{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:00:00Z","timestamp":1790776800934,"version":"4.1.0"},"reference-count":215,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015217","name":"National Key Laboratory of Aerodynamic Design and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015217","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jep.2026.122156","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:08:59Z","timestamp":1783318139000},"page":"122156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Traditional application, Chemical composition, Pharmacological effects, Quality control and Clinical application of Corydalis yanhusuo W. T. Wang dried Rhizome"],"prefix":"10.1016","volume":"372","author":[{"given":"Zhengyang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7482-820X","authenticated-orcid":false,"given":"Xing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningyu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.122156_bib2","series-title":"Sichuan Province Chinese Herbal Slice Processing Specifications","year":"2002"},{"key":"10.1016\/j.jep.2026.122156_bib3","series-title":"Guizhou Province Chinese Herbal Slice Processing Specifications Guizhou Science and Technology Press, Guiyang. Pharmaceuticals), B.M.M.S.A.A.B.F., 2010. Beijing Chinese Herbal Slice Processing Specifications","year":"2005"},{"key":"10.1016\/j.jep.2026.122156_bib4","series-title":"Guangxi Chinese Herbal Slice Processing Specifications","year":"2007"},{"key":"10.1016\/j.jep.2026.122156_bib5","series-title":"Jiangxi Province Chinese Herbal Slice Processing Specifications","year":"2008"},{"key":"10.1016\/j.jep.2026.122156_bib6","series-title":"Guangxi Provincial Pharmacopoeia of Chinese Herbal Decoction Pieces Guangxi","year":"2009"},{"key":"10.1016\/j.jep.2026.122156_bib7","series-title":"Hunan Province Chinese Herbal Slice Processing Specifications","author":"Administration","year":"2010"},{"key":"10.1016\/j.jep.2026.122156_bib10","series-title":"Jilin Province Chinese Herbal Slice Processing Specifications Volume 1","year":"2020"},{"issue":"7","key":"10.1016\/j.jep.2026.122156_bib13","first-page":"282","article-title":"Mechanism of fresh cutting of traditional Chinese medicine:discussion on integration ofTraditional wisdom and modern technology","volume":"32","author":"Bao","year":"2026","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"19","key":"10.1016\/j.jep.2026.122156_bib12","first-page":"10","article-title":"Extraction method research of Corydalis yanhusuo volatile oil","volume":"41","author":"Bao","year":"2014","journal-title":"Guangdong Chemical Industry"},{"key":"10.1016\/j.jep.2026.122156_bib14","series-title":"NLRP3 Inflammasome Inhibitor MCC950 Attenuates Primary Dysmenorrhea in Mice via the NF-\u03baB\/COX-2\/PG Pathway","author":"Biao","year":"2020"},{"key":"10.1016\/j.jep.2026.122156_bib15","series-title":"Zhong Hua Ben Cao","author":"Board","year":"1998"},{"key":"10.1016\/j.jep.2026.122156_bib16","series-title":"Zhong Hua Ben Cao","author":"Board","year":"1999"},{"key":"10.1016\/j.jep.2026.122156_bib17","series-title":"Annotated Ri Huazi Ben Cao","author":"Chang","year":"2016"},{"issue":"7","key":"10.1016\/j.jep.2026.122156_bib22","first-page":"78","article-title":"Research progress on chemical constituents and pharmacological effects ofCorydalis rhizoma","volume":"38","author":"Chen","year":"2021","journal-title":"Information on Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2026.122156_bib18","series-title":"A Treatise on Disease Syndromes and Formulas Based on Three Causes and Ultimate Pathogenesis","author":"Chen","year":"1957"},{"key":"10.1016\/j.jep.2026.122156_bib19","series-title":"Ben Cao Shi Yi. Ben Cao Shi Yi","author":"Chen","year":"1983"},{"key":"10.1016\/j.jep.2026.122156_bib20","series-title":"Compendium of Materia Medica Additions","author":"Chen","year":"1983"},{"key":"10.1016\/j.jep.2026.122156_bib21","series-title":"Complete Good Prescriptions for Women","author":"Chen","year":"2006"},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib30","first-page":"356","article-title":"Succinic acid-driven gut-fat axis orchestrates abdominal fat deposition in chickens via adipocyte-macrophage crosstalk","volume":"17","author":"Chen","year":"2026","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib28","first-page":"1","article-title":"Textual research on the medicine property of Corydalis yanhusuo W. T. wang rhizoma","volume":"38","author":"Chen","year":"2023","journal-title":"Northwest Pharmaceutical Journal"},{"issue":"9","key":"10.1016\/j.jep.2026.122156_bib26","first-page":"2541","article-title":"Research ideas and innovation development trends of quality evaluation ofChinese materia medica","volume":"52","author":"Chen","year":"2021","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"9","key":"10.1016\/j.jep.2026.122156_bib27","first-page":"2533","article-title":"Tetrahydropalmatine alleviated diabetic neuropathic pain by inhibitingactivation of microglia via p38 MAPK signaling pathway","volume":"47","author":"Chen","year":"2022","journal-title":"China J. Chin. Mater. Med."},{"issue":"11","key":"10.1016\/j.jep.2026.122156_bib25","first-page":"901","article-title":"The effect of cangzhu (Corydalis yanhusuo) before and after acetic acid processing on hemorheology in blood stasis model rats","volume":"36","author":"Chen","year":"2016","journal-title":"Chin. J. Hosp. Pharm."},{"issue":"22","key":"10.1016\/j.jep.2026.122156_bib29","first-page":"3431","article-title":"Extraction and analgesic and anti-inflammatory effects of the total alkaloids of Corydalis yanhusuo","volume":"19","author":"Chen","year":"2024","journal-title":"World Chinese Medicine"},{"issue":"7","key":"10.1016\/j.jep.2026.122156_bib23","first-page":"1369","article-title":"Separation of alkaloidal components in corydalis and determination of their content by reverse-phase high-performance liquid chromatography","author":"Chen","year":"2006","journal-title":"Journal of Li-shizhen Traditional Chinese Medicine"},{"issue":"6","key":"10.1016\/j.jep.2026.122156_bib31","doi-asserted-by":"crossref","first-page":"720","DOI":"10.3724\/SP.J.1259.2014.00720","article-title":"Advances in cell biology related to biosynthesis, transport and storage of isoquinoline alkaloids","volume":"49","author":"Cheng","year":"2014","journal-title":"Chin. Bull. Bot."},{"key":"10.1016\/j.jep.2026.122156_bib32","series-title":"Liaoning Province Chinese Materia Medica Processing Specifications 1975","year":"1975"},{"key":"10.1016\/j.jep.2026.122156_bib33","series-title":"Gansu Province Chinese Materia Medica Processing Specifications","year":"1980"},{"key":"10.1016\/j.jep.2026.122156_bib34","series-title":"Pharmacopoeia of the People's Republic of China, Part IV","year":"2025"},{"issue":"6","key":"10.1016\/j.jep.2026.122156_bib37","first-page":"42","article-title":"Study on the analgesic effect and mechanism of tetrahydropalmatine in rats with neuropathic pain","volume":"21","author":"Dai","year":"2023","journal-title":"Journal of China Prescription Drug"},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib36","first-page":"57","article-title":"Research progress on anticancer active components of toosendan fruit and corydalis rhizome","volume":"33","author":"Dai","year":"2018","journal-title":"Journal of Shantou University(Natural Science Edition)"},{"issue":"25","key":"10.1016\/j.jep.2026.122156_bib38","first-page":"85+88","article-title":"The effect of Fufang Chuyan Huasu Solution on the contractility and heart rate of isolated perfused frog hearts","volume":"5","author":"Deng","year":"2017","journal-title":"Cardiovascular Disease Electronic Journal of Integrated Traditional Chinese and Western Medicine"},{"issue":"4","key":"10.1016\/j.jep.2026.122156_bib39","first-page":"694","article-title":"Research progress of benzylisoquinoline components from genus Corydalis","volume":"36","author":"Deng","year":"2024","journal-title":"Natural Product Research and Development"},{"key":"10.1016\/j.jep.2026.122156_bib40","article-title":"The biosynthesis of the alkaloids of corydalis meifolia wall","author":"Dewan","year":"1986","journal-title":"Tetrahedron"},{"issue":"2","key":"10.1016\/j.jep.2026.122156_bib41","first-page":"173","article-title":"Study on the integration of processing and processing of Corydalis yanhusuo in Shaanxi","volume":"29","author":"Dou","year":"2012","journal-title":"Tianjin Journal of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2026.122156_bib42","series-title":"The Pharmacokinetics of Corydalis yan-husuo Extract in Mice After Oral Administration","author":"Du","year":"2017"},{"issue":"4","key":"10.1016\/j.jep.2026.122156_bib43","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3390\/molecules23040714","article-title":"Development and validation of a HPLC-ESI-MS\/MS method for simultaneous quantification of fourteen alkaloids in mouse plasma after oral administration of the extract of Corydalis yanhusuo tuber: application to pharmacokinetic Study","volume":"23","author":"Du","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.122156_bib44","series-title":"Practical Mongolian Pharmacy. Practical Mongolian Pharmacy","author":"Dugen","year":"1987"},{"issue":"4","key":"10.1016\/j.jep.2026.122156_bib45","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1365-313X.2008.03438.x","article-title":"Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants","volume":"54","author":"Facchini","year":"2008","journal-title":"Plant J."},{"key":"10.1016\/j.jep.2026.122156_bib46","article-title":"Records of Tujia medicinal herbs","volume":"1","author":"Fang","year":"2007"},{"issue":"6","key":"10.1016\/j.jep.2026.122156_bib47","first-page":"23","article-title":"Study on HPLC-fingerprint and quality assessment ofRhizomaCorydalis","volume":"26","author":"Fei","year":"2012","journal-title":"Res. Practice on Chin. Med."},{"key":"10.1016\/j.jep.2026.122156_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115511","article-title":"The composition,pharmacological effects,related mechanisms and drug delivery of alkaloids fromCorydalis yanhusuo","volume":"167","author":"Feng","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.122156_bib48","article-title":"Research progress on chemical components and pharmacological effects of Corydalis yanhusuo","author":"Feng","year":"2018","journal-title":"Natural Product Research and Development"},{"issue":"11","key":"10.1016\/j.jep.2026.122156_bib49","first-page":"2000","article-title":"Research progress on chemical components and pharmacological effects of Corydalis yanhusuo","volume":"30","author":"Feng","year":"2018","journal-title":"Natural Product Research and Development"},{"issue":"9","key":"10.1016\/j.jep.2026.122156_bib51","first-page":"125","article-title":"Improvement on quality standard of Yuanhu zhitong oral liquid","volume":"30","author":"Fu","year":"2024","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2026.122156_bib52","series-title":"Zangyao Jingjing Bencao","author":"Ga","year":"2018"},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib53","first-page":"27","article-title":"Study on the effect of levorotatory tetrahydropalmatine on pain threshold in chemotherapy-induced pain rats and its mechanism at the spinal cord level","volume":"29","author":"Gong","year":"2013","journal-title":"Pharmacol. Clin. Chin. Materia Med."},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib56","first-page":"765","article-title":"Exploration of the myocardial protective effects of tetrahydropalmatine in rats with heart failure after myocardial infarction based on MAPK\/ERK signal pathway","volume":"25","author":"Guo","year":"2022","journal-title":"Frontiers in Pharmaceutical Sciences"},{"issue":"3","key":"10.1016\/j.jep.2026.122156_bib54","first-page":"2","article-title":"Brief introduction to volumes 1-3 of Zhongguozangyao","volume":"34","author":"Guo","year":"1999","journal-title":"Chinese Journal of Pharmacy"},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib55","first-page":"68","article-title":"Determination of the contents of three alkaloid components in Corydalis rhizome by HPLC","volume":"27","author":"Guo","year":"2015","journal-title":"Strait Pharmaceutical Journal"},{"key":"10.1016\/j.jep.2026.122156_bib57","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.2147\/OTT.S183558","article-title":"Dehydrocorydaline inhibits cell proliferation, migration and invasion via suppressing MEK1\/2-ERK1\/2 cascade in melanoma","volume":"12","author":"H","year":"2019","journal-title":"OncoTargets Ther."},{"issue":"12","key":"10.1016\/j.jep.2026.122156_bib59","first-page":"1909","article-title":"Research progress on chemical components, pharmacological actions and quality control of Corydalis yanhusuo","author":"He","year":"2007","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"11","key":"10.1016\/j.jep.2026.122156_bib60","first-page":"97","article-title":"Research progress on chemical components, pharmacological activities and toxic adverse effects of Corydalis yanhusuo","volume":"51","author":"He","year":"2017","journal-title":"Shanghai J. Tradit. Chin. Med."},{"issue":"11","key":"10.1016\/j.jep.2026.122156_bib61","first-page":"97","article-title":"Research progress on chemical con-stituents,pharmacological activities and toxic side effects of Rhizoma Corydalis","volume":"51","author":"He","year":"2017","journal-title":"Shanghai J. Tradit. Chin. Med."},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib62","first-page":"69","article-title":"Exploring on the mechanism of Corydalis Rhizoma against angina pectoris based on network pharmacology","volume":"20","author":"Hou","year":"2023","journal-title":"J. Shaoyang Univ.(Natural Sciences)"},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib63","first-page":"69","article-title":"Exploring on the mechanism of Corydalis Rhizoma against angina pectoris based on network pharmacology","volume":"20","author":"Hou","year":"2023","journal-title":"J. Shaoyang Univ.(Natural Sciences)"},{"key":"10.1016\/j.jep.2026.122156_bib65","series-title":"A Study on the Analgesic Mechanism of Tetrahydropalmatine (THP) Based on Gene Sequencing","author":"Hu","year":"2022"},{"key":"10.1016\/j.jep.2026.122156_bib64","series-title":"A Simple Formula for Health Preservation","author":"Hu","year":"1984"},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib67","first-page":"1385","article-title":"Pharmacokinetics of Jinlingzi San and its single medicines in rats by LC-MS\/Ms","volume":"50","author":"Hu","year":"2025","journal-title":"China J. Chin. Mater. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib66","first-page":"9","article-title":"Discussion on the mechanism of treating cancer pain with Yanhusuo-Luxiancao based on network pharmacology and molecular docking technology","volume":"16","author":"Hu","year":"2024","journal-title":"Clin. J. Chin. Med."},{"key":"10.1016\/j.jep.2026.122156_bib68","series-title":"Ben Cao Qiu Zhen","author":"Huang","year":"2008"},{"key":"10.1016\/j.jep.2026.122156_bib69","article-title":"Study the material basis of Corydalis Rhizoma for the treatment of myocardial ischemia","author":"Huang","year":"2019","journal-title":"Tianjin Medical Department"},{"key":"10.1016\/j.jep.2026.122156_bib70","series-title":"Study on the Material Basis of Corydalis yanhusuo in the Treatment of Myocardial Ischemia","author":"Huang","year":"2019"},{"issue":"10","key":"10.1016\/j.jep.2026.122156_bib71","first-page":"2355","article-title":"Virtual screening of material basis of Corydalis Rhizoma for treating myocardialischemia based on molecular docking technology","volume":"50","author":"Huang","year":"2019","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"23","key":"10.1016\/j.jep.2026.122156_bib72","first-page":"4274","article-title":"Mechanism of Yugeng tongyu decoction for treating Angina pectoris based on network pharmacology combined with Molecular Dynamics simulation technique","volume":"22","author":"Huang","year":"2024","journal-title":"Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease"},{"key":"10.1016\/j.jep.2026.122156_bib73","series-title":"Studies on the Quality Standardization and Preparation of Rhizoma Corydalis","author":"Jia","year":"2008"},{"issue":"9","key":"10.1016\/j.jep.2026.122156_bib74","first-page":"70","article-title":"Isolation of Alkaloid from Corydalis Yanhusuo W. T. Wang and their anti-inflammatory","volume":"50","author":"Jiang","year":"2022","journal-title":"Guangzhou Chem. Ind."},{"key":"10.1016\/j.jep.2026.122156_bib76","first-page":"1","article-title":"Research progress on alkaloid chemical constituents of Corydalis yanhusuo and their extraction and separation, analysis and detection, and pharmacological activities","author":"Jin","year":"2025","journal-title":"Natural Product Research and Development"},{"issue":"3","key":"10.1016\/j.jep.2026.122156_bib77","first-page":"648","article-title":"Research progress on alkaloid chemical constituents of Corydalis yanhusuo and their extraction and separation,analysis and detection,and pharmacological activities","volume":"38","author":"Jin","year":"2026","journal-title":"Natural Product Research and Development"},{"issue":"10","key":"10.1016\/j.jep.2026.122156_bib75","first-page":"1184","article-title":"HPLC fingerprinting and principal component analysis of Rhizoma corydalis acid and alkali extracts Practical Pharmacy and Clinical Remedies","volume":"20","author":"Jin","year":"2017"},{"issue":"2","key":"10.1016\/j.jep.2026.122156_bib111","first-page":"235","article-title":"Chemical constituents from Corydalis yanhusuo","volume":"37","author":"L\u00dc","year":"2012","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2026.122156_bib78","article-title":"Leigong's Canon on Paozhi","author":"Lei","year":"1985","journal-title":"Leigong's Canon on Paozhi"},{"key":"10.1016\/j.jep.2026.122156_bib79","series-title":"Leigong Paozhi Lun","author":"Lei","year":"1986"},{"issue":"11","key":"10.1016\/j.jep.2026.122156_bib80","first-page":"980","article-title":"The effect of berberine on the Toll-like receptor 2 signaling pathway and inflammatory factors","volume":"21","author":"Li","year":"2010","journal-title":"China Pharm."},{"key":"10.1016\/j.jep.2026.122156_bib86","series-title":"Differential Proteomic Analysis of Platelets Suggested target-related Proteins in Rabbit Platelets Treated with Rhizoma Corydalis","author":"Li","year":"2016"},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib88","first-page":"211","article-title":"Isolation and structural elucidation of chemical constituents of Corydalis rhizoma","volume":"25","author":"Li","year":"2019","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib89","first-page":"211","article-title":"Isolation and structural elucidation of chemical constituents of Corydalis Rhizoma","volume":"25","author":"Li","year":"2019","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"10","key":"10.1016\/j.jep.2026.122156_bib87","first-page":"748","article-title":"Alkaloids in the Corydalis plants and their biological activities:research advances","volume":"45","author":"Li","year":"2018","journal-title":"J. Internat. Pharmaceut. Res."},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib90","first-page":"18","article-title":"Study on HPLC fingerprint evaluation and content determination of Rhizoma Corydalis","volume":"42","author":"Li","year":"2023","journal-title":"J. Pharmaceut. Res."},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib92","first-page":"23","article-title":"Quantitative analysis of R-synephrine in citrus-based herbal medicines using supercritical fluidchromatography","volume":"40","author":"Li","year":"2026","journal-title":"Acad. J. Shanghai Univ. Trad. Chin. Med."},{"key":"10.1016\/j.jep.2026.122156_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118375","article-title":"Study on quality control methods and pharmacodynamic material basis of different specifications of Corydalis Rhizoma produced in Zhejiang Province","volume":"332","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2026.122156_bib81","first-page":"75","article-title":"Contents comparison of tetrahydropulmatine in decoction pieces and decoction ofCorydalis Rhizoma before and after frying with vinegar","volume":"36","author":"Li","year":"2017","journal-title":"J. Pharmaceut. Res."},{"key":"10.1016\/j.jep.2026.122156_bib82","series-title":"Hai Yao Ben Cao","author":"Li","year":"1997"},{"issue":"27","key":"10.1016\/j.jep.2026.122156_bib83","first-page":"136","article-title":"A study on the action mechanism of Yanhusuo in the treatment of endometriosisdysmenorrhoea based on network pharmacology","volume":"17","author":"Li","year":"2025","journal-title":"Clin. J. Chin. Med."},{"issue":"6","key":"10.1016\/j.jep.2026.122156_bib84","first-page":"205","article-title":"Research progress on processing of Corydalis rhizoma","volume":"22","author":"Li","year":"2020","journal-title":"Journal of Liaoning University of Traditional Chinese Medicine"},{"issue":"6","key":"10.1016\/j.jep.2026.122156_bib93","first-page":"21","article-title":"Study on Yuanhu (Yanhusuo) Chinese herbal medicine-I. Herbal textual research and original plant identification","volume":"17","author":"Lian","year":"2010","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"12","key":"10.1016\/j.jep.2026.122156_bib95","first-page":"1698","article-title":"Chemical pattern recognition research of Corydalis HPLC fingerprint","volume":"26","author":"Liang","year":"2006","journal-title":"Chin. J. Pharmaceut. Anal."},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib94","first-page":"413","article-title":"The protective effect of tetrahydropalmatine on focal cerebral ischemia-reperfusion injury in rats","author":"Liang","year":"1998","journal-title":"Chin. Pharmacol. Bull."},{"key":"10.1016\/j.jep.2026.122156_bib96","article-title":"Study on the ultrasonic extraction process of alkaloid from Corydalis","author":"Liao","year":"2012","journal-title":"Journal of Guangdong Pharmaceutical University"},{"issue":"6","key":"10.1016\/j.jep.2026.122156_bib98","first-page":"9","article-title":"Clinical observation of the effect of Corydalis yanhusuo on coronary microcirculationfunction","volume":"23","author":"Lin","year":"2023","journal-title":"Cardio-cerebrovascular Disease Prevention and Treatment"},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib97","first-page":"57","article-title":"Study on quality standard for vinegar-steamed Corydalis rhizoma","volume":"40","author":"Lin","year":"2022","journal-title":"Journal of Pharmaceutical Practice and Service"},{"issue":"20","key":"10.1016\/j.jep.2026.122156_bib99","doi-asserted-by":"crossref","first-page":"14741","DOI":"10.1074\/jbc.M611908200","article-title":"Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy","volume":"282","author":"Liscombe","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.jep.2026.122156_bib102","first-page":"2511","article-title":"Five-year review on development of quality markers of traditional Chinesemedicine","volume":"52","author":"Liu","year":"2021","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.jep.2026.122156_bib100","series-title":"Pharmacography of Uighur. Xinjiang Science","author":"Liu","year":"1999"},{"key":"10.1016\/j.jep.2026.122156_bib101","series-title":"A Study on the Chemical Components of Corydalis and Their Correlation with Soil Inorganic Elements","author":"Liu","year":"2020"},{"issue":"8","key":"10.1016\/j.jep.2026.122156_bib108","first-page":"1472","article-title":"Quality analysis of yuanhu zhitong tablets based on fingerprint and enantiomer ratio methods","volume":"42","author":"Liu","year":"2022","journal-title":"Chin. J. Pharmaceut. Anal."},{"issue":"8","key":"10.1016\/j.jep.2026.122156_bib109","first-page":"1472","article-title":"Quality analysis of yuanhu zhitong tablets based on fingerprint and enantiomer ratio methods","volume":"42","author":"Liu","year":"2022","journal-title":"Chin. J. Pharmaceut. Anal."},{"issue":"9","key":"10.1016\/j.jep.2026.122156_bib106","first-page":"2150","article-title":"Study on the influence of accessories dosage to the transfer rate of tetrahydropalmatine in Corydalis yanhusuo","volume":"26","author":"Liu","year":"2015","journal-title":"Journal of Li-shizhen Traditional Chinese Medicine"},{"issue":"6","key":"10.1016\/j.jep.2026.122156_bib107","first-page":"99","article-title":"Textual research on Corydalis yanhusuo in ancient materia","volume":"15","author":"Liu","year":"2019","journal-title":"Asia-Pacific Traditional Medicine"},{"issue":"3","key":"10.1016\/j.jep.2026.122156_bib110","first-page":"38","article-title":"Simultaneous determination of 11 nucleosides in different parts ofCorydalis yanhusuo by HPLC","volume":"42","author":"Liu","year":"2023","journal-title":"Chinese Wild Plant Resources"},{"issue":"14","key":"10.1016\/j.jep.2026.122156_bib104","first-page":"2108","article-title":"GC-MS Study of water-soluble non-alkaloidal chemical components in corydalis using trimethylsilyl derivatization","volume":"37","author":"Liu","year":"2012","journal-title":"China J. Chin. Mater. Med."},{"issue":"14","key":"10.1016\/j.jep.2026.122156_bib105","first-page":"2108","article-title":"Study on chemical constituents of water-soluble non-alkaloids in rhizoma corydalis by trimethylsilane derivatization GC-MS","volume":"37","author":"Liu","year":"2012","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2026.122156_bib112","series-title":"Compilation and Collation of the Kai Bao Ben Cao","author":"Lu","year":"2019"},{"issue":"15","key":"10.1016\/j.jep.2026.122156_bib113","first-page":"126","article-title":"Research progress on chemical components and pharmacological actions of Corydalis yanhusuo","volume":"5","author":"Lu","year":"2011","journal-title":"Chinese Journal of Modern Drug Application"},{"issue":"10","key":"10.1016\/j.jep.2026.122156_bib115","first-page":"79","article-title":"Historical evolution and modern research of Prescription-Based Processing of yanhusuo (corydalis rhizoma): a review","volume":"29","author":"Lu","year":"2023","journal-title":"Guiding Journal of Traditional Chinese Medicine and Pharmacy"},{"issue":"2","key":"10.1016\/j.jep.2026.122156_bib116","first-page":"61","article-title":"Determination of vanillin in vanilla pods by Supercritical fluid chromatography","author":"Lu","year":"2026","journal-title":"China Tropical Agriculture"},{"issue":"2","key":"10.1016\/j.jep.2026.122156_bib114","first-page":"235","article-title":"Chemical component study of Corydalis yanhusuo","volume":"37","author":"Lu","year":"2012","journal-title":"China J. Chin. Mater. Med."},{"issue":"9","key":"10.1016\/j.jep.2026.122156_bib119","first-page":"64","article-title":"Simultaneous determination of four chemical constituents in Corydalis yanhusuo by HPLC","volume":"48","author":"Luo","year":"2017","journal-title":"Jiangxi Journal of Traditional Chinese Medicine"},{"issue":"3","key":"10.1016\/j.jep.2026.122156_bib118","first-page":"228","article-title":"The effect of tetrahydropalmatine from Chinese herbal medicine on the ratio of diastolic to systolic periods of the rabbit heart","volume":"32","author":"Luo","year":"2016","journal-title":"Chin. J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib117","first-page":"23","article-title":"Study on the extraction and purification of active ingredients in corydalis","volume":"25","author":"Luo","year":"2014","journal-title":"Journal of Li-shizhen Traditional Chinese Medicine"},{"issue":"7","key":"10.1016\/j.jep.2026.122156_bib120","first-page":"762","article-title":"Anti-inflammatory effect of palmatine hydrochloride and its mechanism in regulation of NF- \u03baB\/p38MAPK signaling pathway and NLRP3 inflammasome","volume":"31","author":"Luo","year":"2020","journal-title":"Tradit. Chin. Drug Res. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2026.122156_bib123","article-title":"2D-HPLC-MS technology combined with molecular network for the identification of components in Tibetan medicine Aconitum pendulum","volume":"202","author":"Ma","year":"2023","journal-title":"J. Vis. Exp."},{"issue":"10","key":"10.1016\/j.jep.2026.122156_bib122","first-page":"1766","article-title":"Protective effect and mechanism of tetrahydropalmatine on hypoxia\/reoxygenation induced injury of cardiac microvascular endothelial cells","volume":"20","author":"Ma","year":"2022","journal-title":"Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease"},{"issue":"11","key":"10.1016\/j.jep.2026.122156_bib121","first-page":"1754","article-title":"Determination of main active components in crude and Processed Corydalis rhizoma samples from different habitats","volume":"36","author":"Ma","year":"2013","journal-title":"J. Chin. Med. Mater."},{"key":"10.1016\/j.jep.2026.122156_bib125","series-title":"Compendium of Herbal Medicine","author":"Ni","year":"2005"},{"issue":"9","key":"10.1016\/j.jep.2026.122156_bib126","first-page":"136","article-title":"Separation and identification of the chemical constituents from the roots of Oplopanax elatus by using off - line liquid chromatography tandem mass","volume":"43","author":"Nie","year":"2015","journal-title":"Guangzhou Chem. Ind."},{"key":"10.1016\/j.jep.2026.122156_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.phyplu.2021.100070","article-title":"A bird's eye view on a therapeutically 'wonder molecule': berberine","author":"Patel","year":"2021","journal-title":"Phytomed. Plus"},{"key":"10.1016\/j.jep.2026.122156_bib128","series-title":"Encylopedia of Traditional Medicine of Chinese Ethnic Minorities","article-title":"Encylopedia of traditional medicine of Chinese ethnic minorities","author":"Qi","year":"2000"},{"key":"10.1016\/j.jep.2026.122156_bib129","series-title":"Fujian Medicinal Materials Records","article-title":"Fujian medicinal materials records","year":"1979"},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib130","first-page":"754","article-title":"Extraction of corydalis alkaloids and study on their anti-hepatocellular carcinoma activity","volume":"26","author":"Sang","year":"2009","journal-title":"J. Zhejiang SCI-TECH Univ."},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib132","first-page":"108","article-title":"Research of Corydalis yanhusuo w.T.Wang pharmacological effects","volume":"39","author":"Shang","year":"2019","journal-title":"Jilin Journal of Chinese Medicine"},{"issue":"12","key":"10.1016\/j.jep.2026.122156_bib133","first-page":"2557","article-title":"Research progress on quality control of Chinese materia medica","volume":"48","author":"She","year":"2017","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"4","key":"10.1016\/j.jep.2026.122156_bib134","first-page":"100","article-title":"The effect of Corydalis yanhusuo before and after processing on the TGF-\u03b21-mediated epithelial-mesenchymal transition","volume":"34","author":"Shen","year":"2018","journal-title":"Pharmacol. Clin. Chin. Materia Med."},{"key":"10.1016\/j.jep.2026.122156_bib135","series-title":"Study on the Druggability of Effective Components of Yuanhu Zhitong Prescription","author":"Shi","year":"2015"},{"issue":"4","key":"10.1016\/j.jep.2026.122156_bib136","first-page":"647","article-title":"Phytochemical investigation of Corydalis yanhusuo","volume":"23","author":"Shi","year":"2011","journal-title":"Natural Product Research and Development"},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib138","first-page":"63","article-title":"Study on multi-component quality control methods before and after processing of Corydalis yanhusuo","volume":"38","author":"Song","year":"2019","journal-title":"Journal of Tianjin University of Traditional Chinese Medicine"},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib137","first-page":"49","article-title":"HPLC fingerprints of Shaanxi rhizome corydalis of the integrationof origin processing and preparation","volume":"35","author":"Song","year":"2018","journal-title":"Information on Traditional Chinese Medicine"},{"issue":"12","key":"10.1016\/j.jep.2026.122156_bib142","doi-asserted-by":"crossref","first-page":"9422","DOI":"10.62347\/CMPK4691","article-title":"Bu-Yi-Xin-Shen formula targets monocytes through PI3K-Akt\/NF-\u03baB signaling in post-percutaneous coronary intervention angina","volume":"17","author":"Su","year":"2025","journal-title":"Am. J. Transl. Res."},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib141","first-page":"5","article-title":"Analysis of active ingredient extracted from Corydalis yanhusuo by reflux method and wet ultramicro-pulverization","volume":"34","author":"Su","year":"2021","journal-title":"Acta Medicinae Sinica"},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib140","first-page":"5","article-title":"Analysis of active ingredient extracted from rhizoma corydalis by reflux method and wet ultramicro-pulverizatio","volume":"34","author":"Su","year":"2021","journal-title":"Acta Medicinae Sinica"},{"issue":"33","key":"10.1016\/j.jep.2026.122156_bib139","first-page":"20418","article-title":"Analysis on volatile constituents of RHIZOMA CORYDALIS from different places","volume":"39","author":"Su","year":"2011","journal-title":"J. Anhui Agric. Sci."},{"issue":"3","key":"10.1016\/j.jep.2026.122156_bib145","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.apsb.2014.04.003","article-title":"Alkaloid profiling of the traditional Chinese medicine Rhizoma corydalis using high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry","volume":"4","author":"Sun","year":"2014","journal-title":"Acta Pharm. Sin. B"},{"issue":"20","key":"10.1016\/j.jep.2026.122156_bib146","first-page":"2462","article-title":"Study on the fingerprint of Crude\/vinegar- processed Corydalis yanhusuo decoction pieces and Their Dispensing granules and content determination of five alkaloids","volume":"31","author":"Sun","year":"2020","journal-title":"China Pharm."},{"issue":"4","key":"10.1016\/j.jep.2026.122156_bib144","first-page":"45","article-title":"Experimental Study on the effect of total alkaloids from Corydalis yanhusuo in the prevention and treatment of acute myocardial ischemia in rats","volume":"40","author":"Sun","year":"2012","journal-title":"Acta Chinese Medicine and Pharmacology"},{"issue":"10","key":"10.1016\/j.jep.2026.122156_bib147","first-page":"96","article-title":"Study on the mechanism of mild moxibustion in treating primary dysmenorrhea rats basedon the regulation of TRPV1 expression based on cAMP-PKA signaling pathway","volume":"31","author":"Sun","year":"2024","journal-title":"Chin. J. Inf. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2026.122156_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2020.101392","article-title":"Coptisine alleviates ischemia\/reperfusion-induced myocardial damage by regulating apoptosis-related proteins","volume":"66","author":"Sun","year":"2020","journal-title":"Tissue Cell"},{"key":"10.1016\/j.jep.2026.122156_bib148","doi-asserted-by":"crossref","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2026.122156_bib149","series-title":"Compendium of Materia Medica with Verified Entries","author":"Tang","year":"1936"},{"issue":"23","key":"10.1016\/j.jep.2026.122156_bib150","first-page":"144","article-title":"A study on chemical composition and pharmacological action of Yanhusuo","volume":"10","author":"Tang","year":"2018","journal-title":"Clin. J. Chin. Med."},{"issue":"prepublish","key":"10.1016\/j.jep.2026.122156_bib151","article-title":"Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells","volume":"327","author":"Tian","year":"2020","journal-title":"Chem. Biol. Interact."},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib153","first-page":"1042","article-title":"Progress of research on the chemical constituents and anti - tumor activity of alkaloidfraction of Corydalis","volume":"20","author":"Wan","year":"2012","journal-title":"Journal of Modern Oncology"},{"key":"10.1016\/j.jep.2026.122156_bib156","series-title":"Boji Fang. Volume One. Photographic Reproduction. Shanghai Scientific and Technological","author":"Wang","year":"1991"},{"key":"10.1016\/j.jep.2026.122156_bib155","series-title":"Taiping Shenghui Fang","author":"Wang","year":"1958"},{"key":"10.1016\/j.jep.2026.122156_bib157","series-title":"Tang Ye Ben Cao","article-title":"Tang Ye Ben Cao","author":"Wang","year":"2008"},{"key":"10.1016\/j.jep.2026.122156_bib159","series-title":"Study on Chemical Components and in Vivo Metabolism of Corydalis yanhusuo","author":"Wang","year":"2018"},{"issue":"11","key":"10.1016\/j.jep.2026.122156_bib160","first-page":"113","article-title":"A comparative Study on the efficacy of prepared and purified Corydalis yanhusuo in formulations for the treatment of chronic appendicitis","volume":"31","author":"Wang","year":"2019","journal-title":"Medical Journal of Chinese People's Health"},{"key":"10.1016\/j.jep.2026.122156_bib158","series-title":"Quality Analysis Study of Corydalis yanhusuo","author":"Wang","year":"2014"},{"issue":"3","key":"10.1016\/j.jep.2026.122156_bib167","first-page":"624","article-title":"RP-HPLC fingerprint of Corydalis yanhusuo and content determination of nine alkaloids","volume":"40","author":"Wang","year":"2017","journal-title":"J. Chin. Med. Mater."},{"issue":"2","key":"10.1016\/j.jep.2026.122156_bib170","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1021\/acs.jnatprod.9b01155","article-title":"Yanhusanines A\u2013F, isoquinoline-derived alkaloid enantiomers from <italic>Corydalis yanhusuo<\/italic> and their biological activity","volume":"83","author":"Wang","year":"2020","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2026.122156_bib172","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.831173","article-title":"Secoyanhusamine A, an oxidatively ring-opened isoquinoline inner salt from Corydalis yanhusuo","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Chem."},{"issue":"4","key":"10.1016\/j.jep.2026.122156_bib165","first-page":"760","article-title":"Study on extraction technology of total alkaloids of Rhizoma Corydalis","volume":"28","author":"Wang","year":"2015","journal-title":"Heilongjiang Medicine Journal"},{"issue":"2","key":"10.1016\/j.jep.2026.122156_bib164","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3724\/SP.J.1259.2012.00149","article-title":"Application of GC-MS technology in the study of metabolites of Corydalis rhizome","volume":"47","author":"Wang","year":"2012","journal-title":"Chin. Bull. Bot."},{"issue":"19","key":"10.1016\/j.jep.2026.122156_bib176","first-page":"6730","article-title":"Quality evaluation of Corydalis Rhizoma from different areas based on fingerprintand multi-index component quantification combined with chemometric analysis","volume":"55","author":"Wang","year":"2024","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"19","key":"10.1016\/j.jep.2026.122156_bib177","first-page":"6730","article-title":"Quality evaluation of Corydalis yanhusuo from different producing areas based on fingerprint chromatograms, multi-component quantification, and chemometrics","volume":"55","author":"Wang","year":"2024","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"9","key":"10.1016\/j.jep.2026.122156_bib168","first-page":"20","article-title":"Simultaneous determination of coptisine, dehydrofusone and tetrahydropalmatinein Corydalis Rhizoma by RP-HPLC","volume":"32","author":"Wang","year":"2018","journal-title":"Chem. Eng. Lond."},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib163","first-page":"36","article-title":"Experimental Study on the anti-ulcer effect of total alkaloids from Corydalis yanhusuo","author":"Wang","year":"1980","journal-title":"Liaoning Journal of Traditional Chinese Medicine"},{"issue":"3","key":"10.1016\/j.jep.2026.122156_bib173","first-page":"336","article-title":"Safety and analgesic effect of total alkaloids of Corydalis yanhusuo patch on neuropathic pain rats","volume":"32","author":"Wang","year":"2023","journal-title":"Modern Journal of Integrated Traditional Chinese and Western Medicine"},{"issue":"31","key":"10.1016\/j.jep.2026.122156_bib161","first-page":"2951","article-title":"Determination of the contents of three alkaloid components in Corydalis yanhusuo by HPLC","volume":"23","author":"Wang","year":"2012","journal-title":"China Pharm."},{"key":"10.1016\/j.jep.2026.122156_bib178","series-title":"Shiyi Deyao Fang","author":"Wei","year":"1964"},{"key":"10.1016\/j.jep.2026.122156_bib179","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9752735","article-title":"Analyses of total alkaloid extract of Corydalis yanhusuo by comprehensive RP \u00d7 RP liquid chromatography with pH difference","volume":"2016","author":"Wei","year":"2016","journal-title":"Journal of Analytical Methods in Chemistry"},{"issue":"23","key":"10.1016\/j.jep.2026.122156_bib184","first-page":"187","article-title":"Exploring effect of levo-tetrahydropalmatine on spinal metabolic profiles of rats with chronic pain based on widely-targeted metabolomics","volume":"30","author":"Wu","year":"2024","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"10.1016\/j.jep.2026.122156_bib180","doi-asserted-by":"crossref","first-page":"10047","DOI":"10.3390\/molecules200610047","article-title":"A 1H-NMR-Based metabonomic study on the anti-depressive effect of the total alkaloid of corydalis rhizoma","volume":"20","author":"Wu","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.122156_bib182","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/1271953","article-title":"Processing and compatibility of Corydalis yanhusuo: phytochemistry, pharmacology, pharmacokinetics, and safety","volume":"2021","author":"Wu","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"16","key":"10.1016\/j.jep.2026.122156_bib183","first-page":"5372","article-title":"Fungal community and diversity of endophytic fungi in different tissues ofCorydalis yanhusuo","volume":"54","author":"Wu","year":"2023","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.jep.2026.122156_bib187","article-title":"(+)\/( )-Yanhusuosines A and B, two dimeric benzylisoquinoline-protoberberine alkaloid atropo-enantiomers featuring polycyclic skeletons from Corydalis yanhusuo","author":"Xia","year":"2023","journal-title":"Chin. Chem. Lett."},{"issue":"6","key":"10.1016\/j.jep.2026.122156_bib185","first-page":"777","article-title":"Study on the pharmacodynamic effect and mechanism of total alkaloids of Rhizoma Corydalis onMice with DSS-induced ulcerative colitis","volume":"33","author":"Xia","year":"2022","journal-title":"Tradit. Chin. Drug Res. Clin. Pharmacol."},{"issue":"21","key":"10.1016\/j.jep.2026.122156_bib188","doi-asserted-by":"crossref","DOI":"10.1016\/j.tetlet.2020.151890","article-title":"(\u00b1)-Bicoryanhunine A, dimeric benzylisoquinoline alkaloid atropo -enantiomers from Corydalis yanhusuo","volume":"61","author":"Xiao","year":"2020","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.jep.2026.122156_bib189","article-title":"A Study on the mechanism of shuangcan Ningxin Capsule in regulating FUNDC1-Mediated mitophagy to protect against myocardial ischemia-reperfusion injury","author":"Xin","year":"2020","journal-title":"China Academy of Chinese Medical Sciences"},{"issue":"3","key":"10.1016\/j.jep.2026.122156_bib192","first-page":"540","article-title":"Herbalogical textual research on Corydalis DC","volume":"27","author":"Xu","year":"2012","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"issue":"6","key":"10.1016\/j.jep.2026.122156_bib191","first-page":"29","article-title":"Research on alkaloid components in Corydalis yanhusuo","author":"Xu","year":"2002","journal-title":"J. China Pharm. Univ."},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib190","first-page":"856","article-title":"Quality evaluation of Corydalis Rhizoma processed by differentmethods based on combinative methods of HPLC fingerprint,quantitative analysis of multi - components and chemometric analysis","volume":"42","author":"Xu","year":"2022","journal-title":"Chin. J. Pharmaceut. Anal."},{"key":"10.1016\/j.jep.2026.122156_bib193","series-title":"Revised Yan's Jisheng Fang","author":"Yan","year":"1980"},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib194","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3724\/cbls.2026013","article-title":"Role and mechanism of SUCNR1 in muscle pathophysiology","volume":"38","author":"Yan","year":"2026","journal-title":"Chin. Bull. Life Sci."},{"key":"10.1016\/j.jep.2026.122156_bib195","series-title":"Ren Zhai Zhi Zhi Fang Lun","author":"Yang","year":"1989"},{"issue":"5","key":"10.1016\/j.jep.2026.122156_bib206","first-page":"31","article-title":"Analysis of flavor and taste characteristics of Hongqu Huangjiu based onElectronic nose, electronic tongue and sensory evaluation","author":"Yang","year":"2026","journal-title":"Liquor-making Sci. Technol."},{"issue":"9","key":"10.1016\/j.jep.2026.122156_bib202","first-page":"513","article-title":"Effect of succinic acid receptor SUCNR1 on insulin secretion in Min6 cells","volume":"46","author":"Yang","year":"2025","journal-title":"Journal of Shandong First Medical University & Shandong Academy of Medical Sciences"},{"issue":"12","key":"10.1016\/j.jep.2026.122156_bib203","first-page":"119","article-title":"Research progress on chemical constituents and pharmacological effects of Corydalis yanhusuo and predictive analysis of quality markers","volume":"43","author":"Yang","year":"2025","journal-title":"Chin. Arch. Trad. Chin. Med."},{"issue":"12","key":"10.1016\/j.jep.2026.122156_bib204","first-page":"119","article-title":"Research progress on chemical composition and pharmacological effects of yanhusuo (Corydalis rhizoma) and predictive analysis og quality markers","volume":"43","author":"Yang","year":"2025","journal-title":"Chin. Arch. Trad. Chin. Med."},{"issue":"12","key":"10.1016\/j.jep.2026.122156_bib205","first-page":"119","article-title":"Research progress on chemical composition and pharmacological effects of yanhusuo (Corydalis rhizoma) and predictive analysis of quality markers","volume":"43","author":"Yang","year":"2025","journal-title":"Chin. Arch. Trad. Chin. Med."},{"issue":"8","key":"10.1016\/j.jep.2026.122156_bib199","first-page":"1057","article-title":"The cardioprotective effect of total alkaloids from Corydalis yanhusuo against isoprenaline-induced myocardial infarction in rats","volume":"29","author":"Yang","year":"2016","journal-title":"Chinese Journal of Clinical Research"},{"issue":"10","key":"10.1016\/j.jep.2026.122156_bib200","first-page":"46","article-title":"Evaluation of the quality of Corydalis yanhusuo from different origins based on HPLC fingerprint and principal component analysis","volume":"17","author":"Yang","year":"2021","journal-title":"Asia-Pacific Traditional Medicine"},{"issue":"4","key":"10.1016\/j.jep.2026.122156_bib201","first-page":"21","article-title":"Based on the NF-\u03baB\/COX-2 inflammatory pathway, the mechanism of renal protection of Yiqi Yangyin Huoxue decoction on diabetic nephropathy rats was discussed","volume":"51","author":"Yang","year":"2023","journal-title":"Acta Chinese Medicine and Pharmacology"},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib197","first-page":"20","article-title":"Study on the material basis of Corydalis yanhusuo","volume":"39","author":"Yang","year":"2014","journal-title":"China J. Chin. Mater. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib198","first-page":"8","volume":"39","author":"Yang","year":"2014","journal-title":"China J. Chin. Mater. Med."},{"issue":"16","key":"10.1016\/j.jep.2026.122156_bib196","first-page":"2200","article-title":"Study on chemical constituents from Corydalis Rhizoma in Pan'an","volume":"44","author":"Yang","year":"2013","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"7","key":"10.1016\/j.jep.2026.122156_bib208","first-page":"123","article-title":"Application of supercritical fluid extraction technology in the preparation of traditional Chinese medicine extracts","volume":"45","author":"Yin","year":"2024","journal-title":"Sci-tech Innovation and Productivity"},{"key":"10.1016\/j.jep.2026.122156_bib207","article-title":"Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines","volume":"6","author":"Yin","year":"2016","journal-title":"Sci. Rep."},{"issue":"23","key":"10.1016\/j.jep.2026.122156_bib209","first-page":"6494","article-title":"Levo-tetrahydropalmatine promotes apoptosis of human hepatocellular carcinoma through switching energy metabolism phenotype via upregulation of mitochondrial reactive oxygen species","volume":"47","author":"Ying","year":"2022","journal-title":"China J. Chin. Mater. Med."},{"issue":"6","key":"10.1016\/j.jep.2026.122156_bib211","first-page":"1435","article-title":"Quality analysis and comparison of different parts of Rhizoma corydalis","volume":"35","author":"Yu","year":"2017","journal-title":"Chin. Arch. Trad. Chin. Med."},{"key":"10.1016\/j.jep.2026.122156_bib210","first-page":"1","article-title":"Pyroptosis and inflammasomes in obstetrical and gynecological diseases","volume":"6382","author":"Yu","year":"2021","journal-title":"Gynecol. Endocrinol."},{"issue":"6","key":"10.1016\/j.jep.2026.122156_bib212","first-page":"884","article-title":"Study on fingerprint and quality of Rhizoma Corydalis from different producing areas","volume":"28","author":"Zan","year":"2008","journal-title":"Chin. J. Pharmaceut. Anal."},{"key":"10.1016\/j.jep.2026.122156_bib213","series-title":"Study on the Separation of Active Anti-tumor Components from Traditional Chinese Medicine Notopterygium and Corydalis Under Activity Guidance and their Anti-tumor Effects","author":"Zhang","year":"2009"},{"issue":"8","key":"10.1016\/j.jep.2026.122156_bib223","first-page":"2464","article-title":"Multi-dimensional evaluation on the quality of Yuanhusuo formula granules based on Q-marker determination and other methods","volume":"44","author":"Zhang","year":"2022","journal-title":"Chin. Tradit. Pat. Med."},{"issue":"8","key":"10.1016\/j.jep.2026.122156_bib224","first-page":"2464","article-title":"Multi-dimensional evaluation on the quality of Yanhusuo formula granules based on Q-marker determination and other methods","volume":"44","author":"Zhang","year":"2022","journal-title":"Chin. Tradit. Pat. Med."},{"issue":"7","key":"10.1016\/j.jep.2026.122156_bib222","first-page":"70","article-title":"Research progress of Corydalis yanhusuo","author":"Zhang","year":"2022","journal-title":"Policy & Scientific Consult"},{"issue":"9","key":"10.1016\/j.jep.2026.122156_bib221","article-title":"A review of the traditional uses, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology of Corydalis yanhusuo","author":"Zhang","year":"2020","journal-title":"Nat. Prod. Commun."},{"issue":"9","key":"10.1016\/j.jep.2026.122156_bib218","first-page":"1458","article-title":"Quality markers research on Chinese materia medica: quality evaluation andquality standards of Corydalis Rhizoma","volume":"47","author":"Zhang","year":"2016","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"9","key":"10.1016\/j.jep.2026.122156_bib217","first-page":"1458","article-title":"Quality markers research on Chinese materia medica: quality evaluation andquality standards of corydalis rhizoma","volume":"47","author":"Zhang","year":"2016","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"9","key":"10.1016\/j.jep.2026.122156_bib219","first-page":"1458","article-title":"Uality markers research on Chinese materia medica:quality evaluation and quality standards of Corydalis Rhizoma","volume":"47","author":"Zhang","year":"2016","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"2","key":"10.1016\/j.jep.2026.122156_bib216","first-page":"449","article-title":"A study on the analgesic and anti-inflammatory effects of different\u70ae\u5236\u54c1 of Corydalis yanhusuo","volume":"20","author":"Zhang","year":"2009","journal-title":"Journal of Li-shizhen Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2026.122156_bib215","first-page":"537","article-title":"Chemical constituents of Corydalis yanhusuo","author":"Zhang","year":"2008","journal-title":"J. Shenyang Pharm. Univ."},{"issue":"3","key":"10.1016\/j.jep.2026.122156_bib225","first-page":"363","article-title":"Research progress of the mechanisms of yanhusuo on treating dysmenorrhea","volume":"43","author":"Zhang","year":"2023","journal-title":"Jilin Journal of Chinese Medicine"},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib220","first-page":"73","article-title":"Determination of Alkaloid content and quality analysis in Corydalis yanhusuo from different origins","volume":"40","author":"Zhang","year":"2017","journal-title":"J. Chin. Med. Mater."},{"key":"10.1016\/j.jep.2026.122156_bib226","volume":"ume 2","author":"Zhao","year":"1962"},{"key":"10.1016\/j.jep.2026.122156_bib227","series-title":"A Study on the Effect and Mechanism of Simulated Microgravity and Tetrahydropalmatine on Apoptosis of Malignant Glioma U251MG Cells","author":"Zhao","year":"2015"},{"issue":"13","key":"10.1016\/j.jep.2026.122156_bib228","first-page":"107","article-title":"Determination of three active components in RhizomaCorydalis by dual wavelength HPLC","volume":"18","author":"Zhao","year":"2012","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"2","key":"10.1016\/j.jep.2026.122156_bib230","first-page":"299","article-title":"Advancements on chemical components and quality controlof alkaloids of Corydalis yanhusuo","volume":"35","author":"Zhao","year":"2017","journal-title":"Chin. Arch. Trad. Chin. Med."},{"issue":"3","key":"10.1016\/j.jep.2026.122156_bib229","first-page":"58","article-title":"Analysis of alkaloids in traditional Chinese medicine Corydalis yanhusuo by HPLC-MSn","volume":"30","author":"Zhao","year":"2016","journal-title":"Res. Practice on Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib231","first-page":"61","article-title":"Research on relevance and regression analysis of stir - frying with vinegar technology,PhysicalParameters and ingredient contents about yanhusuo(rhizoma corydalis)","volume":"40","author":"Zhao","year":"2022","journal-title":"Chin. Arch. Trad. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2026.122156_bib232","first-page":"96","article-title":"Research progress on the application of intelligent sensory technology inTraditional Chinese medicine","volume":"39","author":"Zhao","year":"2025","journal-title":"Chinese Pharmaceutical Affairs"},{"issue":"10","key":"10.1016\/j.jep.2026.122156_bib233","first-page":"139","article-title":"Herbal textual research on yanhusuo","volume":"50","author":"Zheng","year":"2022","journal-title":"J. Anhui Agric. Sci."},{"issue":"3","key":"10.1016\/j.jep.2026.122156_bib234","first-page":"872","article-title":"Research progress on chemical constituents and pharmacological effects of Corydalis yanhusuo","volume":"47","author":"Zheng","year":"2025","journal-title":"Chin. Tradit. Pat. Med."},{"issue":"3","key":"10.1016\/j.jep.2026.122156_bib235","first-page":"872","article-title":"Progress in the study of chemical composition and pharmacological effects of Corydalis yanhusuo","volume":"47","author":"Zheng","year":"2025","journal-title":"Chin. Tradit. Pat. Med."},{"key":"10.1016\/j.jep.2026.122156_bib236","series-title":"Two New Quaternary Protoberberine Alkaloids from Corydalis yanhusuo","author":"Zhou","year":"2012"},{"key":"10.1016\/j.jep.2026.122156_bib239","series-title":"Puji Fang: (Six)","author":"Zhu","year":"1982"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412601010X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412601010X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:27:54Z","timestamp":1790774874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412601010X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":215,"alternative-id":["S037887412601010X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122156","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Traditional application, Chemical composition, Pharmacological effects, Quality control and Clinical application of Corydalis yanhusuo W. T. Wang dried Rhizome","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122156"}}