{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T07:29:54Z","timestamp":1785742194676,"version":"3.56.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52270119"],"award-info":[{"award-number":["52270119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Sciences"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jes.2024.02.009","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T07:56:42Z","timestamp":1708156602000},"page":"385-394","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Synergistic toxic effects of high-strength ammonia and ZnO nanoparticles on biological nitrogen removal systems and role of exogenous C10-HSL regulation"],"prefix":"10.1016","volume":"150","author":[{"given":"Runyu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7692-1071","authenticated-orcid":false,"given":"Ran","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jes.2024.02.009_bib0001","first-page":"835","article-title":"Inhibition of nitrification by ammonia and nitrous-acid","volume":"48","author":"Anthonisen","year":"1976","journal-title":"J. Water Pollut. Control Fed."},{"key":"10.1016\/j.jes.2024.02.009_bib0002","series-title":"Standard Methods for the Examination of Water and Wastewater","author":"Baird","year":"2017"},{"issue":"4","key":"10.1016\/j.jes.2024.02.009_bib0003","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1021\/nl052326h","article-title":"Toxicological impact studies based on Escherichia coli bacteria in ultrafine ZnO nanoparticles colloidal medium","volume":"6","author":"Brayner","year":"2006","journal-title":"Nano Lett."},{"key":"10.1016\/j.jes.2024.02.009_bib0004","first-page":"S212","article-title":"Oxidative stress in microbes after exposure to iron nanoparticles: analysis of aldehydes as oxidative damage products of lipids and proteins","volume":"314","author":"Cajthaml","year":"2019","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.jes.2024.02.009_bib0005","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1021\/cr100311q","article-title":"Chemical challenges to bacterial AHL signaling in the environment","volume":"111","author":"Decho","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jes.2024.02.009_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134061","article-title":"Undesirable effects of exogenous N-acyl homoserine lactones on moving bed biofilm reactor treating medium-strength synthetic wastewater","volume":"696","author":"Fan","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"9","key":"10.1016\/j.jes.2024.02.009_bib0007","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1039\/D2EN00250G","article-title":"Exogenous N-acyl-homoserine lactone-based quorum sensing regulation benefits Nitrosomonas europaea resistance to CeO2 nanoparticle acute stress","volume":"9","author":"Gao","year":"2022","journal-title":"Environ. Sci-Nano"},{"key":"10.1016\/j.jes.2024.02.009_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156911","article-title":"Pluripotency of endogenous AHL-mediated quorum sensing in adaptation and recovery of biological nitrogen removal system under ZnO nanoparticle long-term exposure","volume":"842","author":"Gao","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jes.2024.02.009_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2022.128567","article-title":"New insights into exogenous N-acyl-homoserine lactone manipulation in biological nitrogen removal system against ZnO nanoparticle shock","volume":"370","author":"Gao","year":"2023","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jes.2024.02.009_bib0010","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jes.2018.06.022","article-title":"Long- and short-chain AHLs affect AOA and AOB microbial community composition and ammonia oxidation rate in activated sludge","volume":"78","author":"Gao","year":"2019","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.jes.2024.02.009_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2019.124001","article-title":"Two birds with one stone: Simultaneous improvement of biofilm formation and nitrogen transformation in MBBR treating high ammonia nitrogen wastewater via exogenous N-acyl homoserine lactones","volume":"386","author":"Huang","year":"2020","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jes.2024.02.009_bib0012","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.chemosphere.2016.05.032","article-title":"Acyl-homoserine lactone-based quorum sensing and quorum quenching hold promise to determine the performance of biological wastewater treatments: An overview","volume":"157","author":"Huang","year":"2016","journal-title":"Chemosphere"},{"issue":"9","key":"10.1016\/j.jes.2024.02.009_bib0013","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.chemosphere.2012.04.059","article-title":"Roles of ATP-dependent N-acylhomoserine lactones (AHLs) and extracellular polymeric substances (EPSs) in aerobic granulation","volume":"88","author":"Jiang","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2024.02.009_bib0014","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.biteb.2019.02.014","article-title":"Effect of free ammonia inhibition on process recovery of partial nitritation in a membrane bioreactor","volume":"6","author":"Jiang","year":"2019","journal-title":"Bioresour. Technol. Rep."},{"key":"10.1016\/j.jes.2024.02.009_bib0015","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jenvman.2018.07.084","article-title":"Factors impacting the interactions of engineered nanoparticles with bacterial cells and biofilms: Mechanistic insights and state of knowledge","volume":"225","author":"Joo","year":"2018","journal-title":"J. Environ. Manage."},{"issue":"3","key":"10.1016\/j.jes.2024.02.009_bib0016","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.etap.2015.10.001","article-title":"Effects of zinc oxide nanoparticles on bioaccumulation and oxidative stress in different organs of tilapia (Oreochromis niloticus)","volume":"40","author":"Kaya","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jes.2024.02.009_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.121388","article-title":"Differential responses of encoding-amoA nitrifiers and nir denitrifiers in activated sludge to anatase and rutile TiO2 nanoparticles: What is active functional guild in rate limiting step of nitrogen cycle?","volume":"384","author":"Li","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jes.2024.02.009_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.jwpe.2019.100952","article-title":"Metagenomic analysis of quorum sensing systems in activated sludge and membrane biofilm of a full-scale membrane bioreactor","volume":"32","author":"Li","year":"2019","journal-title":"J. Water Process Eng."},{"key":"10.1016\/j.jes.2024.02.009_bib0019","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.scitotenv.2019.02.261","article-title":"Specific quorum sensing molecules of ammonia oxidizers and their role during ammonium metabolism in Zhalong wetland, China","volume":"666","author":"Liu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jes.2024.02.009_bib0020","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.envint.2018.11.039","article-title":"The roles of free ammonia (FA) in biological wastewater treatment processes: A review","volume":"123","author":"Liu","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.jes.2024.02.009_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.133809","article-title":"Long-term exogenous addition of synthetic acyl homoserine lactone enhanced the anaerobic granulation process","volume":"696","author":"Ma","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jes.2024.02.009_bib0022","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.chemosphere.2019.01.064","article-title":"Roles of quorum sensing in biological wastewater treatment: A critical review","volume":"221","author":"Maddela","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2024.02.009_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2021.126476","article-title":"Bacterial biofilm and extracellular polymeric substances in the moving bed biofilm reactor for wastewater treatment: A review","volume":"345","author":"Mahto","year":"2022","journal-title":"Bioresour. Technol."},{"issue":"3","key":"10.1016\/j.jes.2024.02.009_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.jece.2022.107387","article-title":"Nitrogen removal from wastewater: A comprehensive review of biological nitrogen removal processes, critical operation parameters and bioreactor design","volume":"10","author":"Mishra","year":"2022","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.jes.2024.02.009_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105485","article-title":"Towards a better understanding of Pseudomonas putida biofilm formation in the presence of ZnO nanoparticles (NPs): Role of NP concentration","volume":"137","author":"Ouyang","year":"2020","journal-title":"Environ. Int."},{"issue":"6","key":"10.1016\/j.jes.2024.02.009_bib0026","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.procbio.2009.02.002","article-title":"Modeling kinetics of ammonium oxidation and nitrite oxidation under simultaneous inhibition by free ammonia and free nitrous acid","volume":"44","author":"Park","year":"2009","journal-title":"Process Biochem."},{"issue":"1","key":"10.1016\/j.jes.2024.02.009_bib0027","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/nano7010021","article-title":"Behavior and potential impacts of metal-based engineered nanoparticles in aquatic environments","volume":"7","author":"Peng","year":"2017","journal-title":"Nanomaterials"},{"key":"10.1016\/j.jes.2024.02.009_bib0028","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.scitotenv.2017.12.248","article-title":"Exogenous N-acyl homoserine lactones facilitate microbial adhesion of high ammonia nitrogen wastewater on biocarrier surfaces","volume":"624","author":"Peng","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jes.2024.02.009_bib0029","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.watres.2016.10.028","article-title":"Effects of the residual ammonium concentration on NOB repression during partial nitritation with granular sludge","volume":"106","author":"Poot","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.jes.2024.02.009_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.132097","article-title":"A new filamentous bulking control strategy: The role of N-acyl homoserine lactone (AHL)-mediated quorum sensing in filamentous bacteria proliferation within activated sludge","volume":"428","author":"Shi","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jes.2024.02.009_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2022.127760","article-title":"Investigating the long and short-term effect of free ammonia and free nitrous acid levels on nitritation biomass of a sequencing batch reactor treating thermally pre-treated sludge reject water","volume":"362","author":"Statiris","year":"2022","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jes.2024.02.009_bib0032","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cej.2018.03.047","article-title":"Metagenomics-based interpretation of AHLs-mediated quorum sensing in Anammox biofilm reactors for low-strength wastewater treatment","volume":"344","author":"Sun","year":"2018","journal-title":"Chem. Eng. J."},{"issue":"11","key":"10.1016\/j.jes.2024.02.009_bib0033","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.tibtech.2018.06.009","article-title":"How microbial aggregates protect against nanoparticle toxicity","volume":"36","author":"Tang","year":"2018","journal-title":"Trends Biotechnol."},{"issue":"5","key":"10.1016\/j.jes.2024.02.009_bib0034","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/bit.21018","article-title":"Effect of free ammonia and free nitrous acid concentration on the anabolic and catabolic processes of an enriched Nitrosomonas culture","volume":"95","author":"Vadivelu","year":"2006","journal-title":"Biotechnol. Bioeng."},{"issue":"8","key":"10.1016\/j.jes.2024.02.009_bib0035","first-page":"1163","article-title":"Bioaccumulation of silver nanoparticles in model wastewater biofilms","volume":"4","author":"Walden","year":"2018","journal-title":"Environ. Sci.-Wat. Res."},{"key":"10.1016\/j.jes.2024.02.009_bib0036","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.scitotenv.2019.05.249","article-title":"Quorum sensing signaling distribution during the development of full-scale municipal wastewater treatment biofilms","volume":"685","author":"Wang","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jes.2024.02.009_bib0037","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.watres.2018.01.031","article-title":"Responses of wastewater biofilms to chronic CeO2 nanoparticles exposure: Structural, physicochemical and microbial properties and potential mechanism","volume":"133","author":"Wang","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.jes.2024.02.009_bib0038","article-title":"Recovery behavior of high ammonium inhibition in a sequencing batch biofilm reactor","volume":"9","author":"Wang","year":"2020","journal-title":"Bioresour. Technol. Rep."},{"issue":"17","key":"10.1016\/j.jes.2024.02.009_bib0039","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.1021\/acs.est.7b02776","article-title":"Achieving stable mainstream nitrogen removal via the nitrite pathway by sludge treatment using free ammonia","volume":"51","author":"Wang","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jes.2024.02.009_bib0040","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.biortech.2016.05.099","article-title":"Long-term effects of ZnO nanoparticles on nitrogen and phosphorus removal, microbial activity and microbial community of a sequencing batch reactor","volume":"216","author":"Wang","year":"2016","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jes.2024.02.009_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.jwpe.2021.102002","article-title":"Impacts of influent COD\/N ratio on floc physicochemical characteristics and microbial community of nitrifying sludge under high-strength ammonia conditions","volume":"41","author":"Wang","year":"2021","journal-title":"J. Water Process Eng."},{"key":"10.1016\/j.jes.2024.02.009_bib0042","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.biortech.2016.01.067","article-title":"Extracellular polymeric substances, microbial activity and microbial community of biofilm and suspended sludge at different divalent cadmium concentrations","volume":"205","author":"Wang","year":"2016","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jes.2024.02.009_bib0043","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.chemosphere.2018.09.093","article-title":"Adsorption mechanism of ZnO and CuO nanoparticles on two typical sludge EPS: Effect of nanoparticle diameter and fractional EPS polarity on binding","volume":"214","author":"Wei","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2024.02.009_bib0044","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.watres.2018.09.043","article-title":"Adaption and recovery of Nitrosomonas europaea to chronic TiO2 nanoparticle exposure","volume":"147","author":"Wu","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.jes.2024.02.009_bib0045","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jhazmat.2017.09.022","article-title":"Comparison of the impacts of zinc ions and zinc nanoparticles on nitrifying microbial community","volume":"343","author":"Wu","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jes.2024.02.009_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2022.131121","article-title":"A comprehensive review on the effects of engineered nanoparticles on microalgal treatment of pollutants from wastewater","volume":"344","author":"Xiong","year":"2022","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.jes.2024.02.009_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.135916","article-title":"Responses of nitrogen transformation processes and N2O emissions in biological nitrogen removal system to short-term ZnO nanoparticle stress","volume":"705","author":"Ye","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jes.2024.02.009_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110256","article-title":"Effects of ZnO nanoparticles on flocculation and sedimentation of activated sludge in wastewater treatment process","volume":"192","author":"Ye","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.jes.2024.02.009_bib0049","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.biortech.2015.07.006","article-title":"Effects of CeO2 nanoparticles on production and physicochemical characteristics of extracellular polymeric substances in biofilms in sequencing batch biofilm reactor","volume":"194","author":"You","year":"2015","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.jes.2024.02.009_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2019.115193","article-title":"A sustainable strategy for effective regulation of aerobic granulation: Augmentation of the signaling molecule content by cultivating AHL-producing strains","volume":"169","author":"Zhang","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.jes.2024.02.009_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.ese.2020.100026","article-title":"Quorum sensing systems regulate heterotrophic nitrification-aerobic denitrification by changing the activity of nitrogen-cycling enzymes","volume":"2","author":"Zhu","year":"2020","journal-title":"Environ. Sci. Ecotechnol."}],"container-title":["Journal of Environmental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074224000809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074224000809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:58:56Z","timestamp":1759611536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1001074224000809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":51,"alternative-id":["S1001074224000809"],"URL":"https:\/\/doi.org\/10.1016\/j.jes.2024.02.009","relation":{},"ISSN":["1001-0742"],"issn-type":[{"value":"1001-0742","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic toxic effects of high-strength ammonia and ZnO nanoparticles on biological nitrogen removal systems and role of exogenous C10-HSL regulation","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jes.2024.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}