{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:00:41Z","timestamp":1790776841613,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010971","name":"Yunnan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jep.2026.122226","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:43:09Z","timestamp":1784734989000},"page":"122226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The potential of Kadsura longipedunculata against herb and chemical induced liver injury"],"prefix":"10.1016","volume":"372","author":[{"given":"Ma-Long","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ling","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.122226_bib1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jep.2019.01.006","article-title":"Systematic review of published data on herb induced liver injury","volume":"233","author":"Byeon","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2026.122226_bib2","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1016\/j.apsb.2025.05.003","article-title":"CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury","volume":"15","author":"Chen","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jep.2026.122226_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157647","article-title":"A comprehensive review of herb-induced liver injury: mechanisms, clinical management, and future perspectives in natural product safety","volume":"150","author":"Fan","year":"2026","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.jep.2026.122226_bib4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/prot.340080302","article-title":"Automated docking of substrates to proteins by simulated annealing","volume":"8","author":"Goodsell","year":"1990","journal-title":"Proteins"},{"key":"10.1016\/j.jep.2026.122226_bib5","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s11096-024-01757-3","article-title":"Liver injury associated with endothelin receptor antagonists: a pharmacovigilance study based on FDA adverse event reporting system data","volume":"46","author":"Gu","year":"2024","journal-title":"Int. J. Clin. Pharm."},{"issue":"4","key":"10.1016\/j.jep.2026.122226_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","article-title":"The Nrf2 regulatory network provides an interface between redox and intermediary metabolism","volume":"39","author":"Hayes","year":"2014","journal-title":"Trends Biochem. Sci."},{"issue":"3","key":"10.1016\/j.jep.2026.122226_bib7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/10286020008039912","article-title":"Hydrolyzable tannins and related polyphenols from Eucalyptus globulus","volume":"2","author":"Hou","year":"2000","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"2","key":"10.1016\/j.jep.2026.122226_bib8","first-page":"791","article-title":"Research progress on chemical constituents and pharmacological effects of Kadsura longipedunculata","volume":"40","author":"Hou","year":"2025","journal-title":"Chin. J. Tradit. Chin. Med. Pharm."},{"key":"10.1016\/j.jep.2026.122226_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155117","article-title":"Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K\/Akt signaling and glutathione metabolic pathway: based on transcriptomics and metabolomics","volume":"121","author":"Huang","year":"2023","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.jep.2026.122226_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11418-006-0041-7","article-title":"Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase","volume":"60","author":"Jo","year":"2006","journal-title":"J. Nat. Med."},{"issue":"6","key":"10.1016\/j.jep.2026.122226_bib11","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jhep.2017.07.005","article-title":"Acetaminophen (APAP) hepatotoxicity\u2014Isn\u2019t it time for APAP to go away?","volume":"67","author":"Lee","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2026.122226_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115027","article-title":"Exploring the anti-inflammatory effects of total flavonoids from L. gracile on LPS-induced inflammation: an integrated approach combining network pharmacology, molecular docking, and experimental validation","volume":"161","author":"Li","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2026.122226_bib13","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.phytochem.2007.02.021","article-title":"Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii","volume":"68","author":"Ma","year":"2007","journal-title":"Phytochemistry"},{"issue":"3","key":"10.1016\/j.jep.2026.122226_bib14","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB signaling: navigating the network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.jep.2026.122226_bib15","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/0031-9422(83)80105-8","article-title":"Flavanol glucosides from rhubarb and Rhaphiolepis umbellata","volume":"22","author":"Nonaka","year":"1983","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2026.122226_bib16","series-title":"Clinical Trials-A Practical Approach","article-title":"The size of a clinical trial","author":"Pocock","year":"2013"},{"key":"10.1016\/j.jep.2026.122226_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.120664","article-title":"Crotalaria assamica Benth alleviated acetaminophen-induced liver injury through the upregulation of Nrf2 pathway","volume":"355","author":"Qian","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122226_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119839","article-title":"Alstonia scholaris (L.) R. Br. ameliorated diabetic nephropathy through PPAR-\u03b4 pathway","volume":"348","author":"Qin","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122226_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155142","article-title":"Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: a metabolic mechanism perspective","volume":"122","author":"Rani","year":"2024","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.jep.2026.122226_bib20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.canlet.2015.05.009","article-title":"Interleukin-8 upregulates integrin \u03b23 expression and promotes estrogen receptor-negative breast cancer cell invasion by activating the PI3K\/Akt\/NF-\u03baB pathway","volume":"364","author":"Shao","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jep.2026.122226_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118590","article-title":"Liver injury protection of Artemisia stechmanniana besser through PI3K\/AKT pathway","volume":"334","author":"Tian","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2026.122226_bib22","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1039\/D0NP00054J","article-title":"Triptolide: reflections on two decades of research and prospects for the future","volume":"38","author":"Tong","year":"2021","journal-title":"Nat. Prod. Rep."},{"issue":"3","key":"10.1016\/j.jep.2026.122226_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrm3290","article-title":"PI3K signalling: the path to discovery and understanding","volume":"13","author":"Vanhaesebroeck","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.jep.2026.122226_bib24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.canlet.2005.10.001","article-title":"Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells","volume":"241","author":"Wan","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jep.2026.122226_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1508060","article-title":"Apigenin as an emerging hepatoprotective agent: current status and future perspectives","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2026.122226_bib26","first-page":"551","article-title":"Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway","volume":"25","author":"Wu","year":"2011","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jep.2026.122226_bib27","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.biopha.2017.04.003","article-title":"Toxicity of triptolide and the molecular mechanisms involved","volume":"90","author":"Xi","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.jep.2026.122226_bib28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3724\/SP.J.1009.2009.00111","article-title":"Chemical constituents from the leaves of Camellia assamica var. kucha Chang et Wang","volume":"7","author":"Xu","year":"2009","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2026.122226_bib29","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","article-title":"Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions","volume":"17","author":"Yan","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2026.122226_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115212","article-title":"Huang Bai Jian Pi decoction alleviates diarrhea and represses inflammatory injury via PI3K\/Akt\/NF-\u03baB pathway: in vivo and in vitro studies","volume":"292","author":"Yan","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2026.122226_bib31","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41419-022-04580-8","article-title":"Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy","volume":"13","author":"Ye","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2026.122226_bib32","series-title":"Yunnan Provincial Standard for Chinese Materia Medica-Yi Medicine 2005 (4)","first-page":"20","year":"2005"},{"key":"10.1016\/j.jep.2026.122226_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118364","article-title":"Wogonin mitigates acetaminophen-induced liver injury in mice through inhibition of the PI3K\/AKT signaling pathway","volume":"332","author":"Zhao","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2026.122226_bib34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/14786410701192637","article-title":"Antibacterial phenolic compounds from the spines of Gleditsia sinensis Lam","volume":"21","author":"Zhou","year":"2007","journal-title":"Nat. Prod. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126010809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126010809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:31:29Z","timestamp":1790775089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126010809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":34,"alternative-id":["S0378874126010809"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122226","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The potential of Kadsura longipedunculata against herb and chemical induced liver injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122226"}}