{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:37:51Z","timestamp":1792741071015,"version":"4.5.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jep.2026.122247","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:26:53Z","timestamp":1785281213000},"page":"122247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Shugan Tongbian Decoction ameliorates constipation and mental disorder by inhibiting UPRmt via Wnt\/Retromer axis"],"prefix":"10.1016","volume":"373","author":[{"given":"Jiali","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danting","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanlu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhi","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihua","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-8716","authenticated-orcid":false,"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jep.2026.122247_bib1","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.cell.2016.08.042","article-title":"Neuroendocrine coordination of mitochondrial stress signaling and proteostasis","volume":"166","author":"Berendzen","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jep.2026.122247_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13171","article-title":"Mitochondrial function controls intestinal epithelial stemness and proliferation","volume":"7","author":"Berger","year":"2016","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.jep.2026.122247_bib3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.bpg.2007.07.001","volume":"21","author":"Bharucha","year":"2007","journal-title":"Constipation. Best. Pract. Res. Clin. Gastroenterol."},{"issue":"5","key":"10.1016\/j.jep.2026.122247_bib4","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/j.gastro.2019.12.034","article-title":"Mechanisms, evaluation, and management of chronic constipation","volume":"158","author":"Bharucha","year":"2020","journal-title":"Gastroenterology"},{"issue":"10263","key":"10.1016\/j.jep.2026.122247_bib5","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0140-6736(20)32115-2","article-title":"Functional gastrointestinal disorders: advances in understanding and management","volume":"396","author":"Black","year":"2020","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jep.2026.122247_bib6","first-page":"203","article-title":"The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems","volume":"28","author":"Carabotti","year":"2015","journal-title":"Ann. Gastroenterol."},{"issue":"4","key":"10.1016\/j.jep.2026.122247_bib7","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41564-018-0337-x","article-title":"The neuroactive potential of the human gut microbiota in quality of life and depression","volume":"4","author":"Colomer","year":"2019","journal-title":"Nat. Microbiol."},{"issue":"5775","key":"10.1016\/j.jep.2026.122247_bib8","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.1124856","article-title":"Wnt gradient formation requires Retromer function in Wnt-producing cells","volume":"312","author":"Coudreuse","year":"2006","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.jep.2026.122247_bib9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2165\/00019053-200523050-00006","article-title":"The health-related quality of life and economic burden of constipation","volume":"23","author":"Dennison","year":"2005","journal-title":"Pharmacoeconomics"},{"issue":"1","key":"10.1016\/j.jep.2026.122247_bib10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neulet.2010.11.006","article-title":"Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain","volume":"488","author":"Gong","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.jep.2026.122247_bib11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.devcel.2007.07.016","article-title":"ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans","volume":"13","author":"Haynes","year":"2007","journal-title":"Dev. Cell"},{"issue":"Pt 22","key":"10.1016\/j.jep.2026.122247_bib12","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1242\/jcs.075119","article-title":"The mitochondrial UPR - protecting organelle protein homeostasis","volume":"123","author":"Haynes","year":"2010","journal-title":"J. Cell Sci."},{"issue":"9","key":"10.1016\/j.jep.2026.122247_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000835","article-title":"The chop gene contains an element for the positive regulation of the mitochondrial unfolded protein response","volume":"2","author":"Horibe","year":"2007","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jep.2026.122247_bib14","first-page":"159","article-title":"Psychological disorders in patients with chronic constipation","volume":"4","author":"Hosseinzadeh","year":"2011","journal-title":"Gastroenterol. Hepatol. Bed. Bench."},{"key":"10.1016\/j.jep.2026.122247_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1614429","article-title":"Advances of paeoniflorin in depression: the molecular mechanism and formula application","volume":"16","author":"Hou","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2026.122247_bib16","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00401-019-01993-2","article-title":"Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity","volume":"137","author":"Hu","year":"2019","journal-title":"Acta Neuropathol."},{"issue":"6","key":"10.1016\/j.jep.2026.122247_bib17","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/nmo.12524","article-title":"Irritable bowel syndrome: an integrated explanatory model for clinical practice","volume":"27","author":"Hungin","year":"2015","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.jep.2026.122247_bib18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/164_2021_532","article-title":"WNT signaling is a key player in Alzheimer'S disease","volume":"269","author":"Inestrosa","year":"2021","journal-title":"Handb. Exp. Pharmacol."},{"issue":"8","key":"10.1016\/j.jep.2026.122247_bib19","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.15252\/embj.201694781","article-title":"Mitochondrial chaperone HSP-60 regulates anti-bacterial immunity via p38 MAP kinase signaling","volume":"36","author":"Jeong","year":"2017","journal-title":"EMBO J."},{"issue":"7","key":"10.1016\/j.jep.2026.122247_bib20","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1097\/MCG.0000000000001269","article-title":"Clinical characteristics of different primary constipation subtypes in a Chinese population","volume":"54","author":"Jiang","year":"2020","journal-title":"J. Clin. Gastroenterol."},{"issue":"7","key":"10.1016\/j.jep.2026.122247_bib21","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.cgh.2016.12.032","article-title":"Mood and anxiety disorders precede development of functional gastrointestinal disorders in patients but not in the population","volume":"15","author":"Jones","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2026.122247_bib22","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ceb.2014.12.003","article-title":"The mitochondrial unfolded protein response-synchronizing genomes","volume":"33","author":"Jovaisaite","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"issue":"9","key":"10.1016\/j.jep.2026.122247_bib23","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1136\/gutjnl-2011-300474","article-title":"The brain-gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study","volume":"61","author":"Koloski","year":"2012","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.jep.2026.122247_bib24","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/apt.13738","article-title":"Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study","volume":"44","author":"Koloski","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"16","key":"10.1016\/j.jep.2026.122247_bib25","first-page":"222","article-title":"Bowel disorders","author":"Lacy","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2026.122247_bib26","article-title":"Tongbian decoction restores intestinal microbiota and activates 5-hydroxytryptamine signaling: implication in slow transit constipation","volume":"15","author":"Li","year":"2024","journal-title":"Front. Microbiol."},{"issue":"23","key":"10.1016\/j.jep.2026.122247_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/nu14235013","article-title":"Association between depression, anxiety symptoms and gut microbiota in Chinese elderly with functional constipation","volume":"14","author":"Liang","year":"2022","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.jep.2026.122247_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.115021","article-title":"Probiotics-sensing mechanism in neurons that initiates gut mitochondrial surveillance for pathogen defense","volume":"43","author":"Liu","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2026.122247_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119139","article-title":"Tongbian decoction inhibits cell autophagy via PI3K\/Akt\/mTOR signaling pathway to treat constipation rats","volume":"339","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122247_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2026.1745331","article-title":"A stable rat models in constipation with depression and anxiety: evaluation and validation","volume":"20","author":"Liu","year":"2026","journal-title":"Front. Behav. Neurosci."},{"issue":"12","key":"10.1016\/j.jep.2026.122247_bib31","first-page":"1189","article-title":"Study on the changes in brain function characteristics of chaihu Tongbian decoction in rats with slow transit constipation and depression based on resting-state functional magnetic resonance imaging","volume":"39","author":"Liu","year":"2023","journal-title":"J. NJUTCM."},{"issue":"10","key":"10.1016\/j.jep.2026.122247_bib32","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1021\/acs.jproteome.1c00435","article-title":"Fecal metabolomics and network pharmacology reveal the correlations between constipation and depression","volume":"20","author":"Liu","year":"2021","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jep.2026.122247_bib33","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jff.2019.04.036","article-title":"Effect of Konjac mannan oligosaccharides on diphenoxylate-induced constipation in mice","volume":"57","author":"Liu","year":"2019","journal-title":"J. Funct.Foods"},{"issue":"1","key":"10.1016\/j.jep.2026.122247_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-55013-3","article-title":"Neuronal PRDX-2-Mediated ROS signaling regulates food digestion via peripheral UPRmt activation","volume":"15","author":"Liu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2026.122247_bib35","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jff.2018.01.005","article-title":"Extract of sesame cake and sesamol alleviate chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits","volume":"42","author":"Liu","year":"2018","journal-title":"J. Funct.Foods"},{"issue":"1","key":"10.1016\/j.jep.2026.122247_bib36","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/cells12010020","article-title":"Mitochondrial unfolded protein response and integrated stress response as promising therapeutic targets for mitochondrial diseases","volume":"12","author":"Lu","year":"2022","journal-title":"Cells"},{"issue":"46","key":"10.1016\/j.jep.2026.122247_bib37","doi-asserted-by":"crossref","first-page":"11085","DOI":"10.1523\/JNEUROSCI.1294-17.2017","article-title":"Dysregulation of the mitochondrial unfolded protein response induces non-apoptotic dopaminergic neurodegeneration in C. elegans models of Parkinson's disease","volume":"37","author":"Martinez","year":"2017","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.jep.2026.122247_bib38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12915-018-0548-x","article-title":"The different axes of the mammalian mitochondrial unfolded protein response","volume":"16","author":"M\u00fcnch","year":"2018","journal-title":"BMC Biol."},{"issue":"8","key":"10.1016\/j.jep.2026.122247_bib39","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/ddr.21461","article-title":"Dose translation between laboratory animals and human in preclinical and clinical phases of drug development","volume":"79","author":"Nair","year":"2018","journal-title":"Drug Dev. Res."},{"issue":"7","key":"10.1016\/j.jep.2026.122247_bib40","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1111\/j.1572-0241.2000.02184.x","article-title":"Psychological disorders in patients with evacuation disorders and constipation in a tertiary practice","volume":"95","author":"Nehra","year":"2000","journal-title":"Am. J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.jep.2026.122247_bib41","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3810\/pgm.2013.03.2640","article-title":"Comorbidities in patients with irritable bowel syndrome with constipation or chronic idiopathic constipation: a review of the literature from the past decade","volume":"125","author":"Nellesen","year":"2013","journal-title":"Postgrad. Med. J."},{"issue":"1","key":"10.1016\/j.jep.2026.122247_bib42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10151-021-02518-4","article-title":"Women with chronic constipation have more bothersome urogenital symptoms","volume":"26","author":"Ortega","year":"2021","journal-title":"Tech. Coloproctol."},{"issue":"8","key":"10.1016\/j.jep.2026.122247_bib43","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/s41556-021-00729-3","article-title":"Mitochondrial UPR through generations","volume":"23","author":"Park","year":"2021","journal-title":"Nat. Cell Biol."},{"issue":"7531","key":"10.1016\/j.jep.2026.122247_bib44","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nature13818","article-title":"Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection","volume":"516","author":"Pellegrino","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jep.2026.122247_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/s41593-026-02320-1","article-title":"The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence","author":"Perez J","year":"2026","journal-title":"Nat. Neurosci."},{"issue":"7","key":"10.1016\/j.jep.2026.122247_bib46","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/ajg.2015.128","article-title":"Anxiety and depression increase in a stepwise manner in parallel with multiple FGIDs and symptom severity and frequency","volume":"110","author":"Pinto-Sanchez","year":"2015","journal-title":"Am. J. Gastroenterol."},{"issue":"44","key":"10.1016\/j.jep.2026.122247_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh2584","article-title":"UNC-49 is a redox-sensitive GABA(A) receptor that regulates the mitochondrial unfolded protein response cell nonautonomously","volume":"9","author":"Pohl","year":"2023","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.jep.2026.122247_bib48","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jep.2014.01.004","article-title":"The effect of chaihu-shugan-san and its components on the expression of ERK5 in the hippocampus of depressed rats","volume":"152","author":"Qiu","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.jep.2026.122247_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0239092","article-title":"Behavioral and emotional problems in adolescents with constipation and their association with quality of life","volume":"15","author":"Rajindrajith","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jep.2026.122247_bib50","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jpsychores.2007.05.016","article-title":"Psychological profiles and quality of life differ between patients with dyssynergia and those with slow transit constipation","volume":"63","author":"Rao","year":"2007","journal-title":"J. Psychosom. Res."},{"issue":"5","key":"10.1016\/j.jep.2026.122247_bib51","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/19490976.2016.1218585","article-title":"Irritable bowel syndrome, the microbiota and the gut-brain axis","volume":"7","author":"Raskov","year":"2016","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jep.2026.122247_bib52","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.lfs.2016.06.024","article-title":"The role of the Wnt canonical signaling in neurodegenerative diseases","volume":"158","author":"Rosaliana","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2026.122247_bib53","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.atherosclerosis.2018.12.021","article-title":"Constipation and risk of death and cardiovascular events","volume":"281","author":"Sumida","year":"2019","journal-title":"Atherosclerosis"},{"issue":"11","key":"10.1016\/j.jep.2026.122247_bib54","doi-asserted-by":"crossref","first-page":"7653","DOI":"10.1002\/jcp.29682","article-title":"Glucose, glycolysis, and neurodegenerative diseases","volume":"235","author":"Tang","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jep.2026.122247_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1405393","article-title":"Mitochondrial unfolded protein response (UPRmt): what we know thus far","volume":"12","author":"Torres","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"issue":"9","key":"10.1016\/j.jep.2026.122247_bib56","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/jamapsychiatry.2017.0397","article-title":"A mitochondrial etiology of neuropsychiatric disorders","volume":"74","author":"Wallace","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"5","key":"10.1016\/j.jep.2026.122247_bib57","doi-asserted-by":"crossref","first-page":"e1007947","DOI":"10.1371\/journal.pgen.1007947","article-title":"TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response","volume":"15","author":"Wang","year":"2019","journal-title":"PLoS Genet."},{"issue":"12","key":"10.1016\/j.jep.2026.122247_bib58","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1021\/acschemneuro.1c00115","article-title":"Study of the neurotransmitter changes adjusted by circadian rhythm in depression based on liver transcriptomics and correlation analysis","volume":"12","author":"Wang","year":"2021","journal-title":"ACS Chem. Neurosci."},{"issue":"2","key":"10.1016\/j.jep.2026.122247_bib59","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jep.2011.08.079","article-title":"Meta-analysis of the clinical effectiveness of traditional Chinese medicine formula Chaihu-Shugan-San in depression","volume":"141","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.122247_bib60","doi-asserted-by":"crossref","DOI":"10.1007\/s00384-023-04563-x","article-title":"Constipation is associated with depression of any severity, but not with suicidal ideation: insights from a large cross-sectional study","volume":"38","author":"Wang","year":"2023","journal-title":"Int. J. Colorectal Dis."},{"issue":"34","key":"10.1016\/j.jep.2026.122247_bib61","first-page":"5180","article-title":"Chinese herbal medicine for the treatment of depression: applications, efficacies and mechanisms","volume":"23","author":"Wang","year":"2017","journal-title":"Curr. Pharm. Des."},{"issue":"5","key":"10.1016\/j.jep.2026.122247_bib62","article-title":"When all seems lost: management of refractory constipation-Surgery, rectal irrigation, percutaneous endoscopic colostomy, and more","volume":"30","author":"Wilkinson-Smith","year":"2018","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.jep.2026.122247_bib63","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jad.2024.05.124","article-title":"Identifying the association between depression and constipation: an observational study and Mendelian randomization analysis","volume":"359","author":"Wu","year":"2024","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.jep.2026.122247_bib64","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70226","article-title":"Oral delivery of R-spondin1-Loaded small extracellular vesicles activates WNT signalling pathway to accelerate intestinal injury repair and reverse ageing","volume":"15","author":"Yang","year":"2026","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jep.2026.122247_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2024.100562","article-title":"A data processing and visualization database and R package for traditional Chinese medicine network pharmacology","volume":"14","author":"Ying","year":"2025","journal-title":"Pharmacol. Res. Modern Chin. Med."},{"issue":"16","key":"10.1016\/j.jep.2026.122247_bib66","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1021\/acs.jafc.8b00385","article-title":"Bacterial cellulose relieves diphenoxylate induced constipation in rats","volume":"66","author":"Zhai","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.jep.2026.122247_bib67","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.7150\/thno.81067","article-title":"Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression","volume":"13","author":"Zhang","year":"2023","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.jep.2026.122247_bib68","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.cell.2018.06.029","article-title":"The mitochondrial unfolded protein response is mediated cell-non-autonomously by retromer-dependent wnt signaling","volume":"174","author":"Zhang","year":"2018","journal-title":"Cell"},{"issue":"346","key":"10.1016\/j.jep.2026.122247_bib69","first-page":"S5","article-title":"The WHO traditional medicine strategy 2014-2023: a perspective","volume":"6216","author":"Zhang","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jep.2026.122247_bib70","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/1745-6215-14-366","article-title":"Chinese herbal medicine (Ma Zi Ren Wan) for functional constipation: study protocol for a prospective, double-blinded, double- dummy, randomized controlled trial","volume":"14","author":"Zhong","year":"2023","journal-title":"Trials"},{"key":"10.1016\/j.jep.2026.122247_bib71","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.2147\/JIR.S326416","article-title":"The effect of shaoyao gancao decoction on sphincter of oddi dysfunction in hypercholesterolemic rabbits via protecting the enteric nervous system-interstitial cells of cajal-smooth muscle cells network","volume":"14","author":"Zhu","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.jep.2026.122247_bib72","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.freeradbiomed.2020.12.013","article-title":"Mitochondrial unfolded protein response: an emerging pathway in human diseases","volume":"163","author":"Zhu","year":"2021","journal-title":"Free Radic. Biol. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126011025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126011025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:42:00Z","timestamp":1792737720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126011025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":72,"alternative-id":["S0378874126011025"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122247","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shugan Tongbian Decoction ameliorates constipation and mental disorder by inhibiting UPRmt via Wnt\/Retromer axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122247","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"122247"}}