{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:44:08Z","timestamp":1775072648079,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Sciences"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.jes.2022.06.028","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T08:16:52Z","timestamp":1656490612000},"page":"603-614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Polyhalogenated carbazoles induce hepatic metabolic disorders in mice via alteration in gut microbiota"],"prefix":"10.1016","volume":"127","author":[{"given":"Chenyang","family":"Ji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunkai","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoyao","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0190-7013","authenticated-orcid":false,"given":"Siqing","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meirong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jes.2022.06.028_bib0001","first-page":"501","article-title":"Frequency of Firmicutes and Bacteroidetes in gut microbiota in obese and normal weight Egyptian children and adults","volume":"7","author":"Abdallah","year":"2011","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.jes.2022.06.028_bib0002","doi-asserted-by":"crossref","first-page":"15718","DOI":"10.1073\/pnas.0407076101","article-title":"The gut microbiota as an environmental factor that regulates fat storage","volume":"101","author":"Backhed","year":"2004","journal-title":"P. National. Acad. Sci. USA."},{"issue":"3","key":"10.1016\/j.jes.2022.06.028_bib0003","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1073\/pnas.0605374104","article-title":"Mechanisms underlying the resistance to diet-induced obesity in germ-free mice","volume":"104","author":"Backhed","year":"2007","journal-title":"P. National. Acad. Sci. USA."},{"issue":"4","key":"10.1016\/j.jes.2022.06.028_bib0004","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0301-6226(86)90012-6","article-title":"Hormonal regulation of metabolism in ruminants: A review","volume":"14","author":"Brockman","year":"1986","journal-title":"Livest. Prod. Sci."},{"issue":"4","key":"10.1016\/j.jes.2022.06.028_bib0005","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.diabet.2014.02.004","article-title":"Glucose metabolism: Focus on gut microbiota, the endocannabinoid system and beyond","volume":"40","author":"Cani","year":"2014","journal-title":"Diabetes. Metab."},{"issue":"8","key":"10.1016\/j.jes.2022.06.028_bib0006","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/ismej.2012.8","article-title":"Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms","volume":"6","author":"Caporaso","year":"2012","journal-title":"ISME. J."},{"issue":"6","key":"10.1016\/j.jes.2022.06.028_bib0008","first-page":"53","article-title":"Interference of pollutants with PPARs: Endocrine disruption meets metabolism","volume":"32","author":"Casals-Casas","year":"2009","journal-title":"Int. J. Obesity."},{"issue":"7","key":"10.1016\/j.jes.2022.06.028_bib0009","first-page":"2297","article-title":"Scientific opinion on the risk to public health related to the presence of high levels of dioxins and dioxin-like PCBs in liver from sheep and deer","volume":"9","author":"Chain","year":"2011","journal-title":"EFSA. J."},{"issue":"10","key":"10.1016\/j.jes.2022.06.028_bib0010","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jes.2022.06.028_bib0011","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1021\/acs.jafc.9b00080","article-title":"Intestinal barrier function-NAFLD interactions and possible role of gut microbiota","volume":"67","author":"Cui","year":"2019","journal-title":"J. Agr. Food. Chem."},{"issue":"3","key":"10.1016\/j.jes.2022.06.028_bib0012","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/hbeh.1997.1433","article-title":"Estrogen enhances performance of female rats during acquisition of a radial arm maze","volume":"32","author":"Daniel","year":"1997","journal-title":"Horm. Behav."},{"key":"10.1016\/j.jes.2022.06.028_bib0013","first-page":"1","article-title":"Lipometabolism and glycometabolism in liver diseases","volume":"2018","author":"Ding","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jes.2022.06.028_bib0014","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science"},{"issue":"21","key":"10.1016\/j.jes.2022.06.028_bib0015","doi-asserted-by":"crossref","first-page":"7188","DOI":"10.1093\/nar\/gkm864","article-title":"SILVA: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB","volume":"35","author":"Elmar","year":"2007","journal-title":"Nucleic. Acids. Res."},{"issue":"10","key":"10.1016\/j.jes.2022.06.028_bib0016","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1002\/etc.3416","article-title":"Halogenated carbazoles induce cardiotoxicity in developing zebrafish (Danio rerio) embryos","volume":"35","author":"Fang","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"issue":"2","key":"10.1016\/j.jes.2022.06.028_bib0017","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/humupd\/dml042","article-title":"Estrogen, cognition and female ageing","volume":"13","author":"Genazzani","year":"2007","journal-title":"Hum. Reprod. Update."},{"key":"10.1016\/j.jes.2022.06.028_bib0018","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s11270-010-0451-8","article-title":"Non-target screening of organic contaminants in sediments from the industrial coastal area of Kavala city (NE Greece)","volume":"214","author":"Grigoriadou","year":"2011","journal-title":"Water. Air. Soil. Poll."},{"issue":"1","key":"10.1016\/j.jes.2022.06.028_bib0019","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1021\/acs.est.6b06128","article-title":"Spatial and temporal trends of polyhalogenated carbazoles in sediments of Upper Great Lakes: Insights into their origin","volume":"51","author":"Guo","year":"2017","journal-title":"Environ. Sci. Technol."},{"issue":"7193","key":"10.1016\/j.jes.2022.06.028_bib0020","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature06882","article-title":"Human metabolic phenotype diversity and its association with diet and blood pressure","volume":"453","author":"Holmes","year":"2008","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jes.2022.06.028_bib0021","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1096\/fj.201801209R","article-title":"Gut microbiome catabolites as novel modulators of muscle cell glucose metabolism","volume":"33","author":"Houghton","year":"2018","journal-title":"FASEB. J."},{"key":"10.1016\/j.jes.2022.06.028_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115717","article-title":"Environmental behavior and safety of polyhalogenated carbazoles (PHCZs): A review","volume":"268","author":"Ji","year":"2021","journal-title":"Environ. Pollut."},{"issue":"24","key":"10.1016\/j.jes.2022.06.028_bib0023","doi-asserted-by":"crossref","first-page":"14716","DOI":"10.1021\/acs.est.9b05388","article-title":"AhR agonist activity confirmation of polyhalogenated carbazoles (PHCZs) using an integration of in vitro, in vivo, and in silico models","volume":"53","author":"Ji","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"13","key":"10.1016\/j.jes.2022.06.028_bib0024","doi-asserted-by":"crossref","first-page":"9087","DOI":"10.1021\/acs.est.1c01663","article-title":"Stage dependent enantioselective metabolism of bifenthrin in embryos of zebrafish (Danio rerio) and Japanese medaka (Oryzias latipes)","volume":"55","author":"Ji","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jes.2022.06.028_bib0025","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jhazmat.2019.01.079","article-title":"Evaluation of the developmental toxicity of 2,7-dibromocarbazole to zebrafish based on transcriptomics assay","volume":"368","author":"Ji","year":"2019","journal-title":"J. Hazard. Mater."},{"issue":"APR","key":"10.1016\/j.jes.2022.06.028_bib0026","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.chemosphere.2018.12.158","article-title":"Enantioselectivity in endocrine disrupting effects of four cypermethrin enantiomers based on in vitro models","volume":"220","author":"Ji","year":"2019","journal-title":"Chemosphere"},{"issue":"8","key":"10.1016\/j.jes.2022.06.028_bib0027","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/chir.23254","article-title":"Four cypermethrin isomers induced stereoselective metabolism in H295R cells","volume":"32","author":"Ji","year":"2020","journal-title":"Chirality"},{"key":"10.1016\/j.jes.2022.06.028_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2015.09.004","article-title":"Progression of micronutrient alteration and hepatotoxicity following acute PCB126 exposure","volume":"338","author":"Klaren","year":"2015","journal-title":"Toxicology"},{"issue":"9","key":"10.1016\/j.jes.2022.06.028_bib0029","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nbt.2676","article-title":"Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences","volume":"31","author":"Langille","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jes.2022.06.028_bib0030","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrgastro.2016.85","article-title":"The role of the gut microbiota in NAFLD","volume":"13","author":"Leung","year":"2016","journal-title":"Nat. Rev. Gastro. Hepat."},{"issue":"1","key":"10.1016\/j.jes.2022.06.028_bib0031","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1074\/jbc.M116.762005","article-title":"Sortilin 1 modulates hepatic cholesterol lipotoxicity in mice via functional interaction with liver carboxylesterase 1","volume":"292","author":"Li","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jes.2022.06.028_bib0032","first-page":"1576","article-title":"Environmental behaviors and ecotoxicology of the emerging contaminants polyhalogenated carbazoles","volume":"37","author":"Lin","year":"2016","journal-title":"Environ. Sci."},{"issue":"9","key":"10.1016\/j.jes.2022.06.028_bib0033","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.3389\/fmicb.2018.02494","article-title":"Altered gut microbiota and compositional changes in Firmicutes and Proteobacteria in Mexican undernourished and obese children","volume":"16","author":"M\u00e9ndez-Salazar","year":"2018","journal-title":"Front. Microbiol."},{"issue":"6865","key":"10.1016\/j.jes.2022.06.028_bib0034","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/414821a","article-title":"New drug targets for type 2 diabetes and the metabolic syndrome","volume":"414","author":"Moller","year":"2001","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jes.2022.06.028_bib0035","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1442-200X.1963.tb01066.x","article-title":"Studies on alkaline phosphatase activity in serum and organs in liver damage","volume":"5","author":"Onodera","year":"1963","journal-title":"Pediatr. Int."},{"issue":"1-2","key":"10.1016\/j.jes.2022.06.028_bib0036","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tox.2010.11.003","article-title":"Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice","volume":"280","author":"Ozeki","year":"2011","journal-title":"Toxicology"},{"issue":"10","key":"10.1016\/j.jes.2022.06.028_bib0037","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3858\/emm.2011.43.10.064","article-title":"Insulin-dependent suppression of cholesterol 7\u03b1-hydroxylase is a possible link between glucose and cholesterol metabolisms","volume":"43","author":"Park","year":"2011","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.jes.2022.06.028_bib0038","first-page":"1","article-title":"The gut-liver axis in the control of energy metabolism and food intake in animals","volume":"8","author":"Ringseis","year":"2019","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"10.1016\/j.jes.2022.06.028_bib0039","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/nature18449","article-title":"Microbiology: The dark side of antibiotics","volume":"534","author":"Sana","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jes.2022.06.028_bib0040","first-page":"1","article-title":"Drug discovery based on pharmacological interference with glycometabolism","volume":"37","author":"Sun","year":"2006","journal-title":"J. China Pharmaceut. Univ."},{"issue":"1","key":"10.1016\/j.jes.2022.06.028_bib0041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0138293","article-title":"Administration of non-absorbable antibiotics to pregnant mice to perturb the maternal gut microbiota is associated with alterations in offspring behavior","volume":"11","author":"Tochitani","year":"2016","journal-title":"Plos. One."},{"issue":"5","key":"10.1016\/j.jes.2022.06.028_bib0042","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.3390\/ijms21051645","article-title":"Estrogen-related receptor alpha: An under-appreciated potential target for the treatment of metabolic diseases","volume":"21","author":"Tripathi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"7122","key":"10.1016\/j.jes.2022.06.028_bib0043","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jes.2022.06.028_bib0044","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.envpol.2016.01.016","article-title":"A metabolomic study of fipronil for the anxiety-like behavior in zebrafish larvae at environmentally relevant levels","volume":"211","author":"Wang","year":"2016","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.jes.2022.06.028_bib0045","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/toxsci\/kfr130","article-title":"Involvement of microRNAs in dioxin-induced liver damage in the mouse","volume":"122","author":"Wataru","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.jes.2022.06.028_bib0046","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/wics.147","article-title":"ggplot2","volume":"3","author":"Wickham","year":"2011","journal-title":"Wiley Interdisciplin. Rev. Comput. Stat."},{"issue":"4","key":"10.1016\/j.jes.2022.06.028_bib0047","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1021\/acs.est.6b05733","article-title":"From sediment to top predators: Broad exposure of polyhalogenated carbazoles in San Francisco Bay (USA)","volume":"51","author":"Wu","year":"2017","journal-title":"Environ. Sci. Technol."},{"issue":"8","key":"10.1016\/j.jes.2022.06.028_bib0048","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1021\/acs.est.8b00427","article-title":"Bioaccumulation and spatiotemporal trends of polyhalogenated carbazoles in Great Lakes fish from 2004 to 2016","volume":"52","author":"Wu","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jes.2022.06.028_bib0049","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.etap.2016.10.002","article-title":"Perturbation of metabonome of embryo\/larvae zebrafish after exposure to fipronil","volume":"48","author":"Yan","year":"2016","journal-title":"Environ. Toxicol. Phar."},{"key":"10.1016\/j.jes.2022.06.028_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105729","article-title":"Assessment of endocrine-disrupting effects of emerging polyhalogenated carbazoles (PHCZs): In vitro, in silico, and in vivo evidence","volume":"140","author":"Yue","year":"2020","journal-title":"Environ. Int."}],"container-title":["Journal of Environmental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074222003369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074222003369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:36:12Z","timestamp":1760870172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1001074222003369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":49,"alternative-id":["S1001074222003369"],"URL":"https:\/\/doi.org\/10.1016\/j.jes.2022.06.028","relation":{},"ISSN":["1001-0742"],"issn-type":[{"value":"1001-0742","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polyhalogenated carbazoles induce hepatic metabolic disorders in mice via alteration in gut microbiota","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jes.2022.06.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}