{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:10:53Z","timestamp":1780117853751,"version":"3.54.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872667"],"award-info":[{"award-number":["81872667"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173569"],"award-info":[{"award-number":["82173569"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Sciences"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jes.2023.06.030","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T07:50:04Z","timestamp":1688111404000},"page":"259-268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Enhanced hepatic metabolic perturbation of polystyrene nanoplastics by UV irradiation-induced hydroxyl radical generation"],"prefix":"10.1016","volume":"142","author":[{"given":"Shiyu","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6393-5143","authenticated-orcid":false,"given":"Peili","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jes.2023.06.030_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113292","article-title":"Adsorption of Cu2+ by UV aged polystyrene in aqueous solution","volume":"232","author":"Chen","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jes.2023.06.030_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jox12010001","article-title":"Non-negligible effects of UV irradiation on transformation and environmental risks of microplastics in the water environment","volume":"12","author":"Cheng","year":"2021","journal-title":"J. Xenobiot."},{"key":"10.1016\/j.jes.2023.06.030_bib0003","doi-asserted-by":"crossref","first-page":"46687","DOI":"10.1038\/srep46687","article-title":"Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure","volume":"7","author":"Deng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jes.2023.06.030_bib0004","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.jacc.2020.07.059","article-title":"Time course of LDL cholesterol exposure and cardiovascular disease event risk","volume":"76","author":"Domanski","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jes.2023.06.030_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.129476","article-title":"Toxicity of polystyrene nanoplastics and zinc oxide to mice","volume":"271","author":"Estrela","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2023.06.030_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152850","article-title":"Polystyrene nanoplastics dysregulate lipid metabolism in murine macrophages in vitro","volume":"458","author":"Florance","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.jes.2023.06.030_bib0007","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.5551\/jat.43299","article-title":"Circulating oxidized low-density lipoprotein levels independently predict 10-year progression of subclinical carotid atherosclerosis: a community-based cohort study","volume":"25","author":"Gao","year":"2018","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.jes.2023.06.030_bib0008","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0142-9612(96)85755-3","article-title":"Mechanisms of polymer degradation and erosion","volume":"17","author":"G\u00f6pferich","year":"1996","journal-title":"Biomaterials"},{"key":"10.1016\/j.jes.2023.06.030_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.135662","article-title":"Polystyrene nanoplastics deteriorate lps-modulated duodenal permeability and inflammation in mice via ros drived-nf-\u03bab\/nlrp3 pathway","volume":"307","author":"He","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2023.06.030_bib0010","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1021\/es503003y","article-title":"Ambient water and visible-light irradiation drive changes in graphene morphology, structure, surface chemistry, aggregation, and toxicity","volume":"49","author":"Hu","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jes.2023.06.030_bib0011","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.envpol.2018.01.022","article-title":"Sorption of organic compounds by aged polystyrene microplastic particles","volume":"236","author":"H\u00fcffer","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jes.2023.06.030_bib0012","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3350\/cmh.2021.0127","article-title":"Recent advances in nonalcoholic fatty liver disease metabolomics","volume":"27","author":"Kim","year":"2021","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.jes.2023.06.030_bib0013","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1748-1716.1975.tb05851.x","article-title":"Liver function, liver hemodynamics and intrahepatic distribution of portal blood in cast during slight hypothermia","volume":"93","author":"Krarup","year":"1975","journal-title":"Acta. Physiol. Scand."},{"key":"10.1016\/j.jes.2023.06.030_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.134267","article-title":"Micro(nano)plastics pollution and human health: how plastics can induce carcinogenesis to humans?","volume":"298","author":"Kumar","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2023.06.030_bib0015","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3109\/10409238.2011.562481","article-title":"Insulin signaling to hepatic lipid metabolism in health and disease","volume":"46","author":"Leavens","year":"2011","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.jes.2023.06.030_bib0016","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1021\/acs.est.8b05512","article-title":"Emergence of nanoplastic in the environment and possible impact on human health","volume":"53","author":"Lehner","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jes.2023.06.030_bib0017","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.taap.2008.06.026","article-title":"Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: a rapid in vivo screening method for nanotoxicity","volume":"232","author":"Lei","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jes.2023.06.030_bib0018","first-page":"449","article-title":"Insulin resistance in insulin-resistant and diabetic hamsters (Mesocricetus auratus) is associated with abnormal hepatic expression of genes involved in lipid and glucose metabolism","volume":"59","author":"Li","year":"2009","journal-title":"Comput. Med."},{"key":"10.1016\/j.jes.2023.06.030_bib0019","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1021\/acs.est.9b00493","article-title":"New insights into the aging behavior of microplastics accelerated by advanced oxidation processes","volume":"53","author":"Liu","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jes.2023.06.030_bib0020","doi-asserted-by":"crossref","first-page":"e22942","DOI":"10.1002\/jbt.22942","article-title":"Imbalanced GSH\/ROS and sequential cell death","volume":"36","author":"Liu","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.jes.2023.06.030_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.132944","article-title":"Activation of pyroptosis and ferroptosis is involved in the hepatotoxicity induced by polystyrene microplastics in mice","volume":"291","author":"Mu","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2023.06.030_bib0022","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1021\/tx800101p","article-title":"Structural defects play a major role in the acute lung toxicity of multiwall carbon nanotubes: toxicological aspects","volume":"21","author":"Muller","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jes.2023.06.030_bib0023","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s00726-020-02896-3","article-title":"Creatine metabolism in the uterus: potential implications for reproductive biology","volume":"52","author":"Philip","year":"2020","journal-title":"Amino Acids"},{"key":"10.1016\/j.jes.2023.06.030_bib0024","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.scitotenv.2018.03.233","article-title":"Spatial and temporal distribution of microplastics in water and sediments of a freshwater system (antu\u00e3 river, Portugal)","volume":"633","author":"Rodrigues","year":"2018","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.jes.2023.06.030_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160861","article-title":"Combined negative effects of microplastics and plasticizer dehp: the increased release of nets delays wound healing in mice","volume":"862","author":"Shi","year":"2023","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.jes.2023.06.030_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101084","article-title":"Ros and the DNA damage response in cancer","volume":"25","author":"Srinivas","year":"2019","journal-title":"Redox. Biol."},{"key":"10.1016\/j.jes.2023.06.030_bib0027","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5080843","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.jes.2023.06.030_bib0028","series-title":"Hydrogen Molecular Biology and Medicine","first-page":"61","article-title":"Selective antioxidative effect of hydrogen","author":"Sun","year":"2015"},{"key":"10.1016\/j.jes.2023.06.030_bib0029","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41591-022-01686-6","article-title":"Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease","volume":"28","author":"Talmor-Barkan","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.jes.2023.06.030_bib0030","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1002\/tox.23618","article-title":"Polystyrene nanoplastics exacerbated lipopolysaccharide-induced necroptosis and inflammation via the ROS\/MAPK pathway in mice spleen","volume":"37","author":"Tang","year":"2022","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jes.2023.06.030_bib0031","doi-asserted-by":"crossref","first-page":"R1147","DOI":"10.1016\/j.cub.2017.09.019","article-title":"The liver","volume":"27","author":"Trefts","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jes.2023.06.030_bib0032","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/ina.12791","article-title":"Technical control of nanoparticle emissions from desktop 3D printing","volume":"31","author":"Viitanen","year":"2021","journal-title":"Indoor Air"},{"key":"10.1016\/j.jes.2023.06.030_bib0033","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9912436","article-title":"Reactive oxygen species (ROS) regulates different types of cell death by acting as a rheostat","volume":"2021","author":"Villalpando-Rodriguez","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.jes.2023.06.030_bib0034","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.envpol.2017.08.088","article-title":"Aging of microplastics promotes their ingestion by marine zooplankton","volume":"231","author":"Vroom","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jes.2023.06.030_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2022.04.048","article-title":"Polystyrene nanoplastics induced cardiomyocyte apoptosis and myocardial inflammation in carp by promoting ROS production","volume":"125","author":"Wu","year":"2022","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.jes.2023.06.030_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155825","article-title":"Oxidative stress mediated by the TLR4\/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice","volume":"838","author":"Wu","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.jes.2023.06.030_bib0037","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1507\/endocrj.EJ21-0560","article-title":"Triglyceride glucose index is superior biomarker for predicting type 2 diabetes mellitus in children and adolescents","volume":"69","author":"Yoon","year":"2022","journal-title":"Endocr. J."},{"key":"10.1016\/j.jes.2023.06.030_bib0038","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/2193-1801-2-398","article-title":"Photodegradation and photostabilization of polymers, especially polystyrene: review","volume":"2","author":"Yousif","year":"2013","journal-title":"SpringerPlus"},{"key":"10.1016\/j.jes.2023.06.030_bib0039","doi-asserted-by":"crossref","first-page":"10990","DOI":"10.1021\/es302559v","article-title":"Co-release of hexabromocyclododecane (hbcd) and nano- and microparticles from thermal cutting of polystyrene foams","volume":"46","author":"Zhang","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jes.2023.06.030_bib0040","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.addr.2012.08.005","article-title":"Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine","volume":"64","author":"Zhang","year":"2012","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.jes.2023.06.030_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.115564","article-title":"Long-term phototransformation of microplastics under simulated sunlight irradiation in aquatic environments: Roles of reactive oxygen species","volume":"173","author":"Zhu","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.jes.2023.06.030_bib0042","doi-asserted-by":"crossref","first-page":"8177","DOI":"10.1021\/acs.est.9b01474","article-title":"Formation of environmentally persistent free radicals on microplastics under light irradiation","volume":"53","author":"Zhu","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jes.2023.06.030_bib0043","doi-asserted-by":"crossref","first-page":"7759","DOI":"10.1021\/acs.est.9b00088","article-title":"Dissolved oxygen and visible light irradiation drive the structural alterations and phytotoxicity mitigation of single-layer molybdenum disulfide","volume":"53","author":"Zou","year":"2019","journal-title":"Environ. Sci. Technol."}],"container-title":["Journal of Environmental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074223002917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074223002917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:39:56Z","timestamp":1760870396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1001074223002917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":43,"alternative-id":["S1001074223002917"],"URL":"https:\/\/doi.org\/10.1016\/j.jes.2023.06.030","relation":{},"ISSN":["1001-0742"],"issn-type":[{"value":"1001-0742","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced hepatic metabolic perturbation of polystyrene nanoplastics by UV irradiation-induced hydroxyl radical generation","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jes.2023.06.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}