{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:57:15Z","timestamp":1790571435782,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82675844"],"award-info":[{"award-number":["82675844"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010618","name":"Guangzhou University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2024B03J1259"],"award-info":[{"award-number":["2024B03J1259"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.jep.2026.122403","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:42:08Z","timestamp":1789800128000},"page":"122403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Zuogui Pill alleviates chemotherapy-induced ovarian aging and oogonial stem cell injury by modulating cGAS-STING-mediated inflammatory signaling"],"prefix":"10.1016","volume":"374","author":[{"given":"Yunling","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.122403_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/5584_2025_869","article-title":"Role of ovarian stem cells in postnatal oogenesis and implications in fertility preservation","volume":"1499","author":"Benlioglu","year":"2025","journal-title":"Adv. Exp. Med. Biol."},{"issue":"13","key":"10.1016\/j.jep.2026.122403_bib2","first-page":"3664","article-title":"Zuogui pills and yougui pills in differential treatment of diminished ovarian reserve based on metabolomics","volume":"48","author":"Cao","year":"2023","journal-title":"Zhongguo Zhongyao Zazhi"},{"issue":"4","key":"10.1016\/j.jep.2026.122403_bib3","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1007\/s11357-023-00768-8","article-title":"Ovarian aging in humans: potential strategies for extending reproductive lifespan","volume":"45","author":"Cavalcante","year":"2023","journal-title":"GeroScience"},{"issue":"2","key":"10.1016\/j.jep.2026.122403_bib4","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1080\/01635581.2022.2123531","article-title":"Efficacy and clinical significance of the zuogui pill on premature ovarian failure via the GDF-9\/Smad 2 pathway","volume":"75","author":"Cen","year":"2023","journal-title":"Nutr. Cancer"},{"issue":"1","key":"10.1016\/j.jep.2026.122403_bib5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41420-023-01705-6","article-title":"The EZH2-H3K27me3 axis modulates aberrant transcription and apoptosis in cyclophosphamide-induced ovarian granulosa cell injury","volume":"9","author":"Chen","year":"2023","journal-title":"Cell Death Discov."},{"issue":"12","key":"10.1016\/j.jep.2026.122403_bib6","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glaf230","article-title":"Inhibition of the ISG15 prevents inflammation-dependent ovarian aging","volume":"80","author":"Chen","year":"2025","journal-title":"J. Gerontol., Ser. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.jep.2026.122403_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2024.112989","article-title":"The protective effect of Artemisia capillaris thunb. Extract against UVB-induced apoptosis and inflammation through inhibiting the cGAS\/STING pathway","volume":"258","author":"Chen","year":"2024","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.jep.2026.122403_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2024.115201","article-title":"Triptolide exposure triggers ovarian inflammation by activating cGAS-STING pathway and decrease oocyte quality in mouse","volume":"196","author":"Cheng","year":"2025","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2026.122403_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.672890","article-title":"Premature ovarian insufficiency: past, present, and future","volume":"9","author":"Chon","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.jep.2026.122403_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156130","article-title":"Chronic pelvic inflammation diminished ovarian reserve as indicated by serum Anti M\u00fclerrian hormone","volume":"11","author":"Cui","year":"2016","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jep.2026.122403_bib11","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1007\/s43032-021-00499-1","article-title":"Human umbilical cord mesenchymal stem cells improve ovarian function in chemotherapy-induced premature ovarian failure mice through inhibiting apoptosis and inflammation via a paracrine mechanism","volume":"28","author":"Deng","year":"2021","journal-title":"Reprod. Sci."},{"issue":"1","key":"10.1016\/j.jep.2026.122403_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41422-022-00718-7","article-title":"Unraveling female reproductive senescence to enhance healthy longevity","volume":"33","author":"Dong","year":"2023","journal-title":"Cell Res."},{"issue":"2","key":"10.1016\/j.jep.2026.122403_bib13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.fertnstert.2024.11.007","article-title":"Evidence-based guideline: premature ovarian insufficiency","volume":"123","author":"Eshre","year":"2025","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jep.2026.122403_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.108011","article-title":"Sweroside: a comprehensive review of its biosynthesis, pharmacokinetics, pharmacology, and safety","volume":"222","author":"Gan","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.jep.2026.122403_bib15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.taap.2014.11.017","article-title":"Phosphoramide mustard exposure induces DNA adduct formation and the DNA damage repair response in rat ovarian granulosa cells","volume":"282","author":"Ganesan","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"7973","key":"10.1016\/j.jep.2026.122403_bib16","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"cGAS-STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.jep.2026.122403_bib17","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/humupd\/dmae020","article-title":"Ovarian microenvironment: challenges and opportunities in protecting against chemotherapy-associated ovarian damage","volume":"30","author":"Guo","year":"2024","journal-title":"Hum. Reprod. Update"},{"issue":"1","key":"10.1016\/j.jep.2026.122403_bib18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13048-022-01011-2","article-title":"Female germline stem cells: aging and anti-aging","volume":"15","author":"Hong","year":"2022","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.jep.2026.122403_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8069898","article-title":"Inflamm-aging: a new mechanism affecting premature ovarian insufficiency","volume":"2019","author":"Huang","year":"2019","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.jep.2026.122403_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155630","article-title":"Bushen huoxue recipe ameliorates ovarian function via promoting BMSCs proliferation and homing to ovaries in POI mice","volume":"129","author":"Huang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.122403_bib21","article-title":"Chinese herbal products for female infertility in Taiwan: a population-based cohort study","volume":"95","author":"Hung","year":"2016","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.jep.2026.122403_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107571","article-title":"Chlorogenic acid can improve spermatogenic dysfunction in rats with varicocele by regulating mitochondrial homeostasis and inhibiting the activation of NLRP3 inflammasomes by oxidative mitochondrial DNA and cGAS\/STING pathway","volume":"150","author":"Jia","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"7","key":"10.1016\/j.jep.2026.122403_bib23","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.3390\/cancers17071130","article-title":"cGAS and STING in host myeloid cells are essential for effective cyclophosphamide treatment of advanced breast cancer","volume":"17","author":"Lai","year":"2025","journal-title":"Cancers"},{"key":"10.1016\/j.jep.2026.122403_bib24","article-title":"Dissecting the efficacy of the use of acupuncture and Chinese herbal medicine for the treatment of premature ovarian insufficiency (POI): a systematic review and metaanalysis","volume":"9","author":"Li","year":"2023","journal-title":"Heliyon"},{"issue":"4","key":"10.1016\/j.jep.2026.122403_bib25","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/ptr.6908","article-title":"An evaluation of the effects and safety of zuogui pill for treating osteoporosis:current evidence for an ancient Chinese herbal formula","volume":"35","author":"Li","year":"2021","journal-title":"Phytother Res."},{"issue":"2","key":"10.1016\/j.jep.2026.122403_bib26","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ccell.2025.12.013","article-title":"Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage","volume":"44","author":"Li","year":"2026","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jep.2026.122403_bib27","article-title":"The cGAS-STING pathway and female reproductive system diseases","volume":"15","author":"Li","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2026.122403_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118505","article-title":"Zuogui pills alleviate cyclophosphamide-induced ovarian aging by reducing oxidative stress and restoring the stemness of oogonial stem cells through the Nrf2\/HO-1 signaling pathway","volume":"333","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2026.122403_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119105","article-title":"Zuogui pills ameliorate chemotherapy-induced ovarian aging by improving stemness, regulating cell cycle and reducing apoptosis of oogonial stem cells via the Notch 1\/Nrf2 pathway","volume":"339","author":"Li","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.jep.2026.122403_bib30","doi-asserted-by":"crossref","first-page":"9205","DOI":"10.3390\/ijms24119205","article-title":"Mechanisms of and potential medications for oxidative stress in ovarian granulosa cells: a review","volume":"24","author":"Liu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2026.122403_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13287-024-03705-4","article-title":"Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1\/ATM\/p53 pathway","volume":"15","author":"Liu","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jep.2026.122403_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2026.1771546","article-title":"The inflammatory clock: how cGAS-STING ticks in the aging ovary","volume":"14","author":"Ma","year":"2026","journal-title":"Front. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.jep.2026.122403_bib33","article-title":"Pathophysiological roles of the cGAS-STING inflammatory pathway","volume":"38","author":"Maekawa","year":"2023","journal-title":"Physiology (Bethesda, Md"},{"issue":"1","key":"10.1016\/j.jep.2026.122403_bib34","first-page":"CD004143","article-title":"Long-term hormone therapy for perimenopausal and postmenopausal women","volume":"1","author":"Marjoribanks","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"issue":"4","key":"10.1016\/j.jep.2026.122403_bib35","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s12015-020-10098-3","article-title":"An overview on the complexity of OCT4: at the level of DNA, RNA and protein","volume":"17","author":"Mehravar","year":"2021","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.jep.2026.122403_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111855","article-title":"Zuogui pills inhibit mitochondria-dependent apoptosis of follicles in a rat model of premature ovarian failure","volume":"238","author":"Peng","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2026.122403_bib37","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1038\/s41467-024-47235-2","article-title":"DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells","volume":"15","author":"Ren","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2026.122403_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155404","article-title":"Compound danshen dripping pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction","volume":"128","author":"Shi","year":"2024","journal-title":"Phytomedicine : international journal of phytotherapy and phytopharmacology"},{"issue":"7","key":"10.1016\/j.jep.2026.122403_bib39","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/03630242.2022.2105776","article-title":"Why is the human ovary aging faster than other organs?","volume":"62","author":"Sirard","year":"2022","journal-title":"Women Health"},{"issue":"8","key":"10.1016\/j.jep.2026.122403_bib40","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3390\/cells8080852","article-title":"Mitochondria and female germline stem Cells-A mitochondrial DNA perspective","volume":"8","author":"St John","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jep.2026.122403_bib41","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41514-026-00359-9","article-title":"Hydroxychloroquine alleviates cyclophosphamide-induced premature ovarian failure by attenuating granulosa cell senescence and modulating the mtDNA-cGAS pathway","volume":"12","author":"Su","year":"2026","journal-title":"npj aging"},{"issue":"8","key":"10.1016\/j.jep.2026.122403_bib42","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/molehr\/gaaa043","article-title":"Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging","volume":"26","author":"Szymanska","year":"2020","journal-title":"Mol. Hum. Reprod."},{"issue":"1","key":"10.1016\/j.jep.2026.122403_bib43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/13697137.2018.1543264","article-title":"The existence and potential of germline stem cells in the adult mammalian ovary","volume":"22","author":"Telfer","year":"2019","journal-title":"Climacteric : the journal of the International Menopause Society"},{"issue":"10","key":"10.1016\/j.jep.2026.122403_bib44","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.3390\/ijms27104559","article-title":"cGAS-STING signaling as a molecular bridge between inflammation, ovarian ageing, and reproductive failure","volume":"27","author":"Voros","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2026.122403_bib45","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.theriogenology.2022.12.004","article-title":"Isolation of female germline stem cells from neonatal piglet ovarian tissue and differentiation into oocyte-like cells","volume":"197","author":"Wang","year":"2023","journal-title":"Theriogenology"},{"key":"10.1016\/j.jep.2026.122403_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.158114","article-title":"Zuogui pill ameliorates DNA damage and the senescence-associated secretory phenotype in ovarian stem cells to delay ovarian ageing through activation of SIRT1","volume":"155","author":"Wang","year":"2026","journal-title":"Phytomedicine : international journal of phytotherapy and phytopharmacology"},{"issue":"5","key":"10.1016\/j.jep.2026.122403_bib47","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/humrep\/dew027","article-title":"ESHRE guideline: management of women with premature ovarian insufficiency","volume":"31","author":"Webber","year":"2016","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.jep.2026.122403_bib48","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.ymthe.2017.04.019","article-title":"Tracing and characterizing the development of transplanted female germline stem cells in vivo","volume":"25","author":"Wu","year":"2017","journal-title":"Mol. Ther. : the journal of the American Society of Gene Therapy"},{"issue":"3","key":"10.1016\/j.jep.2026.122403_bib49","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.18632\/aging.101808","article-title":"Resveratrol alleviates chemotherapy-induced oogonial stem cell apoptosis and ovarian aging in mice","volume":"11","author":"Wu","year":"2019","journal-title":"Aging"},{"issue":"1","key":"10.1016\/j.jep.2026.122403_bib50","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13048-025-01661-y","article-title":"Proanthocyanidins delaying the premature ovarian insufficiency through regulatory sirt1-p53-p21 signaling pathway in female germline stem cells","volume":"18","author":"Wu","year":"2025","journal-title":"J. Ovarian Res."},{"issue":"3","key":"10.1016\/j.jep.2026.122403_bib51","article-title":"Impact of premature ovarian failure on mortality and morbidity among Chinese women","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jep.2026.122403_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-69381-9","article-title":"hUMSCs restore ovarian function in POI mice by regulating GSK3\u03b2-mediated mitochondrial dynamic imbalances in theca cells","volume":"14","author":"Xiong","year":"2024","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.jep.2026.122403_bib53","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S1875-5364(24)60572-8","article-title":"Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction","volume":"22","author":"Xiu","year":"2024","journal-title":"Chinese Journal of Natural Medicines"},{"issue":"24","key":"10.1016\/j.jep.2026.122403_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242417193","article-title":"The role of cellular senescence in cyclophosphamide-induced primary ovarian insufficiency","volume":"24","author":"Xu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jep.2026.122403_bib55","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1530\/REP-16-0674","article-title":"Cytosolic DNA sensor-initiated innate immune responses in mouse ovarian granulosa cells","volume":"153","author":"Yan","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.jep.2026.122403_bib56","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.semcancer.2024.08.007","article-title":"cGAS\/STING signalling pathway in senescence and oncogenesis","volume":"106\u2013107","author":"Yu","year":"2024","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.jep.2026.122403_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.153975","article-title":"Zuogui pills maintain the stemness of oogonial stem cells and alleviate cyclophosphamide-induced ovarian aging through notch signaling pathway","volume":"99","author":"Zeng","year":"2022","journal-title":"Phytomedicine : international journal of phytotherapy and phytopharmacology"},{"issue":"8","key":"10.1016\/j.jep.2026.122403_bib58","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1093\/humrep\/deae132","article-title":"Unveiling the role of chronic inflammation in ovarian aging: insights into mechanisms and clinical implications","volume":"39","author":"Zeng","year":"2024","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.jep.2026.122403_bib59","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1146\/annurev-immunol-101721-032910","article-title":"Regulation of the cGAS-STING pathway","volume":"43","author":"Zhang","year":"2025","journal-title":"Annu. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.jep.2026.122403_bib60","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/s41419-023-05859-0","article-title":"Chemotherapy impairs ovarian function through excessive ROS-induced ferroptosis","volume":"14","author":"Zhang","year":"2023","journal-title":"Cell Death Dis."},{"issue":"26","key":"10.1016\/j.jep.2026.122403_bib61","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202520941","article-title":"Inhibiting cGAS-STING to preserve mitochondrial-nuclear communication and stemness in young tendon stem cells: a hydrogel strategy against age-related tendinopathy","volume":"13","author":"Zhang","year":"2026","journal-title":"Adv. Sci."},{"issue":"6","key":"10.1016\/j.jep.2026.122403_bib62","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41577-024-01112-7","article-title":"Regulation of cGAS-STING signalling and its diversity of cellular outcomes","volume":"25","author":"Zhang","year":"2025","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2026.122403_bib63","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/s12964-024-01939-6","article-title":"A ketogenic diet alleviates the apoptosis of granulosa cells by inhibiting the activation of cGAS-STING signaling pathway in PCOS mice","volume":"22","author":"Zhao","year":"2024","journal-title":"Cell Commun. Signal. : CCS"},{"key":"10.1016\/j.jep.2026.122403_bib64","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.omtn.2020.11.020","article-title":"Comparison of RNA m6A and DNA methylation profiles between mouse female germline stem cells and STO cells. Molecular therapy","volume":"23","author":"Zhao","year":"2020","journal-title":"Nucleic acids"},{"key":"10.1016\/j.jep.2026.122403_bib65","article-title":"Rutin ameliorates LPS-induced acute lung injury in mice by inhibiting the cGAS-STING-NLRP3 signaling pathway","volume":"16","author":"Zhou","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2026.122403_bib66","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/ncb1869","article-title":"Production of offspring from a germline stem cell line derived from neonatal ovaries","volume":"11","author":"Zou","year":"2009","journal-title":"Nat. Cell Biol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126012584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126012584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:51:54Z","timestamp":1790571114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126012584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":66,"alternative-id":["S0378874126012584"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122403","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zuogui Pill alleviates chemotherapy-induced ovarian aging and oogonial stem cell injury by modulating cGAS-STING-mediated inflammatory signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122403","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122403"}}