{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:03:37Z","timestamp":1784639017166,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jep.2026.122133","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:02:05Z","timestamp":1782601325000},"page":"122133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Yang-Xue-An-Tai Decoction Treats URSA by regulating the differentiation of proliferating decidual stromal cells through multiple targets"],"prefix":"10.1016","volume":"371","author":[{"given":"Guanshan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3223-7710","authenticated-orcid":false,"given":"Junqin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2026.122133_bib1","first-page":"570","article-title":"FoxO1 is a cell-specific core transcription factor for endometrial remodeling and homeostasis during menstrual cycle and early pregnancy","volume":"27","author":"Adiguzel","year":"2021","journal-title":"Hum. Reprod. Update"},{"issue":"9","key":"10.1016\/j.jep.2026.122133_bib2","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1002\/bit.28431","article-title":"Reconstructing the cell-cell interaction network among mouse immune cells","volume":"120","author":"Azadian","year":"2023","journal-title":"Biotechnol. Bioeng."},{"issue":"6","key":"10.1016\/j.jep.2026.122133_bib3","doi-asserted-by":"crossref","DOI":"10.1093\/jmcb\/mjae023","article-title":"Single-cell analysis defines LGALS1+ fibroblasts that promote proliferation and migration of intrahepatic cholangiocarcinoma","volume":"16","author":"Cao","year":"2024","journal-title":"J. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.jep.2026.122133_bib4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s10020-022-00523-3","article-title":"Temporal changes in cyclinD-CDK4\/CDK6 and cyclinE-CDK2 pathways: implications for the mechanism of deficient decidualization in an immune-based mouse model of unexplained recurrent spontaneous abortion","volume":"28","author":"Chang","year":"2022","journal-title":"Mol Med"},{"key":"10.1016\/j.jep.2026.122133_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150277","article-title":"CRIP1 regulates osteogenic differentiation of bone marrow stromal cells and pre-osteoblasts via the Wnt signaling pathway","volume":"727","author":"Chen","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"Pt A","key":"10.1016\/j.jep.2026.122133_bib6","article-title":"Jiawei Shoutai Pill promotes decidualization by regulating the SGK1\/ENaC pathway in recurrent spontaneous abortion","volume":"318","author":"Di","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2026.122133_bib7","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/cac2.12414","article-title":"Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib","volume":"43","author":"Eun","year":"2023","journal-title":"Cancer Commun."},{"issue":"1","key":"10.1016\/j.jep.2026.122133_bib8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40364-025-00746-6","article-title":"Single-cell multi-omics analysis identifies SPP1(+) macrophages as key drivers of ferroptosis-mediated fibrosis in ligamentum flavum hypertrophy","volume":"13","author":"Fei","year":"2025","journal-title":"Biomark. Res."},{"key":"10.1016\/j.jep.2026.122133_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157013","article-title":"The HIF-1\u03b1 signaling pathway: a key approach to revealing the effects of Scutellaria baicalensis Georgi against lipopolysaccharide-induced spontaneous abortion","volume":"145","author":"Gao","year":"2025","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.jep.2026.122133_bib10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41574-023-00921-5","article-title":"Luteal phase support in assisted reproductive technology","volume":"20","author":"Garg","year":"2024","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jep.2026.122133_bib11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12958-015-0047-7","article-title":"Uterine NDRG2 expression is increased at implantation sites during early pregnancy in mice, and its down-regulation inhibits decidualization of mouse endometrial stromal cells","volume":"13","author":"Gu","year":"2015","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"13","key":"10.1016\/j.jep.2026.122133_bib12","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.jep.2026.122133_bib13","first-page":"620","article-title":"Intervention of integrated Chinese and Western medicine on prethrombotic state in recurrent spontaneous abortion with yangxue antai granules","volume":"9","author":"He","year":"2014","journal-title":"World Journal of Integrated Traditional and Western Medicine"},{"issue":"3","key":"10.1016\/j.jep.2026.122133_bib14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1530\/REP-19-0401","article-title":"Progesterone-induced RNA Hand2os1 regulates decidualization in mice uteri","volume":"159","author":"Jia","year":"2020","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.jep.2026.122133_bib15","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.jep.2026.122133_bib16","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"issue":"11","key":"10.1016\/j.jep.2026.122133_bib17","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1093\/humrep\/deab184","article-title":"Analysis of serum and endometrial progesterone in determining endometrial receptivity","volume":"36","author":"Labarta","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jep.2026.122133_bib18","article-title":"Recurrent pregnancy loss: immunological aetiologies and associations with mental health","volume":"41","author":"Laijawala","year":"2024","journal-title":"Brain Behav Immun Health"},{"issue":"16","key":"10.1016\/j.jep.2026.122133_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612635","article-title":"Endogenous Galectin-1 modulates cell biological properties of immortalized retinal pigment epithelial cells in vitro","volume":"24","author":"Liesenhoff","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.122133_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157635","article-title":"Bushen Guchong decoction facilitates M2 polarization through JAK2\/STAT3 for URSA treatment","volume":"150","author":"Liu","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.122133_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155164","article-title":"Bushen antai recipe alleviates embryo absorption by enhancing immune tolerance and angiogenesis at the maternal-fetal interface via mobilizing MDSCs in abortion-prone mice","volume":"123","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jep.2026.122133_bib22","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","article-title":"DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors","volume":"8","author":"McGinnis","year":"2019","journal-title":"Cell Syst."},{"issue":"4","key":"10.1016\/j.jep.2026.122133_bib23","article-title":"The effect of frozen embryo transfer regimen on the association between serum progesterone and live birth: a multicentre prospective cohort study (ProFET)","volume":"2022","author":"Melo","year":"2022","journal-title":"Hum Rep. Open"},{"issue":"4","key":"10.1016\/j.jep.2026.122133_bib24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1530\/REP-19-0425","article-title":"Resveratrol enhances decidualization of human endometrial stromal cells","volume":"159","author":"Mestre Citrinovitz","year":"2020","journal-title":"Reproduction"},{"issue":"10","key":"10.1016\/j.jep.2026.122133_bib25","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022251","article-title":"The TGF-\u03b2 family in the reproductive tract","volume":"9","author":"Monsivais","year":"2017","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"23","key":"10.1016\/j.jep.2026.122133_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/nu15234882","article-title":"Recent advances in folates and autoantibodies against folate receptors in early pregnancy and miscarriage","volume":"15","author":"Qin","year":"2023","journal-title":"Nutrients"},{"issue":"30","key":"10.1016\/j.jep.2026.122133_bib27","doi-asserted-by":"crossref","first-page":"12064","DOI":"10.1073\/pnas.1207210109","article-title":"Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis","volume":"109","author":"Somekawa","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.jep.2026.122133_bib28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12964-025-02055-9","article-title":"Immunomodulatory effect of efferocytosis at the maternal-fetal interface","volume":"23","author":"Tao","year":"2025","journal-title":"Cell Commun. Signal."},{"issue":"7","key":"10.1016\/j.jep.2026.122133_bib29","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1016\/j.apsb.2025.05.013","article-title":"Single-cell RNA sequencing reveals Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131-TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells","volume":"15","author":"Tao","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"issue":"10","key":"10.1016\/j.jep.2026.122133_bib30","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1210\/endo.141.10.7734","article-title":"Estrogen receptors alpha and beta in rat decidua cells: cell-specific expression and differential regulation by steroid hormones and prolactin","volume":"141","author":"Tessier","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.jep.2026.122133_bib31","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.trsl.2022.10.004","article-title":"Ischemia challenged epicardial adipose tissue stem cells-derived extracellular vesicles alter the gene expression of cardiac fibroblasts to cardiomyocyte like phenotype","volume":"254","author":"Thankam","year":"2023","journal-title":"Transl. Res."},{"issue":"4","key":"10.1016\/j.jep.2026.122133_bib32","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"21","key":"10.1016\/j.jep.2026.122133_bib33","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1016\/j.devcel.2023.08.004","article-title":"Maternal and embryonic signals cause functional differentiation of luminal epithelial cells and receptivity establishment","volume":"58","author":"Wang","year":"2023","journal-title":"Dev. Cell"},{"issue":"20","key":"10.1016\/j.jep.2026.122133_bib34","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1016\/j.cell.2023.08.020","article-title":"Spatiotemporal insight into early pregnancy governed by immune-featured stromal cells","volume":"186","author":"Yang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.jep.2026.122133_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.112016","article-title":"TFAP2A-mediated downregulation of UBE2C is crucial for endometrial decidualization and embryo implantation","volume":"135","author":"Yu","year":"2025","journal-title":"Cell. Signal."},{"key":"10.1016\/j.jep.2026.122133_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2025.154069","article-title":"Cadmium induces spontaneous abortion by impairing endometrial stromal cell decidualization","volume":"511","author":"Zhang","year":"2025","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.jep.2026.122133_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2025.153152","article-title":"Single-cell transcriptome reveals that immune cells inhibit the repairment of IGFBP3 + stromal cells in thin endometrium","volume":"231","author":"Zou","year":"2025","journal-title":"Immunobiology"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126009876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126009876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:24:53Z","timestamp":1784636693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126009876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":37,"alternative-id":["S0378874126009876"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122133","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Yang-Xue-An-Tai Decoction Treats URSA by regulating the differentiation of proliferating decidual stromal cells through multiple targets","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122133"}}