{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:57:12Z","timestamp":1790571432541,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013088","name":"Qinglan Project of Jiangsu Province of China","doi-asserted-by":"publisher","award":["CPU2018GF06"],"award-info":[{"award-number":["CPU2018GF06"]}],"id":[{"id":"10.13039\/501100013088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.jep.2026.122382","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:40:16Z","timestamp":1789688416000},"page":"122382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Efficacy confirmation of traditional Chinese medicine Yuchi powder in preventing dental caries and active ingredients screening"],"prefix":"10.1016","volume":"374","author":[{"given":"Daowen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.122382_bib1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tim.2017.09.008","article-title":"Oral biofilms: Pathogens, matrix, and polymicrobial interactions in microenvironments","volume":"26","author":"Bowen","year":"2018","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jep.2026.122382_bib2","article-title":"Lollipop containing Glycyrrhiza uralensis extract reduces streptococcus mutans colonization and maintains oral microbial diversity in Chinese preschool children","volume":"14","author":"Chen","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2026.122382_bib3","series-title":"Towards Universal Health Coverage for Oral Health by 2030","year":"2022"},{"key":"10.1016\/j.jep.2026.122382_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/0115734099305631240930054417","article-title":"Exploring the mechanism of centipeda minima in treating nasopharyngeal carcinoma based on network pharmacology","volume":"22","author":"Huang","year":"2026","journal-title":"Curr. Comput. Aided Drug Des."},{"issue":"1","key":"10.1016\/j.jep.2026.122382_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10295-013-1369-0","article-title":"Characterization of a marine-derived dextranase and its application to the prevention of dental caries","volume":"41","author":"Jiao","year":"2014","journal-title":"J. Indus. Microbiol. Biotechnol."},{"key":"10.1016\/j.jep.2026.122382_bib6","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1177\/00220345580370060901","article-title":"Dental caries in the molar teeth of rats: II. a method for diagnosing and scoring several types of lesions simultaneously","volume":"37","author":"Keyes","year":"1958","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jep.2026.122382_bib7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fcimb.2015.00010","article-title":"Streptococcus mutans-derived extracellular matrix in cariogenic oral biofilms","volume":"5","author":"Klein","year":"2015","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jep.2026.122382_bib8","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13568-021-01263-z","article-title":"Mechanistic insights into the inhibitory effect of theaflavins on virulence factors production in streptococcus mutans","volume":"11","author":"Kong","year":"2021","journal-title":"AMB Express"},{"key":"10.1016\/j.jep.2026.122382_bib9","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s10096-013-1993-7","article-title":"The virulence of Streptococcus mutans and the ability to form biofilms","volume":"33","author":"Krzy\u015bciak","year":"2014","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.jep.2026.122382_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1213602","article-title":"LC-MS-based metabolomics reveals the mechanism of anti-gouty arthritis effect of wuwei shexiang pill","volume":"14","author":"Lang","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.jep.2026.122382_bib11","article-title":"The biology of Streptococcus mutans","volume":"7","author":"Lemos","year":"2019","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.jep.2026.122382_bib12","article-title":"Curcumin as a promising antibacterial agent: effects on metabolism and biofilm formation in S. mutans","volume":"2018","author":"Li","year":"2018","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2026.122382_bib13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13020-024-01001-0","article-title":"Metabolomics integrated with network pharmacology of blood-entry constituents reveals the bioactive component of xuefu zhuyu decoction and its angiogenic effects in treating traumatic brain injury","volume":"19","author":"Li","year":"2024","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2026.122382_bib14","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3390\/pathogens15030280","article-title":"Classification and anti-streptococcus mutans mechanism summary of Chinese botanical products","volume":"15","author":"Li","year":"2026","journal-title":"Pathogens"},{"key":"10.1016\/j.jep.2026.122382_bib15","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1159\/000538459","article-title":"A right to health-based approach to dental caries: toward a comprehensive control strategy","volume":"58","author":"Mollet","year":"2024","journal-title":"Caries Res."},{"key":"10.1016\/j.jep.2026.122382_bib16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0378-8741(02)00318-5","article-title":"Kuwanon G: an antibacterial agent from the root bark of morus alba against oral pathogens","volume":"84","author":"Park","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122382_bib17","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1080\/13880209.2024.2354341","article-title":"Comprehensive profiling of the chemical constituents in dayuanyin decoction using UPLC-QTOF-MS combined with molecular networking","volume":"62","author":"Peng","year":"2024","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2026.122382_bib18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/0022034517742139","article-title":"Resilience of the oral microbiota in health: mechanisms that prevent dysbiosis","volume":"97","author":"Rosier","year":"2018","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jep.2026.122382_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(07)60031-2","article-title":"Dental caries","volume":"369","author":"Selwitz","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2026.122382_bib20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/0022034510379602","article-title":"The role of bacteria in the caries process: ecological perspectives","volume":"90","author":"Takahashi","year":"2011","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jep.2026.122382_bib21","article-title":"Overview of pharmacodynamical research of traditional Chinese medicine on hyperuricemic nephropathy: from the perspective of dual-regulatory effect on the intestines and kidneys","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2026.122382_bib22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s13205-018-1494-6","article-title":"Orthogonal test design for optimization of the extraction of essential oil from asarum heterotropoides var. mandshuricum and evaluation of its antibacterial activity against periodontal pathogens","volume":"8","author":"Wang","year":"2018","journal-title":"3 Biotech"},{"key":"10.1016\/j.jep.2026.122382_bib23","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2018.1549921","article-title":"Antimicrobial peptide GH12 targets streptococcus mutans to arrest caries development in rats","volume":"11","author":"Wang","year":"2019","journal-title":"J. Oral Microbiol."},{"key":"10.1016\/j.jep.2026.122382_bib24","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ijom.2010.02.024","article-title":"Antimicrobial activity of Chinese medicine herbs against common bacteria in oral biofilm. A pilot study","volume":"39","author":"Wong","year":"2010","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.jep.2026.122382_bib25","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.2174\/1386207326666230823093958","article-title":"Elucidating the mechanism of buyanghuanwu decoction acting onPulmonary fibrosis based on network pharmacology and animal studies","volume":"27","author":"Xing","year":"2024","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.jep.2026.122382_bib26","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.1039\/D1AN00767J","article-title":"Potential and applications of capillary electrophoresis for analyzing traditional Chinese medicine: a critical review","volume":"146","author":"Xu","year":"2021","journal-title":"The Analyst"},{"key":"10.1016\/j.jep.2026.122382_bib27","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.1128\/JCM.41.9.4438-4441.2003","article-title":"Development of a 5\u2032 nuclease-based real-time PCR assay for quantitative detection of cariogenic dental pathogens streptococcus mutans and streptococcus sobrinus","volume":"41","author":"Yoshida","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jep.2026.122382_bib28","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1080\/14786419.2018.1539979","article-title":"Identification of anti-nociceptive constituents from the pollen of typha angustifolia L. using effect-directed fractionation","volume":"34","author":"Zeng","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2026.122382_bib29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.archoralbio.2018.11.005","article-title":"Activity of quercetin and kaemferol against streptococcus mutans biofilm","volume":"98","author":"Zeng","year":"2019","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.jep.2026.122382_bib30","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1177\/0022034515571416","article-title":"Effect of antibacterial dental adhesive on multispecies biofilms formation","volume":"94","author":"Zhang","year":"2015","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jep.2026.122382_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2020.104762","article-title":"Rhodiola rosea extract inhibits the biofilm formation and the expression of virulence genes of cariogenic oral pathogen streptococcus mutans","volume":"116","author":"Zhang","year":"2020","journal-title":"Arch. Oral Biol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126012377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126012377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:49:52Z","timestamp":1790570992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126012377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":31,"alternative-id":["S0378874126012377"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122382","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy confirmation of traditional Chinese medicine Yuchi powder in preventing dental caries and active ingredients screening","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122382","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122382"}}