{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:13:13Z","timestamp":1789423993913,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32202852"],"award-info":[{"award-number":["32202852"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jep.2026.122078","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:37:21Z","timestamp":1781800641000},"page":"122078","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Codonopsis pilosula (Dangshen) decoction promotes NR2F2-dependent pulmonary endothelial repair in an H9N2-induced lung injury model"],"prefix":"10.1016","volume":"370","author":[{"given":"Qian","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaohui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youran","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.122078_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.clicom.2023.07.005","article-title":"Novel approaches that promote lung endothelial and epithelial repair and anti pro inflammatory cytokines could be a future promising agent in the management of ARDS","volume":"4","author":"Alrjoob","year":"2023","journal-title":"Clinical Immunology Communications"},{"key":"10.1016\/j.jep.2026.122078_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157540","article-title":"Codonopsis radix: a comprehensive review for its ethnopharmacology, phytochemistry, pharmacodynamics, pharmacokinetics, toxicity and potential clinical applications","volume":"149","author":"Bai","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.122078_bib3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1165\/rcmb.2018-0101PS","article-title":"The emerging role of neutrophils in repair after acute Lung Injury","volume":"59","author":"Bl\u00e1zquez-Prieto","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jep.2026.122078_bib4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000538490","article-title":"Codonopsis Radix inhibits the inflammatory response and oxidative stress in chronic obstructive pulmonary disease mice through regulation of the Nrf2\/NF-\u03baB signaling pathway","volume":"109","author":"Chen","year":"2024","journal-title":"Pharmacology"},{"key":"10.1016\/j.jep.2026.122078_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1203827","article-title":"Endothelial dysfunction triggers acute respiratory distress syndrome in patients with sepsis: a narrative review","volume":"10","author":"Cusack","year":"2023","journal-title":"Front. Med."},{"key":"10.1016\/j.jep.2026.122078_bib6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/978-1-4939-8570-8_22","article-title":"Mouse models of acute lung injury and ARDS","volume":"1809","author":"D'Alessio","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jep.2026.122078_bib7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ajpath.2020.10.001","article-title":"Mechanisms of endothelial regeneration and vascular repair and their application to regenerative medicine","volume":"191","author":"Evans","year":"2021","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jep.2026.122078_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.pupt.2023.102196","article-title":"Pulmonary drug delivery for acute respiratory distress syndrome","volume":"79","author":"Fei","year":"2023","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.jep.2026.122078_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23071801","article-title":"The polysaccharides from Codonopsis pilosula modulates the immunity and intestinal microbiota of cyclophosphamide-treated immunosuppressed mice","volume":"23","author":"Fu","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.122078_bib10","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1039\/D2FO01221A","article-title":"Codonopsis pilosula polysaccharides attenuate Escherichia coli-induced acute lung injury in mice","volume":"13","author":"Gong","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2026.122078_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.21037\/atm.2017.12.18","article-title":"New insights into the mechanisms of pulmonary edema in acute lung injury","volume":"6","author":"Herrero","year":"2018","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.jep.2026.122078_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3311228","article-title":"Vascular protective effect and its possible mechanism of action on selected active phytocompounds: a review","volume":"2022","author":"Kamaruddin","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2026.122078_bib13","article-title":"Codonopsis lanceolata extract restores smooth muscle vasorelaxation in Rat carotid arteries Even under high extracellular K(+) concentrations","volume":"15","author":"Kim","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2026.122078_bib14","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.devcel.2025.01.010","article-title":"Differentiation of lung tissue-resident c-Kit(+) cells into microvascular endothelial cells alleviates pulmonary vascular remodeling","volume":"60","author":"Li","year":"2025","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jep.2026.122078_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118936","article-title":"Exploiting omic-based approaches to decipher traditional Chinese Medicine","volume":"337","author":"Li","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122078_bib16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13287-016-0395-z","article-title":"Mesenchymal stromal cell treatment prevents H9N2 avian influenza virus-induced acute lung injury in mice","volume":"7","author":"Li","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jep.2026.122078_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11226696","article-title":"Xuebijing administration alleviates pulmonary endothelial inflammation and coagulation dysregulation in the early phase of sepsis in rats","volume":"11","author":"Lv","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jep.2026.122078_bib18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1164\/rccm.200909-1420OC","article-title":"Lung pathology in fatal novel human influenza A (H1N1) infection","volume":"181","author":"Mauad","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jep.2026.122078_bib19","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.stem.2018.07.011","article-title":"Endothelial regeneration of large vessels is a biphasic process driven by local cells with distinct proliferative capacities","volume":"23","author":"Mcdonald","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jep.2026.122078_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120132","article-title":"Exploring the pro-angiogenic potential of Chinese herbal medicines: a comprehensive insight into mechanisms","volume":"351","author":"Munir","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122078_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-1-4939-7896-0_6","article-title":"Isolation and purification of epithelial and endothelial cells from Mouse Lung","volume":"1799","author":"Nakano","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jep.2026.122078_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/cells9010101","article-title":"COUP-TFII in health and disease","volume":"9","author":"Polvani","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jep.2026.122078_bib23","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev-physiol-042222-030731","article-title":"A razor's edge: vascular responses to acute inflammatory Lung Injury\/Acute respiratory distress syndrome","volume":"86","author":"Price","year":"2024","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jep.2026.122078_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/cells14171346","article-title":"Claudin 5 across the vascular landscape: from blood-tissue barrier regulation to disease mechanisms","volume":"14","author":"Selim","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.jep.2026.122078_bib25","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pccm.2024.04.002","article-title":"Mechanisms of pulmonary endothelial barrier dysfunction in acute lung injury and acute respiratory distress syndrome","volume":"2","author":"Su","year":"2024","journal-title":"Chin Med J Pulm Crit Care Med"},{"key":"10.1016\/j.jep.2026.122078_bib26","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41577-020-0343-0","article-title":"COVID-19: the vasculature unleashed","volume":"20","author":"Teuwen","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2026.122078_bib27","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s41379-020-0536-x","article-title":"Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies","volume":"33","author":"Tian","year":"2020","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.jep.2026.122078_bib28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yjmcc.2021.10.009","article-title":"Endothelial repair by stem and progenitor cells","volume":"163","author":"Wang","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jep.2026.122078_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112641","article-title":"Moslea Herba flavonoids alleviated influenza A virus-induced pulmonary endothelial barrier disruption via suppressing NOX4\/NF-\u03baB\/MLCK pathway","volume":"253","author":"Yu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122078_bib30","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1080\/10408347.2023.2242953","article-title":"Insights into genus codonopsis: from past achievements to future perspectives","volume":"54","author":"Yue","year":"2024","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.jep.2026.122078_bib31","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.158079","article-title":"Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations","volume":"7","author":"Zhang","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.jep.2026.122078_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abc4493","article-title":"Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2","volume":"6","author":"Zhao","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jep.2026.122078_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103885","article-title":"Inhibitory effects of belamcanda extract on inflammatory response and antiviral mechanism in H9N2 Avian influenza virus: insights from in vitro and in vivo studies","volume":"103","author":"Zhi","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.jep.2026.122078_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29091945","article-title":"Oxymatrine modulation of TLR3 signaling: a dual-action mechanism for H9N2 Avian influenza virus defense and immune regulation","volume":"29","author":"Zhi","year":"2024","journal-title":"Molecules"}],"updated-by":[{"DOI":"10.1016\/j.jep.2026.122151","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000}}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126009323?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126009323?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:03:16Z","timestamp":1785891796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126009323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":34,"alternative-id":["S0378874126009323"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122078","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Codonopsis pilosula (Dangshen) decoction promotes NR2F2-dependent pulmonary endothelial repair in an H9N2-induced lung injury model","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122078","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"122078"}}