{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:00:58Z","timestamp":1790776858380,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002857","name":"China Pharmaceutical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jep.2026.122147","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:36:37Z","timestamp":1783092997000},"page":"122147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Xiongzhi Qufeng Zhitong Granule alleviates nitroglycerin-induced migraine-like nociception and central neuroinflammation by regulating the HMGB1 \/ TRPV1 \/ MAPK signaling axis"],"prefix":"10.1016","volume":"372","author":[{"given":"Lianzhan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieru","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghan","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5585-9010","authenticated-orcid":false,"given":"Xuansheng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jep.2026.122147_bib1","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.3390\/cells10123323","article-title":"Post-translational modification of HMGB1 disulfide bonds in stimulating and inhibiting inflammation","volume":"10","author":"Andersson","year":"2021","journal-title":"Cells"},{"issue":"19","key":"10.1016\/j.jep.2026.122147_bib2","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1056\/NEJMra1915327","article-title":"Migraine","volume":"383","author":"Ashina","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.jep.2026.122147_bib3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3988\/jcn.2012.8.2.89","article-title":"Sensitization of the trigeminovascular pathway: perspective and implications to migraine pathophysiology","volume":"8","author":"Bernstein","year":"2012","journal-title":"J. Clin. Neurol."},{"issue":"9","key":"10.1016\/j.jep.2026.122147_bib4","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.1007\/s10072-022-06281-8","article-title":"Experimental animal models of migraine","volume":"43","author":"Buzzi","year":"2022","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.jep.2026.122147_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119978","article-title":"Pharmacological effects and mechanisms of alkamides DDA-E and DDA-Z from Asari Radix et Rhizoma in migraine: insights from serum pharmacochemistry, network pharmacology, and experimental validation","volume":"349","author":"Cai","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2026.122147_bib6","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.pain.2013.03.038","article-title":"Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice","volume":"154","author":"Chanda","year":"2013","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.jep.2026.122147_bib7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1474-4422(17)30435-0","article-title":"The pathophysiology of migraine: implications for clinical management","volume":"17","author":"Charles","year":"2018","journal-title":"Lancet Neurol."},{"issue":"2","key":"10.1016\/j.jep.2026.122147_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s12276-022-00736-w","article-title":"The mechanism of HMGB1 secretion and release","volume":"54","author":"Chen","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s10194-019-0968-1","article-title":"Migraine-provoking substances evoke periorbital allodynia in mice","volume":"20","author":"De Logu","year":"2019","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.jep.2026.122147_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105424","article-title":"Widespread brain parenchymal HMGB1 and NF-\u03baB neuroinflammatory responses upon cortical spreading depolarization in familial hemiplegic migraine type 1 mice","volume":"156","author":"Dehghani","year":"2021","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"10.1016\/j.jep.2026.122147_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2026.e00833","article-title":"Overlapping pathways of migraine and the endocannabinoid system: potential therapeutic targets","volume":"23","author":"Della Pietra","year":"2026","journal-title":"Neurotherapeutics"},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s10194-021-01353-0","article-title":"Parenchymal neuroinflammatory signaling and dural neurogenic inflammation in migraine","volume":"22","author":"Erdener","year":"2021","journal-title":"J. Headache Pain"},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s12974-020-01973-4","article-title":"Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages\/microglia polarization and affords neuroprotection after spinal cord injury","volume":"17","author":"Fan","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"7","key":"10.1016\/j.jep.2026.122147_bib14","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1080\/15548627.2024.2330038","article-title":"Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain","volume":"20","author":"Fu","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.jep.2026.122147_bib16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jneumeth.2017.04.010","article-title":"The effects of repeated nitroglycerin administrations in rats; modeling migraine-related endpoints and chronification","volume":"284","author":"Harris","year":"2017","journal-title":"J. Neurosci. Methods"},{"issue":"9","key":"10.1016\/j.jep.2026.122147_bib17","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1177\/0333102412447701","article-title":"Primary trigeminal afferents are the main source for stimulus-induced CGRP release into jugular vein blood and CSF","volume":"32","author":"Hoffmann","year":"2012","journal-title":"Cephalalgia"},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib18","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12871-022-01622-8","article-title":"Real-time ultrasound-guided stellate ganglion block for migraine: an observational study","volume":"22","author":"Hou","year":"2022","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.jep.2026.122147_bib19","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-067670","article-title":"Management of chronic migraine","volume":"379","author":"Hovaguimian","year":"2022","journal-title":"Br. Med. J."},{"key":"10.1016\/j.jep.2026.122147_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114776","article-title":"Qianghuo Shengshi decoction exerts anti-inflammatory and analgesic via MAPKs\/CREB signaling pathway","volume":"284","author":"Hu","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib21","volume":"14","author":"Huang","year":"2026","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.jep.2026.122147_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/cbdd.14451","article-title":"Investigation on the antipyretic mechanism of chaiqin Qingning capsule for the treatment of fever based on network pharmacology, molecular docking, and in vitro experimental validation","volume":"103","author":"Huang","year":"2024","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.jep.2026.122147_bib23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbi.2015.01.017","article-title":"TRPV1 promotes repetitive febrile seizures by pro-inflammatory cytokines in immature brain","volume":"48","author":"Huang","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib24","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s12974-023-02977-6","article-title":"Vesicular HMGB1 release from neurons stressed with spreading depolarization enables confined inflammatory signaling to astrocytes","volume":"20","author":"Kaya","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"5","key":"10.1016\/j.jep.2026.122147_bib25","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1177\/0333102417712719","article-title":"Functional interactions between transient receptor potential M8 and transient receptor potential V1 in the trigeminal system: relevance to migraine pathophysiology","volume":"38","author":"Kayama","year":"2018","journal-title":"Cephalalgia"},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s10194-021-01250-6","article-title":"Burden of migraine and unmet needs from the patients' perspective: a survey across 11 specialized headache clinics in Korea","volume":"22","author":"Kim","year":"2021","journal-title":"J. Headache Pain"},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib27","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s10194-024-01834-y","article-title":"Characterizing barriers to care in migraine: multicountry results from the Chronic Migraine Epidemiology and Outcomes - International (CaMEO-I) study","volume":"25","author":"Lanteri-Minet","year":"2024","journal-title":"J. Headache Pain"},{"issue":"8\u20139","key":"10.1016\/j.jep.2026.122147_bib28","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.phymed.2011.01.008","article-title":"Analgesic effect and mechanism of the three TCM-herbal drug-combination Tou Feng Yu pill on treatment of migraine","volume":"18","author":"Li","year":"2011","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.122147_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.157815","article-title":"Spatial metabolomics combined with MALDI-MSI unveils gut-brain axis mechanisms of angelica dahurica radix in migraine rats","volume":"152","author":"Lian","year":"2026","journal-title":"Phytomedicine"},{"issue":"Pt 3","key":"10.1016\/j.jep.2026.122147_bib30","article-title":"Ethnobotanical usages, phytochemistry, pharmacology, and quality control of chuanxiong rhizoma: a review","volume":"337","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1631\/jzus.B2500209","article-title":"TRPV1: from structure to function-a multidimensional target for therapeutic advances","volume":"27","author":"Liu","year":"2026","journal-title":"J. Zhejiang Univ. - Sci. B"},{"issue":"4","key":"10.1016\/j.jep.2026.122147_bib33","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1523\/JNEUROSCI.2235-16.2016","article-title":"TNF-\u03b1 differentially regulates synaptic plasticity in the Hippocampus and spinal cord by microglia-dependent mechanisms after peripheral nerve injury","volume":"37","author":"Liu","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jep.2026.122147_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116781","article-title":"Shaoyao Gancao decoction alleviates the central hyperalgesia of recurrent NTG-induced migraine in rats by regulating the NGF\/TRPV1\/COX-2 signal pathway","volume":"317","author":"Luo","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122147_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112437","article-title":"Tibetan medicine ru-yi-zhen-bao Pills exhibits anti-migraine effect through mediating PAG anti-nociceptive channel","volume":"249","author":"Luo","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.jep.2026.122147_bib36","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s40265-018-0923-5","article-title":"CGRP and migraine: the role of blocking calcitonin gene-related peptide ligand and receptor in the management of migraine","volume":"78","author":"Maasumi","year":"2018","journal-title":"Drugs"},{"key":"10.1016\/j.jep.2026.122147_bib37","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.exer.2018.04.006","article-title":"TRPV1-dependent ERK1\/2 activation in porcine lens epithelium","volume":"172","author":"Mandal","year":"2018","journal-title":"Exp. Eye Res."},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib38","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s10194-023-01666-2","article-title":"Rethinking headache as a global public health case model for reaching the SDG 3 HEALTH by 2030","volume":"24","author":"Martelletti","year":"2023","journal-title":"J. Headache Pain"},{"issue":"3","key":"10.1016\/j.jep.2026.122147_bib39","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1474-4422(25)00477-6","article-title":"Advances in migraine prevention","volume":"25","author":"Martinelli","year":"2026","journal-title":"Lancet Neurol."},{"issue":"8","key":"10.1016\/j.jep.2026.122147_bib40","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nrneurol.2016.93","article-title":"Chronic migraine: risk factors, mechanisms and treatment","volume":"12","author":"May","year":"2016","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s10194-021-01377-6","article-title":"Assessment of peripheral biomarkers potentially involved in episodic and chronic migraine: a case-control study with a focus on NGF, BDNF, VEGF, and PGE2","volume":"23","author":"Mozafarihashjin","year":"2022","journal-title":"J. Headache Pain"},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib42","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3390\/cells11010018","article-title":"Capsaicin and TRPV1 channels in the cardiovascular System: the role of inflammation","volume":"11","author":"Munjuluri","year":"2021","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.jep.2026.122147_bib43","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1177\/0333102420925540","article-title":"Mechanical punctate pain threshold is associated with headache frequency and phase in patients with migraine","volume":"40","author":"Pan","year":"2020","journal-title":"Cephalalgia"},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib44","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.phymed.2008.10.010","article-title":"Pharmacodynamic action and mechanism of volatile oil from rhizoma Ligustici Chuanxiong Hort. on treating headache","volume":"16","author":"Peng","year":"2009","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.122147_bib45","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ejphar.2015.05.058","article-title":"IL-1 receptor antagonist improves morphine and buprenorphine efficacy in a rat neuropathic pain model","volume":"764","author":"Pilat","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12031-017-0999-5","article-title":"Tetrandrine alleviates nociception in a rat model of Migraine via suppressing S100B and p-ERK activation in satellite glial cells of the trigeminal ganglia","volume":"64","author":"Qin","year":"2018","journal-title":"J. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib47","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s10194-024-01889-x","article-title":"Hallmarks of primary headache: part 1 - migraine","volume":"25","author":"Raggi","year":"2024","journal-title":"J. Headache Pain"},{"issue":"3","key":"10.1016\/j.jep.2026.122147_bib48","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00281-018-0676-y","article-title":"Neurogenic inflammation and its role in migraine","volume":"40","author":"Ramachandran","year":"2018","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.jep.2026.122147_bib49","doi-asserted-by":"crossref","DOI":"10.1186\/s40001-026-04017-4","article-title":"Dual-mechanism preventive therapy in chronic migraine: an exploratory meta-analysis of onabotulinumtoxinA and anti-CGRP monoclonal antibody combination","author":"Sarvari Soltani","year":"2026","journal-title":"Eur. J. Med. Res."},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib50","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s10194-026-02357-4","article-title":"Mechanistic investigation of HMGB1 in an in vitro model of the trigeminovascular system under migraine-like conditions","volume":"27","author":"Song","year":"2026","journal-title":"J. Headache Pain"},{"issue":"3","key":"10.1016\/j.jep.2026.122147_bib51","doi-asserted-by":"crossref","DOI":"10.1177\/03331024261430857","article-title":"Therapeutic dissociation of CGRP-targeted treatments in migraine and complex regional pain syndrome","volume":"46","author":"Sotero","year":"2026","journal-title":"Cephalalgia"},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib52","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3390\/ijms24010700","article-title":"TRP channels: recent development in translational research and potential therapeutic targets in migraine","volume":"24","author":"Spekker","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.122147_bib53","article-title":"Nitroglycerin as a model of migraine: clinical and preclinical review","volume":"12","author":"Sureda-Gibert","year":"2022","journal-title":"Neurobiol Pain"},{"issue":"3","key":"10.1016\/j.jep.2026.122147_bib54","doi-asserted-by":"crossref","DOI":"10.1111\/ene.70562","article-title":"A real-world Study of CGRP monoclonal antibodies for migraine: Long-Term effectiveness and treatment adherence","volume":"33","author":"Suzuki","year":"2026","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.jep.2026.122147_bib55","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.2147\/JPR.S329280","article-title":"Central sensitization in migraine: a narrative review","volume":"15","author":"Suzuki","year":"2022","journal-title":"J. Pain Res."},{"issue":"3","key":"10.1016\/j.jep.2026.122147_bib56","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1177\/0271678X16647398","article-title":"High-mobility group box 1 is an important mediator of microglial activation induced by cortical spreading depression","volume":"37","author":"Takizawa","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"Suppl. 3","key":"10.1016\/j.jep.2026.122147_bib57","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/head.13379","article-title":"History and review of anti-calcitonin gene-related peptide (CGRP) therapies: from translational research to treatment","volume":"58","author":"Tepper","year":"2018","journal-title":"Headache"},{"issue":"2","key":"10.1016\/j.jep.2026.122147_bib58","article-title":"Serum tumor necrosis factor-\u03b1 levels in migraine: a registry for migraine (REFORM) study","volume":"11","author":"Tesfay","year":"2026","journal-title":"Pain Rep"},{"issue":"17","key":"10.1016\/j.jep.2026.122147_bib59","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.3390\/plants11172196","article-title":"Network pharmacology-based investigation on therapeutic mechanisms of the Angelica dahurica Radix and Ligusticum chuanxiong rhizoma herb pair for anti-migraine effect","volume":"11","author":"Thanh","year":"2022","journal-title":"Plants"},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib60","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s10194-025-02191-0","article-title":"Altered expressions of CGRP, SULT1A1, HMGB1, and HIF-1\u03b1 in the trigeminal ganglion in medication overuse headache in female rats","volume":"26","author":"Topa","year":"2025","journal-title":"J. Headache Pain"},{"issue":"4","key":"10.1016\/j.jep.2026.122147_bib61","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s40263-026-01272-1","article-title":"TRPV1 receptor modulators: emerging therapies for neuropathic, osteoarthritic, and perioperative pain","volume":"40","author":"Tsai","year":"2026","journal-title":"CNS Drugs"},{"key":"10.1016\/j.jep.2026.122147_bib62","first-page":"1","article-title":"Preparation and evaluation of gastrodin-ferulic acid co-loaded liposome gel patches for the treatment of migraine","volume":"3","author":"Wang","year":"2025","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib63","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s10194-024-01779-2","article-title":"Environmental enrichment alleviates hyperalgesia by modulating central sensitization in a nitroglycerin-induced chronic migraine model of mice","volume":"25","author":"Wang","year":"2024","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.jep.2026.122147_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156754","article-title":"Xiongshao Zhitong granules alleviate nitroglycerin-induced migraine by regulating the TRPV1-mediated NLRP3 inflammatory pathway in rats","volume":"142","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.122147_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.121043","article-title":"Puerariae Lobatae Radix-Gastrodiae Rhizoma ameliorates nitroglycerin-induced chronic migraine by modulating p38 MAPK\/CREB signaling pathway in the prefrontal cortex-thalamus neural circuit","volume":"358","author":"Wang","year":"2026","journal-title":"J. Ethnopharmacol."},{"issue":"Pt B","key":"10.1016\/j.jep.2026.122147_bib67","article-title":"Blockade of interleukin-17A contributes to a novel mechanism by which casticin relieves chronic migraine","volume":"353","author":"Wen","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122147_bib68","article-title":"Metabolomic profiling integrated with molecular exploring delineates the action of Ligusticum chuanxiong hort","volume":"134","author":"Xing","year":"2024","journal-title":"on migraine. Phytomedicine"},{"key":"10.1016\/j.jep.2026.122147_bib69","article-title":"Xiongshao zhitong recipe attenuates nitroglycerin-induced migraine-like behaviors via the inhibition of inflammation mediated by nitric oxide synthase","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.jep.2026.122147_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116671","article-title":"Microglial macrophage-derived ds-HMGB1 in DRG orchestrates neuropathic pain through immune-neural signaling","volume":"44","author":"Yang","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2026.122147_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.04.012","article-title":"Upregulation of tumor necrosis factor-alpha in the anterior cingulate cortex contributes to neuropathic pain and pain-associated aversion","volume":"130","author":"Yao","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jep.2026.122147_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116384","article-title":"Network pharmacology and experimental verification to explore the anti-migraine mechanism of Yufeng Ningxin Tablet","volume":"310","author":"Yu","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.jep.2026.122147_bib74","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.tins.2024.08.009","article-title":"Neuroimmune interactions in the development and chronification of migraine headache","volume":"47","author":"Zhang","year":"2024","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2026.122147_bib76","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2025.55454","article-title":"Acupuncture for migraine without Aura and connection-based efficacy prediction: a randomized clinical trial","volume":"9","author":"Zhang","year":"2026","journal-title":"JAMA Netw. Open"},{"issue":"21","key":"10.1016\/j.jep.2026.122147_bib78","first-page":"5057","article-title":"[Clinical practice guideline for migraine with traditional Chinese medicine(draft version for comments)]","volume":"45","author":"Zhen-Min","year":"2020","journal-title":"Zhongguo Zhongyao Zazhi"},{"issue":"Pt 3","key":"10.1016\/j.jep.2026.122147_bib79","article-title":"Essential oil from Ligusticum chuanxiong Hort. Alleviates lipopolysaccharide-induced neuroinflammation: integrating network pharmacology and molecular mechanism evaluation","volume":"319","author":"Zuo","year":"2024","journal-title":"J. Ethnopharmacol."}],"updated-by":[{"DOI":"10.1016\/j.jep.2026.122248","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000}}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126010019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126010019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:33:51Z","timestamp":1790775231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126010019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":73,"alternative-id":["S0378874126010019"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122147","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xiongzhi Qufeng Zhitong Granule alleviates nitroglycerin-induced migraine-like nociception and central neuroinflammation by regulating the HMGB1 \/ TRPV1 \/ MAPK signaling axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122147"}}