{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:37:39Z","timestamp":1792741059408,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013792","name":"Chengdu University","doi-asserted-by":"publisher","award":["S202611079031"],"award-info":[{"award-number":["S202611079031"]}],"id":[{"id":"10.13039\/501100013792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jep.2026.122267","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:12:53Z","timestamp":1785856373000},"page":"122267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Polysaccharide PAP55-1-1 derived from Periplaneta americana promotes wound healing via the COX-2\/PGE2\/HIF-1\u03b1 pathway"],"prefix":"10.1016","volume":"373","author":[{"given":"Chunyan","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hujing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.122267_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuint.2024.105747","article-title":"The Janus face of HIF-1\u03b1 in ischemic stroke and the possible associated pathways","volume":"177","author":"Amin","year":"2024","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jep.2026.122267_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijbiomac.2023.124386","article-title":"Structural characterization and anti-inflammatory activity of polysaccharides from Astragalus membranaceus","volume":"241","author":"Chen","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122267_bib3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.phymed.2025.157237","article-title":"Typhae pollen active subfraction exerts antiangiogenic effect in benign prostatic hyperplasia via regulating the VEGF signaling pathway and arachidonic acid metabolism","volume":"147","author":"Chen","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.122267_bib4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.carbpol.2020.115856","article-title":"Structural characterization of a safflower polysaccharide and its promotion effect on steroid-induced osteonecrosis in vivo","volume":"233","author":"Cui","year":"2020","journal-title":"Carbohydr. Polym."},{"issue":"13","key":"10.1016\/j.jep.2026.122267_bib5","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1158\/1078-0432.CCR-17-2725","article-title":"COX-2\/PGE2 axis regulates HIF2\u03b1 activity to promote hepatocellular carcinoma hypoxic response and reduce the sensitivity of sorafenib treatment","volume":"24","author":"Dong","year":"2018","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.jep.2026.122267_bib6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jbc.2021.100910","article-title":"Von Hippel-Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular levels of VHL protein","volume":"297","author":"Frost","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2026.122267_bib7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fcell.2025.1630129","article-title":"DMP1-mediated transformation of DPSCs to CD31+\/CD144+ cells demonstrate endothelial phenotype both in vitro and in vivo","volume":"13","author":"Ganapathy","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jep.2026.122267_bib8","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1016\/j.ijbiomac.2020.08.150","article-title":"Purification, structural characterization and anticoagulant activities of four sulfated polysaccharides from sea cucumber Holothuria fuscopunctata","volume":"164","author":"Gao","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122267_bib9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bcp.2025.117053","article-title":"FATS alleviates ulcerative colitis by inhibiting M1 macrophage polarization and aerobic glycolysis through promoting the ubiquitination-mediated degradation of HIF-1\u03b1","volume":"240","author":"Han","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"3\u20134","key":"10.1016\/j.jep.2026.122267_bib10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.vetpar.2010.02.014","article-title":"Monosaccharide composition of fundic and duodenal mucins in sheep infected with Haemonchus contortus or Teladorsagia circumcincta","volume":"170","author":"Hoang","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.jep.2026.122267_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bcp.2023.115972","article-title":"1,8-Dihydroxy-3-methoxy-anthraquinone inhibits tumor angiogenesis through HIF-1\u03b1 downregulation","volume":"220","author":"Hwang","year":"2024","journal-title":"Biochem. Pharmacol."},{"issue":"19","key":"10.1016\/j.jep.2026.122267_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/adfm.202010461","article-title":"Bioinspired conductive silk Microfiber integrated bioelectronic for diagnosis and wound healing in diabetes","volume":"31","author":"Jia","year":"2021","journal-title":"Adv. Funct. Mater."},{"issue":"21","key":"10.1016\/j.jep.2026.122267_bib13","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1101\/gad.268128.115","article-title":"WSB1 promotes tumor metastasis by inducing pVHL degradation","volume":"29","author":"Kim","year":"2015","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.jep.2026.122267_bib14","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/cr.2016.148","article-title":"WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation","volume":"27","author":"Kim","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.jep.2026.122267_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.carbpol.2024.122360","article-title":"Structure and in vitro antiproliferative activity against breast cancer cells of the cell-wall polysaccharide from the marine bacterium Kangiella japonica KMM 3899T","volume":"341","author":"Kokoulin","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.122267_bib16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.biochi.2015.12.005","article-title":"Regulation of protein kinase CK2 catalytic activity by protein kinase C and phospholipase D2","volume":"121","author":"Lee","year":"2016","journal-title":"Biochimie"},{"issue":"2","key":"10.1016\/j.jep.2026.122267_bib17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.carbpol.2010.08.014","article-title":"Isolation, purification and structure of a new water-soluble polysaccharide from Zizyphus jujuba cv Jinsixiaozao","volume":"83","author":"Li","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.122267_bib21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijbiomac.2024.130357","article-title":"Construction of chitosan-gelatin polysaccharide-protein composite hydrogel via mechanical stretching and its biocompatibility in vivo","volume":"264","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122267_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108858","article-title":"Periplaneta Americana L. as a novel therapeutics accelerates wound repair and regeneration","volume":"114","author":"Li","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.122267_bib20","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ijbiomac.2022.12.272","article-title":"Chitosan electrospun nanofibers derived from Periplaneta americana residue for promoting infected wound healing","volume":"229","author":"Li","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122267_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116439","article-title":"A new application of acetylation for analysis of acidic heteropolysaccharides by liquid chromatography-electrospray mass spectrometry","volume":"245","author":"Li","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jep.2026.122267_bib22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ijbiomac.2025.143855","article-title":"Structural characterization and immunostimulatory effects of polysaccharide AP-1 from ashwagandha (Withania somnifera) roots","volume":"311","author":"Li","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122267_bib23","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ijbiomac.2021.12.018","article-title":"Characterization and diabetic wound healing benefits of protein-polysaccharide complexes isolated from an animal ethno-medicine Periplaneta americana L","volume":"195","author":"Liao","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.jep.2026.122267_bib24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12951-023-01923-1","article-title":"Natural exosome-like nanoparticles derived from ancient medicinal insect Periplaneta americana L. as a novel diabetic wound healing accelerator","volume":"21","author":"Liao","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jep.2026.122267_bib25","first-page":"3645","article-title":"Research progress on chemical constituents and biological activity of Periplaneta americana","volume":"48","author":"Lin","year":"2017","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.jep.2026.122267_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.progpolymsci.2021.101472","article-title":"Mussel-inspired chemistry: a promising strategy for natural polysaccharides in biomedical applications","volume":"123","author":"Liu","year":"2021","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.jep.2026.122267_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117284","article-title":"Assessment of cytotoxicity, acute, subacute toxicities and antioxidant activities (in vitro) of Sanghuangporus vaninii crude polysaccharide","volume":"319","author":"Liu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122267_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2019.104126","article-title":"Dataset of the infrared spectrometry, gas chromatography-mass spectrometry analysis and nuclear magnetic resonance spectroscopy of the polysaccharides from C. militaris","volume":"25","author":"Liu","year":"2019","journal-title":"Data Brief"},{"key":"10.1016\/j.jep.2026.122267_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2026.125022","article-title":"Structural validation and immunogenic characterization of Streptococcus pneumoniae serotype 22A capsular polysaccharide relative to serotype 22F","volume":"380","author":"Meng","year":"2026","journal-title":"Carbohydr. Polym."},{"issue":"41","key":"10.1016\/j.jep.2026.122267_bib30","doi-asserted-by":"crossref","first-page":"30286","DOI":"10.1039\/D4RA06062H","article-title":"MA'AT analysis of the O-glycosidic linkages of oligosaccharides using nonconventional NMR J-couplings: MA'AT and MD models of phi","volume":"14","author":"Meredith","year":"2024","journal-title":"RSC Adv."},{"issue":"4","key":"10.1016\/j.jep.2026.122267_bib31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jbc.2023.103050","article-title":"The 5-lipoxygenase\/cyclooxygenase-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis","volume":"299","author":"Nakashima","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2026.122267_bib32","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.saa.2024.125204","article-title":"A method for the quantitative analysis of Lycium barbarum polysaccharides (LBPs) using Fourier-transform infrared spectroscopy (FTIR): from theoretical computation to experimental application","volume":"326","author":"Nan","year":"2025","journal-title":"Spectroc. Acta Pt. A-Molec. Biomolec. Spectr."},{"key":"10.1016\/j.jep.2026.122267_bib33","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.saa.2023.123584","article-title":"Determining the nanostructure and main axis of gly-his-gly fibrils using the amide I' bands in FTIR, VCD, and Raman spectra","volume":"306","author":"O'Neill","year":"2024","journal-title":"Spectroc. Acta Pt. A-Molec. Biomolec. Spectr."},{"issue":"49","key":"10.1016\/j.jep.2026.122267_bib34","doi-asserted-by":"crossref","first-page":"48690","DOI":"10.1074\/jbc.M308862200","article-title":"The von Hippel Lindau\/Hypoxia-inducible Factor (HIF) Pathway Regulates the Transcription of the HIF-Proline Hydroxylase Genes in Response to Low Oxygen","volume":"278","author":"Peso","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2026.122267_bib35","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jare.2024.05.003","article-title":"Arachidonic acid in aging: new roles for old players","volume":"70","author":"Qian","year":"2025","journal-title":"J. Adv. Res."},{"issue":"3","key":"10.1016\/j.jep.2026.122267_bib36","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1124\/pharmrev.123.000901","article-title":"Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair mediated by EP Receptors 2 and 4","volume":"76","author":"Santiso","year":"2024","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jep.2026.122267_bib37","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pbiomolbio.2023.09.002","article-title":"HIF-1\u03b1 and periodontitis: novel insights linking host-environment interplay to periodontal phenotypes","volume":"184","author":"Shan","year":"2023","journal-title":"Prog. Biophys. Mol. Biol."},{"issue":"13","key":"10.1016\/j.jep.2026.122267_bib38","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2174\/0113894501323980240815113851","article-title":"Prostaglandins in the inflamed central nervous System: potential therapeutic targets","volume":"25","author":"Sheremeta","year":"2024","journal-title":"Curr. Drug Targets"},{"issue":"12","key":"10.1016\/j.jep.2026.122267_bib39","article-title":"Periplaneta americana extracts promote skin wound healing via nuclear factor Kappa B canonical pathway and extracellular signal-regulated kinase signaling. Evid.-based complement","volume":"2017","author":"Song","year":"2017","journal-title":"Altern. Med."},{"issue":"2","key":"10.1016\/j.jep.2026.122267_bib40","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3892\/ijmm.2017.3040","article-title":"JAK\/STAT3 and Smad3 activities are required for the wound healing properties of Periplaneta americana extracts","volume":"40","author":"Song","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2026.122267_bib41","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.tox.2016.09.019","article-title":"Aryl hydrocarbon receptor-ligand axis mediates pulmonary fibroblast migration and differentiation through increased arachidonic acid metabolism","volume":"370","author":"Su","year":"2016","journal-title":"Toxicology"},{"issue":"4","key":"10.1016\/j.jep.2026.122267_bib42","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1159\/000485764","article-title":"Celecoxib down-regulates the hypoxia-induced expression of HIF-1\u03b1 and VEGF through the PI3K\/AKT pathway in retinal pigment epithelial cells","volume":"44","author":"Sun","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2026.122267_bib43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijbiomac.2025.146047","article-title":"A review of advanced strategies for molecular weight determination of insoluble polysaccharides: developments and future trends","volume":"320","author":"Tabani","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122267_bib44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.addr.2018.09.010","article-title":"Therapeutic strategies for enhancing angiogenesis in wound healing","volume":"146","author":"Veith","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.jep.2026.122267_bib45","first-page":"e765","article-title":"Metabolomics biomarkers for breast cancer: an updated perspective. Clin","volume":"25","author":"Vellan","year":"2025","journal-title":"Breast Cancer"},{"issue":"7","key":"10.1016\/j.jep.2026.122267_bib46","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.yexcr.2010.02.026","article-title":"Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays","volume":"316","author":"Walter","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jep.2026.122267_bib47","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijbiomac.2023.127955","article-title":"Effect of monosaccharide composition and proportion on the bioactivity of polysaccharides: a review","volume":"254","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122267_bib48","article-title":"Biomarkers of metabolomics in inflammatory bowel disease and damp-heat syndrome: a preliminary study","volume":"2022","author":"Wu","year":"2022","journal-title":"Evid.-based Complement Altern. Med."},{"key":"10.1016\/j.jep.2026.122267_bib49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijbiomac.2024.135836","article-title":"A polysaccharide from Periplaneta americana promotes macrophage M2 polarization, exhibiting anti-inflammatory and wound-healing activities","volume":"281","author":"Xiao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122267_bib50","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ijbiomac.2024.139133","article-title":"A review on multifunctional calcium alginate fibers for full-time and multipurposed wound treatment: from fundamentals to advanced applications","volume":"290","author":"Xu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122267_bib51","first-page":"2026","article-title":"The dual pathological roles and targeted therapy of PGE2: from receptor signaling networks to disease microenvironment modulation","volume":"17","author":"Yang","year":"2026","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2026.122267_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2026.214722","article-title":"A novel polymeric hydrogel of Periplaneta americana polysaccharide loaded with kaempferol-chitosan microspheres, which possesses antibacterial, hemostatic, antioxidant and wound healing promoting activities","volume":"182","author":"Yang","year":"2026","journal-title":"Biomater. Adv."},{"issue":"4","key":"10.1016\/j.jep.2026.122267_bib54","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.bbrc.2015.11.014","article-title":"Indomethacin-induced intestinal epithelial cell damage is mediated by pVHL activation through the degradation of collagen I and HIF-1\u03b1","volume":"468","author":"Yokoe","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2026.122267_bib55","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijbiomac.2025.141469","article-title":"Pioneering polysaccharide extraction with deep eutectic solvents: a review on impacts to extraction yield, physicochemical properties and bioactivities","volume":"306","author":"Yusoff","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.jep.2026.122267_bib56","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1093\/jme\/tjz081","article-title":"The role of Periplaneta americana (Blattodea: blattidae) in modern versus traditional Chinese medicine","volume":"56","author":"Zeng","year":"2019","journal-title":"J. Med. Entomol."},{"key":"10.1016\/j.jep.2026.122267_bib57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijbiomac.2024.136474","article-title":"Physicochemical properties, structure and biological activity of ginger polysaccharide: effect of microwave infrared dual-field coupled drying","volume":"281","author":"Zeng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2026.122267_bib59","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.carbpol.2022.119433","article-title":"Defensing against oxidative stress in Caenorhabditis elegans of a polysaccharide LFP-05S from Lycii fructus","volume":"289","author":"Zhang","year":"2022","journal-title":"Carbohydr. Polym."},{"issue":"8","key":"10.1016\/j.jep.2026.122267_bib60","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/adma.202408221","article-title":"A bioinspired virus-like mechano-bactericidal nanomotor for ocular multidrug-resistant bacterial infection treatment","volume":"37","author":"Zhang","year":"2025","journal-title":"Adv. Mater."},{"issue":"4","key":"10.1016\/j.jep.2026.122267_bib58","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/gutjnl-2019-319664","article-title":"Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites","volume":"70","author":"Zhang","year":"2021","journal-title":"Gut"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126011220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126011220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:39:39Z","timestamp":1792737579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126011220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":59,"alternative-id":["S0378874126011220"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122267","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polysaccharide PAP55-1-1 derived from Periplaneta americana promotes wound healing via the COX-2\/PGE2\/HIF-1\u03b1 pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122267","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122267"}}