{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:41:34Z","timestamp":1792737694978,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jep.2026.122261","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:12:58Z","timestamp":1785856378000},"page":"122261","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["An efficacy-linked strategy for the quality evaluation of traditional medicine: Chaenomeles speciosa as an example"],"prefix":"10.1016","volume":"373","author":[{"given":"Yinghui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.122261_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116065","article-title":"Structural characterization of a heteropolysaccharide from fruit of Chaenomeles speciosa (Sweet) Nakai and its antitumor activity","volume":"236","author":"Cheng","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.122261_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116553","article-title":"Exploring the chondroprotective effect of Chaenomeles speciosa on Glucose-6-Phosphate Isomerase model mice using an integrated approach of network pharmacology and experimental validation","volume":"314","author":"Duan","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122261_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2022.112314","article-title":"Integrated untargeted metabolome, full-length sequencing, and transcriptome analyses reveal insights into the fruit quality at different harvest times of Chaenomeles speciosa","volume":"164","author":"Fang","year":"2023","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jep.2026.122261_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112658","article-title":"Dimethyl itaconate induces long-term innate immune responses and confers protection against infection","volume":"42","author":"Ferreira","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2026.122261_bib5","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.2147\/DDDT.S512752","article-title":"Oleanolic Acid@SPIONs alleviates lipid-oxidative stress injury of zebrafish blood vessels via regulating the expression of JNK and MAPK signaling pathways in vascular endothelial cells","volume":"19","author":"Gao","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2026.122261_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111866","article-title":"Emerging application of metabolomics on Chinese herbal medicine for depressive disorder","volume":"141","author":"Gu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.122261_bib7","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1039\/C9FO02322D","article-title":"Total triterpenoids from the fruits of Chaenomeles speciosa exerted gastroprotective activities on indomethacin-induced gastric damage via modulating microRNA-423-5p-mediated TFF\/NAG-1 and apoptotic pathways","volume":"11","author":"He","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2026.122261_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118693","article-title":"Chlorogenic acid alleviate kidney fibrosis through regulating TLR4\/NF-\u049bB mediated oxidative stress and inflammation","volume":"335","author":"Jiao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122261_bib9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.plaphy.2020.01.006","article-title":"The effect of developmental and environmental factors on secondary metabolites in medicinal plants","volume":"148","author":"Li","year":"2020","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.jep.2026.122261_bib10","article-title":"In vitro digestion and antioxidant activity of Xuan-Mugua (Chaenomeles fruit) peel and pulp phenolics","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2026.122261_bib11","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1093\/jaoacint\/qsab107","article-title":"Differentiation between Chaenomelis Fructus and its common adulterant, Guangpi Mugua","volume":"104","author":"Lyu","year":"2021","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.jep.2026.122261_bib13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3390\/antiox14030343","article-title":"Hepatoprotective effects of Citri reticulatae Pericarpium and Chaenomeles speciosa (Sweet) Nakai extracts in alcohol-related liver injury: modulation of oxidative stress, lipid metabolism, and gut microbiota","volume":"14","author":"Ma","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2026.122261_bib12","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3390\/foods11071019","article-title":"Comparative metabolomics study of Chaenomeles speciosa (Sweet) Nakai from different geographical regions","volume":"11","author":"Ma","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.jep.2026.122261_bib14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3109\/13880209.2014.936470","article-title":"Anti-inflammatory and antioxidant properties of unripe papaya extract in an excision wound model","volume":"53","author":"Nafiu","year":"2015","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2026.122261_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biopha.2017.10.064","article-title":"Chlorogenic acid (CGA): a pharmacological review and call for further research","volume":"97","author":"Naveed","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.122261_bib16","unstructured":"Pharmacopoeia of People\u2019s Republic of China, 2020. China Medical Science and Technology Press, Beijing, China."},{"key":"10.1016\/j.jep.2026.122261_bib17","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.ijbiomac.2018.05.117","article-title":"Structural elucidation of lignin-carbohydrate complexes (LCCs) from Chinese quince (Chaenomeles sinensis) fruit","volume":"116","author":"Qin","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122261_bib18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3389\/fpls.2013.00159","article-title":"Progress toward the tomato fruit cell wall proteome","volume":"4","author":"Ruiz-May","year":"2013","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.jep.2026.122261_bib19","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.3390\/molecules25173994","article-title":"Analysis of flavonoid metabolites in Chaenomeles petals using UPLC-ESI-MS\/MS","volume":"25","author":"Shen","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.122261_bib20","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3171\/2023.9.JNS231099","article-title":"The story of dexamethasone and how it became one of the most widely used drugs in neurosurgery","volume":"140","author":"Vazquez","year":"2023","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.jep.2026.122261_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.procbio.2021.12.033","article-title":"Structural changes for lignin from Chinese quince during the sequential fractionation of cell wall polysaccharides","volume":"113","author":"Wei","year":"2022","journal-title":"Process Biochem."},{"key":"10.1016\/j.jep.2026.122261_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.141222","article-title":"Developed metabolomics approach reveals the non-volatile color-contributing metabolites during Keemun congou black tea processing","volume":"463","author":"Wen","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2026.122261_bib23","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000041028","article-title":"Network pharmacology unveils the active components and potential mechanism of traditional efficacy of Mugua","volume":"103","author":"Wu","year":"2024","journal-title":"Medicine"},{"key":"10.1016\/j.jep.2026.122261_bib25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3390\/metabo14020117","article-title":"Anti-hyperuricemic effects of extracts from Chaenomeles speciosa (Sweet) Nakai fruits on hyperuricemic rats","volume":"14","author":"Xu","year":"2024","journal-title":"Metabolites"},{"key":"10.1016\/j.jep.2026.122261_bib24","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s12272-023-01475-w","article-title":"Phytochemistry and pharmacology of plants in the genus Chaenomeles","volume":"46","author":"Xu","year":"2023","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2026.122261_bib26","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.3390\/molecules29132984","article-title":"Recent advances in polysaccharides from Chaenomeles speciosa (Sweet) Nakai: extraction, purification, structural characteristics, health benefits, and applications","volume":"29","author":"Yu","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.122261_bib27","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1186\/s12870-025-06949-1","article-title":"Phytochemical profile and antioxidant activity of Dracocephalum kotschyi Boiss. affected by environmental conditions of cultivation regions","volume":"25","author":"Zamani","year":"2025","journal-title":"BMC Plant Biol."},{"key":"10.1016\/j.jep.2026.122261_bib28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3892\/br.2013.193","article-title":"Chaenomeles speciosa: a review of chemistry and pharmacology","volume":"2","author":"Zhang","year":"2014","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.jep.2026.122261_bib29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.pbb.2008.03.014","article-title":"Dopamine transporter inhibitory and antiparkinsonian effect of common flowering quince extract","volume":"90","author":"Zhao","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jep.2026.122261_bib30","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.3390\/molecules23102518","article-title":"Chemical composition, antioxidant activity and \u03b1-glucosidase inhibitory activity of Chaenomeles speciosa from four production areas in China","volume":"23","author":"Zheng","year":"2018","journal-title":"Molecules"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126011165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126011165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:34:06Z","timestamp":1792737246000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126011165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":30,"alternative-id":["S0378874126011165"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122261","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An efficacy-linked strategy for the quality evaluation of traditional medicine: Chaenomeles speciosa as an example","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122261","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122261"}}