{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:54:46Z","timestamp":1791996886323,"version":"4.4.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jep.2026.122223","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:56:20Z","timestamp":1784789780000},"page":"122223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Jiajian Shuyu Pills ameliorates cerebral ischemia-reperfusion injury by regulation hippo signaling and the lipid metabolism-ferroptosis axis"],"prefix":"10.1016","volume":"372","author":[{"given":"Xuecheng","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyue","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-7204","authenticated-orcid":false,"given":"Guosheng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.122223_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149308","article-title":"Pathophysiology of cerebral ischemia-reperfusion injury: an overview of oxidative stress and plant-based therapeutic approaches","volume":"1847","author":"Akhtar","year":"2025","journal-title":"Brain Res."},{"key":"10.1016\/j.jep.2026.122223_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2025.102749","article-title":"Traumatic brain injury persistently increases the incidence of both ischemic and hemorrhagic strokes: potential mechanisms","volume":"248","author":"Barbour","year":"2025","journal-title":"Prog. Neurobiol."},{"issue":"19","key":"10.1016\/j.jep.2026.122223_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251910475","article-title":"Methodological approaches to experimental evaluation of neuroprotective action of potential drugs","volume":"25","author":"Belenichev","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.jep.2026.122223_bib4","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.3390\/ijms17091418","article-title":"Ruscogenin Attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP\/NLRP3 inflammasome activation and the MAPK pathway","volume":"17","author":"Cao","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2026.122223_bib5","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1038\/s41598-018-23190-z","article-title":"Phosphatidylglycerol incorporates into cardiolipin to improve mitochondrial activity and inhibits inflammation","volume":"8","author":"Chen","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2026.122223_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119508","article-title":"Jiajian Shuyu pills effectively ameliorate cognitive impairment via regulating the inflammation of microglia in an Alzheimer's disease mouse model","volume":"343","author":"Chen","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.jep.2026.122223_bib7","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.4251\/wjgo.v13.i11.1725","article-title":"Shuyu pills inhibit immune escape and enhance chemosensitization in hepatocellular carcinoma","volume":"13","author":"Deng","year":"2021","journal-title":"World J. Gastrointest. Oncol."},{"issue":"1","key":"10.1016\/j.jep.2026.122223_bib8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.tcb.2024.04.008","article-title":"Role of lipids in interorganelle communication","volume":"35","author":"Domingues","year":"2025","journal-title":"Trends Cell Biol."},{"issue":"3","key":"10.1016\/j.jep.2026.122223_bib9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s12064-024-00419-2","article-title":"Application of network pharmacology in synergistic action of Chinese herbal compounds","volume":"143","author":"Duan","year":"2024","journal-title":"Theor. Biosci."},{"issue":"12","key":"10.1016\/j.jep.2026.122223_bib10","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1080\/14728222.2024.2446319","article-title":"An update on the role of ferroptosis in ischemic stroke: from molecular pathways to Neuroprotection","volume":"28","author":"Gowtham","year":"2024","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.jep.2026.122223_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155859","article-title":"Polygala tenuifolia willd. Extract alleviates LPS-induced acute lung injury in rats via TLR4\/NF-\u03baB pathway and NLRP3 inflammasome suppression","volume":"132","author":"Guo","year":"2024","journal-title":"Phytomedicine"},{"issue":"20","key":"10.1016\/j.jep.2026.122223_bib12","first-page":"3808","article-title":"Mechanism of Jiajian Shuyu Pill in alleviating depressive-like behaviors in chronic unpredictable mild stress rats via the TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"36","author":"Guo","year":"2025","journal-title":"Lishizhen Med. Mater. Med. Res."},{"key":"10.1016\/j.jep.2026.122223_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103185","article-title":"Developing targeted antioxidant nanomedicines for ischemic penumbra: novel strategies in treating brain ischemia-reperfusion injury","volume":"73","author":"Hou","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2026.122223_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jare.2023.08.007","article-title":"Lipidomic analysis identifies long-chain acylcarnitine as a target for ischemic stroke","volume":"61","author":"Huang","year":"2024","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.jep.2026.122223_bib15","doi-asserted-by":"crossref","DOI":"10.1080\/10495398.2024.2442351","article-title":"Quercetin alleviates metabolic-associated fatty liver disease by tuning hepatic lipid metabolism, oxidative stress and inflammation","volume":"36","author":"Jiang","year":"2025","journal-title":"Anim. Biotechnol."},{"key":"10.1016\/j.jep.2026.122223_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.113970","article-title":"Microencapsulation of multi-component traditional Chinese herbs extracts and its application to traditional Chinese medicines loaded textiles","volume":"240","author":"Jiao","year":"2024","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.jep.2026.122223_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jep.2026.122223_bib18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jare.2024.02.006","article-title":"Single-cell transcriptomic profiling of heart reveals ANGPTL4 linking fibroblasts and angiogenesis in heart failure with preserved ejection fraction","volume":"68","author":"Li","year":"2025","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.jep.2026.122223_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13020-023-00872-z","article-title":"Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic stroke","volume":"19","author":"Li","year":"2024","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2026.122223_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114887","article-title":"Danhong injection improves neurological function in rats with ischemic stroke by enhancing neurogenesis and activating BDNF\/AKT\/CREB signaling pathway","volume":"163","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.122223_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118735","article-title":"Melastoma dodecandrum lour. Protects against cerebral ischemia-reperfusion injury by ameliorating oxidative stress and endoplasmic reticulum stress","volume":"336","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122223_bib22","doi-asserted-by":"crossref","DOI":"10.1177\/26331055241292600","article-title":"Ischemic stroke: pathophysiology and evolving treatment approaches","volume":"19","author":"Majumder","year":"2024","journal-title":"Neurosci. Insights."},{"key":"10.1016\/j.jep.2026.122223_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176264","article-title":"Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2\/HO-1 signaling pathway","volume":"963","author":"Peng","year":"2024","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2026.122223_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113023","article-title":"MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis","volume":"42","author":"Phadnis","year":"2023","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.jep.2026.122223_bib25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s12974-023-02941-4","article-title":"Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia\u2012reperfusion injury by modulating various cells","volume":"20","author":"Ruan","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jep.2026.122223_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1197422","article-title":"Repetitive transcranial magnetic stimulation for stroke rehabilitation: insights into the molecular and cellular mechanisms of neuroinflammation","volume":"14","author":"Sheng","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2026.122223_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156256","article-title":"Advances in the application of network analysis methods in traditional Chinese medicine research","volume":"136","author":"Tie","year":"2025","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.jep.2026.122223_bib28","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1161\/STROKEAHA.124.048251","article-title":"Impact of rurality and geographical accessibility on stroke care and outcomes","volume":"56","author":"Turner","year":"2025","journal-title":"Stroke"},{"issue":"7","key":"10.1016\/j.jep.2026.122223_bib29","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/s41587-023-01937-y","article-title":"Spatial multimodal analysis of transcriptomes and metabolomes in tissues","volume":"42","author":"Vicari","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jep.2026.122223_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156062","article-title":"Network pharmacology provides new insights into the mechanism of traditional Chinese medicine and natural products used to treat pulmonary hypertension","volume":"135","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.122223_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118874","article-title":"Integrative microbiomics, proteomics and lipidomics studies unraveled the preventive mechanism of Shouhui Tongbian Capsules on cerebral ischemic stroke injury","volume":"337","author":"Wei","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"41","key":"10.1016\/j.jep.2026.122223_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202306863","article-title":"Dynamic brain lipid profiles modulate microglial lipid droplet accumulation and inflammation Under ischemic conditions in mice","volume":"11","author":"Wei","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jep.2026.122223_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114619","article-title":"An update on the role of Hippo signaling pathway in ischemia-associated central nervous system diseases","volume":"162","author":"Wei","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.122223_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107229","article-title":"Multi-omics approaches for the understanding of therapeutic mechanism for Huang-Qi-Long-Dan Granule against ischemic stroke","volume":"205","author":"Wu","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"7","key":"10.1016\/j.jep.2026.122223_bib35","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3390\/ph18071074","article-title":"Network pharmacology-driven sustainability: AI and multi-omics synergy for drug discovery in traditional Chinese medicine","volume":"18","author":"Yang","year":"2025","journal-title":"Pharmaceuticals"},{"issue":"4","key":"10.1016\/j.jep.2026.122223_bib36","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.cmet.2024.01.006","article-title":"PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression","volume":"36","author":"Yang","year":"2024","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.jep.2026.122223_bib37","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s11011-024-01387-8","article-title":"Neuroprotective and vasoprotective effects of herb pair of Zhiqiao-Danggui in ischemic stroke uncovered by LC-MS\/MS-based metabolomics approach","volume":"39","author":"Yao","year":"2024","journal-title":"Metab. Brain Dis."},{"issue":"15","key":"10.1016\/j.jep.2026.122223_bib38","doi-asserted-by":"crossref","first-page":"6071","DOI":"10.7150\/thno.100090","article-title":"Hypoxanthine is a metabolic biomarker for inducing GSDME-dependent pyroptosis of endothelial cells during ischemic stroke","volume":"14","author":"Ye","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.jep.2026.122223_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117599","article-title":"Research progress of active compounds from traditional Chinese medicine in the treatment of stroke","volume":"291","author":"Yin","year":"2025","journal-title":"Eur. J. Med. Chem."},{"issue":"10","key":"10.1016\/j.jep.2026.122223_bib40","doi-asserted-by":"crossref","first-page":"7448","DOI":"10.1007\/s12035-024-04050-6","article-title":"Neuroinflammation targeting pyroptosis: molecular mechanisms and therapeutic perspectives in stroke","volume":"61","author":"Yuan","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"11","key":"10.1016\/j.jep.2026.122223_bib41","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.3390\/cimb45110574","article-title":"Lipid peroxidation via regulating the metabolism of docosahexaenoic acid and arachidonic acid in autistic behavioral symptoms","volume":"45","author":"Yui","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"issue":"1","key":"10.1016\/j.jep.2026.122223_bib42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.stem.2017.11.001","article-title":"YAP\/TAZ-Dependent reprogramming of colonic epithelium links ECM remodeling to tissue regeneration","volume":"22","author":"Yui","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jep.2026.122223_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157546","article-title":"Ethanol extract of Corydalis decumbens exerts neuroprotective effects against cerebral ischemia-reperfusion injury by targeting ALOX15 to suppress ferroptosis","volume":"149","author":"Zhang","year":"2025","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.jep.2026.122223_bib44","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1038\/s41401-024-01323-7","article-title":"Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a\/caveolin-1-mediated transcellular and Pdlim5\/YAP\/TAZ-mediated paracellular permeability","volume":"45","author":"Zhang","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"issue":"5","key":"10.1016\/j.jep.2026.122223_bib45","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s11011-023-01196-5","article-title":"Stellate ganglion block suppresses hippocampal ferroptosis to attenuate cerebral ischemia-reperfusion injury via the Hippo pathway","volume":"38","author":"Zhou","year":"2023","journal-title":"Metab. Brain Dis."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126010779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126010779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:34:05Z","timestamp":1790775245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126010779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":45,"alternative-id":["S0378874126010779"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122223","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Jiajian Shuyu Pills ameliorates cerebral ischemia-reperfusion injury by regulation hippo signaling and the lipid metabolism-ferroptosis axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122223","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122223"}}