{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:27:27Z","timestamp":1790782047670,"version":"4.1.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Sciences"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jes.2023.09.032","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:07:18Z","timestamp":1696334838000},"page":"244-258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["4-Nitrophenol at environmentally relevant concentrations mediates reproductive toxicity in Caenorhabditis elegans via metabolic disorders-induced estrogen signaling pathway"],"prefix":"10.1016","volume":"147","author":[{"given":"Jia","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiechen","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danhong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouhong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beijing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchen","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7568-3698","authenticated-orcid":false,"given":"Ran","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.jes.2023.09.032_bib0001","doi-asserted-by":"crossref","first-page":"10930","DOI":"10.1007\/s11356-015-4245-9","article-title":"Suppressive effects of long-term exposure to P-nitrophenol on gonadal development, hormonal profile with disruption of tissue integrity, and activation of caspase-3 in male Japanese quail (Coturnix japonica)","volume":"22","author":"Ahmed","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"2","key":"10.1016\/j.jes.2023.09.032_bib0002","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00204-020-02949-2","article-title":"In vivo toxicometabolomics reveals multi-organ and urine metabolic changes in mice upon acute exposure to human-relevant doses of 3,4-methylenedioxypyrovalerone (MDPV)","volume":"95","author":"Ara\u00fajo","year":"2021","journal-title":"Arch. Toxicol."},{"issue":"5","key":"10.1016\/j.jes.2023.09.032_bib0003","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1021\/jf60201a025","article-title":"Dissipation of parathion and related compounds from field-sprayed lettuce","volume":"23","author":"Archer","year":"1975","journal-title":"J. Agric. Food. Chem."},{"key":"10.1016\/j.jes.2023.09.032_bib0004","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13023-014-0130-8","article-title":"Proposed guidelines for the diagnosis and management of methylmalonic and propionic acidemia","volume":"9","author":"Baumgartner","year":"2014","journal-title":"Orphanet J. Rare Dis."},{"issue":"7","key":"10.1016\/j.jes.2023.09.032_bib0005","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1073\/pnas.061593098","article-title":"SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N- acetylgalactosamine, and UDP-galactose","volume":"98","author":"Berninsone","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"31","key":"10.1016\/j.jes.2023.09.032_bib0006","doi-asserted-by":"crossref","first-page":"16283","DOI":"10.1016\/S0021-9258(18)37590-2","article-title":"A polarized epithelial cell mutant deficient in translocation of UDP-galactose into the Golgi complex","volume":"263","author":"Br\u00e4ndli","year":"1988","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.jes.2023.09.032_bib0007","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0009-9120(86)80008-X","article-title":"Bisphosphorylated metabolites of glycerate, glucose, and fructose: functions, metabolism and molecular pathology","volume":"19","author":"Carreras","year":"1986","journal-title":"Clin. Biochem."},{"issue":"4","key":"10.1016\/j.jes.2023.09.032_bib0008","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/cns.13610","article-title":"Taurine and oxidative stress in retinal health and disease","volume":"27","author":"Castelli","year":"2021","journal-title":"CNS Neurosci. Ther."},{"issue":"22","key":"10.1016\/j.jes.2023.09.032_bib0009","first-page":"5489","article-title":"An L,L-diaminopimelate aminotransferase mutation leads to metabolic shifts and growth inhibition in Arabidopsis","volume":"69","author":"Cavalcanti","year":"2018","journal-title":"J. Exp. Bot."},{"issue":"6349","key":"10.1016\/j.jes.2023.09.032_bib0010","doi-asserted-by":"crossref","first-page":"eaaf9794","DOI":"10.1126\/science.aaf9794","article-title":"Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health","volume":"357","author":"Cervenka","year":"2017","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.jes.2023.09.032_bib0011","first-page":"729","article-title":"Concentration and pollution characteristics of phenolic compounds in Qiantang River","volume":"25","author":"Chen","year":"2005","journal-title":"China Environ. Sci."},{"issue":"11","key":"10.1016\/j.jes.2023.09.032_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2019.165539","article-title":"Heparan sulfate proteoglycans: the sweet side of development turns sour in mucopolysaccharidoses","volume":"1865","author":"De Pasquale","year":"2019","journal-title":"Biochim. Biophys. Acta. Mol. Basis. Dis."},{"key":"10.1016\/j.jes.2023.09.032_bib0013","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jprot.2013.06.004","article-title":"Lipoxidation adducts with peptides and proteins: deleterious modifications or signaling mechanisms?","volume":"92","author":"Domingues","year":"2013","journal-title":"J. Proteomics"},{"issue":"3","key":"10.1016\/j.jes.2023.09.032_bib0014","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/em.22345","article-title":"4-nitrophenol exposure in T24 human bladder cancer cells promotes proliferation, motilities, and epithelial-to-mesenchymal transition","volume":"61","author":"Dong","year":"2020","journal-title":"Environ. Mol. Mutagen."},{"issue":"5","key":"10.1016\/j.jes.2023.09.032_bib0015","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1095\/biolreprod.103.024810","article-title":"Estrogenic activities of nitrophenols in diesel exhaust particles","volume":"70","author":"Furuta","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jes.2023.09.032_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107781","article-title":"\u03b2-alanine supplementation induces taurine depletion and causes alterations of the retinal nerve fiber layer and axonal transport by retinal ganglion cells","volume":"188","author":"Garc\u00eda-Ayuso","year":"2019","journal-title":"Exp. Eye. Res."},{"key":"10.1016\/j.jes.2023.09.032_bib0017","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3389\/fendo.2020.00365","article-title":"The role of the pentose phosphate pathway in diabetes and cancer","volume":"11","author":"Ge","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"1","key":"10.1016\/j.jes.2023.09.032_bib0018","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/bmme.1995.1025","article-title":"Effect of glucose and galactose loading in normal subjects on red and white blood cell uridine diphosphate sugars","volume":"55","author":"Gibson","year":"1995","journal-title":"Biochem. Mol. Med."},{"issue":"2","key":"10.1016\/j.jes.2023.09.032_bib0019","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00253-006-0760-4","article-title":"A rare sugar xylitol. Part II: biotechnological production and future applications of xylitol","volume":"74","author":"Granstr\u00f6m","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jes.2023.09.032_bib0020","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1146\/annurev.bi.56.070187.000431","article-title":"Topography of glycosylation in the rough endoplasmic reticulum and Golgi apparatus","volume":"56","author":"Hirschberg","year":"1987","journal-title":"Annu. Rev. Biochem."},{"issue":"4","key":"10.1016\/j.jes.2023.09.032_bib0021","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1474-9726.2010.00582.x","article-title":"Trehalose extends longevity in the nematode Caenorhabditis elegans","volume":"9","author":"Honda","year":"2010","journal-title":"Aging Cell"},{"issue":"2\u20133","key":"10.1016\/j.jes.2023.09.032_bib0022","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbamcr.2004.03.005","article-title":"Regulation of actin-based cell migration by cAMP\/PKA","volume":"1692","author":"Howe","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"issue":"18","key":"10.1016\/j.jes.2023.09.032_bib0023","doi-asserted-by":"crossref","first-page":"10803","DOI":"10.1111\/jcmm.15705","article-title":"Collagen Type III Alpha 1 chain regulated by GATA-Binding Protein 6 affects type II IFN response and propanoate metabolism in the recurrence of lower grade glioma","volume":"24","author":"Huang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.jes.2023.09.032_bib0024","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jat.3357","article-title":"The C. elegans model in toxicity testing","volume":"37","author":"Hunt","year":"2017","journal-title":"J. Appl. Toxicol."},{"issue":"7","key":"10.1016\/j.jes.2023.09.032_bib0025","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrm.2016.25","article-title":"Metabolomics: beyond biomarkers and towards mechanisms","volume":"17","author":"Johnson","year":"2016","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"Suppl 1","key":"10.1016\/j.jes.2023.09.032_bib0026","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1186\/1423-0127-17-S1-S25","article-title":"Effect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content","volume":"17","author":"Jong","year":"2010","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.jes.2023.09.032_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108916","article-title":"Longitudinal, association of biomarkers of pesticide exposure with cardiovascular disease risk factors in youth with diabetes","volume":"181","author":"Kaur","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.jes.2023.09.032_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.07.037","article-title":"Metabolomics and phenotype assessment reveal cellular toxicity of triclosan in Caenorhabditis elegans","volume":"236","author":"Kim","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2023.09.032_bib0029","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.envint.2015.05.012","article-title":"Estrogenic endocrine disruptors: molecular mechanisms of action","volume":"83","author":"Kiyama","year":"2015","journal-title":"Environ. Int."},{"issue":"10","key":"10.1016\/j.jes.2023.09.032_bib0030","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.1016\/j.bbagen.2013.06.008","article-title":"Molecular insights into 4-nitrophenol-induced hepatotoxicity in zebrafish: transcriptomic, histological and targeted gene expression analyses","volume":"1830","author":"Lam","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.jes.2023.09.032_bib0031","article-title":"Immunostaining for markers of apoptosis in the Caenorhabditis elegans germline","volume":"2014","author":"Lant","year":"2014","journal-title":"Cold. Spring. Harb. Protoc."},{"issue":"5","key":"10.1016\/j.jes.2023.09.032_bib0032","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1038\/sj.bjp.0702654","article-title":"Quantitation of extracellular UTP using a sensitive enzymatic assay","volume":"127","author":"Lazarowski","year":"1999","journal-title":"Br. J. Pharmacol."},{"issue":"39","key":"10.1016\/j.jes.2023.09.032_bib0033","doi-asserted-by":"crossref","first-page":"20315","DOI":"10.1074\/jbc.M116.740464","article-title":"Protein kinase a subunit balance regulates lipid metabolism in Caenorhabditis elegans and mammalian adipocytes","volume":"291","author":"Lee","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jes.2023.09.032_bib0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2006.06.010","article-title":"Estrogenic and anti-androgenic activities of 4-nitrophenol in diesel exhaust particles","volume":"217","author":"Li","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.jes.2023.09.032_bib0035","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s12020-009-9192-0","article-title":"4-Nitrophenol isolated from diesel exhaust particles disrupts regulation of reproductive hormones in immature male rats","volume":"36","author":"Li","year":"2009","journal-title":"Endocrine"},{"key":"10.1016\/j.jes.2023.09.032_bib0036","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.chemosphere.2016.11.011","article-title":"A novel method for assessing the toxicity of silver nanoparticles in Caenorhabditis elegans","volume":"168","author":"Luo","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2023.09.032_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.137306","article-title":"A novel biosensor-based method for the detection of p-nitrophenol in agricultural soil","volume":"313","author":"Ma","year":"2023","journal-title":"Chemosphere"},{"issue":"Suppl 1","key":"10.1016\/j.jes.2023.09.032_bib0038","doi-asserted-by":"crossref","first-page":"2548s","DOI":"10.1093\/jn\/nxaa224","article-title":"Review of lysine metabolism with a focus on humans","volume":"150","author":"Matthews","year":"2020","journal-title":"J. Nutr."},{"issue":"10","key":"10.1016\/j.jes.2023.09.032_bib0039","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1002\/ar.22765","article-title":"Supplementation with quercetin attenuates 4-nitrophenol-induced testicular toxicity in adult male mice","volume":"296","author":"Mi","year":"2013","journal-title":"Anat. Rec. (Hoboken)"},{"issue":"2","key":"10.1016\/j.jes.2023.09.032_bib0040","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1262\/jrd.09-074N","article-title":"Protective effect of quercetin on the reproductive toxicity of 4-nitrophenol in diesel exhaust particles on male embryonic chickens","volume":"56","author":"Mi","year":"2010","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.jes.2023.09.032_bib0041","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2014.07.027","article-title":"Serotonin, tryptophan metabolism and the brain-gut-microbiome axis","volume":"277","author":"O'Mahony","year":"2015","journal-title":"Behav. Brain. Res."},{"issue":"7","key":"10.1016\/j.jes.2023.09.032_bib0042","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2174\/138920011796504536","article-title":"L-carnitine\u2013metabolic functions and meaning in humans life","volume":"12","author":"Pekala","year":"2011","journal-title":"Curr. Drug. Metab."},{"issue":"6","key":"10.1016\/j.jes.2023.09.032_bib0043","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.pbi.2003.09.004","article-title":"Feedback from the wall","volume":"6","author":"Pilling","year":"2003","journal-title":"Curr. Opin. Plant. Biol."},{"key":"10.1016\/j.jes.2023.09.032_bib0044","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3419034","article-title":"D-Lactic acid as a metabolite: toxicology, diagnosis, and detection","volume":"2020","author":"Pohanka","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"6","key":"10.1016\/j.jes.2023.09.032_bib0045","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1210\/er.2008-0007","article-title":"Glycerolipid metabolism and signaling in health and disease","volume":"29","author":"Prentki","year":"2008","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jes.2023.09.032_bib0046","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.clnesp.2019.07.004","article-title":"Fructose, galactose and glucose - in health and disease","volume":"33","author":"Qi","year":"2019","journal-title":"Clin. Nutr. ESPEN"},{"issue":"12","key":"10.1016\/j.jes.2023.09.032_bib0047","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3390\/metabo9120282","article-title":"Glucose-6 phosphate, a central hub for liver carbohydrate metabolism","volume":"9","author":"Rajas","year":"2019","journal-title":"Metabolites"},{"issue":"15","key":"10.1016\/j.jes.2023.09.032_bib0048","doi-asserted-by":"crossref","first-page":"17481","DOI":"10.1007\/s11356-019-05494-3","article-title":"Electrochemical determination of 4-nitrophenol in environmental water samples using porous graphitic carbon nitride-coated screen-printed electrode","volume":"27","author":"Ramalingam","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"33","key":"10.1016\/j.jes.2023.09.032_bib0049","doi-asserted-by":"crossref","first-page":"30413","DOI":"10.1074\/jbc.R300017200","article-title":"Glyceroneogenesis and the triglyceride\/fatty acid cycle","volume":"278","author":"Reshef","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.jes.2023.09.032_bib0050","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41580-019-0108-4","article-title":"Identification of bioactive metabolites using activity metabolomics","volume":"20","author":"Rinschen","year":"2019","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"10","key":"10.1016\/j.jes.2023.09.032_bib0051","article-title":"Glycerol production from glucose and fructose by 3T3-L1 cells: a mechanism of adipocyte defense from excess substrate","volume":"10","author":"Romero Mdel","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jes.2023.09.032_bib0052","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev-arplant-050213-040251","article-title":"Sucrose metabolism: gateway to diverse carbon use and sugar signaling","volume":"65","author":"Ruan","year":"2014","journal-title":"Annu. Rev. Plant. Biol."},{"issue":"10","key":"10.1016\/j.jes.2023.09.032_bib0053","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.chemosphere.2011.11.046","article-title":"Phenol and nitrophenols in the air and dew waters of Santiago de Chile","volume":"86","author":"Rubio","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2023.09.032_bib0054","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jprot.2013.03.025","article-title":"Effect of posttranslational modifications on enzyme function and assembly","volume":"92","author":"Ry\u0161lav\u00e1","year":"2013","journal-title":"J. Proteomics"},{"key":"10.1016\/j.jes.2023.09.032_bib0055","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/1471-2202-14-156","article-title":"The Caenorhabditis elegans interneuron ALA is (also) a high-threshold mechanosensor","volume":"14","author":"Sanders","year":"2013","journal-title":"BMC Neurosci."},{"issue":"19","key":"10.1016\/j.jes.2023.09.032_bib0056","doi-asserted-by":"crossref","first-page":"952","DOI":"10.6026\/97320630009952","article-title":"Insilico characterization and homology modeling of arabitol dehydrogenase (ArDH) from Candida albican","volume":"9","author":"Sarwar","year":"2013","journal-title":"Bioinformation"},{"issue":"12","key":"10.1016\/j.jes.2023.09.032_bib0057","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s13361-016-1469-y","volume":"27","author":"Schrimpe-Rutledge","year":"2016","journal-title":"J. Am. Soc. Mass. Spectrom."},{"key":"10.1016\/j.jes.2023.09.032_bib0058","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.fgb.2018.03.005","article-title":"Galactose metabolism and toxicity in Ustilago maydis","volume":"114","author":"Schuler","year":"2018","journal-title":"Fungal Genet. Biol."},{"issue":"3","key":"10.1016\/j.jes.2023.09.032_bib0059","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pbi.2004.03.004","article-title":"Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside","volume":"7","author":"Seifert","year":"2004","journal-title":"Curr. Opin. Plant. Biol."},{"key":"10.1016\/j.jes.2023.09.032_bib0060","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1937-6448(08)01003-4","article-title":"Galactose metabolism in yeast-structure and regulation of the leloir pathway enzymes and the genes encoding them","volume":"269","author":"Sellick","year":"2008","journal-title":"Int. Rev. Cell. Mol. Biol."},{"issue":"3","key":"10.1016\/j.jes.2023.09.032_bib0061","first-page":"495","article-title":"Toxic effects and oxidative damage of 4-nitrophenol on rat liver","volume":"9","author":"Song","year":"2014","journal-title":"J. Ecotoxicol."},{"issue":"3","key":"10.1016\/j.jes.2023.09.032_bib0062","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/brv.12140","article-title":"The return of metabolism: biochemistry and physiology of the pentose phosphate pathway","volume":"90","author":"Stincone","year":"2015","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"issue":"9","key":"10.1016\/j.jes.2023.09.032_bib0063","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1002\/etc.1931","article-title":"p-Nitrophenol toxicity to and its removal by three select soil isolates of microalgae: the role of antioxidants","volume":"31","author":"Subashchandrabose","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"issue":"13","key":"10.1016\/j.jes.2023.09.032_bib0064","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1182\/blood.2019001034","article-title":"Amino acid metabolism in hematologic malignancies and the era of targeted therapy","volume":"134","author":"Tabe","year":"2019","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.jes.2023.09.032_bib0065","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1248\/bpb.27.835","article-title":"Estrogenic and anti-androgenic activity of nitrophenols in diesel exhaust particles (DEP)","volume":"27","author":"Taneda","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jes.2023.09.032_bib0066","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.envpol.2016.05.040","article-title":"Effects of 4-nitrophenol on expression of the ER-\u03b1 and AhR signaling pathway-associated genes in the small intestine of rats","volume":"216","author":"Tang","year":"2016","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.jes.2023.09.032_bib0067","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.neuint.2010.06.001","article-title":"Beta-alanine as a small molecule neurotransmitter","volume":"57","author":"Tiedje","year":"2010","journal-title":"Neurochem. Int."},{"issue":"2","key":"10.1016\/j.jes.2023.09.032_bib0068","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/neu.10245","article-title":"Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans","volume":"56","author":"Tsalik","year":"2003","journal-title":"J. Neurobiol."},{"issue":"6","key":"10.1016\/j.jes.2023.09.032_bib0069","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nmeth.3393","article-title":"MS-DIAL: data-independent MS\/MS deconvolution for comprehensive metabolome analysis","volume":"12","author":"Tsugawa","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jes.2023.09.032_bib0070","unstructured":"US EPA (U.S. Environmental Protection Agency), 1976. Water Quality Criteria. http:\/\/water.epa.gov\/scitech\/swguidance\/standards\/criteria\/current\/upload\/2009_01_13_criteria_redbook.pdf."},{"issue":"4","key":"10.1016\/j.jes.2023.09.032_bib0071","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00239-002-2340-2","article-title":"Molecular evolution of the lysine biosynthetic pathways","volume":"55","author":"Velasco","year":"2002","journal-title":"J. Mol. Evol."},{"issue":"42","key":"10.1016\/j.jes.2023.09.032_bib0072","doi-asserted-by":"crossref","first-page":"17504","DOI":"10.1073\/pnas.1108673108","article-title":"Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin","volume":"108","author":"Vidal-Gadea","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"5","key":"10.1016\/j.jes.2023.09.032_bib0073","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11274-021-03042-1","article-title":"Advances in biotechnological production of \u03b2-alanine","volume":"37","author":"Wang","year":"2021","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.jes.2023.09.032_bib0074","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.769196","article-title":"The role of succinic acid metabolism in ovarian cancer","volume":"11","author":"Xia","year":"2021","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.jes.2023.09.032_bib0075","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2131\/jts.41.371","article-title":"Potential protective effect of arginine against 4-nitrophenol-induced ovarian damage in rats","volume":"41","author":"Xu","year":"2016","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.jes.2023.09.032_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111170","article-title":"Non-targeted metabolomic profiling of atrazine in Caenorhabditis elegans using UHPLC-QE Orbitrap\/MS","volume":"206","author":"Yin","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jes.2023.09.032_bib0077","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ecoenv.2018.07.066","article-title":"Di (2-ethylhexyl) phthalate-induced reproductive toxicity involved in dna damage-dependent oocyte apoptosis and oxidative stress in Caenorhabditis elegans","volume":"163","author":"Yin","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jes.2023.09.032_bib0078","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envpol.2017.04.088","article-title":"4-Nitrophenol (PNP) inhibits the expression of estrogen receptor \u03b2 and disrupts steroidogenesis during the ovarian development in female rats","volume":"229","author":"Zhang","year":"2017","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.jes.2023.09.032_bib0079","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.toxlet.2013.09.011","article-title":"4-Nitrophenol induces Leydig cells hyperplasia, which may contribute to the differential modulation of the androgen receptor and estrogen receptor-\u03b1 and -\u03b2 expression in male rat testes","volume":"223","author":"Zhang","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jes.2023.09.032_bib0080","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.toxrep.2015.04.007","article-title":"Supplemental dietary phytosterin protects against 4-nitrophenol-induced oxidative stress and apoptosis in rat testes","volume":"2","author":"Zhang","year":"2015","journal-title":"Toxicol. Rep."}],"container-title":["Journal of Environmental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074223004291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074223004291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T22:55:36Z","timestamp":1724453736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1001074223004291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":80,"alternative-id":["S1001074223004291"],"URL":"https:\/\/doi.org\/10.1016\/j.jes.2023.09.032","relation":{},"ISSN":["1001-0742"],"issn-type":[{"value":"1001-0742","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"4-Nitrophenol at environmentally relevant concentrations mediates reproductive toxicity in Caenorhabditis elegans via metabolic disorders-induced estrogen signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jes.2023.09.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}