{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:32:56Z","timestamp":1777426376143,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Sciences"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jes.2024.03.029","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T20:55:16Z","timestamp":1711140916000},"page":"616-626","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Ferulic acid alleviates long-term avermectin-induced damage to the spleen of carp and restores its inflammatory response and oxidative balance"],"prefix":"10.1016","volume":"151","author":[{"given":"Hanyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenye","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzhuang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoshi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimiao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jilei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9379-0282","authenticated-orcid":false,"given":"Zibo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jes.2024.03.029_bib0001","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/71938","article-title":"Transgenic zebrafish for detecting mutations caused by compounds in aquatic environments","volume":"18","author":"Amanuma","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jes.2024.03.029_bib0002","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.chemosphere.2016.03.113","article-title":"Eco-toxicological effects of the avermectin family with a focus on abamectin and ivermectin","volume":"154","author":"Bai","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2024.03.029_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.135059","article-title":"Comprehensive fitness evaluation of common carp (Cyprinus carpio L.) after twelve weeks of atrazine exposure","volume":"718","author":"Blahova","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jes.2024.03.029_bib0004","first-page":"1","article-title":"Veterinary medicines in the environment","volume":"180","author":"Boxall","year":"2004","journal-title":"Rev. Environ. Contam. Toxicol."},{"issue":"5","key":"10.1016\/j.jes.2024.03.029_bib0005","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.immuni.2013.10.010","article-title":"The spleen in local and systemic regulation of immunity","volume":"39","author":"Bronte","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jes.2024.03.029_bib0006","first-page":"305","article-title":"Ferulic acid regulates the Nrf2\/heme oxygenase-1 system and counteracts trimethyltin-induced neuronal damage in the human neuroblastoma cell line SH-SY5Y","volume":"6","author":"Catino","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jes.2024.03.029_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113846","article-title":"Impact of chronic exposure to trichlorfon on intestinal barrier, oxidative stress, inflammatory response and intestinal microbiome in common carp (Cyprinus carpio L.)","volume":"259","author":"Chang","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jes.2024.03.029_bib0008","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fphar.2019.00027","article-title":"Ferulic acid protects hyperglycemia-induced kidney damage by regulating oxidative insult, inflammation and autophagy","volume":"10","author":"Chowdhury","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jes.2024.03.029_bib0009","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.scitotenv.2018.08.034","article-title":"Acesulfame potassium: its ecotoxicity measured through oxidative stress biomarkers in common carp (Cyprinus carpio)","volume":"647","author":"Cruz-Rojas","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"12","key":"10.1016\/j.jes.2024.03.029_bib0010","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1080\/09553002.2016.1230241","article-title":"Ferulic acid (FA) abrogates ionizing radiation-induced oxidative damage in murine spleen","volume":"92","author":"Das","year":"2016","journal-title":"Int. J. Radiat. Biol."},{"issue":"3","key":"10.1016\/j.jes.2024.03.029_bib0011","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.etap.2015.04.008","article-title":"Toxic effects of sub-chronic exposure of male albino rats to emamectin benzoate and possible ameliorative role of Foeniculum vulgare essential oil","volume":"39","author":"El-Sheikh el","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.jes.2024.03.029_bib0012","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3390\/life13020388","article-title":"Ferulic acid treats gastric ulcer via suppressing oxidative stress and inflammation","volume":"13","author":"Ermis","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.jes.2024.03.029_bib0013","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jes.2024.03.029_bib0014","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.fct.2018.05.029","article-title":"Ameliorative role of ferulic acid against diabetes associated oxidative stress induced spleen damage","volume":"118","author":"Ghosh","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.jes.2024.03.029_bib0015","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s12016-019-08748-7","article-title":"Innate B cells: the archetype of protective immune cells","volume":"58","author":"Grasseau","year":"2020","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jes.2024.03.029_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2020.105528","article-title":"Abamectin at environmentally-realistic concentrations cause oxidative stress and genotoxic damage in juvenile fish (Schizothorax prenanti)","volume":"225","author":"Hong","year":"2020","journal-title":"Aquat. Toxicol."},{"issue":"9","key":"10.1016\/j.jes.2024.03.029_bib0017","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.1074\/jbc.M114.603738","article-title":"Activation of the UPR protects against cigarette smoke-induced RPE apoptosis through up-regulation of Nrf2","volume":"290","author":"Huang","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.jes.2024.03.029_bib0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0225171","article-title":"Avermectin induces the oxidative stress, genotoxicity, and immunological responses in the Chinese Mitten Crab, Eriocheir sinensis","volume":"14","author":"Huang","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jes.2024.03.029_bib0019","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.chemosphere.2019.04.026","article-title":"Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway","volume":"227","author":"Jia","year":"2019","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.jes.2024.03.029_bib0020","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1084\/jem.129.6.1275","article-title":"The enhancement of bacterial phagocytosis by serum. The role of complement components and two cofactors","volume":"129","author":"Johnston","year":"1969","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.jes.2024.03.029_bib0021","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/135475099230778","article-title":"Xenobiotic-induced apoptosis: significance and potential application as a general biomarker of response","volume":"4","author":"Leonard","year":"1999","journal-title":"Biomarkers"},{"key":"10.1016\/j.jes.2024.03.029_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119921","article-title":"Ferulic acid: a review of its pharmacology, pharmacokinetics and derivatives","volume":"284","author":"Li","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.jes.2024.03.029_bib0023","article-title":"Avermectin induces toxic effects in insect nontarget cells involves DNA damage and its associated programmed cell death","volume":"249","author":"Li","year":"2021","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.jes.2024.03.029_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108883","article-title":"Baicalin suppressed necroptosis and inflammation against chlorpyrifos toxicity; involving in ER stress and oxidative stress in carp gills","volume":"139","author":"Li","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jes.2024.03.029_bib0025","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ecoenv.2018.10.110","article-title":"Hepatotoxicity and immunotoxicity of MC-LR on silver carp","volume":"169","author":"Li","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jes.2024.03.029_bib0026","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.fsi.2018.06.050","article-title":"Long-term crowding stress causes compromised nonspecific immunity and increases apoptosis of spleen in grass carp (Ctenopharyngodon idella)","volume":"80","author":"Lin","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jes.2024.03.029_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109249","article-title":"Cancer and ER stress: mutual crosstalk between autophagy, oxidative stress and inflammatory response","volume":"118","author":"Lin","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jes.2024.03.029_bib0028","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cbi.2013.12.015","article-title":"Effects of avermectin on immune function and oxidative stress in the pigeon spleen","volume":"210","author":"Liu","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jes.2024.03.029_bib0029","article-title":"Effects of dietary ferulic acid on the intestinal microbiota and the associated changes on the growth performance, serum cytokine profile, and intestinal morphology in ducks","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jes.2024.03.029_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115339","article-title":"Ferulic acid attenuated difenoconazole-induced immunotoxicity in carp by inhibiting TRAF\/TAK1\/NF-\u03baB, Nrf2 and p53 pathways","volume":"262","author":"Ma","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"8","key":"10.1016\/j.jes.2024.03.029_bib0031","doi-asserted-by":"crossref","first-page":"7910","DOI":"10.1007\/s11356-019-07532-6","article-title":"Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2\/HO-1 signaling in methotrexate-induced rats","volume":"27","author":"Mahmoud","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"2\u20133","key":"10.1016\/j.jes.2024.03.029_bib0032","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/07388550490491467","article-title":"Ferulic acid: an antioxidant found naturally in plant cell walls and feruloyl esterases involved in its release and their applications","volume":"24","author":"Mathew","year":"2004","journal-title":"Crit. Rev. Biotechnol."},{"issue":"8","key":"10.1016\/j.jes.2024.03.029_bib0033","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/S0002-9343(00)00412-5","article-title":"The evolution of free radicals and oxidative stress","volume":"108","author":"McCord","year":"2000","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jes.2024.03.029_bib0034","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.fsi.2019.02.061","article-title":"Complement component 3 (C3): an important role in grass carp (Ctenopharyngodon idella) experimentally exposed to Aeromonas hydrophila","volume":"88","author":"Meng","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jes.2024.03.029_bib0035","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ecoenv.2018.10.040","article-title":"Effects of maduramicin on adult zebrafish (Danio rerio): acute toxicity, tissue damage and oxidative stress","volume":"168","author":"Ni","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jes.2024.03.029_bib0036","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.chemosphere.2015.10.004","article-title":"Impact of runoff water from an experimental agricultural field applied with Vertimec\u00ae 18EC (abamectin) on the survival, growth and gill morphology of zebrafish juveniles","volume":"144","author":"Novelli","year":"2016","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.jes.2024.03.029_bib0037","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.chemosphere.2011.08.047","article-title":"Lethal effects of abamectin on the aquatic organisms Daphnia similis, Chironomus xanthus and Danio rerio","volume":"86","author":"Novelli","year":"2012","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.jes.2024.03.029_bib0038","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ecoenv.2011.08.016","article-title":"Field and laboratory studies to assess the effects of Vertimec(\u00ae) 18EC on Daphnia similis","volume":"75","author":"Novelli","year":"2012","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"11","key":"10.1016\/j.jes.2024.03.029_bib0039","doi-asserted-by":"crossref","first-page":"15896","DOI":"10.1007\/s11356-021-16965-x","article-title":"Assessment of reproductive toxicity of carbofuran and copper sulfate in male Nile tilapia (Oreochromis niloticus)","volume":"29","author":"Oda","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.jes.2024.03.029_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.marenvres.2023.106145","article-title":"Biological responses of stellate sturgeon fingerlings (Acipenser stellatus) immersed in HSP inducer to salinity changes","volume":"191","author":"Vahdatiraad","year":"2023","journal-title":"Mar. Environ. Res."},{"issue":"10","key":"10.1016\/j.jes.2024.03.029_bib0041","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1080\/15563650.2022.2104729","article-title":"Intentional avermectin pesticide ingestion: a retrospective multicenter study","volume":"60","author":"Wu","year":"2022","journal-title":"Clin. Toxicol. (Phila)"},{"key":"10.1016\/j.jes.2024.03.029_bib0042","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.rvsc.2019.08.018","article-title":"Ferulic acid inhibits bovine endometrial epithelial cells against LPS-induced inflammation via suppressing NK-\u03baB and MAPK pathway","volume":"126","author":"Yin","year":"2019","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.jes.2024.03.029_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113961","article-title":"Avermectin induces carp neurotoxicity by mediating blood-brain barrier dysfunction, oxidative stress, inflammation, and apoptosis through PI3K\/Akt and NF-\u03baB pathways","volume":"243","author":"Zhang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jes.2024.03.029_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2022.105190","article-title":"Non-target toxic effects of avermectin on carp spleen involve oxidative stress, inflammation, and apoptosis","volume":"187","author":"Zhang","year":"2022","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.jes.2024.03.029_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143054","article-title":"Environmentally relevant concentration of cypermethrin or\/and sulfamethoxazole induce neurotoxicity of grass carp: involvement of blood-brain barrier, oxidative stress and apoptosis","volume":"762","author":"Zhao","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jes.2024.03.029_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129268","article-title":"The multiple biotoxicity integrated study in grass carp (Ctenopharyngodon idella) caused by Ochratoxin A: oxidative damage, apoptosis and immunosuppression","volume":"436","author":"Zhao","year":"2022","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.jes.2024.03.029_bib0047","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10695-015-0119-9","article-title":"Isolation, characterization, and tissue-specific expression of GABA A receptor \u03b11 subunit gene of Carassius auratus gibelio after avermectin treatment","volume":"42","author":"Zhao","year":"2016","journal-title":"Fish Physiol. Biochem."}],"container-title":["Journal of Environmental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074224001451?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074224001451?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T13:13:57Z","timestamp":1730380437000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1001074224001451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":47,"alternative-id":["S1001074224001451"],"URL":"https:\/\/doi.org\/10.1016\/j.jes.2024.03.029","relation":{},"ISSN":["1001-0742"],"issn-type":[{"value":"1001-0742","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferulic acid alleviates long-term avermectin-induced damage to the spleen of carp and restores its inflammatory response and oxidative balance","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jes.2024.03.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}