{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:55:03Z","timestamp":1790574903778,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LMS26H270005"],"award-info":[{"award-number":["LMS26H270005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004410"],"award-info":[{"award-number":["82004410"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.jep.2026.122345","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:30:53Z","timestamp":1788589853000},"page":"122345","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Synaptic remodeling and functional recovery: Huan Le Ning decoction mitigates perimenopausal anxiety and depression symptoms via hippocampal reorganization"],"prefix":"10.1016","volume":"374","author":[{"given":"Xian","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5770-4208","authenticated-orcid":false,"given":"Yixuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9845-4099","authenticated-orcid":false,"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.jep.2026.122345_bib1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1042\/CS20255841","article-title":"Impact of the natural female reproductive aging on the rat serum lipidome","volume":"139","author":"Baudin","year":"2025","journal-title":"Clin. Sci."},{"issue":"1","key":"10.1016\/j.jep.2026.122345_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.neumar.2024.100004","article-title":"Peering into the nervous system","volume":"1","author":"Bitan","year":"2024","journal-title":"NeuroMarkers"},{"issue":"9","key":"10.1016\/j.jep.2026.122345_bib3","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrm2009","article-title":"Notch signalling: a simple pathway becomes complex","volume":"7","author":"Bray","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.jep.2026.122345_bib4","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3390\/medicina55090602","article-title":"The controversial history of hormone replacement therapy","volume":"55","author":"Cagnacci","year":"2019","journal-title":"Medicina"},{"issue":"June 2024","key":"10.1016\/j.jep.2026.122345_bib5","article-title":"Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling","volume":"128","author":"Chai","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jep.2026.122345_bib8","article-title":"Leveraging cell death patterns to predict metastasis in prostate adenocarcinoma and targeting PTGDS for tumor suppression","volume":"14","author":"Chen","year":"2024","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.jep.2026.122345_bib7","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1007\/s43032-020-00325-0","article-title":"Protective effects of puerarin on premature ovarian failure via regulation of Wnt\/\u03b2-Catenin signaling pathway and oxidative stress","volume":"28","author":"Chen","year":"2021","journal-title":"Reprod. Sci."},{"issue":"17","key":"10.1016\/j.jep.2026.122345_bib6","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"Fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2026.122345_bib9","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.nbd.2019.04.003","article-title":"A Parkinson\u2019s disease gene, DJ-1, regulates anti-inflammatory roles of astrocytes through prostaglandin D2 synthase expression","volume":"127","author":"Choi","year":"2019","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.jep.2026.122345_bib10","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1093\/bioinformatics\/bts196","article-title":"RNA-SeQC: Rna-seq metrics for quality control and process optimization","volume":"28","author":"DeLuca","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2026.122345_bib11","series-title":"Molecular Mechanisms of Notch Signaling","first-page":"223","article-title":"Notch and neurogenesis","volume":"vol 1066","author":"Engler","year":"2018"},{"issue":"1","key":"10.1016\/j.jep.2026.122345_bib12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1749-8104-3-24","article-title":"A synaptic nidogen: developmental regulation and role of Nidogen-2 at the neuromuscular junction","volume":"3","author":"Fox","year":"2008","journal-title":"Neural Dev."},{"issue":"May 2025","key":"10.1016\/j.jep.2026.122345_bib13","article-title":"SARM1 deletion inhibits astrogliosis and BBB damage through Jagged-1\/Notch-1\/NF-\u03baB signaling to improve neurological function after ischemic stroke","volume":"208","author":"Fu","year":"2025","journal-title":"Neurobiol. Dis."},{"issue":"March 2024","key":"10.1016\/j.jep.2026.122345_bib14","article-title":"Kuntai capsule attenuates premature ovarian insufficiency by activating the FOXO3\/SIRT5 signaling pathway in mice: a comprehensive study using UHPLC-LTQ-Orbitrap and integrated pharmacology","volume":"322","author":"Gong","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.122345_bib15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/GME.0000000000002098","article-title":"Effects of nutritional interventions on the severity of depressive and anxiety symptoms of women in the menopausal transition and menopause: a systematic review, meta-analysis, and meta-regression","volume":"30","author":"Grigolon","year":"2023","journal-title":"Menopause"},{"issue":"45","key":"10.1016\/j.jep.2026.122345_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adi2167","article-title":"Context-dependent regulation of notch signaling in glial development and tumorigenesis","volume":"9","author":"Guo","year":"2023","journal-title":"Sci. Adv."},{"issue":"10","key":"10.1016\/j.jep.2026.122345_bib17","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1007\/s43032-021-00610-6","article-title":"Roles of the notch signaling pathway in ovarian functioning","volume":"28","author":"Guo","year":"2021","journal-title":"Reprod. Sci."},{"issue":"4","key":"10.1016\/j.jep.2026.122345_bib16","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.pnpbp.2009.03.022","article-title":"Notch1 signaling, hippocampal neurogenesis and behavioral responses to chronic unpredicted mild stress in adult ischemic rats","volume":"33","author":"Guo","year":"2009","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatr."},{"issue":"5","key":"10.1016\/j.jep.2026.122345_bib19","first-page":"1449","article-title":"Expression levels of HES1, C-MYC and NF-kB in peripheral blood of patients with T cell acute lymphoblastic leukemia and their significance","volume":"27","author":"Hai-Li","year":"2019","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"issue":"3","key":"10.1016\/j.jep.2026.122345_bib20","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.3390\/ijms24032828","article-title":"Overnight corticosterone and gene expression in mouse hippocampus: time course during resting period","volume":"24","author":"Jaszczyk","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jep.2026.122345_bib21","first-page":"1331","article-title":"Clinical research on huanle'ning recipe combined with foot Bath treatment for syndrome of disharmony between heart and kidney of menopausal transition syndrome","volume":"30","author":"jin-jin","year":"2012","journal-title":"Chin. Archi. Trad. Chin. Med."},{"issue":"6","key":"10.1016\/j.jep.2026.122345_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/pro.70652","article-title":"Span Style=\"font-Variant:Small-Caps;\">KEGG<\/span> syntax for comparison of organisms, organism groups, and viruses by conserved gene repertoires","volume":"35","author":"Kanehisa","year":"2026","journal-title":"Protein Sci."},{"issue":"2","key":"10.1016\/j.jep.2026.122345_bib23","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cell.2009.03.045","article-title":"The canonical notch signaling pathway: unfolding the activation mechanism","volume":"137","author":"Kopan","year":"2009","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jep.2026.122345_bib24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1475-2891-9-42","article-title":"Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review","volume":"9","author":"Lakhan","year":"2010","journal-title":"Nutr. J."},{"issue":"12","key":"10.1016\/j.jep.2026.122345_bib25","doi-asserted-by":"crossref","first-page":"9414","DOI":"10.1074\/jbc.M111.330662","article-title":"Lipocalin-type prostaglandin D2 synthase protein regulates glial cell migration and morphology through myristoylated alanine-rich C-Kinase substrate","volume":"287","author":"Lee","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.jep.2026.122345_bib29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1167\/iovs.66.5.31","article-title":"Single-cell RNA sequencing of the primary visual cortex in mice with optic nerve injury","volume":"66","author":"Li","year":"2025","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.jep.2026.122345_bib27","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s12974-021-02303-y","article-title":"Rifaximin-mediated gut microbiota regulation modulates the function of microglia and protects against CUMS-induced depression-like behaviors in adolescent rat","volume":"18","author":"Li","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"10","key":"10.1016\/j.jep.2026.122345_bib28","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.4103\/1673-5374.369124","article-title":"Astrocyte-neuron communication mediated by the notch signaling pathway: focusing on glutamate transport and synaptic plasticity","volume":"18","author":"Li","year":"2023","journal-title":"Neural Regen. Res."},{"issue":"2","key":"10.1016\/j.jep.2026.122345_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000109479","article-title":"Localization of prostaglandin G\/H synthase gene expression in rat brain by in situ hybridization","volume":"2","author":"Li","year":"1993","journal-title":"Neurosignals"},{"issue":"4","key":"10.1016\/j.jep.2026.122345_bib30","doi-asserted-by":"crossref","first-page":"598","DOI":"10.3390\/medicina60040598","article-title":"Dietary supplementation of myo-inositol, cocoa polyphenols, and soy isoflavones improves vasomotor symptoms and metabolic profile in menopausal women with metabolic syndrome: a retrospective clinical study","volume":"60","author":"Mainini","year":"2024","journal-title":"Medicina"},{"issue":"1","key":"10.1016\/j.jep.2026.122345_bib31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1750-1326-9-26","article-title":"Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats","volume":"9","author":"Repunte-Canonigo","year":"2014","journal-title":"Mol. Neurodegener."},{"issue":"September 2021","key":"10.1016\/j.jep.2026.122345_bib32","article-title":"Reproductive aging in caenorhabditis elegans: from molecules to ecology","volume":"9","author":"Scharf","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.jep.2026.122345_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/9412776","article-title":"Analysis of ADORA2A , MTA1 , PTGDS , PTGS2 , NSF , and HNMT gene expression levels in peripheral blood of patients with early stages of Parkinson's disease","volume":"2023","author":"Semenova","year":"2023","journal-title":"Biomed Res. Int."},{"issue":"1","key":"10.1016\/j.jep.2026.122345_bib34","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/s42003-022-03602-7","article-title":"Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota","volume":"5","author":"Song","year":"2022","journal-title":"Commun. Biol."},{"issue":"12","key":"10.1016\/j.jep.2026.122345_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.248","article-title":"Implication of NOTCH1 gene in susceptibility to anxiety and depression among sexual abuse victims","volume":"6","author":"Steine","year":"2016","journal-title":"Transl. Psychiatry"},{"issue":"5","key":"10.1016\/j.jep.2026.122345_bib36","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/hipo.20660","article-title":"Basement membrane protein Nidogen\u20101 shapes hippocampal synaptic plasticity and excitability","volume":"20","author":"Vasudevan","year":"2010","journal-title":"Hippocampus"},{"issue":"7","key":"10.1016\/j.jep.2026.122345_bib38","doi-asserted-by":"crossref","first-page":"266","DOI":"10.31083\/j.fbl2907266","article-title":"Based on NF-\u03baB and Notch1\/Hes1 signaling pathways, the mechanism of artesunate on inflammation in osteoporosis in ovariectomized rats was investigated","volume":"29","author":"Wang","year":"2024","journal-title":"Front. Biosci.-Landmark"},{"issue":"1","key":"10.1016\/j.jep.2026.122345_bib37","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/13697137.2020.1832461","article-title":"The treatment of menopausal symptoms by traditional Chinese medicine in Asian countries","volume":"24","author":"Wang","year":"2021","journal-title":"Climacteric"},{"issue":"5","key":"10.1016\/j.jep.2026.122345_bib39","first-page":"1126","article-title":"Experimental study on effect of huanlening recipe(decoction for PMS) on levels of Kiss-1,NKB and DYN and their related receptor GPR54,NK3 and KOR in hypothalamus of perimenopausal mice","volume":"35","author":"Xian","year":"2017","journal-title":"Chin. Archi. Trad. Chin. Med."},{"issue":"October 2019","key":"10.1016\/j.jep.2026.122345_bib40","article-title":"Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-\/- mice through a PGC-1\u03b1\/ER\u03b1 pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis","volume":"148","author":"Yang","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"10","key":"10.1016\/j.jep.2026.122345_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2019.152553","article-title":"NID2 can serve as a potential prognosis prediction biomarker and promotes the invasion and migration of gastric cancer","volume":"215","author":"Yu","year":"2019","journal-title":"Pathol. Res. Pract."},{"issue":"1","key":"10.1016\/j.jep.2026.122345_bib42","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13195-016-0206-x","article-title":"Protective effect of melatonin on soluble A\u03b21\u201342-Induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1\/Notch1\/Hes1 signaling pathway in the rat hippocampus","volume":"8","author":"Zhang","year":"2016","journal-title":"Alzheimers Res. Ther."},{"issue":"2","key":"10.1016\/j.jep.2026.122345_bib43","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00429-017-1521-0","article-title":"Voluntary running-enhanced synaptic plasticity, learning and memory are mediated by Notch1 signal pathway in C57BL mice","volume":"223","author":"Zhang","year":"2018","journal-title":"Brain Struct. Funct."},{"issue":"August 2019","key":"10.1016\/j.jep.2026.122345_bib44","article-title":"The notch signaling pathway inhibitor dapt alleviates autism-like behavior, autophagy and dendritic spine density abnormalities in a valproic acid-induced animal model of autism","volume":"94","author":"Zhang","year":"2019","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatr."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126012006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126012006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:57:15Z","timestamp":1790571435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126012006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":44,"alternative-id":["S0378874126012006"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122345","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synaptic remodeling and functional recovery: Huan Le Ning decoction mitigates perimenopausal anxiety and depression symptoms via hippocampal reorganization","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122345","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"122345"}}