{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:44:50Z","timestamp":1792050290843,"version":"4.4.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2508300"],"award-info":[{"award-number":["2023YFC2508300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.jep.2026.122420","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:07:16Z","timestamp":1790867236000},"page":"122420","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Prunella vulgaris L. ameliorates goiter in Wistar rats is associated with changes in Rap1GAP\/CREB3L1\/PI3K-AKT signaling pathway"],"prefix":"10.1016","volume":"374","author":[{"given":"Guowei","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-2380","authenticated-orcid":false,"given":"Zhongyan","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2026.122420_bib1","first-page":"1","article-title":"Indications for the surgical management of benign goiter in adults","volume":"115","author":"Bartsch","year":"2018","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.jep.2026.122420_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155804","article-title":"Rhodiolin inhibits the PI3K\/AKT\/mTOR signaling pathway via the glycolytic enzyme GPI in human papillary thyroid cancer","volume":"132","author":"Bo","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2026.122420_bib3","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1007\/s00259-023-06274-5","article-title":"The EANM guideline on radioiodine therapy of benign thyroid disease","volume":"50","author":"Campenn\u00ec","year":"2023","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"key":"10.1016\/j.jep.2026.122420_bib5","series-title":"Establishment and Evaluation of Animal Model of iodine-deficient Goiter","first-page":"111","author":"Chong","year":"2005"},{"key":"10.1016\/j.jep.2026.122420_bib6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12943-015-0404-3","article-title":"RUNX2 and the PI3K\/AKT axis reciprocal activation as a driving force for tumor progression","volume":"14","author":"Cohen-Solal","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jep.2026.122420_bib7","first-page":"893","article-title":"Therapeutic effect and mechanism of aqueous extract of Prunella vulgaris L. on experimental autoimmune thyroiditis","volume":"42","author":"Fu","year":"2020","journal-title":"Zhejiang Med. J."},{"key":"10.1016\/j.jep.2026.122420_bib8","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1242\/jcs.211102","article-title":"CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells","volume":"130","author":"Garc\u00eda","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jep.2026.122420_bib9","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1242\/jcs.211102","article-title":"CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells","volume":"130","author":"Garc\u00eda","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jep.2026.122420_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5902","article-title":"Development and validation of a liquid chromatography-tandem mass spectrometry method for simultaneous quantification of eight Xiakucao oral liquid-related compounds in rat plasma and its application in pharmacokinetic study","volume":"38","author":"Jin","year":"2024","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jep.2026.122420_bib11","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3390\/antiox13111313","article-title":"The role of rosmarinic acid in cancer prevention and therapy: mechanisms of antioxidant and anticancer activity","volume":"13","author":"Kowalczyk","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2026.122420_bib12","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1089\/thy.2019.0067","article-title":"Efficacy and safety of long-term universal salt iodization on thyroid disorders: epidemiological evidence from 31 provinces of mainland China","volume":"30","author":"Li","year":"2020","journal-title":"Thyroid"},{"key":"10.1016\/j.jep.2026.122420_bib13","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3390\/nu15041004","article-title":"Iodine deficiency and iodine prophylaxis: an overview and update","volume":"15","author":"Lisco","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2026.122420_bib14","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3390\/nu15041004","article-title":"Iodine deficiency and iodine prophylaxis: an overview and update","volume":"15","author":"Lisco","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2026.122420_bib15","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1210\/jc.2008-1042","article-title":"Loss of Rap1GAP in papillary thyroid cancer","volume":"94","author":"Nellore","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jep.2026.122420_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9734576","article-title":"Integrated bioinformatics analysis of master regulators in Anaplastic thyroid carcinoma","volume":"2019","author":"Pan","year":"2019","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.jep.2026.122420_bib18","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1080\/15384047.2020.1803009","article-title":"The differences of regulatory networks between papillary and anaplastic thyroid carcinoma: an integrative transcriptomics study","volume":"21","author":"Pan","year":"2020","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.jep.2026.122420_bib19","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12943-022-01658-x","article-title":"CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment","volume":"21","author":"Pan","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jep.2026.122420_bib20","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12943-022-01658-x","article-title":"CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment","volume":"21","author":"Pan","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jep.2026.122420_bib21","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/j.apsb.2024.02.003","article-title":"Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery","volume":"14","author":"Qian","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jep.2026.122420_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110288","article-title":"Prunella vulgaris L. attenuates experimental autoimmune thyroiditis by inducing indoleamine 2,3-dioxygenase 1 expression and regulatory T cell expansion","volume":"128","author":"Qiu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2026.122420_bib23","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1038\/s41388-017-0088-9","article-title":"MicroRNA-146b promotes PI3K\/AKT pathway hyperactivation and thyroid cancer progression by targeting PTEN","volume":"37","author":"Ram\u00edrez-Moya","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.jep.2026.122420_bib24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1089\/thy.1992.2.263","article-title":"Thyroid hormone suppressive therapy of sporadic nontoxic goiter","volume":"2","author":"Ross","year":"1992","journal-title":"Thyroid"},{"key":"10.1016\/j.jep.2026.122420_bib25","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jep.2026.122420_bib26","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1056\/NEJMoa054022","article-title":"Effect of iodine intake on thyroid diseases in China","volume":"354","author":"Teng","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2026.122420_bib27","first-page":"4569","article-title":"Characterization of chemical components and antioxidant activities in different parts of Prunella vulgaris L. by UPLC-Q-TOF-MS\/MS combined with UPLC","volume":"48","author":"Wu","year":"2023","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2026.122420_bib29","first-page":"484","article-title":"Effects of aqueous extract of Prunella vulgaris L. on 5-HT and Th17 in rats with autoimmune thyroiditis","volume":"41","author":"Zhang","year":"2022","journal-title":"J. Tianjin Univ. Trad. Chin. Med."},{"key":"10.1016\/j.jep.2026.122420_bib28","first-page":"403","article-title":"Emerging therapeutic role of Prunella vulgaris in thyroid disease","volume":"14","author":"Zhang","year":"2022","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.jep.2026.122420_bib31","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1158\/0008-5472.CAN-09-2812","article-title":"Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors","volume":"70","author":"Zuo","year":"2010","journal-title":"Cancer Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126012754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874126012754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:46:25Z","timestamp":1792046785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874126012754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":28,"alternative-id":["S0378874126012754"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2026.122420","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prunella vulgaris L. ameliorates goiter in Wistar rats is associated with changes in Rap1GAP\/CREB3L1\/PI3K-AKT signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2026.122420","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"122420"}}