{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:39:52Z","timestamp":1780346392960,"version":"3.54.1"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012554","name":"Hubei Provincial Department of Education","doi-asserted-by":"publisher","award":["Q20212503"],"award-info":[{"award-number":["Q20212503"]}],"id":[{"id":"10.13039\/100012554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2021CFB243"],"award-info":[{"award-number":["2021CFB243"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD2400900"],"award-info":[{"award-number":["2023YFD2400900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171619"],"award-info":[{"award-number":["32171619"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32201388"],"award-info":[{"award-number":["32201388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Sciences"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jes.2024.11.013","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T04:16:02Z","timestamp":1732162562000},"page":"314-329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Probiotic Lactobacillus rhamnosus alleviates microcystin-LR induced visual system defects and dysfunction in zebrafish by modulating apoptosis, retinal inflammation, and phototransduction"],"prefix":"10.1016","volume":"157","author":[{"given":"Ning","family":"Luan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien-Chieh","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jes.2024.11.013_bib0001","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12876-018-0831-x","article-title":"A practical guide for probiotics applied to the case of antibiotic-associated diarrhea in The Netherlands","volume":"18","author":"Agamennone","year":"2018","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.jes.2024.11.013_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.hal.2023.102429","article-title":"Cyanobacterial bloom monitoring and assessment in Latin America","volume":"125","author":"Aguilera","year":"2023","journal-title":"Harmful Algae"},{"issue":"2","key":"10.1016\/j.jes.2024.11.013_bib0003","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The molecular basis of retinal ganglion cell death in glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog. Retinal Eye Res."},{"key":"10.1016\/j.jes.2024.11.013_bib0004","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3389\/fnins.2017.00742","article-title":"Neuronal migration and lamination in the vertebrate retina","volume":"11","author":"Amini","year":"2018","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/j.jes.2024.11.013_bib0005","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ntt.2006.02.001","article-title":"Teratogenic effects of ethanol exposure on zebrafish visual system development","volume":"28","author":"Arenzana","year":"2006","journal-title":"Neurotoxicol. Teratol."},{"issue":"1","key":"10.1016\/j.jes.2024.11.013_bib0006","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.crvi.2014.10.005","article-title":"Cadmium effects on the retina of adult Danio rerio","volume":"338","author":"Avallone","year":"2015","journal-title":"C. R. Biol."},{"key":"10.1016\/j.jes.2024.11.013_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126172","article-title":"Sex-dependent and organ-specific toxicity of silver nanoparticles in livers and intestines of adult zebrafish","volume":"249","author":"Bao","year":"2020","journal-title":"Chemosphere"},{"issue":"7","key":"10.1016\/j.jes.2024.11.013_bib0008","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ni.2604","article-title":"Compartmentalized and systemic control of tissue immunity by commensals","volume":"14","author":"Belkaid","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jes.2024.11.013_bib0009","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.envpol.2016.06.055","article-title":"High diversity of microcystins in a Microcystis bloom from an Algerian lake","volume":"216","author":"Bouhaddada","year":"2016","journal-title":"Environ. Pollut."},{"issue":"11","key":"10.1016\/j.jes.2024.11.013_bib0010","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1128\/aem.62.11.4086-4094.1996","article-title":"Enzymatic pathway for the bacterial degradation of the cyanobacterial cyclic peptide toxin microcystin LR","volume":"62","author":"Bourne","year":"1996","journal-title":"Appl. Environ. Microbiol."},{"issue":"6","key":"10.1016\/j.jes.2024.11.013_bib0011","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.preteyeres.2009.07.001","article-title":"Cellular signaling and factors involved in M\u00fcller cell gliosis: neuroprotective and detrimental effects","volume":"28","author":"Bringmann","year":"2009","journal-title":"Prog. Retin. Eye Res."},{"issue":"19","key":"10.1016\/j.jes.2024.11.013_bib0012","doi-asserted-by":"crossref","first-page":"7111","DOI":"10.1523\/JNEUROSCI.0347-11.2011","article-title":"Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice","volume":"31","author":"Brooks","year":"2011","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.jes.2024.11.013_bib0013","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00204-016-1913-6","article-title":"Cyanotoxins: producing organisms, occurrence, toxicity, mechanism of action and human health toxicological risk evaluation","volume":"91","author":"Buratti","year":"2017","journal-title":"Arch. Toxicol."},{"issue":"12","key":"10.1016\/j.jes.2024.11.013_bib0014","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.7150\/ijms.20962","article-title":"GLP-1 treatment improves diabetic retinopathy by alleviating autophagy through GLP-1R-ERK1\/2-HDAC6 signaling pathway","volume":"14","author":"Cai","year":"2017","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.jes.2024.11.013_bib0015","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.aquatox.2016.11.020","article-title":"Alteration of development and gene expression induced by in ovo-nanoinjection of 3-hydroxybenzo[c]phenanthrene into Japanese medaka (Oryzias latipes) embryos","volume":"182","author":"Chen","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.jes.2024.11.013_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2020.105542","article-title":"Visual system: an understudied target of aquatic toxicology","volume":"225","author":"Chen","year":"2020","journal-title":"Aquat. Toxicol."},{"issue":"6","key":"10.1016\/j.jes.2024.11.013_bib0017","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/etc.2168","article-title":"Acute exposure to DE-71 causes alterations in visual behavior in zebrafish larvae","volume":"32","author":"Chen","year":"2013","journal-title":"Environ. Toxicol. Chem."},{"issue":"12","key":"10.1016\/j.jes.2024.11.013_bib0018","doi-asserted-by":"crossref","first-page":"7494","DOI":"10.1021\/acs.est.0c02345","article-title":"Probiotic modulation of lipid metabolism disorders caused by perfluorobutanesulfonate pollution in zebrafish","volume":"54","author":"Chen","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jes.2024.11.013_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquatox.2018.05.018","article-title":"Accumulation of perfluorobutane sulfonate (PFBS) and impairment of visual function in the eyes of marine medaka after a life-cycle exposure","volume":"201","author":"Chen","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.jes.2024.11.013_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jes.2022.03.043","article-title":"Risk assessment and identification of factors influencing the historical concentrations of microcystin in Lake Taihu, China","volume":"127","author":"Cheng","year":"2023","journal-title":"J. Environ. Sci."},{"issue":"2","key":"10.1016\/j.jes.2024.11.013_bib0022","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1474-9726.2010.00660.x","article-title":"Age-related alterations in the dynamic behavior of microglia","volume":"10","author":"Damani","year":"2010","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.jes.2024.11.013_bib0023","doi-asserted-by":"crossref","first-page":"33726","DOI":"10.1038\/srep33726","article-title":"Lactobacillus plantarum attenuates anxiety-related behavior and protects against stress-induced dysbiosis in adult zebrafish","volume":"6","author":"Davis","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.jes.2024.11.013_bib0024","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/raq.12272","article-title":"Probiotic application for sustainable aquaculture","volume":"11","author":"Dawood","year":"2018","journal-title":"Rev. Aquacult."},{"issue":"1","key":"10.1016\/j.jes.2024.11.013_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vascn.2013.09.002","article-title":"Early safety assessment of human oculotoxic drugs using the zebrafish visualmotor response","volume":"69","author":"Deeti","year":"2014","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"7","key":"10.1016\/j.jes.2024.11.013_bib0026","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.3390\/nu13072176","article-title":"Probiotics in pediatrics. A review and practical guide","volume":"13","author":"Depoorter","year":"2021","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.jes.2024.11.013_bib0027","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nm.2717","article-title":"NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components","volume":"18","author":"Doyle","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.jes.2024.11.013_bib0028","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1058925","article-title":"Chemical signaling in the developing avian retina: focus on cyclic AMP and AKT-dependent pathways","volume":"10","author":"Duarte-Silva","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.jes.2024.11.013_bib0029","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1006\/dbio.1996.0335","article-title":"The development of vision in the zebrafish (Danio rerio)","volume":"180","author":"Easter","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jes.2024.11.013_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119567","article-title":"Asiatic acid attenuates diabetic retinopathy through TLR4\/MyD88\/NF-\u03baB p65 mediated modulation of microglia polarization","volume":"277","author":"Fang","year":"2021","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.jes.2024.11.013_bib0031","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.taap.2004.08.012","article-title":"Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin","volume":"203","author":"Fischer","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jes.2024.11.013_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.168572","article-title":"Imidacloprid affects the visual behavior of adult zebrafish (Danio rerio) by mediating the expression of opsin and phototransduction genes and altering the metabolism of neurotransmitters","volume":"910","author":"Fu","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"6491","key":"10.1016\/j.jes.2024.11.013_bib0033","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.aba0478","article-title":"Microbial\u2013host molecular exchange and its functional consequences in early mammalian life","volume":"368","author":"Ganal-Vonarburg","year":"2020","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.jes.2024.11.013_bib0034","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.immuni.2018.11.018","article-title":"Commensals suppress intestinal epithelial cell retinoic acid synthesis to regulate interleukin-22 activity and prevent microbial dysbiosis","volume":"49","author":"Grizotte-Lake","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.jes.2024.11.013_bib0035","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.chemosphere.2018.10.218","article-title":"Neurobehavioral effects of bisphenol S exposure in early life stages of zebrafish larvae (Danio rerio)","volume":"217","author":"Gu","year":"2019","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.jes.2024.11.013_bib0036","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/MCG.0b013e3182549092","article-title":"World gastroenterology organisation global guidelines","volume":"46","author":"Guarner","year":"2012","journal-title":"J. Clin. Gastroenterol."},{"issue":"7","key":"10.1016\/j.jes.2024.11.013_bib0037","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tim.2017.11.002","article-title":"Human gut microbiome: function matters","volume":"26","author":"Heintz-Buschart","year":"2018","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jes.2024.11.013_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127409","article-title":"Probiotic modulation of perfluorobutanesulfonate toxicity in zebrafish: disturbances in retinoid metabolism and visual physiology","volume":"258","author":"Hu","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2024.11.013_bib0039","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jhazmat.2013.07.030","article-title":"Phenanthrene causes ocular developmental toxicity in zebrafish embryos and the possible mechanisms involved","volume":"261","author":"Huang","year":"2013","journal-title":"J. Hazard. Mater."},{"issue":"29","key":"10.1016\/j.jes.2024.11.013_bib0040","doi-asserted-by":"crossref","first-page":"73018","DOI":"10.1007\/s11356-023-27629-3","article-title":"Fish to learn: insights into the effects of environmental chemicals on eye development and visual function in zebrafish","volume":"30","author":"Huang","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"5","key":"10.1016\/j.jes.2024.11.013_bib0041","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121422","article-title":"Exposure to organic solvents used in dry cleaning reduces low and high level visual function","volume":"10","author":"Jim\u00e9nez Barbosa","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jes.2024.11.013_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101799","article-title":"Oxidative stress and diabetic retinopathy: molecular mechanisms, pathogenetic role and therapeutic implications","volume":"37","author":"Kang","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.jes.2024.11.013_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105194","article-title":"Multimedia distributions, bioaccumulation, and trophic transfer of microcystins in the Geum River Estuary, Korea: application of compound-specific isotope analysis of amino acids","volume":"133","author":"Kim","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.jes.2024.11.013_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142362","article-title":"Rapid freshwater discharge on the coastal ocean as a mean of long distance spreading of an unprecedented toxic cyanobacteria bloom","volume":"754","author":"Kruk","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"43","key":"10.1016\/j.jes.2024.11.013_bib0045","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100566118","article-title":"Short-term high-fat feeding exacerbates degeneration in retinitis pigmentosa by promoting retinal oxidative stress and inflammation","volume":"118","author":"Kutsyr","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jes.2024.11.013_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117620","article-title":"In situ use of bivalves and passive samplers to reveal water contamination by microcystins along a freshwater-marine continuum in France","volume":"204","author":"Lance","year":"2021","journal-title":"Water Res."},{"issue":"6","key":"10.1016\/j.jes.2024.11.013_bib0047","doi-asserted-by":"crossref","first-page":"5404","DOI":"10.3390\/ijms24065404","article-title":"Environmental enrichment protects against neurotoxic effects of lipopolysaccharide: a comprehensive overview","volume":"24","author":"Landolfo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.jes.2024.11.013_bib0048","doi-asserted-by":"crossref","first-page":"10378","DOI":"10.3390\/ijms241210378","article-title":"Lactobacillus fermentum HY7302 improves dry eye symptoms in a mouse model of benzalkonium chloride-induced eye dysfunction and human conjunctiva epithelial cells","volume":"24","author":"Lee","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jes.2024.11.013_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.167167","article-title":"Advances in investigating microcystin-induced liver toxicity and underlying mechanisms","volume":"905","author":"Li","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.jes.2024.11.013_bib0050","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/toxsci\/kfx030","article-title":"Editor's highlight: periodic exposure to smartphone-mimic low-luminance blue light induces retina damage through Bcl-2\/BAX-dependent apoptosis","volume":"157","author":"Lin","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jes.2024.11.013_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.151749","article-title":"The presence of polystyrene nanoplastics enhances the MCLR uptake in zebrafish leading to the exacerbation of oxidative liver damage","volume":"818","author":"Ling","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jes.2024.11.013_bib0052","article-title":"Causal effects of gut microbiota on diabetic retinopathy: a mendelian randomization study","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jes.2024.11.013_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114832","article-title":"Dietary administration of probiotic Lactobacillus rhamnosus modulates the neurological toxicities of perfluorobutanesulfonate in zebrafish","volume":"265","author":"Liu","year":"2020","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.jes.2024.11.013_bib0054","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.fsi.2013.04.010","article-title":"Comparison of adhesive gut bacteria composition, immunity, and disease resistance in juvenile hybrid tilapia fed two different Lactobacillus strains","volume":"35","author":"Liu","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jes.2024.11.013_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.168058","article-title":"Probiotic Lactobacillus rhamnosus alleviates the neurotoxicity of microcystin-LR in zebrafish (Danio rerio) through the gut-brain axis","volume":"908","author":"Luan","year":"2024","journal-title":"Sci. Total Environ."},{"issue":"17","key":"10.1016\/j.jes.2024.11.013_bib0056","doi-asserted-by":"crossref","first-page":"13338","DOI":"10.3390\/ijms241713338","article-title":"Targeting the gut\u2013eye axis: an emerging strategy to face ocular diseases","volume":"24","author":"Maria","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jes.2024.11.013_bib0057","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ecoenv.2017.10.026","article-title":"Biomarker and histopathological responses of Lates calcarifer on exposure to sub lethal concentrations of chlorpyrifos","volume":"148","author":"Marigoudar","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"17","key":"10.1016\/j.jes.2024.11.013_bib0058","doi-asserted-by":"crossref","first-page":"8094","DOI":"10.1093\/nar\/gkt595","article-title":"Estrogen receptor \u03b1 can selectively repress dioxin receptor-mediated gene expression by targeting DNA methylation","volume":"41","author":"Marques","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jes.2024.11.013_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbd.2022.100993","article-title":"Sex-dependent host-microbiome dynamics in zebrafish: implications for toxicology and gastrointestinal physiology","volume":"42","author":"Martyniuk","year":"2022","journal-title":"Comp. Biochem. Physiol. Part D Genomics Proteomics"},{"issue":"4","key":"10.1016\/j.jes.2024.11.013_bib0060","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1021\/acs.est.9b07540","article-title":"Micro- and nanoplastics in alpine snow: a new method for chemical identification and (semi)quantification in the nanogram range","volume":"54","author":"Materi\u0107","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.jes.2024.11.013_bib0061","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.toxicon.2005.03.013","article-title":"Removal of the cyanobacterial toxin microcystin-LR by human probiotics","volume":"46","author":"Meriluoto","year":"2005","journal-title":"Toxicon"},{"issue":"14","key":"10.1016\/j.jes.2024.11.013_bib0062","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1021\/jf506326t","article-title":"Probiotics as potential antioxidants: a systematic review","volume":"63","author":"Mishra","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jes.2024.11.013_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104251","article-title":"Microbial communities modulating brain functioning and behaviors in zebrafish: a mechanistic approach","volume":"145","author":"Mohanta","year":"2020","journal-title":"Microb. Pathog."},{"issue":"10","key":"10.1016\/j.jes.2024.11.013_bib0064","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.18632\/aging.101583","article-title":"Long-term intake of Lactobacillus paracasei KW3110 prevents age-related chronic inflammation and retinal cell loss in physiologically aged mice","volume":"10","author":"Morita","year":"2018","journal-title":"Aging"},{"key":"10.1016\/j.jes.2024.11.013_bib0065","article-title":"Cyanotoxins in groundwater; occurrence, potential sources, health impacts and knowledge gap for public health","volume":"226","author":"Mulalo","year":"2023","journal-title":"Toxicon"},{"key":"10.1016\/j.jes.2024.11.013_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2019.100778","article-title":"Innate immune response in retinal homeostasis and inflammatory disorders","volume":"74","author":"Murakami","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"issue":"1","key":"10.1016\/j.jes.2024.11.013_bib0067","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/neu.10165","article-title":"Behavioral genetic approaches to visual system development and function in zebrafish","volume":"54","author":"Neuhauss","year":"2003","journal-title":"J. Neurobiol."},{"issue":"3","key":"10.1016\/j.jes.2024.11.013_bib0069","article-title":"Combining hyperspectral imaging and chemometrics to assess and interpret the effects of environmental stressors on zebrafish eye images at tissue level","volume":"11","author":"Olmos","year":"2017","journal-title":"J. Biophotonics"},{"key":"10.1016\/j.jes.2024.11.013_bib0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2020.111500","article-title":"Are there concerns regarding cHAB in coastal bathing waters affected by freshwater-brackish continuum?","volume":"159","author":"Overling\u0117","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.jes.2024.11.013_bib0071","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.marenvres.2015.10.015","article-title":"Insights into neurosensory toxicity of mercury in fish eyes stemming from tissue burdens, oxidative stress and synaptic transmission profiles","volume":"113","author":"Pereira","year":"2016","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.jes.2024.11.013_bib0072","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.chemosphere.2016.05.038","article-title":"Microcystin-LR induced developmental toxicity and apoptosis in zebrafish (Danio rerio) larvae by activation of ER stress response","volume":"157","author":"Qi","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2024.11.013_bib0073","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.aquatox.2017.09.012","article-title":"Short-term and persistent impacts on behaviors related to locomotion, anxiety, and startle responses of Japanese medaka (Oryzias latipes) induced by acute, sublethal exposure to chlorpyrifos","volume":"192","author":"Qiu","year":"2017","journal-title":"Aquat. Toxicol."},{"issue":"3","key":"10.1016\/j.jes.2024.11.013_bib0074","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00128-016-1849-9","article-title":"Effects of chronic dietary selenomethionine exposure on the visual system of adult and F1 generation zebrafish (Danio rerio)","volume":"97","author":"Raine","year":"2016","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.jes.2024.11.013_bib0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119973","article-title":"Exercise training and probiotic supplementation effects on skeletal muscle apoptosis prevention in type-\u0399 diabetic rats","volume":"285","author":"Rezaee","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.jes.2024.11.013_bib0076","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.fsi.2021.12.037","article-title":"Probiotics, prebiotics and synbiotics improved the functionality of aquafeed: upgrading growth, reproduction, immunity and disease resistance in fish","volume":"120","author":"Rohani","year":"2022","journal-title":"Fish Shellfish Immunol."},{"issue":"22","key":"10.1016\/j.jes.2024.11.013_bib0077","doi-asserted-by":"crossref","first-page":"E4472","DOI":"10.1073\/pnas.1702302114","article-title":"Involvement of a gut\u2013retina axis in protection against dietary glycemia-induced age-related macular degeneration","volume":"114","author":"Rowan","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"5","key":"10.1016\/j.jes.2024.11.013_bib0078","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s12038-019-9931-1","article-title":"Connect between gut microbiome and diseases of the human eye","volume":"44","author":"Shivaji","year":"2019","journal-title":"J. Biosci."},{"key":"10.1016\/j.jes.2024.11.013_bib0079","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.toxicon.2021.02.004","article-title":"Occurrence of microcystins, anabaenopeptins and other cyanotoxins in fish from a freshwater wildlife reserve impacted by harmful cyanobacterial blooms","volume":"194","author":"Skafi","year":"2021","journal-title":"Toxicon"},{"key":"10.1016\/j.jes.2024.11.013_bib0080","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.777665","article-title":"Lactic acid-producing probiotic saccharomyces cerevisiae attenuates ulcerative colitis via suppressing macrophage pyroptosis and modulating gut microbiota","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Immunol."},{"issue":"37","key":"10.1016\/j.jes.2024.11.013_bib0081","doi-asserted-by":"crossref","first-page":"15109","DOI":"10.1073\/pnas.1303551110","article-title":"Cone photoreceptor types in zebrafish are generated by symmetric terminal divisions of dedicated precursors","volume":"110","author":"Suzuki","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jes.2024.11.013_bib0082","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.aquatox.2013.01.009","article-title":"Effects of chronic dietary selenomethionine exposure on repeat swimming performance, aerobic metabolism and methionine catabolism in adult zebrafish (Danio rerio)","volume":"130","author":"Thomas","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.jes.2024.11.013_bib0083","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3389\/fcimb.2019.00221","article-title":"Lactobacillus plantarum TW1-1 alleviates diethylhexylphthalate-induced testicular damage in mice by modulating gut microbiota and decreasing inflammation","volume":"9","author":"Tian","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.jes.2024.11.013_bib0084","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1017\/S0952523899163168","article-title":"Cloning and characterization of six zebrafish photoreceptor opsin cDNAs and immunolocalization of their corresponding proteins","volume":"16","author":"Vihtelic","year":"1999","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.jes.2024.11.013_bib0085","first-page":"1","article-title":"Hyperreflective intraretinal spots in diabetics without and with nonproliferative diabetic retinopathy: an in vivo study using spectral domain OCT","volume":"2013","author":"Vujosevic","year":"2013","journal-title":"J. Diabetes Res."},{"issue":"2","key":"10.1016\/j.jes.2024.11.013_bib0086","article-title":"From unusual suspect to serial killer: cyanotoxins boosted by climate change may jeopardize megafauna","volume":"2","author":"Wang","year":"2021","journal-title":"Innovation"},{"issue":"12","key":"10.1016\/j.jes.2024.11.013_bib0087","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.049568","article-title":"Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants","volume":"15","author":"Wang","year":"2022","journal-title":"Dis. Models Mech."},{"issue":"6","key":"10.1016\/j.jes.2024.11.013_bib0088","doi-asserted-by":"crossref","DOI":"10.1289\/EHP12034","article-title":"Effects of cyanobacterial harmful algal bloom toxin microcystin-LR on gonadotropin-dependent ovarian follicle maturation and ovulation in mice","volume":"131","author":"Wang","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.jes.2024.11.013_bib0089","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.119791","article-title":"Microcystin pollution in lakes and reservoirs: a nationwide meta-analysis and assessment in China","volume":"309","author":"Wei","year":"2022","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.jes.2024.11.013_bib0090","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/tox.22689","article-title":"The sonic hedgehog signaling pathway is suppressed following PCB1254 exposure during retinal development","volume":"34","author":"Wei","year":"2018","journal-title":"Environ. Toxicol."},{"issue":"12","key":"10.1016\/j.jes.2024.11.013_bib0091","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1039\/C8EN00865E","article-title":"Parental transfer of titanium dioxide nanoparticle aggravated MCLR-induced developmental toxicity in zebrafish offspring","volume":"5","author":"Wu","year":"2018","journal-title":"Environ. Sci. Nano"},{"key":"10.1016\/j.jes.2024.11.013_bib0092","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.envpol.2016.03.048","article-title":"Microcystin-LR exposure induces developmental neurotoxicity in zebrafish embryo","volume":"213","author":"Wu","year":"2016","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.jes.2024.11.013_bib0093","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.etap.2012.10.004","article-title":"Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae","volume":"35","author":"Xu","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jes.2024.11.013_bib0094","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/bs.vh.2017.05.001","article-title":"Thyroid hormone signaling in retinal development, survival, and disease","volume":"106","author":"Yang","year":"2018","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.jes.2024.11.013_bib0095","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.aquatox.2014.01.021","article-title":"The role of apoptosis in MCLR-induced developmental toxicity in zebrafish embryos","volume":"149","author":"Zeng","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.jes.2024.11.013_bib0096","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ecoenv.2015.04.026","article-title":"PCB1254 exposure contributes to the abnormalities of optomotor responses and influence of the photoreceptor cell development in zebrafish larvae","volume":"118","author":"Zhang","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"34","key":"10.1016\/j.jes.2024.11.013_bib0097","doi-asserted-by":"crossref","first-page":"9788","DOI":"10.1021\/acs.jafc.1c03301","article-title":"Lactobacillus rhamnosus GG ameliorated long-term exposure to TiO2 nanoparticles induced microbiota-mediated liver and colon inflammation and fructose-caused metabolic abnormality in metabolism syndrome mice","volume":"69","author":"Zhao","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jes.2024.11.013_bib0098","doi-asserted-by":"crossref","first-page":"40826","DOI":"10.1038\/srep40826","article-title":"Association of the intestinal microbiome with the development of neovascular age-related macular degeneration","volume":"7","author":"Zinkernagel","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jes.2024.11.013_bib0099","article-title":"The role of the gut microbiome in eye diseases","volume":"92","author":"Zysset-Burri","year":"2022","journal-title":"Prog. Retin. Eye Res."}],"container-title":["Journal of Environmental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074224005485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074224005485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:22:37Z","timestamp":1778577757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1001074224005485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":97,"alternative-id":["S1001074224005485"],"URL":"https:\/\/doi.org\/10.1016\/j.jes.2024.11.013","relation":{},"ISSN":["1001-0742"],"issn-type":[{"value":"1001-0742","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Probiotic Lactobacillus rhamnosus alleviates microcystin-LR induced visual system defects and dysfunction in zebrafish by modulating apoptosis, retinal inflammation, and phototransduction","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jes.2024.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}