{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:01:03Z","timestamp":1790776863332,"version":"4.1.0"},"reference-count":150,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jep.2026.122135","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T14:20:02Z","timestamp":1782656402000},"page":"122135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Harnessing natural herbaceous plants against ferroptosis: Implications for managing polycystic ovary syndrome"],"prefix":"10.1016","volume":"372","author":[{"given":"Jianquan","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caide","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.122135_bib1","first-page":"130","article-title":"Nelumbo nucifera gaertn. (lotus): importance in reproductive healthcare. J. Drug","volume":"10","author":"Acharya","year":"2025","journal-title":"Res. Ayu. Sci."},{"key":"10.1016\/j.jep.2026.122135_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41392-024-02088-5","article-title":"In defence of ferroptosis","volume":"10","author":"Alves","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jep.2026.122135_bib3","article-title":"From pathophysiology to treatment: the role of ferroptosis in PCOS","volume":"30","author":"An","year":"2025","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.jep.2026.122135_bib4","first-page":"20","article-title":"Study of ErChen decoction on the treatment of obesity polycystic ovary syndrome and obesity infertility","volume":"40","author":"Cai","year":"2022","journal-title":"J. Pharmaceutical. Service"},{"key":"10.1016\/j.jep.2026.122135_bib6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13048-025-01700-8","article-title":"Plumbagin ameliorates ferroptosis of ovarian granulosa cells in polycystic ovary syndrome by down-regulating SLC7A5 m6A methylation modification through inhibition of YTHDF1","volume":"18","author":"Cai","year":"2025","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.jep.2026.122135_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117377","article-title":"Tauroursodeoxycholic acid ameliorates palmitic acid induced endoplasmic reticulum stress and impaired autophagy via IRE1- XBP1-FoxO1 pathway in KGN cells","volume":"242","author":"Cao","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2026.122135_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2022.101198","article-title":"Endoplasmic reticulum stress and lipids in health and diseases","volume":"89","author":"Celik","year":"2023","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.jep.2026.122135_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1529231","article-title":"Effect and mechanism of resveratrol against polycystic ovary syndrome: a review","volume":"16","author":"Chang","year":"2025","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2026.122135_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2022.01.012","article-title":"Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway","volume":"180","author":"Chen","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2026.122135_bib11","article-title":"Effects of TCM on polycystic ovary syndrome and its cellular endocrine mechanism","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2026.122135_bib12","article-title":"Effects of Erchen decoction on oxidative stress-related cytochrome P450 metabolites of arachidonic acid in dyslipidemic mice with Phlegm-Dampness retention syndrome: a randomized, controlled trial on the correspondence between prescription and syndrome","volume":"2022","author":"Chen","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2026.122135_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154808","article-title":"Erchen decoction to reduce oxidative stress in dyslipidemia phlegm-dampness retention syndrome mice: in vivo mechanism revealed by metabolomics (liquid chromatography-mass spectrometry)","volume":"115","author":"Chen","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.122135_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202506497","article-title":"Disruption of gut microbiota-mediated de novo NAD+ synthesis contributes to the development of polycystic ovary syndrome","volume":"12","author":"Chen","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jep.2026.122135_bib15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s13048-025-01788-y","article-title":"Diosmetin ameliorates inflammation and apoptosis in the pathomechanism of PCOS through the NRF2\/AKT\/PPAR\u03b3 signalling pathway","volume":"18","author":"Chen","year":"2025","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.jep.2026.122135_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167182","article-title":"Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2\/ALOX15 axis in polycystic ovary syndrome","volume":"1870","author":"Chen","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.jep.2026.122135_bib17","first-page":"615","article-title":"Effects and mechanism of Erchen decoction on the regulation of phospholipid hydroperoxide glutathione peroxidase\/cyclooxygenase-2 mediated oxidative damage and ferroptosis on polycystic ovary syndrome","volume":"38","author":"Cong","year":"2023","journal-title":"Chin. J. Trad. Chin. Med. Pharmacy."},{"key":"10.1016\/j.jep.2026.122135_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.70089","article-title":"N6-methyladenosine modification on the function of female reproductive development and related diseases","volume":"12","author":"Cui","year":"2024","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.jep.2026.122135_bib19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.phrs.2015.08.021","article-title":"The effects of baicalein and baicalin on mitochondrial function and dynamics: a review","volume":"100","author":"de Oliveira","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2026.122135_bib20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/1440-1681.13732","article-title":"Research trends in ferroptosis since the origin of the concept: a bibliometric analysis","volume":"50","author":"Deng","year":"2023","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.jep.2026.122135_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e38633","article-title":"Pharmacological and toxicological characteristics of baicalin in preventing spontaneous abortion and recurrent pregnancy loss: a multi-level critical review","volume":"10","author":"Deng","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2026.122135_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156800","article-title":"Nuciferine activates intestinal TAS2R46 to attenuate metabolic disorders and hyperlipidemia via hepatic VLDL regulation","volume":"142","author":"Ding","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.122135_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2024.104078","article-title":"Endoplasmic reticulum stress-mediated ferroptosis in granulosa cells contributes to follicular dysfunction of polycystic ovary syndrome driven by hyperandrogenism","volume":"49","author":"Ding","year":"2024","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.jep.2026.122135_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2026.122135_bib25","first-page":"556","article-title":"Baicalin alleviates acute lung injury by activating the SIRT3\/GPX4 pathway to inhibit lung epithelial cell ferroptosis","volume":"55","author":"Du","year":"2025","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.jep.2026.122135_bib26","first-page":"105","article-title":"Study on the possible mechanism of Shoutai pill in the treatment of unexplained recurrent abortion","volume":"29","author":"Fang","year":"2025","journal-title":"Afr. J. Reprod. Health"},{"key":"10.1016\/j.jep.2026.122135_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117698","article-title":"Traditional Chinese medicine formulae: a complementary method for the treatment of polycystic ovary syndrome","volume":"323","author":"Fu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122135_bib28","doi-asserted-by":"crossref","first-page":"5604","DOI":"10.1002\/ptr.8498","article-title":"Nrf2-mediated ferroptosis is involved in berberine-induced alleviation of diabetic kidney disease","volume":"39","author":"Gao","year":"2025","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2026.122135_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1388540","article-title":"Garlic ameliorates atherosclerosis by regulating ferroptosis pathway: an integrated strategy of network pharmacology, bioinformatic and experimental verification","volume":"15","author":"Gao","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2026.122135_bib30","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3390\/antiox13060714","article-title":"Nuciferine protects cochlear hair cells from ferroptosis through inhibiting NCOA4-mediated ferritinophagy","volume":"13","author":"Gao","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2026.122135_bib31","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1021\/acschembio.8b00199","article-title":"Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis","volume":"13","author":"Gaschler","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jep.2026.122135_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.explore.2024.103040","article-title":"Berberine as adjuvant therapy for treating reduced fertility potential in women with polycystic ovary syndrome: a meta-analysis of randomized controlled trials","volume":"20","author":"Ha","year":"2024","journal-title":"Explore"},{"key":"10.1016\/j.jep.2026.122135_bib33","doi-asserted-by":"crossref","DOI":"10.1177\/2515690X241304519","article-title":"Anti-inflammatory and antioxidant effects of gundelia tournefortii aqueous extract on the liver and kidney of PCOS mice","volume":"30","author":"Hachem","year":"2025","journal-title":"J. Evid. Based. Integr. Med."},{"key":"10.1016\/j.jep.2026.122135_bib34","first-page":"67","article-title":"Exploration of therapeutic mechanism of modified Shoutai pill on early threatened abortion patients with PCOS from perspective of iron death. Acta","volume":"51","author":"Han","year":"2023","journal-title":"Chin. Med. Pharm."},{"key":"10.1016\/j.jep.2026.122135_bib35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3233\/HAB-240011","article-title":"Free radicals and oxidative stress: mechanisms and therapeutic targets","volume":"32","author":"Hassan","year":"2024","journal-title":"Hum. Antibodies"},{"key":"10.1016\/j.jep.2026.122135_bib36","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41574-024-01057-w","article-title":"Polycystic ovary syndrome as a metabolic disease","volume":"21","author":"Helvaci","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jep.2026.122135_bib37","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaab067","article-title":"Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome","volume":"27","author":"Hu","year":"2021","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jep.2026.122135_bib38","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.placenta.2025.04.012","article-title":"Baicalein prevents pregnancy loss by maintaining regulatory T cell activation through inhibition of the TLR4\/NF-\u03baB signaling pathway","volume":"165","author":"Huang","year":"2025","journal-title":"Placenta"},{"key":"10.1016\/j.jep.2026.122135_bib39","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1080\/21655979.2022.2045834","article-title":"Platycodin D regulates high glucose-induced ferroptosis of HK-2 cells through glutathione peroxidase 4 (GPX4)","volume":"13","author":"Huang","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.jep.2026.122135_bib40","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.freeradbiomed.2024.11.021","article-title":"Leonurine restrains granulosa cell ferroptosis through SLC7A11\/GPX4 axis to promote the treatment of polycystic ovary syndrome","volume":"226","author":"Huang","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2026.122135_bib41","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4274\/tjod.galenos.2023.70033","article-title":"Protective and\/or therapeutic effects of berberine in a model of premature ovarian failure induced by cyclophosphamide in rats","volume":"20","author":"\u0130lgen","year":"2023","journal-title":"Turk. J. Obstet. Gynecol."},{"key":"10.1016\/j.jep.2026.122135_bib42","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.freeradbiomed.2024.09.033","article-title":"Platycodin D ameliorates polycystic ovary syndrome-induced ovarian damage by upregulating CD44 to attenuate ferroptosis","volume":"224","author":"Ji","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2026.122135_bib43","article-title":"The role of microbial indole metabolites in tumor. Gut","volume":"16","author":"Jia","year":"2024","journal-title":"Micro"},{"key":"10.1016\/j.jep.2026.122135_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110914","article-title":"Nuciferine protects against lipopolysaccharide-induced endometritis via inhibiting ferroptosis and modulating AMPK\u03b1\/mTOR\/HIF-1\u03b1 signaling axis","volume":"124","author":"Jiang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2026.122135_bib45","doi-asserted-by":"crossref","DOI":"10.1530\/REP-25-0121","article-title":"Polycystic ovary syndrome: origins and implications: epidemiological aspects of polycystic ovary syndrome","volume":"170","author":"Joham","year":"2025","journal-title":"Reproduction"},{"key":"10.1016\/j.jep.2026.122135_bib46","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1530\/REP-22-0265","article-title":"Oxidative phosphorylation inhibitors inhibit proliferation of endometriosis cells","volume":"165","author":"Kapur","year":"2023","journal-title":"Reproduction"},{"key":"10.1016\/j.jep.2026.122135_bib47","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1538\/expanim.20-0080","article-title":"The effect of a natural molecule in ovary ischemia reperfusion damage: does lycopene protect ovary?","volume":"70","author":"Kirmizi","year":"2021","journal-title":"Exp. Anim."},{"key":"10.1016\/j.jep.2026.122135_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251910636","article-title":"Impact of gut microbiota and SCFAs in the pathogenesis of PCOS and the effect of metformin therapy","volume":"25","author":"Kukaev","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.122135_bib49","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4103\/0974-8520.182750","article-title":"Comparative toxicity profiles of plumbago zeylanica L. root petroleum ether, acetone and hydroalcoholic extracts in Wistar rats","volume":"36","author":"Kumar","year":"2015","journal-title":"Ayu"},{"key":"10.1016\/j.jep.2026.122135_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117028","article-title":"Modified Shoutai pill inhibited ferroptosis to alleviate recurrent pregnancy loss","volume":"319","author":"Lai","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122135_bib51","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s10555-025-10252-8","article-title":"Ferroptosis: iron release mechanisms in the bioenergetic process","volume":"44","author":"Lee","year":"2025","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.jep.2026.122135_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155312","article-title":"Nuciferine reduces inflammation induced by cerebral ischemia-reperfusion injury through the PI3K\/Akt\/NF-\u03baB pathway","volume":"125","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.122135_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/4975867","article-title":"Effect of Wenshentiaojing decoction on hormone level and follicular number in patients with menstrual disorder of polycystic ovary syndrome","volume":"2021","author":"Li","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2026.122135_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.116029","article-title":"Inhibition of SLC7A11-GPX4 signal pathway is involved in aconitine-induced ferroptosis in vivo and in vitro","volume":"303","author":"Li","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122135_bib55","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.7150\/thno.100080","article-title":"Ferroptosis at the nexus of metabolism and metabolic diseases","volume":"14","author":"Li","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.jep.2026.122135_bib56","first-page":"855","article-title":"Chlorogenic acid regulates the proliferation and migration of high-grade serous ovarian cancer cells through modulating the miR199a5p\/DDR1 axis","volume":"69","author":"Li","year":"2022","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.jep.2026.122135_bib57","first-page":"4007","article-title":"Effects of baicalin on the proliferation and apoptosis of ovarian granulosa cells in polycystic ovary syndrome","volume":"24","author":"Li","year":"2024","journal-title":"Prog. Mod. Biomed."},{"key":"10.1016\/j.jep.2026.122135_bib59","article-title":"Exploring the causal associations between diet-derived circulating antioxidants and the risk of endometriosis: a Mendelian randomization study","volume":"11","author":"Li","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jep.2026.122135_bib58","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hoae013","article-title":"Ovarian ferroptosis induced by androgen is involved in pathogenesis of PCOS","volume":"2024","author":"Li","year":"2024","journal-title":"Hum. Reprod. Open."},{"key":"10.1016\/j.jep.2026.122135_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.714909","article-title":"Medical significance of uterine corpus endometrial carcinoma patients infected with SARS-CoV-2 and pharmacological characteristics of plumbagin","volume":"12","author":"Li","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2026.122135_bib62","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.7150\/ijbs.68224","article-title":"SCM-198 alleviates endometriosis by suppressing estrogen-ER\u03b1 mediated differentiation and function of CD4+CD25+ regulatory T cells","volume":"18","author":"Li","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2026.122135_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155423","article-title":"Baicalein improves the symptoms of polycystic ovary syndrome by mitigating oxidative stress and ferroptosis in the ovary and gravid placenta","volume":"128","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.122135_bib64","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1002\/ptr.7806","article-title":"Berberine and health outcomes: an umbrella review","volume":"37","author":"Li","year":"2023","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2026.122135_bib60","first-page":"41","article-title":"Clinical analysis of the effect of kidney-warming and menstruation-regulating therapy on menstrual disorders in patients with primary hypothyroidism","volume":"8","author":"Li","year":"2021","journal-title":"Electronic. J. Practical. Gynecological. Endocrinology."},{"key":"10.1016\/j.jep.2026.122135_bib65","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the intersection of lipid metabolism and cellular signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jep.2026.122135_bib66","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/08916934.2021.2010050","article-title":"Berberine inhibits the development of endometrial cancer through circ_ZNF608\/miR-377-3p\/COX2 axis","volume":"55","author":"Liang","year":"2022","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jep.2026.122135_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e35283","article-title":"Predicting TCM patterns in PCOS patients: an exploration of feature selection methods and multi-label machine learning models","volume":"10","author":"Lim","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2026.122135_bib68","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1093\/abbs\/gmab095","article-title":"SCM-198 ameliorates endometrial inflammation via suppressing the LPS-JNK-cJUN\/cFOS-TLR4-NF-\u03baB pathway","volume":"53","author":"Lin","year":"2021","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.jep.2026.122135_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177870","article-title":"Chlorogenic acid mitigates DHEA-induced oxidative stress in granulosa cells and alleviates ferroptosis via the NF-\u03baB signaling pathway in PCOS","volume":"1002","author":"Lin","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2026.122135_bib70","first-page":"21","article-title":"Observation of therapeutic effect of Xionggui Erchen decoction combined with metformin on polycystic ovary syndrome and its effects on menstrual cycle","volume":"56","author":"Liu","year":"2024","journal-title":"J. New. Chin. Med."},{"key":"10.1016\/j.jep.2026.122135_bib71","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/10799893.2020.1830110","article-title":"Berberine modulates keratin 17 to inhibit cervical cancer cell viability and metastasis","volume":"41","author":"Liu","year":"2021","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.jep.2026.122135_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115415","article-title":"The emerging role of ferroptosis in female reproductive disorders","volume":"166","author":"Liu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.122135_bib73","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2174\/0113862073274708231028185333","article-title":"Shoutai pill enhances endometrial receptivity in controlled ovarian hyperstimulation mice by improving the in-vivo immune environment","volume":"28","author":"Liu","year":"2025","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.jep.2026.122135_bib74","doi-asserted-by":"crossref","DOI":"10.1111\/aji.70163","article-title":"The role of cryptotanshinone regulates HTR-8\/SVneo cells activity through the p53\/STAT3 pathway in unexplained recurrent spontaneous abortion","volume":"94","author":"Lu","year":"2025","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jep.2026.122135_bib75","doi-asserted-by":"crossref","first-page":"12516","DOI":"10.1021\/acs.jafc.3c08490","article-title":"Platycodin D ameliorates cognitive impairment in type 2 diabetes mellitus mice via regulating PI3K\/Akt\/GSK3\u03b2 signaling pathway","volume":"72","author":"Lu","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2026.122135_bib76","article-title":"Advancements in lead therapeutic phytochemicals polycystic ovary syndrome: a review","volume":"13","author":"Luo","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2026.122135_bib77","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12948","article-title":"Melatonin MT1 receptors regulate the Sirt1\/Nrf2\/Ho-1\/Gpx4 pathway to prevent \u03b1-synuclein-induced ferroptosis in Parkinson's disease","volume":"76","author":"Lv","year":"2024","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.jep.2026.122135_bib78","article-title":"The role of gut microbiota mediated ferroptosis in PCOS and the therapeutic potential of Chinese herbal medicine","volume":"13","author":"Lv","year":"2026","journal-title":"Front. Med."},{"key":"10.1016\/j.jep.2026.122135_bib79","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s13048-026-02054-5","article-title":"Interconnected cell death pathways: central mechanisms and therapeutic targets in impaired follicular development of polycystic ovary syndrome","volume":"19","author":"Ma","year":"2022","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.jep.2026.122135_bib80","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41392-022-01090-z","article-title":"ALOX15-launched PUFA-Phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage","volume":"7","author":"Ma","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jep.2026.122135_bib81","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/humupd\/dmaf030","article-title":"Prevalence of polycystic ovary syndrome: a global and regional systematic review and meta-analysis","volume":"32","author":"Neven","year":"2026","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jep.2026.122135_bib82","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3892\/ol.2023.13722","article-title":"Platycodin D inhibits the proliferation, invasion and migration of endometrial cancer cells by blocking the PI3K\/Akt signaling pathway via ADRA2A upregulation","volume":"25","author":"Ni","year":"2023","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jep.2026.122135_bib83","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s43032-024-01619-3","article-title":"Development of an endoplasmic reticulum stress-related diagnostic signature in polycystic ovary syndrome","volume":"32","author":"Niu","year":"2025","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.jep.2026.122135_bib85","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s002040050537","article-title":"The toxic mechanism and metabolic effects of atractyloside in precision-cut pig kidney and liver slices","volume":"72","author":"Obatomi","year":"1998","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jep.2026.122135_bib84","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0278-6915(98)00002-7","article-title":"Biochemistry and toxicology of the diterpenoid glycoside atractyloside","volume":"36","author":"Obatomi","year":"1998","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2026.122135_bib86","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s13104-024-06921-6","article-title":"Acetate attenuates hypothalamic pyroptosis in experimentally induced polycystic ovarian syndrome","volume":"17","author":"Olaniyi","year":"2024","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.jep.2026.122135_bib87","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s10787-026-02117-5","article-title":"Polycystic ovary syndrome (PCOS): current insights, emerging therapeutics, and future treatment strategies","volume":"34","author":"Panchpuri","year":"2026","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2026.122135_bib88","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1070264","article-title":"Metformin improves polycystic ovary syndrome in mice by inhibiting ovarian ferroptosis","volume":"14","author":"Peng","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2026.122135_bib89","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jphs.2023.07.004","article-title":"Berberine protects cyclophosphamide and busulfan-induced premature ovarian insufficiency in mouse model","volume":"153","author":"Peng","year":"2023","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.jep.2026.122135_bib90","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s12602-024-10223-5","article-title":"Gut microbiota and polycystic ovary syndrome (PCOS): understanding the pathogenesis and the role of probiotics as a therapeutic strategy","volume":"16","author":"Salehi","year":"2024","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.jep.2026.122135_bib91","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s10735-024-10257-7","article-title":"METTL3 silencing inhibits ferroptosis to suppress ovarian fibrosis in PCOS by upregulating m6A modification of GPX4","volume":"55","author":"Shen","year":"2024","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.jep.2026.122135_bib92","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1007\/s43032-021-00826-6","article-title":"Curcumin and polycystic ovary syndrome: a systematic review","volume":"29","author":"Shojaei-Zarghani","year":"2022","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.jep.2026.122135_bib93","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1007\/s10815-022-02625-7","article-title":"A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS)","volume":"39","author":"Siddiqui","year":"2022","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.jep.2026.122135_bib94","doi-asserted-by":"crossref","first-page":"778","DOI":"10.4062\/biomolther.2024.083","article-title":"Atractylodes lancea and its constituent, atractylodin, ameliorates metabolic dysfunction-associated steatotic liver disease via AMPK activation","volume":"32","author":"Song","year":"2024","journal-title":"Biomol. Ther (Seoul)."},{"key":"10.1016\/j.jep.2026.122135_bib95","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40360-016-0094-5","article-title":"Pharmacokinetics, toxicity, and cytochrome P450 modulatory activity of plumbagin","volume":"17","author":"Sumsakul","year":"2016","journal-title":"BMC. Pharmacol. Toxicol."},{"key":"10.1016\/j.jep.2026.122135_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114550","article-title":"Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway","volume":"155","author":"Sun","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2026.122135_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156362","article-title":"Stigmasterol from Prunella vulgaris L. alleviates LPS-Induced mammary gland injury by inhibiting inflammation and ferroptosis","volume":"137","author":"Sun","year":"2025","journal-title":"Phytomedicine"},{"issue":"25","key":"10.1016\/j.jep.2026.122135_bib98","first-page":"820","article-title":"Berberine suppresses colorectal cancer progression by inducing ferroptosis-mediated energy metabolism disorders","volume":"S2090\u20131232","author":"Sun","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jep.2026.122135_bib99","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.967151","article-title":"MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome","volume":"13","author":"Tan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2026.122135_bib100","doi-asserted-by":"crossref","DOI":"10.1530\/EC-22-0459","article-title":"NEDD4L facilitates granulosa cell ferroptosis by promoting GPX4 ubiquitination and degradation","volume":"12","author":"Tang","year":"2023","journal-title":"Endocr. Connect."},{"key":"10.1016\/j.jep.2026.122135_bib101","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.70720","article-title":"Different derivatives of plumbagin analogue: bioavailability and their toxicity studies","volume":"13","author":"Thekkumkara","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.jep.2026.122135_bib102","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262110381","article-title":"Ferroptosis in the ovarian follicular microenvironment: a redox-dependent cell death pathway with emerging roles in PCOS, oocyte quality, and IVF outcomes","volume":"26","author":"Voros","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.122135_bib103","article-title":"Lycopene ameliorates polycystic ovary syndrome in rats by inhibiting ovarian ferroptosis through activation of the AMPK\/Nrf2 pathway","volume":"39","author":"Wang","year":"2025","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.jep.2026.122135_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.108089","article-title":"Exploring the efficacy of wenshentiaojing decoction in PCOS: network pharmacology and mouse model insights","volume":"154","author":"Wang","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jep.2026.122135_bib106","article-title":"Broadening Horizons: the role of ferroptosis in polycystic ovary syndrome","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2026.122135_bib105","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3390\/genes15040507","article-title":"Assessment of the effect of leonurine hydrochloride in a mouse model of PCOS by gene expression profiling","volume":"15","author":"Wang","year":"2024","journal-title":"Genes"},{"key":"10.1016\/j.jep.2026.122135_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.144014","article-title":"Deciphering the mechanism of baicalein in cervical cancer via bioinformatics, machine learning and computational simulations: PIM1 and CDK2 are key target proteins","volume":"311","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122135_bib108","doi-asserted-by":"crossref","first-page":"5265","DOI":"10.1007\/s12010-023-04825-y","article-title":"Berberine protects against dihydrotestosterone-induced human ovarian granulosa cell injury and ferroptosis by regulating the Circ_0097636\/MiR-186-5p\/SIRT3 pathway","volume":"196","author":"Wang","year":"2024","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.jep.2026.122135_bib109","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12902-025-02113-w","article-title":"Dysregulated iron metabolism related to ferroptosis in polycystic ovary syndrome: a meta-analysis and a case-control study in pregnant women","volume":"26","author":"Wang","year":"2025","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.jep.2026.122135_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115956","article-title":"Cryptotanshinone suppresses ovarian cancer via simultaneous inhibition of glycolysis and oxidative phosphorylation","volume":"170","author":"Wang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.122135_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109186","article-title":"Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2\/SLC7A11\/GPX4 axis to inhibit PM2.5-mediated lung injury in mice","volume":"112","author":"Wang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2026.122135_bib112","first-page":"200","article-title":"Treatment of 98 cases of kidney yang deficiency-related bleeding with self-formulated wenshentiaojing decoction","volume":"3","author":"Wang","year":"2004","journal-title":"J. Liaoning. Univ. Trad. Chin. Med."},{"key":"10.1016\/j.jep.2026.122135_bib113","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1007\/s10495-023-01850-4","article-title":"Sodium butyrate induces ferroptosis in endometrial cancer cells via the RBM3\/SLC7A11 axis","volume":"28","author":"Wang","year":"2023","journal-title":"Apoptosis"},{"key":"10.1016\/j.jep.2026.122135_bib114","first-page":"2271","article-title":"Research progress on ferroptosis regulation of female reproduction. Biol. Trace","volume":"204","author":"Wang","year":"2026","journal-title":"El Resid."},{"key":"10.1016\/j.jep.2026.122135_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2023.119480","article-title":"The role of ferroptosis in metabolic diseases","volume":"1870","author":"Xie","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.jep.2026.122135_bib116","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13048-026-01968-4","article-title":"The interaction between endoplasmic reticulum stress and ferroptosis in ovarian diseases","volume":"19","author":"Xing","year":"2026","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.jep.2026.122135_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116016","article-title":"Analysis of gut microbiota metabolites of platycodin D and activity verification","volume":"242","author":"Xu","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2026.122135_bib118","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1007\/s12035-024-04443-7","article-title":"Curcumin alleviates microglia-mediated neuroinflammation and neuronal ferroptosis following experimental subarachnoid hemorrhage by modulating the Nrf2\/HO-1 signaling pathway","volume":"62","author":"Xu","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jep.2026.122135_bib119","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1039\/D3FO03632D","article-title":"Asiatic acid ameliorates hepatic lipid accumulation and insulin resistance in mice consuming a high-fat diet","volume":"15","author":"Yan","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2026.122135_bib120","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/jat.4697","article-title":"Nuciferine protects hyperandrogen-injured ovarian granulosa cells by inhibiting ferroptosis via SOX2-mediated activation of the SLC7A11\/GPX4 axis","volume":"45","author":"Yang","year":"2025","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.jep.2026.122135_bib121","article-title":"Research on the medication rules of Chinese herbal formulas on treatment of threatened abortion","volume":"43","author":"Yang","year":"2021","journal-title":"Compl. Ther. Clin. Pract."},{"key":"10.1016\/j.jep.2026.122135_bib122","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ijbiomac.2022.12.285","article-title":"Mussel inspired multifunctional bovine serum albumin (BSA) coatings loaded with baicalein (BAI) to enhance osteogenesis and resist oxidative stress for potential application on implant","volume":"229","author":"Yang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122135_bib123","first-page":"3851","article-title":"Cryptotanshinone alleviates polycystic ovary syndrome in rats by regulating the HMGB1\/TLR4\/NF-\u03baB signaling pathway","volume":"22","author":"Yang","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2026.122135_bib124","article-title":"Comparative efficacy and safety of different traditional Chinese medicine external therapies for polycystic ovary syndrome in women: a network meta-analysis","volume":"104","author":"Ye","year":"2025","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.jep.2026.122135_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103615","article-title":"GPX4 deficiency-induced ferroptosis drives endometrial epithelial fibrosis in polycystic ovary syndrome","volume":"83","author":"Ye","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2026.122135_bib126","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.7150\/ijbs.102859","article-title":"Mechanism of ferroptosis and its role in disease development","volume":"21","author":"Ye","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2026.122135_bib127","doi-asserted-by":"crossref","first-page":"6189","DOI":"10.3390\/cimb44120422","article-title":"Baicalein relieves ferroptosis-mediated phagocytosis inhibition of macrophages in ovarian endometriosis","volume":"44","author":"Yi","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.jep.2026.122135_bib128","first-page":"615","article-title":"Effect and mechanism study of modified erchen decoction treating endometriosis of kidney-deficiency and phlegm-dampness. Information. Trad","volume":"36","author":"Yuan","year":"2019","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2026.122135_bib129","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202300379","article-title":"Ferroptosis detection: from approaches to applications","volume":"62","author":"Zeng","year":"2023","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"10.1016\/j.jep.2026.122135_bib130","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cmet.2024.10.006","article-title":"Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathology via suppressing ferroptosis","volume":"37","author":"Zha","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.jep.2026.122135_bib131","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.21037\/atm-21-4174","article-title":"Involvement of ferroptosis in the granulosa cells proliferation of PCOS through the circRHBG\/miR-515\/SLC7A11 axis","volume":"9","author":"Zhang","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.jep.2026.122135_bib132","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13020-025-01297-6","article-title":"Acupuncture of polycystic ovary syndrome: delving into bile acid metabolism","volume":"21","author":"Zhang","year":"2026","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2026.122135_bib133","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156852","article-title":"Erchen decoction ameliorates the rat model of polycystic ovary syndrome by regulating the steroid biosynthesis pathway","volume":"143","author":"Zhang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.122135_bib134","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1080\/21655979.2021.1956403","article-title":"Transferrin receptor-mediated reactive oxygen species promotes ferroptosis of KGN cells via regulating NADPH oxidase 1\/PTEN induced kinase 1\/acyl-CoA synthetase long chain family member 4 signaling","volume":"12","author":"Zhang","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.jep.2026.122135_bib135","first-page":"327","article-title":"Ethnopharmacology, phytochemistry, pharmacology and product application of platycodon grandiflorum: a review","volume":"16","author":"Zhang","year":"2024","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.jep.2026.122135_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114706","article-title":"Mechanisms of ferroptosis regulating oxidative stress and energy metabolism in myocardial ischemia-reperfusion injury and a novel perspective of natural plant active ingredients for its treatment","volume":"165","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.122135_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2025.102380","article-title":"Berberine inhibits metastasis of ovarian cancer by blocking lipid metabolism, alleviating aging of adipose tissue and increasing tumor infiltrating immune cells","volume":"56","author":"Zhang","year":"2025","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.jep.2026.122135_bib138","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.7150\/ijbs.128537","article-title":"Mitochondria and polycystic ovary syndrome: the role of ferroptosis, inflammasomes, and endoplasmic reticulum stress","volume":"22","author":"Zhang","year":"2026","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2026.122135_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120247","article-title":"Shoutai pill synergistically inhibits internal reproductive organ apoptosis: coordinated EGFR\/PI3K\/AKT modulation in primary ovarian insufficiency","volume":"352","author":"Zhang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122135_bib140","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/s12964-024-01939-6","article-title":"A ketogenic diet alleviates the apoptosis of granulosa cells by inhibiting the activation of cGAS-STING signaling pathway in PCOS mice","volume":"22","author":"Zhao","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.jep.2026.122135_bib141","doi-asserted-by":"crossref","first-page":"271","DOI":"10.7150\/ijms.119968","article-title":"Polycystic ovary syndrome revisited: novel insights and updates","volume":"23","author":"Zhao","year":"2026","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.jep.2026.122135_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102175","article-title":"Embryonal erythropoiesis and aging exploit ferroptosis","volume":"48","author":"Zheng","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2026.122135_bib143","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/s43018-025-00937-y","article-title":"Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity","volume":"6","author":"Zhou","year":"2025","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.jep.2026.122135_bib144","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jep.2026.122135_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113817","article-title":"Atractylodin alleviates polycystic ovary syndrome by inhibiting granule cells ferroptosis through pyruvate dehydrogenase kinase 4-mediated JAK-STAT3 pathway","volume":"146","author":"Zhou","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jep.2026.122135_bib146","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41419-024-07013-w","article-title":"RAB17 promotes endometrial cancer progression by inhibiting TFRC-Dependent ferroptosis","volume":"15","author":"Zhou","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2026.122135_bib147","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00404-022-06438-y","article-title":"Berberine attenuates hyperalgesia in mice with adenomyosis","volume":"306","author":"Zhu","year":"2022","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.jep.2026.122135_bib148","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116093","article-title":"Ampelopsis japonica aqueous extract improves ovulatory dysfunction in PCOS by modulating lipid metabolism","volume":"170","author":"Zhu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.122135_bib149","article-title":"The clinical effectiveness and safety of traditional Chinese medicine jinfeng pill in adjuvant treatment of infertility with polycystic ovary syndrome: a protocol for systematic review and meta-analysis","volume":"101","author":"Zhu","year":"2022","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.jep.2026.122135_bib150","doi-asserted-by":"crossref","first-page":"18769","DOI":"10.1021\/acs.jafc.3c05735","article-title":"Nuciferine protects against obesity-induced nephrotoxicity through its hypolipidemic, anti-inflammatory, and antioxidant effects","volume":"71","author":"Zhu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2026.122135_bib151","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2026.104034","article-title":"Methylation reader MBD2-mediated GPX4 transcriptional repression drives ovarian granulosa cell ferroptosis in PCOS","volume":"90","author":"Zhu","year":"2026","journal-title":"Redox Biol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412600989X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412600989X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:34:32Z","timestamp":1790775272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412600989X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":150,"alternative-id":["S037887412600989X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122135","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Harnessing natural herbaceous plants against ferroptosis: Implications for managing polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122135"}}