{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:09:33Z","timestamp":1792174173913,"version":"4.4.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Sciences"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jes.2023.02.021","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:30:50Z","timestamp":1677025850000},"page":"287-301","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Prenatal amoxicillin exposure induces developmental toxicity in fetal mice and its characteristics"],"prefix":"10.1016","volume":"137","author":[{"given":"Yongguo","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-8661","authenticated-orcid":false,"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jes.2023.02.021_bib0001","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1097\/AOG.0000000000003700","article-title":"Prelabor rupture of membranes: ACOG practice bulletin, number 217","volume":"135","year":"2020","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jes.2023.02.021_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2020.110236","article-title":"Removal of caffeine, nicotine and amoxicillin from (waste)waters by various adsorbents. A review","volume":"261","author":"Anastopoulos","year":"2020","journal-title":"J. Environ. Manage."},{"key":"10.1016\/j.jes.2023.02.021_bib0003","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0118092","article-title":"Maternal antibiotic-induced early changes in microbial colonization selectively modulate colonic permeability and inducible heat shock proteins, and digesta concentrations of alkaline phosphatase and TLR-stimulants in swine offspring","volume":"10","author":"Arnal","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jes.2023.02.021_bib0004","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1177\/0960327115607948","article-title":"Evidence for neurotoxicity associated with amoxicillin in juvenile rats","volume":"35","author":"Atli","year":"2016","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.jes.2023.02.021_bib0005","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/etc.3339","article-title":"Pharmaceuticals in the environment\u2013Global occurrences and perspectives","volume":"35","author":"aus der Beek","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.jes.2023.02.021_bib0006","first-page":"1","article-title":"Environmental and individual exposure and the risk of congenital anomalies: a review of recent epidemiological evidence","volume":"42","author":"Baldacci","year":"2018","journal-title":"Epidemiol. Prev."},{"key":"10.1016\/j.jes.2023.02.021_bib0007","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1113\/jphysiol.2014.271460","article-title":"The biology of developmental plasticity and the predictive adaptive response hypothesis","volume":"592","author":"Bateson","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.jes.2023.02.021_bib0008","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/bdrb.20281","article-title":"ILSI\/HESI maternal toxicity workshop summary: maternal toxicity and its impact on study design and data interpretation","volume":"92","author":"Beyer","year":"2011","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"key":"10.1016\/j.jes.2023.02.021_bib0009","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1213\/ANE.0b013e31828a4b54","article-title":"Nonsteroidal anti-inflammatory drugs during pregnancy and the initiation of lactation","volume":"116","author":"Bloor","year":"2013","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.jes.2023.02.021_bib0010","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.2527\/jas.2010-3311","article-title":"Feed supplemented with 3 different antibiotics improved food intake and decreased the activation of the humoral immune response in healthy weaned pigs but had differing effects on intestinal microbiota","volume":"89","author":"Bosi","year":"2011","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.jes.2023.02.021_bib0011","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cbi.2018.06.017","article-title":"Electrochemical remediation of amoxicillin: detoxification and reduction of antimicrobial activity","volume":"291","author":"Brito","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jes.2023.02.021_bib0012","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/tera.1420460108","article-title":"Fetal dexamethasone exposure alters macromolecular characteristics of rat brain development: a critical period for regionally selective alterations?","volume":"46","author":"Carlos","year":"1992","journal-title":"Teratology"},{"key":"10.1016\/j.jes.2023.02.021_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2019.152302","article-title":"Serum metabolic profile characteristics of offspring rats before and after birth caused by prenatal caffeine exposure","volume":"427","author":"Chen","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.jes.2023.02.021_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.149084","article-title":"Maternally derived low glucocorticoid mediates adrenal developmental programming alteration in offspring induced by dexamethasone","volume":"797","author":"Chen","year":"2021","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.jes.2023.02.021_bib0015","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.taap.2018.05.005","article-title":"Course-, dose-, and stage-dependent toxic effects of prenatal dexamethasone exposure on long bone development in fetal mice","volume":"351","author":"Chen","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jes.2023.02.021_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2018.01.008","article-title":"Course-, dose-, and stage-dependent toxic effects of prenatal dexamethasone exposure on fetal articular cartilage development","volume":"286","author":"Chen","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jes.2023.02.021_bib0017","doi-asserted-by":"crossref","first-page":"279","DOI":"10.24425\/pjvs.2019.129218","article-title":"Effect of genistein on the gene expressions of androgen generating key enzymes StAR, P450scc and CYP19 in rat ovary","volume":"22","author":"Chi","year":"2019","journal-title":"Pol. J. Vet. Sci."},{"key":"10.1016\/j.jes.2023.02.021_bib0018","doi-asserted-by":"crossref","first-page":"e05379","DOI":"10.1016\/j.heliyon.2020.e05379","article-title":"Genotoxic impact of emerging contaminant amoxicillin residue on zebra fish (Danio rerio) embryos","volume":"6","author":"Chowdhury","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.jes.2023.02.021_bib0019","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1177\/0192623310374329","article-title":"Histology atlas of the developing mouse hepatobiliary system with emphasis on embryonic days 9.5-18.5","volume":"38","author":"Crawford","year":"2010","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.jes.2023.02.021_bib0020","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0301-2115(00)00545-5","article-title":"Augmentin treatment during pregnancy and the prevalence of congenital abnormalities: a population-based case-control teratologic study","volume":"97","author":"Czeizel","year":"2001","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.jes.2023.02.021_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.154095","article-title":"Prenatal dexamethasone exposure induced pancreatic \u03b2-cell dysfunction and glucose intolerance of male offspring rats: role of the epigenetic repression of ACE2","volume":"826","author":"Dai","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.jes.2023.02.021_bib0022","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.reprotox.2021.09.009","article-title":"Identification and validation of reference genes for RT-qPCR analysis in fetal rat pancreas","volume":"105","author":"Dai","year":"2021","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.jes.2023.02.021_bib0023","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1021\/acs.jafc.0c06748","article-title":"Prenatal exposure to retrorsine induces developmental toxicity and hepatotoxicity of fetal rats in a sex-dependent manner: the role of pregnane X receptor activation","volume":"69","author":"Dai","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jes.2023.02.021_bib0024","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1111\/bcp.14118","article-title":"The safety of amoxicillin and clavulanic acid use during the first trimester of pregnancy","volume":"85","author":"Daniel","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jes.2023.02.021_bib0025","doi-asserted-by":"crossref","first-page":"skaa181","DOI":"10.1093\/jas\/skaa181","article-title":"The effect of maternal antibiotic use in sows on intestinal development in offspring","volume":"98","author":"de Greeff","year":"2020","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.jes.2023.02.021_bib0026","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/ipd.12184","article-title":"Amoxicillin diminishes the thickness of the enamel matrix that is deposited during the secretory stage in rats","volume":"26","author":"de Souza","year":"2016","journal-title":"Int. J. Paediatr. Dent."},{"key":"10.1016\/j.jes.2023.02.021_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.147827","article-title":"Environmental contamination by pet pharmaceuticals: a hidden problem","volume":"788","author":"Domingo-Echaburu","year":"2021","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.jes.2023.02.021_bib0028","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.chemosphere.2015.12.064","article-title":"Effects of fluoride and aluminum on expressions of StAR and P450scc of related steroidogenesis in guinea pigs' testis","volume":"147","author":"Dong","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2023.02.021_bib0029","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s10266-022-00699-4","article-title":"How prenatal environmental factors affect rat molar enamel formation?","volume":"110","author":"Duman","year":"2022","journal-title":"Odontology"},{"key":"10.1016\/j.jes.2023.02.021_bib0030","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1111\/jog.12466","article-title":"Effects of a single course versus repeated courses of antenatal corticosteroids on fetal growth, placental morphometry and the differential regulation of vascular endothelial growth factor","volume":"40","author":"Elfayomy","year":"2014","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.jes.2023.02.021_bib0031","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1203\/00006450-200110000-00009","article-title":"Body mass index, body composition, and leptin at onset of puberty in male and female rats after intrauterine growth retardation and after early postnatal food restriction","volume":"50","author":"Engelbregt","year":"2001","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jes.2023.02.021_bib0032","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014373","article-title":"Exposure to amoxicillin in early life is associated with changes in gut microbiota and reduction in blood pressure: findings from a study on rat dams and offspring","volume":"9","author":"Galla","year":"2020","journal-title":"J. Am. Heart. Assoc."},{"key":"10.1016\/j.jes.2023.02.021_bib0033","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1186\/s12916-021-02173-4","article-title":"P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss","volume":"19 (1)","author":"Ge","year":"2021","journal-title":"BMC Med."},{"key":"10.1016\/j.jes.2023.02.021_bib0034","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1056\/NEJMe058187","article-title":"Developmental origins of health and disease","volume":"353","author":"Gillman","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jes.2023.02.021_bib0035","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s11011-020-00610-6","article-title":"Exposure to a high dose of amoxicillin causes behavioral changes and oxidative stress in young zebrafish","volume":"35","author":"Gon\u00e7alves","year":"2020","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jes.2023.02.021_bib0036","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.4317\/medoral.18807","article-title":"Prenatal effects by exposing to amoxicillin on dental enamel in Wistar rats","volume":"19","author":"Gottberg","year":"2014","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"10.1016\/j.jes.2023.02.021_bib0037","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.3390\/nu13072331","article-title":"\u03b1-Lipoic acid alleviates hepatic lipid deposition by inhibiting FASN expression via miR-3548 in rats","volume":"13","author":"Guo","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jes.2023.02.021_bib0038","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1152\/physrev.00029.2013","article-title":"Early developmental conditioning of later health and disease: physiology or pathophysiology?","volume":"94","author":"Hanson","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jes.2023.02.021_bib0039","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1136\/pgmj.2010.103606","article-title":"Prescribing in pregnancy and during breast feeding: using principles in clinical practice","volume":"87","author":"Henderson","year":"2011","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.jes.2023.02.021_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioelechem.2020.107687","article-title":"Recent advances in electrochemical sensors for amoxicillin detection in biological and environmental samples","volume":"137","author":"Hrioua","year":"2021","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.jes.2023.02.021_bib0041","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.tox.2019.02.008","article-title":"Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C\/EBP\u03b1-SIRT1 pathway","volume":"417","author":"Hu","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.jes.2023.02.021_bib0042","article-title":"Decreased H3K9 acetylation level of LXR\u03b1 mediated dexamethasone-induced placental cholesterol transport dysfunction","volume":"1864","author":"Huang","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.jes.2023.02.021_bib0043","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.cbi.2019.03.014","article-title":"Extenuation of in utero toxic effects of MeHg in the developing neurons by Fisetin via modulating the expression of synaptic transmission and plasticity regulators in hippocampus of the rat offspring","volume":"305","author":"Jacob","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jes.2023.02.021_bib0044","doi-asserted-by":"crossref","first-page":"e14154","DOI":"10.14814\/phy2.14154","article-title":"Effect of sex on glomerular filtration rate in programmed rats by prenatal dexamethasone","volume":"7","author":"Jain","year":"2019","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.jes.2023.02.021_bib0045","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1046\/j.1365-2125.2003.01750.x","article-title":"A population-based study of maternal use of amoxicillin and pregnancy outcome in Denmark","volume":"55","author":"Jepsen","year":"2003","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jes.2023.02.021_bib0046","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mce.2008.06.020","article-title":"Fetal programming of glucose\u2013insulin metabolism","volume":"297","author":"Jones","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jes.2023.02.021_bib0047","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.placenta.2016.12.008","article-title":"Review: sexual dimorphism in the formation, function and adaptation of the placenta","volume":"54","author":"Kalisch-Smith","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.jes.2023.02.021_bib0048","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1749-6632.2010.05683.x","article-title":"Fetal origins of adult diabetes","volume":"1205","author":"Kanaka-Gantenbein","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jes.2023.02.021_bib0049","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0221719","article-title":"Fetal programming of adrenal PNMT and hypertension by glucocorticoids in WKY rats is dose and sex-dependent","volume":"14","author":"Khurana","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jes.2023.02.021_bib0050","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1242\/dev.105536","article-title":"A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation","volume":"142","author":"Kozhemyakina","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.jes.2023.02.021_bib0051","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/toxsci\/19.4.545","article-title":"Prenatal dexamethasone exposure in rats: effects of dose, age at exposure, and drug-induced hupophagia on malformations and fetal organ weights","volume":"19","author":"Laborde","year":"1992","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jes.2023.02.021_bib0052","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1111\/brv.12396","article-title":"Epigenetics and the maintenance of developmental plasticity: extending the signalling theory framework","volume":"93","author":"Laubach","year":"2018","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.jes.2023.02.021_bib0053","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/s11626-020-00487-w","article-title":"Crocin promotes osteogenesis differentiation of bone marrow mesenchymal stem cells. In Vitro Cell Dev","volume":"56","author":"Li","year":"2020","journal-title":"Biol. Anim."},{"key":"10.1016\/j.jes.2023.02.021_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115306","article-title":"MiR-133a-3p\/Sirt1 epigenetic programming mediates hypercholesterolemia susceptibility in female offspring induced by prenatal dexamethasone exposure","volume":"206","author":"Li","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jes.2023.02.021_bib0055","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/EDE.0b013e318258cb05","article-title":"Maternal exposure to amoxicillin and the risk of oral clefts","volume":"23","author":"Lin","year":"2012","journal-title":"Epidemiology"},{"key":"10.1016\/j.jes.2023.02.021_bib0056","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/s41401-021-00789-z","article-title":"Prenatal dexamethasone exposure programs the decreased testosterone synthesis in offspring rats by low level of endogenous glucocorticoids","volume":"43","author":"Liu","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jes.2023.02.021_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127880","article-title":"Chronic exposure of BPA impairs male germ cell proliferation and induces lower sperm quality in male mice","volume":"262","author":"Liu","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2023.02.021_bib0058","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/jvp.12363","article-title":"Residue depletion of amoxicillin and its major metabolites in eggs","volume":"40","author":"Liu","year":"2017","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.jes.2023.02.021_bib0060","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1113\/JP271402","article-title":"The consequences of fetal growth restriction on brain structure and neurodevelopmental outcome","volume":"594","author":"Miller","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.jes.2023.02.021_bib0059","article-title":"Developmental toxicity and programming alterations of multiple organs in offspring induced by medication during pregnancy","author":"Lu","year":"2023","journal-title":"Acta Pharm. Sin. B. 13 (2), 460-477"},{"key":"10.1016\/j.jes.2023.02.021_bib0061","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jsbmb.2016.03.009","article-title":"Disorders in the initial steps of steroid hormone synthesis","volume":"165","author":"Miller","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jes.2023.02.021_bib0062","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00467-009-1407-3","article-title":"Fetal growth restriction, catch-up growth and the early origins of insulin resistance and visceral obesity","volume":"25","author":"Morrison","year":"2010","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.jes.2023.02.021_bib0063","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1111\/bcp.13364","article-title":"Use of antibiotics during pregnancy and the risk of major congenital malformations: a population based cohort study","volume":"83","author":"Muanda","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jes.2023.02.021_bib0064","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/AOG.0b013e31825189dc","article-title":"Effect of antenatal corticosteroids on fetal growth and gestational age at birth","volume":"119","author":"Murphy","year":"2012","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jes.2023.02.021_bib0065","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/ddr.21461","article-title":"Dose translation between laboratory animals and human in preclinical and clinical phases of drug development","volume":"79","author":"Nair","year":"2018","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.jes.2023.02.021_bib0066","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1681\/ASN.V115874","article-title":"In utero and in vitro exposure to beta-lactams impair kidney development in the rat","volume":"11","author":"Nathanson","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jes.2023.02.021_bib0067","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1067\/mjd.2001.117432","article-title":"Estrogen production and action","volume":"45","author":"Nelson","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jes.2023.02.021_bib0068","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2174\/1574886315666200626164001","article-title":"Poor and unsatisfactory disposal of expired and unused pharmaceuticals: a global issue","volume":"15","author":"Nepal","year":"2020","journal-title":"Curr. Drug. Saf."},{"key":"10.1016\/j.jes.2023.02.021_bib0069","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1172\/JCI1567","article-title":"Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring","volume":"101","author":"Nyirenda","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jes.2023.02.021_bib0070","doi-asserted-by":"crossref","first-page":"E863","DOI":"10.1152\/ajpendo.00137.2004","article-title":"Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology","volume":"287","author":"O'Regan","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.jes.2023.02.021_bib0071","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.etap.2013.07.019","article-title":"Effects of oxytetracycline and amoxicillin on development and biomarkers activities of zebrafish (Danio rerio)","volume":"36","author":"Oliveira","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jes.2023.02.021_bib0072","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/S0140-6736(20)30053-2","article-title":"Mass drug administration: time to consider drug pollution?","volume":"395","author":"Orive","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jes.2023.02.021_bib0073","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.07.054","article-title":"Genotoxic and cytotoxic alterations induced by environmentally-relevant concentrations of amoxicillin in blood cells of Cyprinus carpio","volume":"236","author":"Orozco-Hern\u00e1ndez","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2023.02.021_bib0074","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/01.HYP.0000049763.51269.51","article-title":"Prenatal dexamethasone programs hypertension and renal injury in the rat","volume":"41","author":"Ortiz","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.jes.2023.02.021_bib0075","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/AOG.0000000000000982","article-title":"The most commonly dispensed prescription medications among pregnant women enrolled in the U.S. medicaid program","volume":"126","author":"Palmsten","year":"2015","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jes.2023.02.021_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112664","article-title":"Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways","volume":"158","author":"Petrov","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jes.2023.02.021_bib0077","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1597\/05-208.1","article-title":"Drug treatment during pregnancy and isolated orofacial clefts in hungary","volume":"44","author":"Puh\u00f3","year":"2007","journal-title":"Cleft Palate Craniofac. J."},{"key":"10.1016\/j.jes.2023.02.021_bib0078","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/(SICI)1097-0177(199901)214:1<26::AID-DVDY3>3.0.CO;2-V","article-title":"Restoration of normal bone development by human homologue of collagen type II (COL2A1) gene in Col2a1 null mice","volume":"214","author":"Rani","year":"1999","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.jes.2023.02.021_bib0079","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.biocel.2009.07.020","article-title":"Biliary differentiation and bile duct morphogenesis in development and disease","volume":"43","author":"Raynaud","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jes.2023.02.021_bib0080","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.jes.2023.02.021_bib0081","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.07.074","article-title":"Effects of chronic glyphosate exposure to pregnant mice on hepatic lipid metabolism in offspring","volume":"254","author":"Ren","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jes.2023.02.021_bib0082","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0022-3476(88)80330-5","article-title":"Hepatic veno-occlusive disease in newborn infant of a woman drinking herbal tea","volume":"112","author":"Roulet","year":"1988","journal-title":"J. Pediatr."},{"key":"10.1016\/j.jes.2023.02.021_bib0083","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.3390\/ijerph17051629","article-title":"Time-cumulative toxicity of neonicotinoids: experimental evidence and implications for environmental risk assessments","volume":"17","author":"S\u00e1nchez-Bayo","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.jes.2023.02.021_bib0084","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2019.02.021","article-title":"Preterm premature rupture of the membranes: Guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF)","volume":"236","author":"Schmitz","year":"2019","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.jes.2023.02.021_bib0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115264","article-title":"Positive programming of the GC-IGF1 axis mediates adult osteoporosis susceptibility in male offspring rats induced by prenatal dexamethasone exposure","volume":"206","author":"Shangguan","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jes.2023.02.021_bib0086","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1473-3099(17)30724-7","article-title":"Classifying antibiotics in the WHO essential medicines list for optimal use-be AWaRe","volume":"18","author":"Sharland","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jes.2023.02.021_bib0087","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.foodchem.2015.07.028","article-title":"Quantitative analysis of amoxicillin, its major metabolites and ampicillin in eggs by liquid chromatography combined with electrospray ionization tandem mass spectrometry","volume":"192","author":"Sun","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.jes.2023.02.021_bib0088","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.steroids.2016.08.006","article-title":"Sex differences in renal transcriptome and programmed hypertension in offspring exposed to prenatal dexamethasone","volume":"115","author":"Tain","year":"2016","journal-title":"Steroids"},{"key":"10.1016\/j.jes.2023.02.021_bib0089","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tox.2013.04.007","article-title":"The molecular basis of simple relationships between exposure concentration and toxic effects with time","volume":"309","author":"Tennekes","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.jes.2023.02.021_bib0090","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1096\/fj.15-274399","article-title":"Intrauterine low-functional programming of IGF1 by prenatal nicotine exposure mediates the susceptibility to osteoarthritis in female adult rat offspring","volume":"30","author":"Tie","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.jes.2023.02.021_bib0091","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40104-021-00557-3","article-title":"Maternal antibiotic treatment affects offspring gastric sensing for umami taste and ghrelin regulation in the pig","volume":"12","author":"Trevisi","year":"2021","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.jes.2023.02.021_bib0092","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1210\/en.2010-1134","article-title":"A novel functional role for the oocyte-specific transcription factor newborn ovary homeobox (NOBOX) during early embryonic development in cattle","volume":"152","author":"Tripurani","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.jes.2023.02.021_bib0093","doi-asserted-by":"crossref","first-page":"7911","DOI":"10.1523\/JNEUROSCI.1314-16.2016","article-title":"Distinct functions of Syntaxin-1 in neuronal maintenance, synaptic vesicle docking, and fusion in mouse neurons","volume":"36","author":"Vardar","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jes.2023.02.021_bib0094","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1056\/NEJMoa071453","article-title":"Long-term outcomes after repeat doses of antenatal corticosteroids","volume":"357","author":"Wapner","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jes.2023.02.021_bib0095","doi-asserted-by":"crossref","first-page":"5563","DOI":"10.1096\/fj.201701557R","article-title":"Intrauterine programming mechanism for hypercholesterolemia in prenatal caffeine-exposed female adult rat offspring","volume":"32","author":"Xu","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.jes.2023.02.021_bib0096","first-page":"502","article-title":"Evaluation of the amoxicillin concentrations in amniotic fluid, placenta, umbilical cord blood and maternal serum two hours after oral administration","volume":"38","author":"Zareba-Szczudlik","year":"2017","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.jes.2023.02.021_bib0097","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jnutbio.2014.10.009","article-title":"Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression","volume":"26","author":"Zhou","year":"2015","journal-title":"J. Nutr. Biochem."}],"container-title":["Journal of Environmental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074223000670?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074223000670?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:36:44Z","timestamp":1760870204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1001074223000670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":97,"alternative-id":["S1001074223000670"],"URL":"https:\/\/doi.org\/10.1016\/j.jes.2023.02.021","relation":{},"ISSN":["1001-0742"],"issn-type":[{"value":"1001-0742","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal amoxicillin exposure induces developmental toxicity in fetal mice and its characteristics","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jes.2023.02.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}