","author":"Zhang","year":"2025","journal-title":"Apoptosis"},{"issue":"Pt 2","key":"10.1016\/j.jep.2026.122063_bib65","article-title":"Exploratory studies of the antidepressant effect of Cordyceps sinensis polysaccharide and its potential mechanism","volume":"277","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122063_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2026.121192","article-title":"Polysaccharide from Tetrastigma hemsleyanum Diels et Gilg attenuates Poly(I:C)-induced acute lung injury by preserving epithelial barrier integrity and modulating STING\/TBK1-NF-\u03baB and IRF1-STAT1 signaling","volume":"360","author":"Zhao","year":"2026","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2026.122063_bib67","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.7150\/ijbs.34211","article-title":"Caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK\/NF-\u03baB and A2aR signaling in LPS-Induced THP-1 macrophages","volume":"15","author":"Zhao","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2026.122063_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120472","article-title":"Coptisine mitigates acute lung injury by alleviating ferroptosis through the PI3K\/AKT\/Nrf2 pathway","volume":"354","author":"Zhou","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122063_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.117076","article-title":"Integrating proteomics, metabolomics, and network pharmacology to investigate the mechanism of Cordyceps sinensis in the treatment of COPD rats","volume":"266","author":"Zhou","year":"2025","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2026.122063_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115833","article-title":"Xuanfei baidu formula attenuates LPS-induced acute lung injury by inhibiting the NF-\u03baB signaling pathway","volume":"301","author":"Zhu","year":"2023","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126009177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126009177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:13:07Z","timestamp":1782821587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126009177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":70,"alternative-id":["S0378874126009177"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122063","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cordyceps sinensis polysaccharide disrupts the macrophage pyroptosis-neutrophil extracellular traps axis to ameliorate acute lung injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122063"}}