{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:01:01Z","timestamp":1777885261306,"version":"3.51.4"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011319","name":"Jianghan University","doi-asserted-by":"publisher","award":["2023XKZ029"],"award-info":[{"award-number":["2023XKZ029"]}],"id":[{"id":"10.13039\/501100011319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2 2193051"],"award-info":[{"award-number":["2 2193051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21607059"],"award-info":[{"award-number":["21607059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Environmental Sciences"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jes.2025.07.055","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T10:27:25Z","timestamp":1755253645000},"page":"731-740","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Oxygen-dependent conformation change of hemoglobin modulates methylmercury binding"],"prefix":"10.1016","volume":"163","author":[{"given":"Tian","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiming","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2066-2784","authenticated-orcid":false,"given":"Lufeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongguang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2212-6694","authenticated-orcid":false,"given":"Yong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jes.2025.07.055_bib0001","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s00244-001-0005-6","article-title":"In vitro study of methylmercury in blood of bottlenose dolphins (Tursiops truncatus)","volume":"42","author":"Ancora","year":"2002","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.jes.2025.07.055_bib0002","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.scitotenv.2017.08.260","article-title":"Species- and habitat-specific bioaccumulation of total mercury and methylmercury in the food web of a deep oligotrophic lake","volume":"612","author":"Arcagni","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.jes.2025.07.055_bib0003","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s13280-023-01831-6","article-title":"Our evolved understanding of the human health risks of mercury","volume":"52","author":"Basu","year":"2023","journal-title":"Ambio"},{"issue":"Suppl 1","key":"10.1016\/j.jes.2025.07.055_bib0004","doi-asserted-by":"crossref","first-page":"6","DOI":"10.7241\/ourd.2021S1.2","article-title":"The contribution of direct immunofluorescence in the diagnosis of inflammatory skin dermatoses","volume":"12","author":"Belmourida","year":"2021","journal-title":"Our Dermatol. Online"},{"issue":"12","key":"10.1016\/j.jes.2025.07.055_bib0005","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S0045-6535(99)00283-0","article-title":"Ecological effects, transport, and fate of mercury: a general review","volume":"40","author":"Boening","year":"2000","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2025.07.055_bib0006","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.dsr2.2014.07.004","article-title":"Mercury in the north atlantic ocean: the U.S. geotraces zonal and meridional sections","volume":"116","author":"Bowman","year":"2015","journal-title":"Deep Sea Res. Part II"},{"issue":"6","key":"10.1016\/j.jes.2025.07.055_bib0007","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/icb\/37.6.633","article-title":"The challenges of living in hypoxic and hypercapnic aquatic environments","volume":"37","author":"Burnett","year":"1997","journal-title":"Am. Zool."},{"key":"10.1016\/j.jes.2025.07.055_bib0008","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.chemosphere.2019.01.137","article-title":"Toxic effects of Cr(VI) on the bovine hemoglobin and human vascular endothelial cells: molecular interaction and cell damage","volume":"222","author":"Cao","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2025.07.055_bib0009","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.saa.2019.02.108","article-title":"Fluorescence enhancement via aggregation effect due to microenvironmental alterations in human hemoglobin protein in presence of carbon quantum dots (CQD): comparative spectroscopic approach","volume":"215","author":"Chakraborty","year":"2019","journal-title":"Spectrochim. Acta A"},{"issue":"8","key":"10.1016\/j.jes.2025.07.055_bib0010","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.7150\/thno.39944","article-title":"The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jes.2025.07.055_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.130011","article-title":"Release of legacy mercury and effect of aquaculture on mercury biogeochemical cycling in highly polluted Ya-Er Lake, China","volume":"275","author":"Chen","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.jes.2025.07.055_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.707797","article-title":"Stability of maleimide-peg and mono-sulfone-peg conjugation to a novel engineered cysteine in the human hemoglobin alpha subunit","volume":"9","author":"Cooper","year":"2021","journal-title":"Front. Chem."},{"issue":"2","key":"10.1016\/j.jes.2025.07.055_bib0013","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.etap.2014.01.021","article-title":"Study of the interaction between mercury (II) and bovine serum albumin by spectroscopic methods","volume":"37","author":"Dai","year":"2014","journal-title":"J. Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jes.2025.07.055_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcmd.2020.102520","article-title":"Modulation of red blood cell oxygen affinity with a novel allosteric modifier of hemoglobin is additive to the Bohr effect","volume":"87","author":"Evans","year":"2021","journal-title":"Blood Cells Mol. Dis."},{"issue":"4","key":"10.1016\/j.jes.2025.07.055_bib0015","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10646-024-02747-x","article-title":"Global mercury concentrations in biota: their use as a basis for a global biomonitoring framework","volume":"33","author":"Evers","year":"2024","journal-title":"Ecotoxicology"},{"issue":"3","key":"10.1016\/j.jes.2025.07.055_bib0016","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/cyto.990200307","article-title":"Scatchard analysis of fluorescent concanavalin a binding to lymphocytes","volume":"20","author":"Gordon","year":"1995","journal-title":"Cytometry"},{"issue":"9","key":"10.1016\/j.jes.2025.07.055_bib0017","first-page":"922","article-title":"Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free radic","volume":"27","author":"Griffith","year":"1999","journal-title":"Biol. Med."},{"issue":"2","key":"10.1016\/j.jes.2025.07.055_bib0018","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1056\/NEJMoa0801581","article-title":"Arterial blood gases and oxygen content in climbers on mount everest","volume":"360","author":"Grocott","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.jes.2025.07.055_bib0019","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1016\/S0021-9258(18)97129-2","article-title":"The rates of reaction of the sulfhydryl groups of human hemoglobin","volume":"240","author":"Guidotti","year":"1965","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jes.2025.07.055_bib0020","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0160-4120(01)00059-9","article-title":"Mercury pollution in the tapajos River basin, amazon: mercury level of head hair and health effects","volume":"27","author":"Harada","year":"2001","journal-title":"Environ. Int."},{"issue":"13","key":"10.1016\/j.jes.2025.07.055_bib0021","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1182\/blood.2021012070","article-title":"Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin","volume":"138","author":"Henry","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jes.2025.07.055_bib0022","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.coemr.2019.12.001","article-title":"Acute high-altitude pathologies and their treatment","volume":"11","author":"Jackson","year":"2020","journal-title":"Curr. Opin. Endocr. Metab. Res."},{"issue":"5","key":"10.1016\/j.jes.2025.07.055_bib0023","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.bbagen.2015.08.018","article-title":"Dissecting ITC data of metal ions binding to ligands and proteins","volume":"1860","author":"Johnson","year":"2016","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"issue":"34","key":"10.1016\/j.jes.2025.07.055_bib0024","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1021\/jp402292b","article-title":"Subunit disassembly pathway of human hemoglobin revealing the site-specific role of its cysteine residues","volume":"117","author":"Kan","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jes.2025.07.055_bib0025","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00244-017-0502-x","article-title":"Children\u2019s hair mercury concentrations and seafood consumption in five regions of Japan","volume":"74","author":"Kusanagi","year":"2018","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"9","key":"10.1016\/j.jes.2025.07.055_bib0026","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/jez.2054","article-title":"Effects of hypoxia and hypercapnic hypoxia on oxygen transport and acid\u2013base status in the atlantic blue crab, callinectes sapidus, during exercise","volume":"325","author":"Lehtonen","year":"2016","journal-title":"J. Exp. Zool., Part A"},{"key":"10.1016\/j.jes.2025.07.055_bib0027","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.jallcom.2016.06.119","article-title":"Rapid and sensitive detection of hemoglobin with gold nanoparticles based fluorescence sensor in aqueous solution","volume":"685","author":"Li","year":"2016","journal-title":"J. Alloys Compd."},{"key":"10.1016\/j.jes.2025.07.055_bib0028","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jconrel.2017.05.018","article-title":"pH triggered re-assembly of nanosphere to nanofiber: the role of peptide conformational change for enhanced cancer therapy","volume":"260","author":"Liang","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jes.2025.07.055_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123063","article-title":"Isothermal titration calorimetry (ITC) as a promising tool in pharmaceutical nanotechnology","volume":"641","author":"Lima Cavalcanti","year":"2023","journal-title":"Int. J. Pharm."},{"issue":"5","key":"10.1016\/j.jes.2025.07.055_bib0030","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/j.bbagen.2012.09.008","article-title":"Glutathione synthesis","volume":"1830","author":"Lu","year":"2013","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"issue":"3","key":"10.1016\/j.jes.2025.07.055_bib0031","first-page":"40","article-title":"Mathematical analysis of scatchard plots for hormone-receptor molecular interactions","volume":"7","author":"Luo","year":"1980","journal-title":"Prog. Biochem. Biophys."},{"issue":"3","key":"10.1016\/j.jes.2025.07.055_bib0032","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1021\/acs.est.0c06269","article-title":"In vivo formation of HgSe nanoparticles and Hg\u2013tetraselenolate complex from methylmercury in seabirds\u2014Implications for the Hg\u2013Se antagonism","volume":"55","author":"Manceau","year":"2021","journal-title":"Environ. Sci. Technol."},{"issue":"45","key":"10.1016\/j.jes.2025.07.055_bib0033","doi-asserted-by":"crossref","first-page":"14904","DOI":"10.1021\/jp9062115","article-title":"Fluorescence spectroscopic characterization of the interaction of human adult hemoglobin and two isatins, 1-methylisatin and 1-phenylisatin: a comparative study","volume":"113","author":"Mandal","year":"2009","journal-title":"J. Phys. Chem. B"},{"issue":"12","key":"10.1016\/j.jes.2025.07.055_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2019.01.006","article-title":"Methylmercury\u2019s chemistry: from the environment to the mammalian brain","volume":"1863","author":"Nogara","year":"2019","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"issue":"9","key":"10.1016\/j.jes.2025.07.055_bib0035","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1139\/f73-209","article-title":"Uptake of methyl mercuric chloride and mercuric chloride by trout: a study of uptake pathways into the whole animal and uptake by erythrocytes in vitro","volume":"30","author":"Olson","year":"1973","journal-title":"J. Fish. Res. Board Can."},{"issue":"20","key":"10.1016\/j.jes.2025.07.055_bib0036","first-page":"11466","article-title":"Updated global and oceanic mercury budgets for the United Nations global mercury assessment 2018","volume":"52","author":"Outridge","year":"2018","journal-title":"Environ. Sci. Technol."},{"issue":"4","key":"10.1016\/j.jes.2025.07.055_bib0037","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1006\/jmbi.1996.0124","article-title":"Crystal structure of t state haemoglobin with oxygen bound at all four haems","volume":"256","author":"Paoli","year":"1996","journal-title":"J. Mol. Biol."},{"issue":"3","key":"10.1016\/j.jes.2025.07.055_bib0038","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jmb.2006.05.036","article-title":"1.25A resolution crystal structures of human haemoglobin in the oxy, deoxy and carbonmonoxy forms","volume":"360","author":"Park","year":"2006","journal-title":"J. Mol. Biol."},{"issue":"4","key":"10.1016\/j.jes.2025.07.055_bib0039","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s00216-013-7274-6","article-title":"Hemoglobin as a major binding protein for methylmercury in white-sided dolphin liver","volume":"406","author":"Pedrero Zayas","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jes.2025.07.055_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2023.104086","article-title":"Ventilatory function and oxygen delivery at high altitude in the himalayas","volume":"314","author":"Prosperi","year":"2023","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"5","key":"10.1016\/j.jes.2025.07.055_bib0041","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1021\/acs.molpharmaceut.6b01124","article-title":"Biophysical study on the interaction between eperisone hydrochloride and human serum albumin using spectroscopic, calorimetric, and molecular docking analyses","volume":"14","author":"Rabbani","year":"2017","journal-title":"Mol. Pharm."},{"issue":"4","key":"10.1016\/j.jes.2025.07.055_bib0042","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1085\/jgp.39.4.585","article-title":"Sulfhydrl groups and the structure ure of hemoglobin","volume":"39","author":"Riggs","year":"1956","journal-title":"J. Gen. Physiol."},{"issue":"2","key":"10.1016\/j.jes.2025.07.055_bib0043","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0022-2836(67)90141-6","article-title":"On the mechanism of the dissociation of haemoglobin","volume":"25","author":"Rosemeyer","year":"1967","journal-title":"J. Mol. Biol."},{"issue":"6","key":"10.1016\/j.jes.2025.07.055_bib0044","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/BF01024769","article-title":"Binding of thyroid hormones to human hemoglobin and localization of the binding site","volume":"9","author":"Sakata","year":"1990","journal-title":"J. Protein Chem."},{"issue":"1","key":"10.1016\/j.jes.2025.07.055_bib0045","first-page":"57","article-title":"Python: a programming language for software integration and development","volume":"17","author":"Sanner","year":"1999","journal-title":"J. Mol. Graph. Model."},{"issue":"1\u20133","key":"10.1016\/j.jes.2025.07.055_bib0046","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cis.2005.05.006","article-title":"Thirty years of haemoglobin electrochemistry","volume":"116","author":"Scheller","year":"2005","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.jes.2025.07.055_bib0047","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jphotobiol.2018.07.007","article-title":"Binding interaction of phenazinium-based cationic photosensitizers with human hemoglobin: exploring the effects of pH and chemical structure","volume":"186","author":"Sen","year":"2018","journal-title":"J. Photochem. Photobiol., B"},{"issue":"4","key":"10.1016\/j.jes.2025.07.055_bib0048","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/15257770.2021.1880010","article-title":"Spectroscopic and docking molecular study of new anticancer Pt complex binding with human serum albumin","volume":"40","author":"Shiekhzadeh","year":"2021","journal-title":"Nucleos. Nucleot. Nucl."},{"issue":"1","key":"10.1016\/j.jes.2025.07.055_bib0049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00128336","article-title":"Mopac: a semiempirical molecular orbital program","volume":"4","author":"Stewart","year":"1990","journal-title":"J. Comput. -Aided Mol. Des."},{"issue":"4","key":"10.1016\/j.jes.2025.07.055_bib0050","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s11325-019-01784-9","article-title":"The correct measurement of oxygen saturation at high altitude","volume":"23","author":"Tannheimer","year":"2019","journal-title":"Sleep Breath"},{"key":"10.1016\/j.jes.2025.07.055_bib0051","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.saa.2018.12.040","article-title":"Multi-spectroscopic approaches and molecular simulation research of the intermolecular interaction between the angiotensin-converting enzyme inhibitor (ACE inhibitor) benazepril and bovine serum albumin (BSA)","volume":"212","author":"Wang","year":"2019","journal-title":"Spectrochim. Acta, Part A"},{"key":"10.1016\/j.jes.2025.07.055_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127279","article-title":"Adsorption isotherm models: classification, physical meaning, application and solving method","volume":"258","author":"Wang","year":"2020","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.jes.2025.07.055_bib0053","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1021\/j100809a020","article-title":"Oxygen quenching of fluorescence in solution: an experimental study of the diffusion process","volume":"66","author":"Ware","year":"1962","journal-title":"J. Phys. Chem."},{"issue":"12","key":"10.1016\/j.jes.2025.07.055_bib0054","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1164\/rccm.201207-1323CI","article-title":"High-altitude medicine","volume":"186","author":"West","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jes.2025.07.055_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.132665","article-title":"In vitro studies of hemoglobin\u2019s affinity for the vitamin b9 and control of its stability character","volume":"271","author":"Wiglusz","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.jes.2025.07.055_bib0056","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.3390\/nu13103448","article-title":"Dose- and sex-dependent changes in hemoglobin oxygen affinity by the micronutrient 5-hydroxymethylfurfural and \u03b1-ketoglutaric acid","volume":"13","author":"Woyke","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jes.2025.07.055_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2019.117306","article-title":"Probing the interaction between levamlodipine and hemoglobin based on spectroscopic and molecular docking methods","volume":"223","author":"Xu","year":"2019","journal-title":"Spectrochim. Acta, Part A"},{"key":"10.1016\/j.jes.2025.07.055_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.123297","article-title":"Photochemical demethylation of methylmercury (MeHg) in aquatic systems: a review of MeHg species, mechanisms, and influencing factors","volume":"344","author":"Yu","year":"2024","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.jes.2025.07.055_bib0059","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10661-011-1948-3","article-title":"Risk assessment for methylmercury in fish from the songhua river, china: 30 years after mercury-containing wastewater outfalls were eliminated","volume":"184","author":"Zhu","year":"2012","journal-title":"Environ. Monit. Assess."},{"issue":"06","key":"10.1016\/j.jes.2025.07.055_bib0060","first-page":"466","article-title":"Scatchard plotting and parameter resolution method","volume":"8","author":"Zhu","year":"1986","journal-title":"Acta Acad. Med. Sin."},{"key":"10.1016\/j.jes.2025.07.055_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.112975","article-title":"Mercury accumulation in freshwater and marine fish from the wild and from aquaculture ponds","volume":"255","author":"Zupo","year":"2019","journal-title":"Environ. Pollut."}],"container-title":["Journal of Environmental Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074225004863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1001074225004863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:55:50Z","timestamp":1777604150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1001074225004863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":61,"alternative-id":["S1001074225004863"],"URL":"https:\/\/doi.org\/10.1016\/j.jes.2025.07.055","relation":{},"ISSN":["1001-0742"],"issn-type":[{"value":"1001-0742","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxygen-dependent conformation change of hemoglobin modulates methylmercury binding","name":"articletitle","label":"Article Title"},{"value":"Journal of Environmental Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jes.2025.07.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}