{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:54:58Z","timestamp":1790574898672,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["73441"],"award-info":[{"award-number":["73441"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.jep.2026.122339","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:31:27Z","timestamp":1787787087000},"page":"122339","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Experimental phytochemical characterization and OECD guideline evaluation of the acute and 28-day oral toxicity of a hydroethanolic peel extract of Citrus medica L. in Wistar rats"],"prefix":"10.1016","volume":"374","author":[{"given":"Laleh","family":"Khodaie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajad","family":"Parvin Y","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Ghanbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8355-8795","authenticated-orcid":false,"given":"Mina","family":"Islambulchilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jep.2026.122339_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.71259","article-title":"Antioxidant potential of polyphenolic compounds, sources, extraction, purification and characterization techniques: a focused review","volume":"13","author":"Ahmad","year":"2025","journal-title":"Food Sci. Nutr."},{"issue":"9","key":"10.1016\/j.jep.2026.122339_bib2","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.3390\/pr11092771","article-title":"Polyphenols as antioxidant\/pro-oxidant compounds and donors of reducing species: relationship with human antioxidant metabolism","volume":"11","author":"Andr\u00e9s","year":"2023","journal-title":"Processes"},{"issue":"2","key":"10.1016\/j.jep.2026.122339_bib3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.yrtph.2009.03.001","article-title":"Subchronic toxicity of Citrus aurantium L. (Rutaceae) extract and p-synephrine in mice","volume":"54","author":"Arbo","year":"2009","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2026.122339_bib4","first-page":"42","article-title":"Laboratory routines cause animal stress","volume":"43","author":"Balcombe","year":"2004","journal-title":"Contemp. Top. Lab. Anim. Sci."},{"issue":"15","key":"10.1016\/j.jep.2026.122339_bib5","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1021\/jf8006568","article-title":"Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity","volume":"56","author":"Benavente-Garcia","year":"2008","journal-title":"J. Agric. Food Chem."},{"issue":"12","key":"10.1016\/j.jep.2026.122339_bib6","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.3390\/plants12122267","article-title":"An insight into Citrus medica Linn.: a systematic review on phytochemical profile and biological activities","volume":"12","author":"Benedetto","year":"2023","journal-title":"Plants"},{"issue":"8","key":"10.1016\/j.jep.2026.122339_bib7","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.3390\/molecules30081676","article-title":"Flavonoids and furanocoumarins involved in drug interactions","volume":"30","author":"Berteina-Raboin","year":"2025","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.jep.2026.122339_bib8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3329\/jsr.v1i2.1760","article-title":"Constituents of peel and leaf essential oils of Citrus medica L","volume":"1","author":"Bhuiyan","year":"2009","journal-title":"J. Sci. Res."},{"issue":"3_Suppl. l","key":"10.1016\/j.jep.2026.122339_bib9","doi-asserted-by":"crossref","first-page":"39S","DOI":"10.1177\/10915818211040027","article-title":"Safety assessment of citrus plant-and seed-derived ingredients as used in cosmetics","volume":"40","author":"Burnett","year":"2021","journal-title":"Int. J. Toxicol."},{"issue":"3","key":"10.1016\/j.jep.2026.122339_bib10","article-title":"Estimation of total flavonoid content in propolis by two complementary colorimetric methods","volume":"10","author":"Chang","year":"2002","journal-title":"J. Food Compos. Anal."},{"issue":"1","key":"10.1016\/j.jep.2026.122339_bib11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ijbiomac.2006.12.003","article-title":"Interaction of flavonoids with red blood cell membrane lipids and proteins: antioxidant and antihemolytic effects","volume":"41","author":"Chaudhuri","year":"2007","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.jep.2026.122339_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/metabo15060362","article-title":"Bridging ethnobotanical knowledge and multi-omics approaches for plant-derived natural product discovery","volume":"15","author":"Chele","year":"2025","journal-title":"Metabolites"},{"issue":"4","key":"10.1016\/j.jep.2026.122339_bib13","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1039\/C7FO02035J","article-title":"Citrus medica: nutritional, phytochemical composition and health benefits\u2013a review","volume":"9","author":"Chhikara","year":"2018","journal-title":"Food Funct."},{"issue":"2","key":"10.1016\/j.jep.2026.122339_bib14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3390\/scipharm90020028","article-title":"Preclinical safety profile of an oral naringenin\/hesperidin dosage form by in vivo toxicological tests","volume":"90","author":"Cicero-Sarmiento","year":"2022","journal-title":"Sci. Pharm."},{"issue":"5","key":"10.1016\/j.jep.2026.122339_bib15","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/ptr.2077","article-title":"In vitro activities of Citrus medica L. cv. Diamante (Diamante citron) relevant to treatment of diabetes and Alzheimer's disease","volume":"21","author":"Conforti","year":"2007","journal-title":"Phytother Res."},{"issue":"11","key":"10.1016\/j.jep.2026.122339_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142757","article-title":"The distribution of coumarins and furanocoumarins in Citrus species closely matches Citrus phylogeny and reflects the organization of biosynthetic pathways","volume":"10","author":"Dugrand-Judek","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jep.2026.122339_bib17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3109\/10408444.2013.835786","article-title":"Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: a case study with phenobarbital as a model constitutive androstane receptor (CAR) activator","volume":"44","author":"Elcombe","year":"2014","journal-title":"Crit. Rev. Toxicol."},{"issue":"2","key":"10.1016\/j.jep.2026.122339_bib18","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1039\/C8FO01997E","article-title":"The effects of polyphenols and other bioactives on human health","volume":"10","author":"Fraga","year":"2019","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.jep.2026.122339_bib19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jssc.200800404","article-title":"Essential oil composition of Citrus medica L. Cv. Diamante (Diamante citron) determined after using different extraction methods","volume":"32","author":"Gabriele","year":"2009","journal-title":"J. Sep. Sci."},{"issue":"3","key":"10.1016\/j.jep.2026.122339_bib20","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.freeradbiomed.2004.04.034","article-title":"Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties","volume":"37","author":"Galati","year":"2004","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.jep.2026.122339_bib21","first-page":"312","article-title":"Modern in Silico molecular docking perspective for investigation of Rindera lanata Bunge var. lanata targeting: phytochemical profile, phytotoxicity and bioactivity assays","volume":"30","author":"Ghanbari","year":"2024","journal-title":"Pharm. Sci."},{"issue":"5","key":"10.1016\/j.jep.2026.122339_bib22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1080\/10408444.2022.2082269","article-title":"Adverse outcome pathway (AOP): \u03b12u-globulin nephropathy and kidney tumors in male rats","volume":"52","author":"Goyak","year":"2022","journal-title":"Crit. Rev. Toxicol."},{"issue":"11","key":"10.1016\/j.jep.2026.122339_bib23","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.3390\/molecules21111530","article-title":"The chemistry and pharmacology of citrus limonoids","volume":"21","author":"Gualdani","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2026.122339_bib24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.fct.2018.05.050","article-title":"Phytochemicals of herbs and spices: health versus toxicological effects","volume":"119","author":"Guldiken","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"7","key":"10.1016\/j.jep.2026.122339_bib25","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1177\/0192623312448935","article-title":"Liver hypertrophy: a review of adaptive (adverse and non-adverse) changes\u2014conclusions from the 3rd International ESTP Expert Workshop","volume":"40","author":"Hall","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.jep.2026.122339_bib26","first-page":"459","article-title":"Evaluating antiproliferative and antioxidant activity of Marrubium crassidens","volume":"4","author":"Hamedeyazdan","year":"2014","journal-title":"Adv. Pharmaceut. Bull."},{"issue":"3","key":"10.1016\/j.jep.2026.122339_bib27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ptr.5256","article-title":"Antioxidant and anti\u2010inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models","volume":"29","author":"Hamideh","year":"2015","journal-title":"Phytother Res."},{"issue":"4","key":"10.1016\/j.jep.2026.122339_bib28","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1080\/10408440802368642","article-title":"A comparison of rat chronic progressive nephropathy with human renal disease\u2014implications for human risk assessment","volume":"39","author":"Hard","year":"2009","journal-title":"Crit. Rev. Toxicol."},{"issue":"1","key":"10.1016\/j.jep.2026.122339_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jfda.2016.11.008","article-title":"Chemistry and health effects of furanocoumarins in grapefruit","volume":"25","author":"Hung","year":"2017","journal-title":"J. Food Drug Anal."},{"issue":"12","key":"10.1016\/j.jep.2026.122339_bib30","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2131\/jts.46.569","article-title":"Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats","volume":"46","author":"Kodama","year":"2021","journal-title":"J. Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2026.122339_bib31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0041-008X(92)90190-4","article-title":"Biochemical basis for mouse resistance to hyaline droplet nephropathy: lack of relevance of the \u03b12u-globulin protein superfamily in this male rat-specific syndrome","volume":"112","author":"Lehman-McKeeman","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2026.122339_bib32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.yrtph.2019.04.001","article-title":"Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats","volume":"105","author":"Li","year":"2019","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.122339_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/jcpt.12595","article-title":"Screening of furanocoumarin derivatives as cytochrome P450 3A4 inhibitors in citrus","volume":"43","author":"Masuda","year":"2018","journal-title":"J. Clin. Pharm. Therapeut."},{"issue":"7","key":"10.1016\/j.jep.2026.122339_bib34","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.fct.2011.03.048","article-title":"Phytochemical profile, antioxidant, anti-inflammatory and hypoglycemic potential of hydroalcoholic extracts from Citrus medica L. cv Diamante flowers, leaves and fruits at two maturity stages","volume":"49","author":"Menichini","year":"2011","journal-title":"Food Chem. Toxicol."},{"issue":"8","key":"10.1016\/j.jep.2026.122339_bib35","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1021\/acs.chemrestox.1c00166","article-title":"Role of Citrus medica L. Fruits extract in combatting the hematological and hepatic toxic effects of carbofuran","volume":"34","author":"Mondal","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jep.2026.122339_bib36","series-title":"Guide for the Care and Use of Laboratory Animals","year":"2011"},{"issue":"37","key":"10.1016\/j.jep.2026.122339_bib37","article-title":"Platelets and inflammation: relations between platelet counts and markers of inflammation","volume":"17","author":"Nirmay","year":"2021","journal-title":"Eur. Sci. J."},{"issue":"8","key":"10.1016\/j.jep.2026.122339_bib38","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.3390\/antiox11081613","article-title":"Hormesis and oxidative distress: pathophysiology of reactive oxygen species and the open question of antioxidant modulation and supplementation","volume":"11","author":"Nitti","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2026.122339_bib39","series-title":"OECD Guidelines for the Testing of Chemicals","article-title":"Test No. 423: acute oral Toxicity\u2013 acute toxic class method","year":"2002"},{"key":"10.1016\/j.jep.2026.122339_bib40","series-title":"OECD Guidelines for the Testing of Chemicals","article-title":"Test No. 407: repeated dose 28-Day oral toxicity Study in rodents","year":"2008"},{"issue":"2","key":"10.1016\/j.jep.2026.122339_bib41","doi-asserted-by":"crossref","first-page":"173","DOI":"10.20527\/jbk.v17i2.11692","article-title":"Hesperidin Interaction with HMG-CoA-reductase enzyme in hypercholesterolemia: a study in silico","volume":"17","author":"Oktaviani","year":"2021","journal-title":"Berk. Kedokt."},{"issue":"5","key":"10.1016\/j.jep.2026.122339_bib42","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/ajcn\/83.5.1097","article-title":"A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice\u2013felodipine interaction","volume":"83","author":"Paine","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"issue":"2","key":"10.1016\/j.jep.2026.122339_bib43","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4103\/0976-500X.81895","article-title":"Toxicological screening","volume":"2","author":"Parasuraman","year":"2011","journal-title":"J. Pharmacol. Pharmacother."},{"issue":"7","key":"10.1016\/j.jep.2026.122339_bib44","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"issue":"9","key":"10.1016\/j.jep.2026.122339_bib45","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1080\/10408444.2023.2168178","article-title":"Nephrotoxicity induced by natural compounds from herbal medicines\u2013a challenge for clinical application","volume":"52","author":"Rao","year":"2022","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.jep.2026.122339_bib46","series-title":"Bioactive Food as Dietary Interventions for Diabetes","first-page":"515","article-title":"Chapter 34 - a review of the effects of Citrus paradisi (Grapefruit) and its flavonoids, naringin, and naringenin in Metabolic syndrome","author":"Razavi","year":"2019"},{"key":"10.1016\/j.jep.2026.122339_bib47","first-page":"327","article-title":"Total phenolic compounds and antioxidant potential of rokrose (Cistus salviifolius) leaves and flowers grown in Tunisia. Int. J. Pharmacogn","volume":"8","author":"Rebaya","year":"2016","journal-title":"Phytochem. Res"},{"key":"10.1016\/j.jep.2026.122339_bib48","series-title":"Hesperidin and Naringenin, A Centum of Valuable Plant Bioactives","first-page":"403","author":"Rehman","year":"2021"},{"issue":"2","key":"10.1016\/j.jep.2026.122339_bib49","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s40495-024-00353-3","article-title":"Redoxification (of the organism) through diet and supplementation with a focus on natural polymeric redox modulators","volume":"10","author":"Sahakyan","year":"2024","journal-title":"Curr. Pharmacol. Rep."},{"issue":"4","key":"10.1016\/j.jep.2026.122339_bib50","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/17425255.2020.1746268","article-title":"Nuclear receptor CAR-mediated liver cancer and its species differences","volume":"16","author":"Shizu","year":"2020","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"2","key":"10.1016\/j.jep.2026.122339_bib51","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s13105-019-00678-4","article-title":"Hesperetin is a potent bioactivator that activates SIRT1-AMPK signaling pathway in HepG2 cells","volume":"75","author":"Shokri Afra","year":"2019","journal-title":"J. Physiol. Biochem."},{"issue":"8","key":"10.1016\/j.jep.2026.122339_bib52","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3390\/antiox13080933","article-title":"The double-edged sword of total antioxidant capacity: clinical significance and personal experience","volume":"13","author":"Silvestrini","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2026.122339_bib53","series-title":"Methods in Enzymology","isbn-type":"print","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0076-6879(99)99017-1","article-title":"[14] Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent","author":"Singleton","year":"1999","ISBN":"https:\/\/id.crossref.org\/isbn\/9780121822002"},{"issue":"1","key":"10.1016\/j.jep.2026.122339_bib54","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0041-008X(89)90053-7","article-title":"The comparative pathobiology of \u03b12u-globulin nephropathy","volume":"97","author":"Swenberg","year":"1989","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.122339_bib55","article-title":"Safety of water extract of Cistanche tubulosa stems as a Novel food pursuant to Regulation (EU) 2015\/2283","volume":"19","author":"Turck","year":"2021","journal-title":"EFSA J."},{"key":"10.1016\/j.jep.2026.122339_bib56","series-title":"WHO Guidelines on the Assessment of Herbal Drugs","year":"2020"},{"issue":"36","key":"10.1016\/j.jep.2026.122339_bib57","doi-asserted-by":"crossref","first-page":"32526","DOI":"10.1021\/acsomega.3c02861","article-title":"Evaluation of the antioxidant potential of Citrus medica from different geographical regions and characterization of phenolic constituents by LC\u2013MS","volume":"8","author":"Xia","year":"2023","journal-title":"ACS Omega"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126011943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126011943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:55:32Z","timestamp":1790571332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126011943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":57,"alternative-id":["S0378874126011943"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122339","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experimental phytochemical characterization and OECD guideline evaluation of the acute and 28-day oral toxicity of a hydroethanolic peel extract of Citrus medica L. in Wistar rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122339","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122339"}}