{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:47:27Z","timestamp":1785887247373,"version":"3.56.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472914"],"award-info":[{"award-number":["82472914"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jep.2026.122080","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:50:18Z","timestamp":1782283818000},"page":"122080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Annexin A2 as a therapeutic target of Artemisiae Scopariae Herba-derived quercetin in preventing malignant progression from primary sclerosing cholangitis to cholangiocarcinoma: An integrative study"],"prefix":"10.1016","volume":"371","author":[{"given":"Weihan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinci","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanying","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jep.2026.122080_bib1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1080\/17460441.2023.2241366","article-title":"Drug design strategies that aim to improve the low solubility and poor bioavailability conundrum in quercetin derivatives","volume":"18","author":"Alizadeh","year":"2023","journal-title":"Expert Opin. Drug Discov."},{"issue":"6","key":"10.1016\/j.jep.2026.122080_bib2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1039\/C9NP00011A","article-title":"Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2","volume":"36","author":"Caesar","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.jep.2026.122080_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110513","article-title":"Recent progress in the study of Artemisiae Scopariae Herba (Yin Chen), a promising medicinal herb for liver diseases","volume":"130","author":"Cai","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jep.2026.122080_bib4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s12906-023-04146-x","article-title":"Combination of bioaffinity ultrafiltration-UFLC-ESI-Q\/TOF-MS\/MS, in silico docking and multiple complex networks to explore antitumor mechanism of topoisomerase I inhibitors from Artemisiae Scopariae Herba","volume":"23","author":"Chen","year":"2023","journal-title":"BMC Complement. Med. Ther."},{"issue":"1","key":"10.1016\/j.jep.2026.122080_bib5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13020-021-00423-4","article-title":"Network pharmacology based research into the effect and mechanism of Yinchenhao Decoction against Cholangiocarcinoma","volume":"16","author":"Chen","year":"2021","journal-title":"Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.122080_bib6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0254-6272(13)60107-7","article-title":"Anticancer, antiobesity, and anti-inflammatory activity of Artemisia species in vitro","volume":"33","author":"Choi","year":"2013","journal-title":"J. Tradit. Chin. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2026.122080_bib7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/liv.14089","article-title":"Surgery for cholangiocarcinoma","volume":"39","author":"Cillo","year":"2019","journal-title":"Liver Int."},{"issue":"1","key":"10.1016\/j.jep.2026.122080_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13020-025-01156-4","article-title":"Herb-drug interactions in oncology: pharmacodynamic\/pharmacokinetic mechanisms and risk prediction","volume":"20","author":"Duan","year":"2025","journal-title":"Chin. Med."},{"issue":"4","key":"10.1016\/j.jep.2026.122080_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2024.01.004","article-title":"Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice","volume":"187","author":"Fu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.jep.2026.122080_bib10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jep.2015.10.032","article-title":"Three new anti-HBV active constituents from the traditional Chinese herb of Yin-Chen (Artemisia scoparia)","volume":"176","author":"Geng","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2026.122080_bib11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41575-022-00741-4","article-title":"Immunology and immunotherapy of cholangiocarcinoma","volume":"20","author":"Greten","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"18","key":"10.1016\/j.jep.2026.122080_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e38173","article-title":"Bioinformatics analysis based on extracted ingredients combined with network pharmacology, molecular docking and molecular dynamics simulation to explore the mechanism of jinbei oral liquid in the therapy of idiopathic pulmonary fibrosis","volume":"10","author":"Han","year":"2024","journal-title":"Heliyon"},{"issue":"9","key":"10.1016\/j.jep.2026.122080_bib13","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1136\/gutjnl-2023-331773","article-title":"Comprehensive single-cell analysis deciphered microenvironmental dynamics and immune regulator olfactomedin 4 in pathogenesis of gallbladder cancer","volume":"73","author":"He","year":"2024","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.jep.2026.122080_bib14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S2468-1253(16)30010-3","article-title":"Advances in primary sclerosing cholangitis","volume":"1","author":"Horsley-Silva","year":"2016","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.jep.2026.122080_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.7082","article-title":"Quercetin-induced degradation of RhoC suppresses hepatocellular carcinoma invasion and metastasis","volume":"13","author":"Huang","year":"2024","journal-title":"Cancer Med."},{"issue":"1","key":"10.1016\/j.jep.2026.122080_bib16","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41420-025-02469-x","article-title":"ANXA2 in cancer: aberrant regulation of tumour cell apoptosis and its immune interactions","volume":"11","author":"Huang","year":"2025","journal-title":"Cell Death Discov."},{"issue":"2","key":"10.1016\/j.jep.2026.122080_bib17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrclinonc.2017.157","article-title":"Cholangiocarcinoma - evolving concepts and therapeutic strategies","volume":"15","author":"Ilyas","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.jep.2026.122080_bib18","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3892\/or.2016.5283","article-title":"Evaluation of antitumor activity of Artemisia capillaris extract against hepatocellular carcinoma through the inhibition of IL-6\/STAT3 signaling axis","volume":"37","author":"Jang","year":"2017","journal-title":"Oncol. Rep."},{"issue":"2","key":"10.1016\/j.jep.2026.122080_bib19","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/jcb.21859","article-title":"Quercetin-induced ubiquitination and down-regulation of Her-2\/neu","volume":"105","author":"Jeong","year":"2008","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.jep.2026.122080_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.aca.2009.10.024","article-title":"Recent analytical approaches in quality control of traditional Chinese medicines--a review","volume":"657","author":"Jiang","year":"2010","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jep.2026.122080_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ebiom.2019.11.014","article-title":"Compounds targeting YadC of uropathogenic Escherichia coli and its host receptor annexin A2 decrease bacterial colonization in bladder","volume":"50","author":"Li","year":"2019","journal-title":"EBioMedicine"},{"issue":"22","key":"10.1016\/j.jep.2026.122080_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/molecules30224441","article-title":"Quercetin and its metabolites: mechanistic insights as the basis of their therapeutic potential in NAFLD and HCC","volume":"30","author":"Li","year":"2025","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.jep.2026.122080_bib23","doi-asserted-by":"crossref","first-page":"869","DOI":"10.2174\/138620710793360301","article-title":"Recent advances in quality control of traditional Chinese medicines","volume":"13","author":"Liu","year":"2010","journal-title":"Comb. Chem. High Throughput Screen."},{"issue":"1","key":"10.1016\/j.jep.2026.122080_bib24","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s12032-014-0392-y","article-title":"Overexpression of ANXA2 predicts adverse outcomes of patients with malignant tumors: a systematic review and meta-analysis","volume":"32","author":"Liu","year":"2015","journal-title":"Med. Oncol."},{"key":"10.1016\/j.jep.2026.122080_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2026.121249","article-title":"Deciphering the scientific basis of traditional Chinese medicine via a multifunctional molecular networking","volume":"361","author":"Luo","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122080_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2025.1674507","article-title":"Quercetin reverses beta(1)-adrenoceptor autoantibody-induced heart failure by promoting MDM2-mediated ubiquitination and degradation of p53 in cardiomyocytes","volume":"12","author":"Ma","year":"2025","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jep.2026.122080_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ctrv.2019.06.003","article-title":"FGFR2 genomic aberrations: achilles heel in the management of advanced cholangiocarcinoma","volume":"78","author":"Mahipal","year":"2019","journal-title":"Cancer Treat Rev."},{"issue":"Pt B","key":"10.1016\/j.jep.2026.122080_bib28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.fct.2016.08.034","article-title":"Hepatoprotective effect of quercetin: from chemistry to medicine","volume":"108","author":"Miltonprabu","year":"2017","journal-title":"Food Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.jep.2026.122080_bib29","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1053\/j.gastro.2005.08.017","article-title":"High-dose ursodeoxycholic acid in primary sclerosing cholangitis: a 5-year multicenter, randomized, controlled study","volume":"129","author":"Olsson","year":"2005","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.jep.2026.122080_bib30","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/ptr.6155","article-title":"Anticancer potential of quercetin: a comprehensive review","volume":"32","author":"Rauf","year":"2018","journal-title":"Phytother Res."},{"issue":"9935","key":"10.1016\/j.jep.2026.122080_bib31","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/S0140-6736(13)61903-0","article-title":"Cholangiocarcinoma","volume":"383","author":"Razumilava","year":"2014","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.jep.2026.122080_bib32","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1002\/ijc.31817","article-title":"Annexin A2 (ANX A2): an emerging biomarker and potential therapeutic target for aggressive cancers","volume":"144","author":"Sharma","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jep.2026.122080_bib33","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.micron.2016.03.008","article-title":"ANXA2 enhances the progression of hepatocellular carcinoma via remodeling the cell motility associated structures","volume":"85","author":"Shi","year":"2016","journal-title":"Micron"},{"issue":"1","key":"10.1016\/j.jep.2026.122080_bib34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s12016-019-08764-7","article-title":"Cholangiocarcinoma in patients with Primary Sclerosing Cholangitis (PSC): a comprehensive review","volume":"58","author":"Song","year":"2020","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"7","key":"10.1016\/j.jep.2026.122080_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202402793","article-title":"Deciphering the pharmacological mechanism of compound purpura decoction in treating Henoch-Schonlein Purpura by network pharmacology, molecular docking and experimental validation","volume":"22","author":"Su","year":"2025","journal-title":"Chem. Biodivers."},{"issue":"15","key":"10.1016\/j.jep.2026.122080_bib36","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1021\/acs.jafc.8b06929","article-title":"Comprehensive analyses of Quercetin conjugates by LC\/MS\/MS revealed that Isorhamnetin-7- O-glucuronide-4'- O-sulfate is a major metabolite in plasma of rats fed with Quercetin glucosides","volume":"67","author":"Tanaka","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"8","key":"10.1016\/j.jep.2026.122080_bib37","article-title":"Interactions between medical plant-derived bioactive compounds: focus on antimicrobial combination effects","volume":"11","author":"Vaou","year":"2022","journal-title":"Antibiotics (Basel)"},{"issue":"1","key":"10.1016\/j.jep.2026.122080_bib38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s41065-025-00620-3","article-title":"Multimethodological and multiscale investigation of the therapeutic mechanism of Qian Ji Sheng Xue Pian in treating primary immune thrombocytopenia","volume":"163","author":"Wang","year":"2025","journal-title":"Hereditas"},{"key":"10.1016\/j.jep.2026.122080_bib39","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ibneur.2025.01.013","article-title":"Exploring the effect and mechanism of Shaoyao Gancao Decoction in the treatment of pain in Parkinson's disease using network pharmacology and molecular docking","volume":"18","author":"Xu","year":"2025","journal-title":"IBRO Neurosci Rep"},{"issue":"11","key":"10.1016\/j.jep.2026.122080_bib40","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1631\/jzus.B1300059","article-title":"An approach to optimize the batch mixing process for improving the quality consistency of the products made from traditional Chinese medicines","volume":"14","author":"Yan","year":"2013","journal-title":"J. Zhejiang Univ. - Sci. B"},{"issue":"10","key":"10.1016\/j.jep.2026.122080_bib41","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.ijpara.2010.05.002","article-title":"Up-regulation of annexin A2 in cholangiocarcinoma caused by Opisthorchis viverrini and its implication as a prognostic marker","volume":"40","author":"Yonglitthipagon","year":"2010","journal-title":"Int. J. Parasitol."},{"issue":"2","key":"10.1016\/j.jep.2026.122080_bib42","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.canlet.2015.09.008","article-title":"Intrahepatic cholangiocarcinoma: epidemiology, risk factors, diagnosis and surgical management","volume":"379","author":"Zhang","year":"2016","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.jep.2026.122080_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12020128","article-title":"Synergistic mechanisms of constituents in herbal extracts during intestinal absorption: focus on natural occurring nanoparticles","volume":"12","author":"Zhao","year":"2020","journal-title":"Pharmaceutics"},{"issue":"4","key":"10.1016\/j.jep.2026.122080_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2026.101611","article-title":"Clarifying the active ingredients & pharmacological mechanisms of traditional Chinese medicines via modern pharmaceutical analysis techniques","volume":"16","author":"Zhou","year":"2026","journal-title":"J. Pharm. Anal."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126009347?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126009347?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:58:49Z","timestamp":1785884329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126009347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":44,"alternative-id":["S0378874126009347"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122080","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Annexin A2 as a therapeutic target of Artemisiae Scopariae Herba-derived quercetin in preventing malignant progression from primary sclerosing cholangitis to cholangiocarcinoma: An integrative study","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122080"}}