{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:53:52Z","timestamp":1785876832589,"version":"3.56.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20231147"],"award-info":[{"award-number":["BK20231147"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007956","name":"Nanjing University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX25 _2395"],"award-info":[{"award-number":["KYCX25 _2395"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jep.2026.122132","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T15:45:25Z","timestamp":1782575125000},"page":"122132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Bu-Sui-Dan promotes angiogenesis to mitigate age-related osteoporosis via the ZEB1\/Notch1 axis"],"prefix":"10.1016","volume":"371","author":[{"given":"Yitao","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingming","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanyu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jep.2026.122132_bib1","first-page":"168","article-title":"Effects of Cervi cornu aqua-acupuncture on lipid metabolisms and osteoporosis in ovariectomized rats","volume":"17","author":"Abadjieva","year":"1996","journal-title":"J. Kor. Med."},{"key":"10.1016\/j.jep.2026.122132_bib2","series-title":"Commiphora Myrrha (Nees) Engl. (Burseraceae), Handbook of 200 Medicinal Plants: a Comprehensive Review of their Traditional Medical Uses and Scientific Justifications","first-page":"701","author":"Akbar","year":"2020"},{"issue":"7392","key":"10.1016\/j.jep.2026.122132_bib3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature10908","article-title":"Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling","volume":"484","author":"Benedito","year":"2012","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jep.2026.122132_bib4","first-page":"179","article-title":"[Effects of active ingredients in three kidney-tonifying Chinese herbal drugs on gene expression profile of bone marrow stromal cells from a rat model of corticosterone-induced osteoporosis]","volume":"9","author":"Bian","year":"2011","journal-title":"Zhong xi yi jie he xue bao = J. Chin. Integr. Med."},{"key":"10.1016\/j.jep.2026.122132_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152860","article-title":"Effect and mechanism of psoralidin on promoting osteogenesis and inhibiting adipogenesis","volume":"61","author":"Cao","year":"2019","journal-title":"Phytomedicine : int. J. Phytotherapy and phytopharmacol."},{"key":"10.1016\/j.jep.2026.122132_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155628","article-title":"Morinda Officinalis-derived extracellular vesicle-like particles: anti-osteoporosis effect by regulating MAPK signaling pathway","volume":"129","author":"Cao","year":"2024","journal-title":"Phytomedicine : int. J. Phytotherapy and phytopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2026.122132_bib7","first-page":"24","article-title":"Busui Dan in the treatment of osteoporosis with syndrome of kidney-yang deficiency: a randomized controlled trial","volume":"36","author":"Chao","year":"2024","journal-title":"J. Tradit. Chin. Orthoped. Traumatol."},{"issue":"4","key":"10.1016\/j.jep.2026.122132_bib8","article-title":"Corylin inhibits vascular cell inflammation, proliferation and migration and reduces atherosclerosis in ApoE-Deficient mice","volume":"9","author":"Chen","year":"2020","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"10","key":"10.1016\/j.jep.2026.122132_bib9","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1001\/jama.2017.21995","article-title":"Treatment of osteoporosis","volume":"319","author":"Cotts","year":"2018","journal-title":"Jama"},{"issue":"4","key":"10.1016\/j.jep.2026.122132_bib10","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202402545R","article-title":"Notch signaling pathway in osteogenesis, bone development, metabolism, and diseases","volume":"39","author":"Dilawar","year":"2025","journal-title":"FASEB J. : official publ. Federat. Am. Soc. Exper. Biol."},{"key":"10.1016\/j.jep.2026.122132_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2026.121281","article-title":"Guilu Erxian Glue combined with Wuzi Yanzong Pill attenuates granulosa cell apoptosis and ameliorates cyclophosphamide-induced diminished ovarian reserve via the lncRNA NEAT1\/miR-204-5p\/ESR1 axis","volume":"362","author":"Dong","year":"2026","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2026.122132_bib12","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/s41574-023-00866-9","article-title":"Long-term and sequential treatment for osteoporosis","volume":"19","author":"Foessl","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.jep.2026.122132_bib13","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41467-019-14076-3","article-title":"Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis","volume":"11","author":"Fu","year":"2020","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.jep.2026.122132_bib14","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3109\/13880209.2014.916310","article-title":"Anti-atherosclerotic effect of geniposidic acid in a rabbit model and related cellular mechanisms","volume":"53","author":"Gao","year":"2015","journal-title":"Pharm. Biol."},{"issue":"5","key":"10.1016\/j.jep.2026.122132_bib15","first-page":"3469","article-title":"ER\u03b1 and Wnt\/\u03b2-catenin signaling pathways are involved in angelicin-dependent promotion of osteogenesis","volume":"19","author":"Ge","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"6554","key":"10.1016\/j.jep.2026.122132_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc8479","article-title":"Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span","volume":"373","author":"Grunewald","year":"2021","journal-title":"Science (New York, N.Y.)"},{"issue":"1","key":"10.1016\/j.jep.2026.122132_bib17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13020-023-00786-w","article-title":"Dual effect of aucubin on promoting VEGFR2 mediated angiogenesis and reducing RANKL-induced bone resorption","volume":"18","author":"He","year":"2023","journal-title":"Chin. Med."},{"issue":"4","key":"10.1016\/j.jep.2026.122132_bib18","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/joor.13642","article-title":"DLL4\/Notch blockade disrupts mandibular advancement-induced condylar osteogenesis by inhibiting H-type angiogenesis","volume":"51","author":"Hu","year":"2024","journal-title":"J. Oral Rehabil."},{"key":"10.1016\/j.jep.2026.122132_bib19","article-title":"Eucommia ulmoides (Tochu) and its extract geniposidic acid reduced blood pressure and improved renal hemodynamics","volume":"141","author":"Ishimitsu","year":"2021","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"issue":"2","key":"10.1016\/j.jep.2026.122132_bib20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ecl.2022.10.009","article-title":"Osteoporosis: review of etiology, mechanisms, and approach to management in the aging population","volume":"52","author":"Khandelwal","year":"2023","journal-title":"Endocrinol Metab. Clin. N. Am."},{"issue":"7492","key":"10.1016\/j.jep.2026.122132_bib21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature13145","article-title":"Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone","volume":"507","author":"Kusumbe","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jep.2026.122132_bib22","series-title":"In Vitro Vascular Effects of Eucommia ulmoides Oliv.\u2014A Plausible Scientific Basis for its Use in the Elimination of Blood Stagnation in Traditional Chinese Medicine (Kanpo)\u2014, International Symposium on Eucommia ulmoides","first-page":"11","author":"Kwan","year":"2007"},{"issue":"10","key":"10.1016\/j.jep.2026.122132_bib23","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s00198-021-05900-y","article-title":"The clinician's guide to prevention and treatment of osteoporosis","volume":"33","author":"LeBoff","year":"2022","journal-title":"Osteoporos. Int. : J. established as result of Cooperat. between the Eur. Found. Osteoporosis Nat. Osteoporosis Foundat. USA"},{"key":"10.1016\/j.jep.2026.122132_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118690","article-title":"Bu-Sui-Dan enhances osteoblast differentiation by upregulating VGLL4 to counteract TEAD4-Mediated RUNX2 transcription suppression in ovariectomized rats","volume":"335","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.122132_bib25","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1038\/s41598-025-33728-7","article-title":"Pilose antler extract promotes angiogenesis and vascular maturation to accelerate wound healing","volume":"16","author":"Li","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jep.2026.122132_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41413-025-00417-0","article-title":"Cell communication and relevant signaling pathways in osteogenesis-angiogenesis coupling","volume":"13","author":"Li","year":"2025","journal-title":"Bone Res."},{"issue":"2","key":"10.1016\/j.jep.2026.122132_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics18020279","article-title":"Psoralen promotes direct chemical reprogramming of mouse embryonic fibroblasts into osteoblast-like cells","volume":"18","author":"Li","year":"2026","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.jep.2026.122132_bib28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40779-025-00596-1","article-title":"Strategies for promoting neurovascularization in bone regeneration","volume":"12","author":"Li","year":"2025","journal-title":"Milit. Med. Res."},{"key":"10.1016\/j.jep.2026.122132_bib29","article-title":"Aucubin impeded preosteoclast fusion and enhanced CD31(hi) EMCN(hi) vessel angiogenesis in ovariectomized mice","volume":"2022","author":"Li","year":"2022","journal-title":"Stem Cell. Int."},{"issue":"4","key":"10.1016\/j.jep.2026.122132_bib30","first-page":"24","article-title":"A clinical study of Busui Dan in treatment of senile osteoporosis with syndrome of kidney-yang deficiency","volume":"38","author":"Liao","year":"2026","journal-title":"J. Tradit. Chin. Orthoped. Traumatol."},{"issue":"29","key":"10.1016\/j.jep.2026.122132_bib31","article-title":"The effect OF BU-SUI-dan combined with alendronate sodium tablets on chronic pain in senile osteoporosis: a randomized controlled trial","volume":"104","author":"Liao","year":"2025","journal-title":"Medicine"},{"key":"10.1016\/j.jep.2026.122132_bib32","first-page":"272","article-title":"Corylin in treatment of metabolic bone diseases: a review","author":"Lin","year":"2024","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2026.122132_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1236545","article-title":"Type H vessels: functions in bone development and diseases","volume":"11","author":"Liu","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jep.2026.122132_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.116052","article-title":"Pilose antler (Cervus elaphus Linnaeus) polysaccharide and polypeptide extract inhibits bone resorption in high turnover type osteoporosis by stimulating the MAKP and MMP-9 signaling pathways","volume":"304","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122132_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.998971","article-title":"Modified Qing' e Pills exerts anti-osteoporosis effects and prevents bone loss by enhancing type H blood vessel formation","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.jep.2026.122132_bib36","doi-asserted-by":"crossref","first-page":"426","DOI":"10.7150\/thno.34126","article-title":"Type H blood vessels in bone modeling and remodeling","volume":"10","author":"Peng","year":"2020","journal-title":"Theranostics"},{"issue":"8","key":"10.1016\/j.jep.2026.122132_bib37","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/ncb3555","article-title":"Dll4 and notch signalling couples sprouting angiogenesis and artery formation","volume":"19","author":"Pitulescu","year":"2017","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.jep.2026.122132_bib38","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12974-022-02636-2","article-title":"The role of the ZEB1-neuroinflammation axis in CNS disorders","volume":"19","author":"Poonaki","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2026.122132_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111933","article-title":"Animal-derived medicinal products in Russia: current nomenclature and specific aspects of quality control","volume":"240","author":"Prokopov","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"7492","key":"10.1016\/j.jep.2026.122132_bib40","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature13146","article-title":"Endothelial Notch activity promotes angiogenesis and osteogenesis in bone","volume":"507","author":"Ramasamy","year":"2014","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jep.2026.122132_bib41","doi-asserted-by":"crossref","first-page":"238","DOI":"10.52711\/2231-5713.2021.00039","article-title":"Babchi (Psoralea corylifolia): from a variety of traditional medicinal application to its novel roles in various diseases: a review","volume":"11","author":"Shaikh","year":"2021","journal-title":"Asian J. Pharm. Technol."},{"issue":"6","key":"10.1016\/j.jep.2026.122132_bib42","first-page":"170","article-title":"Overview and comparison of Chinese and Western medical treatments for osteoporosis","volume":"30","author":"Song","year":"2024","journal-title":"Alternative Ther. Health Med."},{"key":"10.1016\/j.jep.2026.122132_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2026.121649","article-title":"A specific pilose antler peptide LVLVEAELRE ameliorates cognitive deficits in SAMP8 mice via Celsr2","volume":"366","author":"Sun","year":"2026","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.122132_bib44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1242\/dev.125.1.21","article-title":"DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages","volume":"125","author":"Takagi","year":"1998","journal-title":"Development (Cambridge, England)"},{"issue":"5","key":"10.1016\/j.jep.2026.122132_bib45","first-page":"631","article-title":"Exploration of the mechanism of Busui DAN in regulating NSCs-Exos in PMOP based on SEMA3A-NRP1 axis","volume":"31","author":"Tang","year":"2025","journal-title":"Chin. J. Osteoporos."},{"key":"10.1016\/j.jep.2026.122132_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115399","article-title":"Protective effect of du-zhong-wan against osteoporotic fracture by targeting the osteoblastogenesis and angiogenesis couple factor SLIT3","volume":"295","author":"Tian","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"21","key":"10.1016\/j.jep.2026.122132_bib47","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1056\/NEJMcp2307353","article-title":"Postmenopausal osteoporosis","volume":"389","author":"Walker","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.jep.2026.122132_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.36","article-title":"Human type H vessels are a sensitive biomarker of bone mass","volume":"8","author":"Wang","year":"2017","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.jep.2026.122132_bib49","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1182\/blood-2005-03-1000","article-title":"Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function","volume":"107","author":"Williams","year":"2006","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jep.2026.122132_bib50","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0888-7543(05)80307-6","article-title":"The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2","volume":"14","author":"Williams","year":"1992","journal-title":"Genomics"},{"issue":"2","key":"10.1016\/j.jep.2026.122132_bib51","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jep.2012.12.008","article-title":"Deer antler base as a traditional Chinese medicine: a review of its traditional uses, chemistry and pharmacology","volume":"145","author":"Wu","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"24","key":"10.1016\/j.jep.2026.122132_bib52","doi-asserted-by":"crossref","first-page":"7140","DOI":"10.7150\/thno.35988","article-title":"Acetyl-11-keto-\u03b2-boswellic acid attenuates titanium particle-induced osteogenic inhibition via activation of the GSK-3\u03b2\/\u03b2-catenin signaling pathway","volume":"9","author":"Xiong","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jep.2026.122132_bib53","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.freeradbiomed.2023.01.017","article-title":"Corylifol A protects against ovariectomized-induced bone loss and attenuates RANKL-induced osteoclastogenesis via ROS reduction, ERK inhibition, and NFATc1 activation","volume":"196","author":"Xu","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2026.122132_bib54","article-title":"MiR-497\u223c195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1\u03b1 activity","volume":"8","author":"Yang","year":"2017","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.jep.2026.122132_bib55","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1097\/gme.0b013e3182507e18","article-title":"The osteoprotective effect of psoralen in ovariectomy-induced osteoporotic rats via stimulating the osteoblastic differentiation from bone mesenchymal stem cells","volume":"19","author":"Yang","year":"2012","journal-title":"Menopause (New York, N.Y.)"},{"key":"10.1016\/j.jep.2026.122132_bib56","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jep.2017.06.009","article-title":"Animal-derived natural products of Sowa Rigpa medicine: their pharmacopoeial description, current utilization and zoological identification","volume":"207","author":"Yeshi","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122132_bib58","article-title":"Isobavachin modulates bone homeostasis via Pi3k-Akt signaling","volume":"75","author":"Zhang","year":"2025","journal-title":"Int. Dent. J."},{"key":"10.1016\/j.jep.2026.122132_bib57","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jep.2016.05.025","article-title":"Traditional Chinese medicine formulas for the treatment of osteoporosis: implication for antiosteoporotic drug discovery","volume":"189","author":"Zhang","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"22","key":"10.1016\/j.jep.2026.122132_bib59","doi-asserted-by":"crossref","first-page":"28209","DOI":"10.1021\/acsami.4c04677","article-title":"Deferoxamine-Loaded injectable chitosan-grafted chlorogenic acid\/oxidized hyaluronic acid hybrid hydrogel with antibacterial, anti-inflammatory, and angiogenesis-promoting properties for diabetic wound repair","volume":"16","author":"Zhong","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.jep.2026.122132_bib60","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1186\/s13018-021-02797-5","article-title":"Total glycosides from Eucommia ulmoides seed promoted osteogenic differentiation of adipose-derived mesenchymal stem cells and bone formation in ovariectomized rats through regulating Notch signaling pathway","volume":"16","author":"Zhou","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"issue":"1","key":"10.1016\/j.jep.2026.122132_bib61","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1186\/s13018-022-03312-0","article-title":"ZEB1 regulates bone metabolism in osteoporotic rats through inducing POLDIP2 transcription","volume":"17","author":"Zhu","year":"2022","journal-title":"J. Orthop. Surg. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126009864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126009864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:34:51Z","timestamp":1785875691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126009864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":61,"alternative-id":["S0378874126009864"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122132","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bu-Sui-Dan promotes angiogenesis to mitigate age-related osteoporosis via the ZEB1\/Notch1 axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122132"}}